| Co-Investigator(Kenkyū-buntansha) |
吉岡 芳親 大阪大学, 免疫学フロンティア研究センター, 教授 (00174897)
下瀬川 恵久 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (30370258)
島岡 要 三重大学, 医学(系)研究科(研究院), 教授 (40281133)
中江 文 大阪大学, 免疫学フロンティア研究センター, 准教授 (60379170)
畑澤 順 大阪大学, 医学(系)研究科(研究院), 教授 (70198745)
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| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2012: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Outline of Final Research Achievements |
The purpose of this research is to unify the anaesthetics' mechanism by verifying the effect of anaesthetics on glia cells. In vivo study using SD rats, we examined the sevoflurane anesthetized animals with different concentrations and verified that the inhalation anesthetic sevoflurane is acting on glial cells, by analyzing the Wash-out rate of Acetate-PET. We established a glial cell model and a framework to show that functional control of its surface receptor integrin is linked with anesthesia mechanism. The study also showed the need to further investigate the influence of anesthetics on new signal transduction pathways by exosomes.
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