The prospective study for the effects of culture-expanded bone marrow cells on the regeneration bone.

• Project/Area Number: 24249076
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya University
• Principal Investigator: Ishiguro Naoki 名古屋大学, 医学(系)研究科(研究院), 教授 (20212871)
• Co-Investigator(Kenkyū-buntansha): MIZUNO MASAAKI 名古屋大学, 医学部附属病院, 病院教授 (70283439) ; NISHIDA YOSHIHIRO 名古屋大学, 医学系研究科, 准教授 (50332698) ; KITOH HIROSHI 名古屋大学, 医学系研究科, 准教授 (40291174) ; SAKAI TADAHIRO 名古屋大学, 医学部附属病院, 病院講師 (60378198) ; KATOH KATHUYOSHI 名古屋大学, 医学部附属病院, 講師 (80595520) ; MISHIMA KENICHI 名古屋大学, 医学系研究科, 寄附講座助教 (40646519) ; KANEKO HIROSHI 名古屋大学, 医学系研究科, 寄附講座助教 (60566975)
• Co-Investigator(Renkei-kenkyūsha): OHNO KINJI 名古屋大学, 医学系研究科, 教授 (80397455) ; NARUSE KEIJI 岡山大学, 大学院医歯薬学総合研究科, 教授 (40252233)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000); Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000); Fiscal Year 2014: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000); Fiscal Year 2013: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000); Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
• Keywords: ヒト幹細胞 / 臨床研究 / 培養骨髄細胞 / 脚延長術 / 培養骨芽細胞 / 骨髄幹細胞 / RUNX2 / 骨芽細胞 / 脚延長

Outline of Final Research Achievements

Bone marrow derived mesenchymal stem cells (BMC) can be directed towards the osteogenic lineage if cultured in the suitable condition. We have introduced a novel cell therapy of BMC and Platelet rich plasma (PRP) transplantation in lower limb lengthenings. Retrospective studies demonstrated that transplantation of culture expanded BMC and PRP into the distracted callus shortened the treatment periods and reduced associated complications. We conducted the prospective single arm clinical study in accordance with the regulation. We successfully enrolled the enough number of patients during the study term. Also we did preclinical experiment reveal the effects of the transplanted cells on the regeneration of bone with animal models. We showed that cells locally transplanted were not detected in other tissues at two weeks after transplantation.We concluded that donor cells do not migrate to other tissues or organs and do not show any negative effects to the recipients.

Research Products

• [Journal Article] Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters. (2016)
  • Author(s): Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 470(2) Issue: 2 Pages: 356-61
  • DOI: 10.1016/j.bbrc.2016.01.044
  • Peer Reviewed / Open Access
• [Journal Article] Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients (2016)
  • Author(s): Kojima, T., Takahashi, N., Kaneko, A., Kida, D., Hirano, Y., Fujibayashi, T., Yabe, Y., Takagi, H., Oguchi, T., Miyake, H., Kato, T., Watanabe, T., Hayashi, M., Shioura, T., Kanayama, Y., Funahashi, K., Asai, S., Yoshioka, Y., Terabe, K., Takemoto, T., Asai, N., Ishiguro, N.
  • Journal Title: Clinical Rheumatology Volume: 35 Issue: 1 Pages: 219-25
  • DOI: 10.1007/s10067-015-3135-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Disease activity early in treatment as a predictor of future low disease activity in RA patients treated with iguratimod. (2016)
  • Author(s): Yoshioka Y, Takahashi N, Kaneko A, Hirano Y, Kanayama Y, Kanda H, Takagi H, Ito T, Kato T, Saito K, Funahashi K, Asai S, Takemoto T, Terabe K, Asai N, Ishiguro N, Kojima T.
  • Journal Title: Mod Rheumatol. Volume: 26(2) Issue: 2 Pages: 169-74
  • DOI: 10.3109/14397595.2015.1069475
  • Peer Reviewed
• [Journal Article] Lansoprazole upregulates polyubiquitination of TRAF6 and facilitates Runx2-mediated osteoblastogenesis (2015)
  • Author(s): Kenichi Mishima, Hiroshi Kitoh, Bisei Ohkawara, Tatsuya Okuno, Mikako Ito, Akio Masuda, Naoki Ishiguro, Kinji Ohno
  • Journal Title: EBio Medicin Volume: 2 Issue: 12 Pages: 20462061-20462061
  • DOI: 10.1016/j.ebiom.2015.11.024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Concomitant Methotrexate Protects Against Total Knee Arthroplasty in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors. (2015)
  • Author(s): Asai S, Takahashi N, Funahashi K, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N, Kojima T.
  • Journal Title: J Rheumatol. Volume: 42(12) Issue: 12 Pages: 2255-60
  • DOI: 10.3899/jrheum.150410
  • Peer Reviewed
• [Journal Article] Concomitant methotrexate and tacrolimus augment the clinical response to abatacept in patients with rheumatoid arthritis with a prior history of biological DMARD use. (2015)
  • Author(s): Takahashi N, Fujibayashi T, Kida D, Hirano Y, Kato T, Kato D, Saito K, Kaneko A, Yabe Y, Takagi H, Oguchi T, Miyake H, Watanabe T, Hayashi M, Kanayama Y, Funahashi K, Hanabayashi M, Hirabara S, Asai S, Takemoto T, Terabe K, Asai N, Yoshioka Y, Ishiguro N, Kojima T.
  • Journal Title: Rheumatol Int. Volume: 35(10) Issue: 10 Pages: 1707-16
  • DOI: 10.1007/s00296-015-3283-4
  • Peer Reviewed
• [Journal Article] Longterm efficacy and safety of abatacept in patients with rheumatoid arthritis treated in routine clinical practice: effect of concomitant methotrexate after 24 weeks. (2015)
  • Author(s): Takahashi N, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N.
  • Journal Title: J Rheumatol. Volume: 42(5) Issue: 5 Pages: 786-93
  • DOI: 10.3899/jrheum.141288
  • Peer Reviewed
• [Journal Article] Effects of Concomitant Methotrexate on Large Joint Replacement in Patients With Rheumatoid Arthritis Treated With Tumor Necrosis Factor Inhibitors: A Multicenter Retrospective Cohort Study in Japan. (2015)
  • Author(s): Asai S, Kojima T, Oguchi T, Kaneko A, Hirano Y, Yabe Y, Kanayama Y, Takahashi N, Funahashi K, Hanabayashi M, Hirabara S, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N.
  • Journal Title: Arthritis Care Res (Hoboken). Volume: 67(10) Issue: 10 Pages: 1363-70
  • DOI: 10.1002/acr.22596
  • Peer Reviewed
• [Journal Article] Prediction of clinically significant leg-length discrepancy in congenital disorders (2015)
  • Author(s): Mishima K, Kitoh H, Kadono I, Mastushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N
  • Journal Title: Orthopedics Volume: 38 Issue: 10 Pages: 919-924
  • DOI: 10.3928/01477447-20151002-60
  • Peer Reviewed / Open Access
• [Journal Article] High incidence of regional and in-transit lymph node metastasis in patients with alveolar rhabdomyosarcoma. (2014)
  • Author(s): Nishida Y, Tsukushi S, Urakawa H, Sugiura H, Nakashima H, Yamada Y, Ishiguro N.
  • Journal Title: Int J Clin Oncol Volume: 19(3) Issue: 3 Pages: 536-43
  • DOI: 10.1007/s10147-013-0571-4
  • Peer Reviewed / Open Access
• [Journal Article] Hyaluronan expression as a significant prognostic factor in patients with ma lignant peripheral nerve sheath tumors. (2014)
  • Author(s): Ikuta K, Urakawa H, Kozawa E, Arai E, Zhuo L, Futamura N, Hamada S, Kimata K, Ishiguro N, Nishida Y.
  • Journal Title: Clin Exp Metastasis Volume: 31 Issue: 6 Pages: 715-725
  • DOI: 10.1007/s10585-014-9662-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Early and late fracture following extensive limb lengthening in achondroplasia and hypochondroplasia. (2014)
  • Author(s): Kitoh H, Kaneko H, Mishima K, Matsushita M, Kadono I, Nishida Y, Ishiguro N.
  • Journal Title: Bone Joint J Volume: 96-B(9) Issue: 9 Pages: 1269-1273
  • DOI: 10.1302/0301-620x.96b9.33840
  • Peer Reviewed / Open Access
• [Journal Article] Radiographic characteristics of the hand and cervical spine in fibrodysplasia ossificans progressiva (2014)
  • Author(s): Mishima K, Kitoh H, Haga N, Nakashima Y, Kamizono J, Katagiri T, Susami T, Matsushita M, Ishiguro N.
  • Journal Title: Intractable & Rare Diseases Research Volume: 3 Issue: 2 Pages: 46-51
  • DOI: 10.5582/irdr.2014.01009
  • NAID: 130005008088
  • ISSN: 2186-361X, 2186-3644
  • Peer Reviewed / Open Access
• [Journal Article] Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy. (2014)
  • Author(s): Hoover-Fong J, Sobreira N, Jurgens J, Modaff P, Blout C, Moser A, Kim OH, Cho TJ, Cho SY, Kim SJ, Jin DK, Kitoh H, Park WY, Ling H, Hetrick KN, Doheny KF, Valle D, Pauli RM.
  • Journal Title: Am J Hum Genet Volume: 94(1) Issue: 1 Pages: 105-112
  • DOI: 10.1016/j.ajhg.2013.11.018
  • Peer Reviewed / Open Access
• [Journal Article] Benign prenatal hypophosphatasia: a treatable disease not to be missed. (2014)
  • Author(s): Matsushita M, Kitoh H, Michigami T, Tachikawa K, Kaneko H, Mishima K, Ishiguro N.
  • Journal Title: Ped Radiol Volume: 44(3) Issue: 3 Pages: 340-343
  • DOI: 10.1007/s00247-013-2805-z
  • Peer Reviewed / Open Access
• [Journal Article] 骨形成促進効果を有する既存薬の同定とその臨床応用の可能性 (2014)
  • Author(s): 三島 健一、鬼頭 浩史、金子 浩史、松下 雅樹、石黒 直樹
  • Journal Title: 日本小児整形外科学会雑誌 Volume: 22(2) Pages: 374-378
• [Journal Article] Biodistribution of locally or systemically transplanted osteoblast-like cells. (2014)
  • Author(s): Y.T. Okabe, T. Kondo, K. Mishima, Y. Hayase, K. Kato, M. Mizuno, N. Ishiguro and H. Kitoh
  • Journal Title: Bone Joint Res Volume: 3 Issue: 3 Pages: 76-81
  • DOI: 10.1302/2046-3758.33.2000257
  • Peer Reviewed / Open Access
• [Journal Article] A novel in-frame deletion of the RUNX2 gene causes a classic form of cleidocranial dysplasia (2013)
  • Author(s): Mastushita M., Kitoh H., Kaneko H., Mishima K., Itoh Y., Tokita Y., Ishiguro N.
  • Journal Title: J Bone Miner Metab Volume: 未定 Issue: 1 Pages: 96-99
  • DOI: 10.1007/s00774-013-0456-7
  • Peer Reviewed / Open Access
• [Journal Article] Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial. (2013)
  • Author(s): Kitoh H, Achiwa M, Kaneko H, Mishima K, Matsushita M, Kadono I, Horowitz JD, Sallustio BC, Ohno K, Ishiguro N.
  • Journal Title: Orphanet J Rare Dis. Volume: 8 Issue: 1 Pages: 163-163
  • DOI: 10.1186/1750-1172-8-163
  • Peer Reviewed
• [Journal Article] A comparative study of blade plate fixation and external fixation in osteotomies for slipped capital femoral epiphysis. (2013)
  • Author(s): Kitoh H, Kitakoji T, Hattori T, Kaneko H, Mishima K, Matsushita M, Ishiguro N.
  • Journal Title: J Pediatr Orthop B. Volume: 22(6) Issue: 6 Pages: 542-7
  • DOI: 10.1097/bpb.0b013e3283637070
  • Peer Reviewed
• [Journal Article] Long-term outcome of gradual reduction using overhead traction for developmental dysplasia of the hip over 6 months of age. (2013)
  • Author(s): Kaneko H, Kitoh H, Mishima K, Matsushita M, Ishiguro N.
  • Journal Title: J Pediatr Orthop. Volume: 33(6) Issue: 6 Pages: 628-34
  • DOI: 10.1097/bpo.0b013e31829b2d8b
  • Peer Reviewed
• [Journal Article] Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia. (2013)
  • Author(s): Matsushita, M., Kitoh, H., Ohkawara, B., Mishima, K., Kaneko, H., Ito, M., Masuda, A., Ishiguro, N. and Ohno, K.
  • Journal Title: PLOS ONE Volume: 8(12) Issue: 12 Pages: 81569-81569
  • DOI: 10.1371/journal.pone.0081569
  • Peer Reviewed
• [Journal Article] Midterm outcome of risedronate therapy for patients with Paget's disease of bone in the central part of Japan. (2013)
  • Author(s): Nishida Y, Yamada Y, Tsukushi S, Sugiura H, Urakawa H, Ishiguro N.
  • Journal Title: Clin Rheumatol. Volume: 32(2) Issue: 2 Pages: 241-5
  • DOI: 10.1007/s10067-012-2109-y
  • Peer Reviewed
• [Journal Article] Metastasis of osteosarcoma to stomach made clinically evident by hematemesis: a case report. (2013)
  • Author(s): Urakawa H, Tsukushi S, Tsurudome I, Hirata A, Arai E, Kozawa E, Futamura N, Miyahara R, Ishiguro N, Nishida Y.
  • Journal Title: World J Surg Oncol. Volume: 11 Issue: 1 Pages: 48-48
  • DOI: 10.1186/1477-7819-11-48
  • Peer Reviewed
• [Journal Article] MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. (2013)
  • Author(s): Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, Lotz MK, Asahara H, Ishiguro N.
  • Journal Title: Arthritis Res Ther. Volume: 15(1)
  • NAID: 40020134052
  • Peer Reviewed
• [Journal Article] SURFACE MARKERS AND GENE EXPRESSION TO CHARACTERIZE THE DIFFERENTIATION OF MONOLAYER EXPANDED HUMAN ARTICULAR CHONDROCYTES (2013)
  • Author(s): TAKASHI HAMADA, TADAHIRO SAKAI, HIDEKI HIRAIWA, MOTOSHIGE NAKASHIMA, YOHEI ONO, HIROHITO MITSUYAMA and NAOKI ISHIGURO
  • Journal Title: Nagoya J. Med. Sci. Volume: 75(1-2) Pages: 101-111
  • NAID: 120005227637
  • Peer Reviewed
• [Journal Article] Is it possible to identify clinically useful prognostic groups for patients with desmoid tumors? (2012)
  • Author(s): Nishida Y, Tsukushi S, Urakawa H, Arai E, Ishiguro N.
  • Journal Title: J Clin Oncol. Volume: 30(12) Issue: 12 Pages: 1390-1390
  • DOI: 10.1200/jco.2011.39.8636
  • Peer Reviewed
• [Journal Article] Therapeutic potential of hyaluronan oligosaccharides for bone metastasis of breast cancer. (2012)
  • Author(s): Urakawa H, Nishida Y, Knudson W, Knudson CB, Arai E, Kozawa E, Futamura N, Wasa J, Ishiguro N.
  • Journal Title: J Orthop Res. Volume: 30 Issue: 4 Pages: 662-72
  • DOI: 10.1002/jor.21557
  • Peer Reviewed
• [Journal Article] Versican V1 isoform regulates cell-associated matrix formation and cell behavior differentially from aggrecan in Swarm rat chondrosarcoma cells. (2012)
  • Author(s): Wasa J, Nishida Y, Shinomura T, Isogai Z, Futamura N, Urakawa H, Arai E, Kozawa E, Tsukushi S, Ishiguro N.
  • Journal Title: Int J Cancer. Volume: 130 Issue: 10 Pages: 2271-81
  • DOI: 10.1002/ijc.26230
  • Peer Reviewed
• [Journal Article] Clinicopathological prognostic factors of superficial non-small round cell soft tissue sarcomas. (2012)
  • Author(s): Tsukushi S, Nishida Y, Shido Y, Wasa J, Ishiguro N.
  • Journal Title: J Surg Oncol. Volume: 105(7) Issue: 7 Pages: 668-72
  • DOI: 10.1002/jso.23025
  • Peer Reviewed
• [Journal Article] Osteochondroma with metaphyseal abnormalities after total body irradiation followed by stem cell transplantation. (2012)
  • Author(s): Shido Y, Maeda N, Kato K, Horibe K, Tsukushi S, Ishiguro N, Nishida Y.
  • Journal Title: J Pediatr Hematol Oncol. Volume: 34(5) Issue: 5 Pages: 378-82
  • DOI: 10.1097/mph.0b013e3182332296
  • Peer Reviewed
• [Journal Article] Novel compound heterozygous mutations in the cathepsin K gene in Japanese female siblings with pyknodysostosis. (2012)
  • Author(s): Matsushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Hattori T, Ishiguro N.
  • Journal Title: Mol Syndromol Volume: 2 Pages: 254-258
  • Peer Reviewed
• [Journal Article] Chondroblastoma of the femoral neck as a cause of hip synovitis (2012)
  • Author(s): Kaneko H, Kitoh H, Wasa J, Nishida Y, Ishiguro N
  • Journal Title: J Pediatr Orthop B Volume: 21 Issue: 2 Pages: 179-182
  • DOI: 10.1097/bpb.0b013e3283484c31
  • Peer Reviewed
• [Journal Article] Isolated bifid rib: Clinical and radiological findings in children. (2012)
  • Author(s): Kaneko H, Kitoh H, Mabuchi A, Mishima K, Matsushita M, Ishiguro N.
  • Journal Title: Pediatr Int Volume: 54 Issue: 6 Pages: 820-823
  • DOI: 10.1111/j.1442-200x.2012.03672.x
  • Peer Reviewed
• [Presentation] Lansoprazole regulates osteoclast formation and function. (2016)
  • Author(s): Mishima K, Kitoh H, Matsushita M, Sugiura H, Hasegawa S, Ishiguro N
  • Organizer: Orthopaedic Research Society
  • Place of Presentation: オーランド、アメリカ
  • Year and Date: 2016-03-05
  • Int'l Joint Research
• [Presentation] Radical Therapeutic Strategy For Foramen Magnum Stenosis And Spinal Canal Stenosis In Achondroplasia. (2016)
  • Author(s): Matsushita M, Kitoh H, Mishima K, Sugiura H, Hasegawa S, Ishiguro N, Ohno K
  • Organizer: Orthopaedic Research Society
  • Place of Presentation: オーランド、アメリカ
  • Year and Date: 2016-03-05
  • Int'l Joint Research
• [Presentation] 関節リウマチの手術療法Update (2015)
  • Author(s): 石黒直樹
  • Organizer: 第30回日本臨床リウマチ学会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-11-21
  • Invited
• [Presentation] Predictive Factors for Achieving Low Disease Activity at 52 Weeks after Switching from Tumor Necrosis Factor Inhibitors to Abatacept: Results from a Multicenter Observational Cohort Study of Japanese Patients. (2015)
  • Author(s): Kojima T, Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, Ishiguro N
  • Organizer: American College of Rheumatology
  • Place of Presentation: サンフランシスコ、アメリカ
  • Year and Date: 2015-11-06
  • Int'l Joint Research
• [Presentation] Relationship between index of activity speed (Time Up and Go test) and patient-reported outcome in patients with long-standing rheumatoid arthritis : multicenter prospective cohort study for evaluation of joint surgery on physical function (2015)
  • Author(s): Kojima T, Ishikawa H, Nishida K, Hashimoto J, Miyahara H, Tanaka S, Haga N, Niki Y, Kojima M, Ishiguro N
  • Organizer: American College of Rheumatology
  • Place of Presentation: サンフランシスコ、アメリカ
  • Year and Date: 2015-11-06
  • Int'l Joint Research
• [Presentation] 軟骨細胞におけるSOX9発現を促進させる既存薬の検索 (2015)
  • Author(s): 長谷川幸,鬼頭浩史,三島健一,松下雅樹,杉浦洋,北村暁子,西田佳弘,石黒直樹,大野欽司
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場、ＡＮＡクラウンプラザホテル富山、富山市民プラザ（富山県富山市）
  • Year and Date: 2015-10-22
• [Presentation] Meclozineは軟骨無形成症における大後頭孔および脊柱管狭窄を改善しうる (2015)
  • Author(s): 松下雅樹,鬼頭浩史,三島健一,杉浦洋,長谷川幸,北村暁子,西田佳弘,石黒直樹,大野欽司
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場、ＡＮＡクラウンプラザホテル富山、富山市民プラザ（富山県富山市）
  • Year and Date: 2015-10-22
• [Presentation] 骨芽細胞におけるFGF23の発現を抑制する既存薬の検索 (2015)
  • Author(s): 杉浦洋,鬼頭浩史,三島健一,松下雅樹,長谷川幸,北村暁子,大河原美静,西田佳弘,石黒直樹,大野欽司
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場、ＡＮＡクラウンプラザホテル富山、富山市民プラザ（富山県富山市）
  • Year and Date: 2015-10-22
• [Presentation] 軟骨無形成症における根本的治療薬の開発 (2015)
  • Author(s): 松下雅樹,鬼頭浩史,三島健一,杉浦洋,長谷川幸,北村暁子,西田佳弘,石黒直樹,大野欽司
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場、ＡＮＡクラウンプラザホテル富山、富山市民プラザ（富山県富山市）
  • Year and Date: 2015-10-22
• [Presentation] 超音波ガイド下腕神経叢ブロックによる肩関節授動術 (2015)
  • Author(s): 高松晃，酒井忠博，平岩秀樹，濱田恭，小田智之，山下暁士，宮本健太郎，岸本烈純，土谷早穂，石黒直樹
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸ポートピアホテル、神戸国際会議場、神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-21
• [Presentation] 鏡視下Bankart修復術後のアンカー孔の経時的変化について (2015)
  • Author(s): 平岩秀樹，酒井忠博，濱田恭，小田智之，高松晃，山下暁士，宮本健太郎，岸本烈純，土谷早穂，石黒直樹
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸ポートピアホテル、神戸国際会議場、神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-21
• [Presentation] 当科における鏡視下Bankart修復術の術後成績と影響を与える因子の統計学的検討 (2015)
  • Author(s): 酒井忠博，平岩秀樹，濱田恭，小田智之，高松晃，宮本健太郎，岸本烈純，土谷早穂，石黒直樹
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸ポートピアホテル、神戸国際会議場、神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-21
• [Presentation] 先天性股関節脱臼（ＤＤＨ）に対するリューメンビューゲル（ＲＢ）法の治療成績不良因子の検討 (2015)
  • Author(s): 三島健一,鬼頭浩史,松下雅樹,門野泉,杉浦洋,長谷川幸,北村暁子,西田佳弘,石黒直樹
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸ポートピアホテル、神戸国際会議場、神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-21
• [Presentation] 骨系統疾患の診断と治療－わが国の現状と展望－ (2015)
  • Author(s): 鬼頭浩史,三島健一,松下雅樹,杉浦洋,長谷川幸,北村暁子,石黒直樹
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸ポートピアホテル、神戸国際会議場、神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-21
• [Presentation] ランソプラゾールによる骨形成促進効果の解析 (2015)
  • Author(s): 三島健一,鬼頭浩史,杉浦洋,松下雅樹,長谷川幸,北村暁子,門野泉,西田佳弘,石黒直樹
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸ポートピアホテル、神戸国際会議場、神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-21
• [Presentation] 【抗リウマチ薬市販後調査の報告】 「イグラチモド」 (2015)
  • Author(s): 石黒直樹
  • Organizer: 第59回日本リウマチ学会総会・学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-04-23
  • Invited
• [Presentation] 関節リウマチ治療のピットフォール (2015)
  • Author(s): 石黒直樹
  • Organizer: 第124回中部日本整形外科災害外科学会
  • Place of Presentation: ホテル日航金沢（石川県金沢市）
  • Year and Date: 2015-04-10
  • Invited
• [Presentation] Meclozine enhances skeletal growth in transgenic achondroplasia mice with a constitutive active FGFR3 mutation (2015)
  • Author(s): Matsushita, Masaki; Kitoh, Hiroshi; Kenichi Mishima; Ishiguro Naoki; Ohno Kinji
  • Organizer: 2015 Annual Meeting - Orthopaedic Research Society
  • Place of Presentation: Las Vegas(USA)
  • Year and Date: 2015-03-28 – 2015-03-31
• [Presentation] Wnt/β-カテニンシグナル制御を介した変形性関節症治療薬の探索 (2015)
  • Author(s): 宮本健太郎、大河原美静、酒井忠博、高松晃、石黒直樹、大野欽司
  • Organizer: 第28回日本軟骨代謝学会
  • Place of Presentation: 東京医科歯科大学（東京都文京区）
  • Year and Date: 2015-03-06 – 2015-03-07
• [Presentation] meclozineはオフラベル効能によりFGFR3シグナルを抑制し軟骨無形成症の根本的治療薬となりうる (2015)
  • Author(s): 松下 雅樹、 鬼頭 浩史、 三島 健一、西田 佳弘、石黒 直樹、 大野 欽司
  • Organizer: 第28回日本軟骨代謝学会
  • Place of Presentation: 東京医科歯科大学（東京都文京区）
  • Year and Date: 2015-03-06 – 2015-03-07
• [Presentation] 乗り物酔い止めOTC薬meclozineはFGFR3シグナルを抑制して軟骨無形成症の低身長をレスキューする (2014)
  • Author(s): 松下 雅樹、 鬼頭 浩史、 三島 健一、石黒 直樹、 大野 欽司
  • Organizer: 第32回小児代謝性骨疾患研究会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府豊中市）
  • Year and Date: 2014-12-06
• [Presentation] PRPゲルを用いた自家培養軟骨細胞移植術（PRP-ACI) (2014)
  • Author(s): 酒井忠博、平岩秀樹、濱田恭、石黒直樹
  • Organizer: 第42回日本関節病学会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2014-11-06 – 2014-11-07
• [Presentation] 関節軟骨細胞におけるＣＤ４４の断片化とその意義について (2014)
  • Author(s): 高橋伸典、寺部健哉、Cheryl B. Knudson、Warren Knudson、小嶋俊久、石黒直樹
  • Organizer: 第46回日本結合組織学会学術大会
  • Place of Presentation: ウインク愛知（愛知県名古屋市）
  • Year and Date: 2014-06-05 – 2014-06-07
• [Presentation] Long-term outcome of gradual reduction with overhead traction for developmental dysplasia of the hip in children over six months of age. (2013)
  • Author(s): Hiroshi Kaneko, Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishguro.
  • Organizer: Annual meeting of Pediatric Orthopedic Society of North America
  • Place of Presentation: Toronto（Canada)
• [Presentation] A novel Sox9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome. (2013)
  • Author(s): Hiroshi Kaneko, Hioroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishiguro.
  • Organizer: International Skeletal Dysplasia Meeting
  • Place of Presentation: Bologna(Italy)
• [Presentation] Meclozine facilitates chondrocyte proliferation and differentiation by attenuating abnormally activated fibroblast growth factor receptor 3 (FGFR3) signaling in achondroplasia. (2013)
  • Author(s): Masaki Matsushita, Hiroshi Kitoh, Hiroshi Kaneko, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno.
  • Organizer: International Skeletal Dysplasia Meeting
  • Place of Presentation: Bologna(Italy)
• [Presentation] 大腿骨頭すべり症に対する創外固定法による矯正骨切り術の短期成績―プレート法との比較―. (2013)
  • Author(s): 鬼頭浩史、金子浩史、三島健一、松下雅樹、石黒直樹.
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: リーガロイヤルホテル広島、NTTクレドホール、 広島グリーンアリーナ、メルパルク広島（広島市）
• [Presentation] Dysplasia epiphysealis hemimelica generalized typeの右股関節病変について. (2013)
  • Author(s): 松下雅樹、鬼頭浩史、金子浩史、三島健一、門野泉、石黒直樹.
  • Organizer: 第52回小児股関節研究会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] Meclozineは軟骨無形成症におけるFGFR3シグナルによる軟骨細胞の増殖・分化抑制をレスキューする. (2013)
  • Author(s): 松下雅樹、鬼頭浩史、金子浩史、三島健一、石黒直樹、大野欽司.
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 幕張メッセ国際会議場（千葉市）
• [Presentation] 先天性垂直距骨の外科的治療法の検討. (2013)
  • Author(s): 松下雅樹、鬼頭浩史、金子浩史、三島健一、石黒直樹.
  • Organizer: 第17回東海足と靴の研究会
  • Place of Presentation: 興和株式会社 本店ビル（名古屋市）
• [Presentation] 骨延長後の骨折に関連する因子. (2013)
  • Author(s): 鬼頭浩史、金子浩史、三島健一、松下雅樹、門野泉、杉浦洋、長谷川幸、石黒直樹.
  • Organizer: 第24回日本小児整形外科学会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] DDH整復後の遺残性臼蓋形成不全に対するソルター骨盤骨切り術の長期成績不良因子. (2013)
  • Author(s): 金子浩史、鬼頭浩史、北小路隆彦、三島健一、松下雅樹、門野泉、杉浦洋、長谷川幸、北村暁子、石黒直樹、服部義.
  • Organizer: 第24回日本小児整形外科学会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] 下肢長不等例における脚長差の経時的変化. (2013)
  • Author(s): 三島健一、鬼頭浩史、金子浩史、松下雅樹、杉浦洋、長谷川幸、北村暁子、石黒直樹.
  • Organizer: 第24回日本小児整形外科学会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Potential clinical application of meclizine, an anti-histamine drug, for short stature in FGFR3-related skeletal dysplasias. (2013)
  • Author(s): Masaki Matsushita, Hiroshi Kitoh, Hiroshi Kaneko, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno.
  • Organizer: 第24回日本小児整形外科学会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] 軟骨無形成症に対する下腿骨延長後の歩行解析. (2013)
  • Author(s): 馬渕晃好、鬼頭浩史、金子浩史、三島健一、松下雅樹.
  • Organizer: 第24回日本小児整形外科学会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] 軟骨無形成症に対する下肢骨延長術に伴う下肢関節可動域制限. (2013)
  • Author(s): 門野泉、鬼頭浩史、金子浩史、三島健一、松下雅樹、杉浦洋、長谷川幸、杉浦洋、石黒直樹.
  • Organizer: 第24回日本小児整形外科学会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Proximal focal femoral deficiencyの重症例. (2013)
  • Author(s): 松下雅樹、鬼頭浩史、金子浩史、三島健一、門野泉、西田佳弘、石黒直樹.
  • Organizer: 第25回日本整形外科学会骨系統疾患研究会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] 進行性骨化性線維異形成症におけるレントゲン学的診断指針. (2013)
  • Author(s): 三島健一、鬼頭浩史、芳賀信彦、中島康晴、金子浩史、松下雅樹、門野泉、西田佳弘、石黒直樹.
  • Organizer: 第25回日本整形外科学会骨系統疾患研究会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] High Incidence of Regional and In-transit Lymph Node Metastasis in Patients with Alveolar Rhabdomyosarcoma (2013)
  • Author(s): Nishida Y, Sugiura H, Tsukushi S, Urakawa H, Arai E, Kozawa E, Futamura N, Ishiguro N.
  • Organizer: 2013 Annual Meeting of American Academy of Orthopaedic Surgeons,
  • Place of Presentation: Chicago (USA)
• [Presentation] Radiosensitization Effects of Hyaluronan Synthesis Inhibitor on Bone Metastasis of Lung Cancer (2013)
  • Author(s): Futamura N, Nishida Y, Urakawa H, Arai E, Kozawa E, Ikuta K, Hamada S, Ishiguro N.
  • Organizer: 2013 Annual Meeting of American Academy of Orthopaedic Surgeons,
  • Place of Presentation: Chicago (USA)
• [Presentation] 軟骨再生とヒアルロン酸： ヒアルロン酸産生阻害はATDC5の軟骨分化を抑制する (2013)
  • Author(s): 吉岡裕，西田佳弘，石黒直樹
  • Organizer: 第26回日本軟骨代謝学会 シンポジウム
  • Place of Presentation: 大阪
  • Invited
• [Presentation] OA治療学の疫学から治療まで 「鎮痛をターゲットとしたOA治療 -可能性と課題-」 (2012)
  • Author(s): 石黒直樹
  • Organizer: 第56回日本リウマチ学会総会・学術集会 シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] リウマチ頚椎病変は今 「生物製剤のRA頚椎病変に対する進行予防効果」 (2012)
  • Author(s): 石黒直樹
  • Organizer: 第56回日本リウマチ学会総会・学術集会 シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] Challenges In Successive Approach To Extra-Peritoneal Desmoid Tumors, As Intermediate Group of Tumors (2012)
  • Author(s): Nishida Y, Tsukushi S, Urakawa H, Arai E, Kozawa E, Ishiguro N.
  • Organizer: The 9th Asia Pacific Musculoskeletal Tumor Society Meeting,
  • Place of Presentation: Kuala Lumpur (Malaysia)
• [Presentation] Factors Correlated With The Pathological Fracture And Clinical Outcome In Patients With Unicameral Bone Cyst. (2012)
  • Author(s): Urakawa H, Hosono K, Sugiura H, Nakashima H, Yamada Y, Tsukushi S, Arai E, Kozawa E, Futamura N, Ishiguro N, Nishida Y.
  • Organizer: The 9th Asia Pacific Musculoskeletal Tumor Society Meeting,
  • Place of Presentation: Kuala Lumpur (Malaysia)
• [Presentation] Residual Tumor After Unplanned Excision Has An Impact On Prognosis In Patients With Soft Tissue Sarcom (2012)
  • Author(s): Arai E, Sugiura H, Nakashima H, Tsukushi S, Urakawa H, Kozawa E, Ishiguro N, Nishida Y.
  • Organizer: The 9th Asia Pacific Musculoskeletal Tumor Society Meeting,
  • Place of Presentation: Kuala Lumpur (Malaysia)
• [Presentation] Tumor Suppression With Anti-Interleukin-2 And Anti-CD25 Monoclonal Antibodies In A Murine Osteosarcoma Model (2012)
  • Author(s): Sugiura H, Kozawa E, Kohyama K, Yamada K, Nishida Y, Taguchi O.
  • Organizer: The 9th Asia Pacific Musculoskeletal Tumor Society Meeting,
  • Place of Presentation: Kuala Lumpur (Malaysia)
• [Presentation] Soft Tissue Sarcoma Adjacent To Critical Structures (Bone, Major Vessels And Major Nerves) (2012)
  • Author(s): Tsukushi S, Nishida Y, Urakawa H, Arai E, Kozawa E, Ishiguro N.
  • Organizer: The 9th Asia Pacific Musculoskeletal Tumor Society Meeting,
  • Place of Presentation: Kuala Lumpur (Malaysia)
• [Presentation] Correlation Between Equivalent Cross-Relaxation Rate Imaging And Cellular Imaging In Musculoskeletal Tumours (2012)
  • Author(s): Hamada S, Matsushima S, Sugiura H, Yamada K, Nishida Y, Ishiguro N.
  • Organizer: The 9th Asia Pacific Musculoskeletal Tumor Society Meeting,
  • Place of Presentation: Kuala Lumpur (Malaysia)
• [Presentation] Clinical Outcome Of Recurrent Giant Cell Tumor Of Bone In Extremities (2012)
  • Author(s): Futamura N, Tsukushi S, Urakawa H, Arai E, Kozawa E, Nakashima H, Sugiura H, Yamada Y, Ishiguro N, Nishida Y.
  • Organizer: The 9th Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: Kuala Lumpur (Malaysia)
• [Presentation] Successive Multimodality Approach To Extra-Peritoneal Desmoid Tumors (2012)
  • Author(s): Nishida Y, Tsukushi S, Urakawa H, Arai E, Kozawa E, Futamura N, Ishiguro N.
  • Organizer: 17th Anuual Meeting of the Connective Tissue Oncology Society,
  • Place of Presentation: Prague (Czech Republic)
• [Presentation] 骨・軟部腫瘍治療の基礎研究 －多方面からのアプローチ－： 腫瘍微小環境：細胞外マトリックス制御による悪性骨腫瘍抑制効果 (2012)
  • Author(s): 西田 佳弘, 細野 幸三, 和佐 潤志, 浦川 浩, 新井 英介, 二村 尚久, 石黒 直樹
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 縮小手術の現状と可能性： 縮小手術に向けて 難治性良性骨腫瘍に対する掻爬後温水処理 (2012)
  • Author(s): 西田 佳弘, 杉浦 英志, 中島 浩敦, 筑紫 聡, 浦川 浩, 新井 英介, 小澤 英史, 二村 尚久, 石黒 直樹
  • Organizer: 第45回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 先天性股関節脱臼に対する新しい適応を用いたリーメンビューゲルによる短期治療成績 (2012)
  • Author(s): 鬼頭浩史、金子浩史、松下雅樹、石黒直樹
  • Organizer: 第85回日本整形外科学会学術総会
  • Place of Presentation: 京都
• [Presentation] 軟骨無形成症に対する治療の展望 (2012)
  • Author(s): 鬼頭浩史
  • Organizer: 第85回日本整形外科学会学術総会
  • Place of Presentation: 京都
• [Presentation] 軟骨細胞におけるFGFR3シグナルを抑制する既存薬の検索 (2012)
  • Author(s): 松下雅樹、鬼頭浩史、金子浩史、三島健一、石黒直樹、大野欽司
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋
• [Presentation] 膝軟部肉腫広範切除術後に膝蓋腱及び外側支持機構の再建を行った１例 (2012)
  • Author(s): 酒井忠博、平岩秀樹、濱田恭、大間知孝顕、中島基成、石塚真哉、小田智之、高松晃、山下暁士、筑紫聡、石黒直樹
  • Organizer: 第4回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 沖縄
• [Presentation] 膝屈曲位側面XPを用いたCR-TKA術後患者に対するPCL機能評価 (2012)
  • Author(s): 平岩秀樹、酒井忠博、濱田恭、大間知孝顕、中島基成、石塚真哉、松川哲也、小田智之、高松晃、山下暁士、石黒直樹
  • Organizer: 第4回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 沖縄
• [Presentation] 鏡視下Bankart修復術後成績に影響を与える因子の統計学的検討 (2012)
  • Author(s): 酒井忠博、平岩秀樹、濱田恭、中島基成、石塚真哉、小田智之、高松晃、山下暁士、石黒直樹
  • Organizer: 第39回日本肩関節学会
  • Place of Presentation: 東京
• [Book] 先端医療シリーズ44 臨床医のための最新整形外科 (2013)
  • Author(s): 三島健一、鬼頭浩史、石黒直樹 、 戸山芳昭、桃原茂樹、吉川秀樹、越智光夫、松下 隆、吉田宗人、松本守雄、久保俊一、井樋栄二、小宮節郎、土屋弘行、望月一男、田中良哉、松山幸弘、田中 栄、金 郁喆、馬場久敏、等
  • Total Pages: 570
  • Publisher: 先端医療技術研究所
• [Book] 運動器診療 最新ガイドライン (2012)
  • Author(s): 西田佳弘 他
  • Total Pages: 768
  • Publisher: 総合医学社