Exploit of new strategy of prediction, prevention, treatment of preeclampsia using
Project/Area Number |
24249080
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Osaka University |
Principal Investigator |
KIMURA Tadashi 大阪大学, 医学(系)研究科(研究院), 教授 (90240845)
|
Co-Investigator(Kenkyū-buntansha) |
SAWADA Kenjiro 大阪大学, 大学院医学系研究科, 助教 (00452392)
TOMIMATSU Takuji 大阪大学, 大学院医学系研究科, 講師 (30346209)
KANAGAWA Takeshi 大阪大学, 大学院医学系研究科, 助教 (40346218)
MIMURA Kazuya 大阪大学, 大学院医学系研究科, 助教 (50437422)
NAKAMURA Hitomi 大阪大学, 大学院医学系研究科, 助教 (80467571)
KUMASAWA Keiichi 大阪大学, 大学院医学系研究科, 助教 (90444546)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2013: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2012: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
|
Keywords | 妊娠高血圧症候群 |
Outline of Final Research Achievements |
Pregnancy induced hypertension (preeclampsia) is observed in 5~10% of pregnant women, and both maternal and fetal lives will be endangered if it proceeds. Thus far the fundamental therapy available is to terminate the pregnancy. It often leads to preterm birth. By this grant, we successfully carried out 3 theme of investigations. First we have found out predictive markers for onset of preeclampsia with model mice. Second, we developed novel method to make model mice for severe preeclampsia. Third, we have successfully screened the most effective drug, which induces PlGF biosynthesis to endothelial cells from a library of approved drugs. These achievements will lead to develop novel strategy for prediction, prevention, and treatment of preeclampsia.
|
Report
(4 results)
Research Products
(252 results)
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[Journal Article] Perioperative venous thromboembolism in patients with gynecological malignancies: a lesson from four years of recent clinical experience2014
Author(s)
Morimoto, A. Ueda, Y. Yokoi, T. Tokizawa, Y. Yoshino, K. Fujita, M. Toshihiro Kimura Kobayashi, E. Matsuzaki, S. Egawa-Takata, T. Sawada, K. Tsutsui, T. Kimura, T.
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Journal Title
Anticancer Res
Volume: 34
Pages: 3589-3595
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[Journal Article] Combination treatment with trabectedin and irinotecan or topotecan has synergistic effects against ovarian clear cell carcinoma cells2014
Author(s)
Kawano, M. Mabuchi, S. Kishimoto, T. Hisamatsu, T. Matsumoto, Y. Sasano, T. Takahashi, R. Sawada, K. Takahashi, K. Takahashi, T. Hamasaki, T. Kimura, T.
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Journal Title
Int J Gynecol Cancer
Volume: 24
Issue: 5
Pages: 829-837
DOI
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Peer Reviewed
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[Journal Article] A case of neonatal alloimmune thrombocytopenia in the presence of both anti-HPA-4b and anti-HPA-5b antibody: clinical and serological analysis of the subsequent pregnancy2014
Author(s)
Kiyokawa, T. Koh, Y. Mimura, K. Nakayama, K. Hosokawa, M. Sakuragi, M. Morikawa, T. Nakao, M. Aochi, H. Fukumori, Y. Kanagawa, T. Nagamine, K. Kimura, T. Tomiyama, Y.
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Journal Title
Int J Hematol
Volume: 100
Issue: 4
Pages: 398-401
DOI
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radioresistant feature2014
Author(s)
Mabuchi, S. Matsumoto, Y. Kawano, M. Minami, K. Seo, Y. Sasano, T. Takahashi, R. Kuroda, H. Hisamatsu, T. Kakigano, A. Hayashi, M. Sawada, K. Hamasaki, T. Morii, E. Kurachi, H. Matsuura, N. Kimura, T.
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Journal Title
J Natl Cancer Inst
Volume: 106
Issue: 7
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition2014
Author(s)
Minakami, H. Maeda, T. Fujii, T. Hamada, H. Iitsuka, Y. Itakura, A. Itoh, H. Iwashita, M. Kanagawa, T., et al.
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Journal Title
J Obstet Gynaecol Res
Volume: 40
Issue: 6
Pages: 1469-1499
DOI
Related Report
Peer Reviewed
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[Journal Article] Three-dimensional sonography in the differential diagnosis of interstitial, angular, and intrauterine pregnancies in a septate uterus2014
Author(s)
Tanaka, Y. Mimura, K. Kanagawa, T. Kajimoto, E. Takahashi, K. Kakigano, A. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Kimura, T.
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Journal Title
J Ultrasound Med
Volume: 33
Issue: 11
Pages: 2031-2035
DOI
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Peer Reviewed / Open Access
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[Journal Article] Low serum concentrations of anti-Mullerian hormone are common in 53 female childhood cancer survivors2014
Author(s)
Miyoshi Y, Ohta H, Namba N, Tachibana M, Miyamura T, Miyashita E, Hashii Y, Oue T, Isobe A, Tsutsui T, Kimura T, Ozono K
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Journal Title
Hormone Research in Paediatrics
Volume: 79
Issue: 1
Pages: 17-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Hypoxic preconditioning increases triiodothyronine (T3) level in the developing rat brain.2013
Author(s)
Minato K, Tomimatsu T, Mimura K, Jugder O, Kakigano A, Kanayama T, Fujita S, Taniguchi Y, Kanagawa T, Endo M, Kimura T.
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Journal Title
Brain Res
Volume: 1501
Pages: 89-97
DOI
Related Report
Peer Reviewed
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[Journal Article] Disease flare-ups and obstetric outcomes in pregnant women with systemic lupus erythematosus2013
Author(s)
Takahashi, K. Mimura, K. Kanagawa, T. Kinugasa-Taniguchi, Y. Endo, M. Matsuzaki, S. Kumasawa, K. Hashimoto, K. Tomimatsu, T. Kimura, T.
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Journal Title
Hypertens Res Pregnancy
Volume: 2
Pages: 1-5
NAID
Related Report
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[Journal Article] Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR302013
Author(s)
Noda-Seino, H. Sawada, K. Hayakawa, J. Ohyagi-Hara, C. Mabuchi, S. Takahashi, K. Nishio, Y. Sakata, M. Kurachi, H. Kimura, T.
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Journal Title
J Endocrinol Invest
Volume: 36
Pages: 21-27
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[Journal Article] Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary.2013
Author(s)
Hisamatsu T, Mabuchi S, Matsumoto Y, Kawano M, Sasano T, Takahashi R, Sawada K, Ito K, Kurachi H, Schilder RJ, Testa JR, Kimura T.
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Journal Title
Mol Cancer Ther.
Volume: 12
Issue: 7
Pages: 1367-77
DOI
Related Report
Peer Reviewed
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[Journal Article] Targeting interleukin-6 receptor inhibits preterm delivery induced by inflammation2013
Author(s)
Wakabayashi, A. Sawada, K. Nakayama, M. Toda, A. Kimoto, A. Mabuchi, S. Kinose, Y. Nakamura, K. Takahashi, K. Kurachi, H. Kimura, T.
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Journal Title
Mol Hum Reprod
Volume: 19
Issue: 11
Pages: 718-26
DOI
Related Report
Peer Reviewed
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[Journal Article] Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report2013
Author(s)
Kakigano, A. Mimura, K. Kanagawa, T. Nakayama, M. Kanayama, T. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Tomimatsu, T. Kimura, T.
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Journal Title
Placenta
Volume: 34
Issue: 7
Pages: 628-630
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice.2013
Author(s)
Uchida K, Nakahira K, Mimura K, Shimizu T, De Seta F, Wakimoto T, Kawai Y, Nomiyama M, Kuwano K, Guaschino S, Yanagihara I.
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Journal Title
J Reprod Immunol.
Volume: 100(2)
Issue: 2
Pages: 118-127
DOI
Related Report
Peer Reviewed
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[Journal Article] A case of simultaneous transvaginal NOTES gastrectomy and vaginal hysterectomy in a patient with gastric submucosal tumor and uterine prolapsed2012
Author(s)
Hirota, M. Nakajima, K. Hara, J. Takahashi, T. Yamasaki, M. Tsutsui , T. Kobayashi, E. Kurokawa, Y. Miyata, H. Takiguchi, S. Mori, M. Doki, Y.
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Journal Title
Asian J Endosc Surg
Volume: 5
Issue: 4
Pages: 168-171
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Related Report
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[Journal Article] Salvage chemotherapy using gemcitabine for taxane/platinum-resistant recurrent ovarian cancer: a single institutional experience2012
Author(s)
Yoshino, K. Hiramatsu, K. Enomoto, T. Fujita, M. Ueda, Y. Kimura, T. Kobayashi, E. Kiyohara, Y. Tsutsui, T. Kimura, T.
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Journal Title
Anticancer Res
Volume: 32
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Peer Reviewed
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[Presentation] Mechanism responsible for the chemoresistance of uterine cervical cancer displaying tumor-related leukocytosis2014
Author(s)
Kawano, M. Mabuchi, S. Matsumoto, Y. Sasano, T. Takahashi, R. Kuroda, H. Hashimoto, K. Isobe, A. Sawada, K. Sakata, M. Kimura, T.
Organizer
15th Biennial Meeting of The International Gynecologic Cancer Society
Place of Presentation
Melbourne, Australia
Year and Date
2014-11-08 – 2014-11-11
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[Presentation] Maternal arterial stiffness in normotensive and chronically hypertensive women who subsequently delivered babies with small-for-gestational age2014
Author(s)
Tomimatsu, T. Fujime, M. Kanayama, T. Mimura, K. Koyama, S. Kanagawa, T. Endo, M. Shimoya, K. Kimura, T.
Organizer
46th International Congress on Pathophysiology of Pregnancy
Place of Presentation
Tokyo, JAPAN
Year and Date
2014-09-18 – 2014-09-20
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[Presentation] Immune tolerance induction using chorionic villus sampling (CVS) technique in rodent models2014
Author(s)
Endo, M. Takahashi, K. Miyoshi, T. Tsuritani, M. Shimazu, Y. Fujita, S. Kakigano, A. Taniguchi, Y. Mimura, K. Kanagawa, T. Hosoda, H. Kimura, T. Tamai, K. Yoshimatsu, J.
Organizer
24th World Congress on Ultrasound in Obstetrics and Gynecology
Place of Presentation
Barcelona, Spain
Year and Date
2014-09-14 – 2014-09-17
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[Presentation] The effect of raloxifene hydrochloride for the prevention of health care problems of patients who underwent surgeries for endometrial cancer: A multicenter clinical trial2014
Author(s)
Nakamura, K. Sawada, K. Sugiyama, M. Mabuchi, S. Hisamatsu, T. Nishio, Y. Ito, K. Kimura, T. Kamiura, S. Morishige, K.
Organizer
50th Annual Meeting of the American Society of Clinical Oncology
Place of Presentation
Chicago, U.S.A.
Year and Date
2014-05-30 – 2014-06-03
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[Presentation] Raloxifene hydrochloride improves health care problems of patients who underwent surgeries for endometrial cancer - a multicenter clinical trial2013
Author(s)
Nakamura, K. Sawada, K. Sugiyama, M. Mabuchi, S. Hisamatsu, T. Nishio, Y. Ito, K. Morishige, K. Kimura, T. Kamiura, S.
Organizer
第3回アジア婦人科腫瘍学会・第55回日本婦人科腫瘍学会
Place of Presentation
京都
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[Presentation] A novel IKKβ inhibitor, IMD-0354, suppresses ovarian cancer dissemination by inhibiting VEGF production : a potential for an anti-angiogenic therapy2013
Author(s)
Kinose, Y. Sawada, K. Hashimoto, K. Makino, H. Mizuno, T. Suzuki, N. Nakamura, K. Mabuchi, S. Sakata, M. Morishige, K. Kimura, T.
Organizer
第3回アジア婦人科腫瘍学会・第55回日本婦人科腫瘍学会
Place of Presentation
京都
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[Presentation] The significance of vascular endothelial growth factor C in the lymphangiogenesis and lymph node metastasis of ovarian cancer2013
Author(s)
Hisamatsu, T. Mabuchi, S. Sasano, T. Takahashi, R. Kawano, M. Matsumoto, Y. Hashimoto, K. Isobe, A. Sawada, K. Sakata, M. Kimura, T.
Organizer
The 104th Annual Meeting American Association for Cancer Research
Place of Presentation
Washington DC, U.S.A
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