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Development of adjuvant therapy for head and neck cancer by activation of NKT cells via nasal mucosa

Research Project

Project/Area Number 24249081
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionChiba University

Principal Investigator

Okamoto Yoshitaka  千葉大学, 大学院医学研究院, 教授 (40169157)

Co-Investigator(Kenkyū-buntansha) 櫻井 大樹  千葉大学, 医学(系)研究科(研究院), 講師 (10375636)
関 直彦  千葉大学, 医学(系)研究科(研究院), 准教授 (50345013)
本橋 新一郎  千葉大学, 医学(系)研究科(研究院), 教授 (60345022)
福本 一郎  千葉大学, 医学部附属病院, 医員 (70748764)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2012: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
KeywordsNKT細胞 / 癌免疫療法 / 頭頸部癌 / 扁平上皮癌 / 悪性黒色腫 / 細胞障害性T細胞 / アジュバント療法 / 先進医療 / アジュバンド療法
Outline of Final Research Achievements

To develop an effective adjuvant treatment for head and neck cancer, we have conducted the following studies.
1,Scientific evaluation of the efficacy of the nasal submucosal administration of α-galactocylceramide(αGalCer) pulsed antigen presenting cells(APCs) to the patients with head and neck squamous cell carcinoma, 2, Clarification of characteristics of the anti-tumor immune suppression observed in the patients with head and neck cancer, 3 Basic studies to improve the anti-tumor immune suppression in the patients with head and neck cancer, 4 Development of αGalCer pulsed APCs administration in patients with non-squamous cell carcinoma of head and neck. The adjuvant treatment with the nasal submucosal administration of αGalCer pulsed APCs to the patients with advanced head and neck squamous cell carcinoma following the standard treatments to suppress the recurrence, has been admitted as an Advanced Treatment B recognized by the government and continues to show final results.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (63 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (34 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 33 results,  Open Access: 14 results,  Acknowledgement Compliant: 1 results) Presentation (29 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Definitive carbon-ion radiotherapy for locally advanced parotid gland carcinomas.2017

    • Author(s)
      Koto M, Hasegawa A, Takagi R, Ikawa H, Naganawa K, Mizoe JE, Jingu K, Tsujii H, Tsuji H, Kamada T, Okamoto Y.
    • Journal Title

      Head Neck.

      Volume: 39 Issue: 4 Pages: 724-729

    • DOI

      10.1002/hed.24671

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma.2017

    • Author(s)
      Keiichi Koshizuka, Toyoyuki Hanazawa, Ichiro Fukumoto, Naoko Kikkawa, Yoshitaka Okamoto, Naohiko Seki.
    • Journal Title

      Journal of Human Genetics

      Volume: 62 Issue: 1 Pages: 3-13

    • DOI

      10.1038/jhg.2016.105

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma.2017

    • Author(s)
      Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Matsushita R, Mataki H, Mizuno K, Okamoto Y, Seki N.
    • Journal Title

      Journal of Human Genetics

      Volume: 62 Issue: 1 Pages: 113-121

    • DOI

      10.1038/jhg.2016.47

    • NAID

      40021036343

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs.2017

    • Author(s)
      Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Okamoto Y, Seki N.
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 18 Pages: 30288-30304

    • DOI

      10.18632/oncotarget.16327

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells.2016

    • Author(s)
      Kamata T, Suzuki A, Mise N, Ihara F, Takami T, Makita Y, Horinaka A, Harada K, Kunii K, Yoshida S, Yoshino I, Nakayama T, and Motohashi S.
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 65 Issue: 12 Pages: 1477-1489

    • DOI

      10.1007/s00262-016-1901-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers.2016

    • Author(s)
      Aoki T, Hino M, Koh K, Kyushiki, M, Kishimoto H, Arakawa Y, Hanada R, Kawashima H, Kurihara J, Shimojo N, and Motohashi S.
    • Journal Title

      Pediatr. Blood Cancer

      Volume: 63 Issue: 8 Pages: 1461-1464

    • DOI

      10.1002/pbc.26018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.2016

    • Author(s)
      Hosokawa H, Tanaka T, Endo Y, Kato M, Shinoda K, Suzuki A, Motohashi S, Matsumoto M, Nakayama K, Nakayama T.
    • Journal Title

      Nat Commun.

      Volume: - Issue: 1 Pages: 11289-11289

    • DOI

      10.1038/ncomms11289

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term outcomes after carbon-ion radiotherapy for oral mucosal malignant melanoma.2016

    • Author(s)
      Nakagawa K, Koto M, Takagi R, Hasegawa A, Ikawa H, Schimozato K, Kamada T, Okamoto Y.
    • Journal Title

      Journal of Medical Case Reports

      Volume: 10:284 Pages: 1-4

    • NAID

      130007397897

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base.2016

    • Author(s)
      Koto M, Hasegawa A, Takagi R, Ikawa H, Naganawa K, Mizoe JE, Jingu K, Tsujii H, Tsuji H, Kamada T, Okamoto Y
    • Journal Title

      Head Neck.

      Volume: 印刷中 Issue: S1

    • DOI

      10.1002/hed.24397

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basal cell adenoma of the parotid gland; MR features and differentiation from pleomorphic adenoma.2016

    • Author(s)
      Mukai H, Motoori K, Horikoshi T, Takishima H, Nagai Y, Okamoto Y, Uno T.
    • Journal Title

      Dentomaxillofac Radiol.

      Volume: 45(4) Pages: 20150322-20150322

    • Related Report
      2016 Annual Research Report
  • [Journal Article] The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma.2016

    • Author(s)
      Fukumoto I, Koshizuka K, Hanazawa T, Kikkawa N, Matsushita R, Kurozumi A, Kato M, Okato A, Okamoto Y, Seki N.
    • Journal Title

      Int J Oncol.

      Volume: 49(3) Issue: 3 Pages: 1119-29

    • DOI

      10.3892/ijo.2016.3602

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma2016

    • Author(s)
      Ichiro Fukumoto, Naoko Kikkawa, Ryosuke Matsushita, Mayuko Kato, Akira Kurozumi, Rika Nishikawa, Yusuke Goto, Keiichi Koshizuka, Toyoyuki Hanazawa, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
    • Journal Title

      Journal of Human Genetics

      Volume: 61 Issue: 2 Pages: 109

    • DOI

      10.1038/jhg.2015.120

    • NAID

      40020742209

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Invariant NKT cells are resistant to circulating CD15(+) myeloid-derived suppressor cells in patients with head and neck cancer.2016

    • Author(s)
      Horinaka A, Sakurai D, Ihara F, Makita Y, Kunii N, Motohashi S, Nakayama T, Okamoto Y.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 3 Pages: 207-16

    • DOI

      10.1111/cas.12866

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear.2016

    • Author(s)
      Koto M, Hasegawa A, Takagi R, Sasahara G, Ikawa H, Mizoe JE, Jingu K, Tsujii H, Kamada T, Okamoto Y
    • Journal Title

      Head Neck.

      Volume: 38(4) Issue: 4 Pages: 512-6

    • DOI

      10.1002/hed.23905

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basal cell adenoma of the parotid gland; MR features and differentiation from pleomorphic adenoma.2016

    • Author(s)
      Mukai H, Motoori K, Horikoshi T, Takishima H, Nagai Y, Okamoto Y, Uno T.
    • Journal Title

      Dentomaxillofac Radiol.

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibody-dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant natural killer T cells.2016

    • Author(s)
      Mise N, Takami M, Suzuki A, Kamata T, Harada K, Hishiki T, Saito T, Terui K, Mitsunaga T, Nakata M, Ikeuchi T, Nakayama T, Yoshida H, Motohashi S
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 3 Pages: 233-241

    • DOI

      10.1111/cas.12882

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Initial experience of radiotherapy plus cetuximab for Japanese head and neck cancer patients.2015

    • Author(s)
      Kurokawa M, Watanabe Nemoto M, Harada R, Kobayashi H, Horikoshi T, Kanazawa A, Togasaki G, Abe Y, Chazono H, Hanazawa T, Okamoto Y, Uno T.
    • Journal Title

      J Radiat Res.

      Volume: 56(5) Issue: 5 Pages: 849-55

    • DOI

      10.1093/jrr/rrv038

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells.2015

    • Author(s)
      Frigault, M. J., Lee, J., Basil, M., Carpenito, C., Motohashi, S., Scholler, J., Kawalekar, O. U., Guedan, S., McGettigan, S., Posey, A Jr., Ang, S., Cooper, L. J., Platt, J., Johnson, F. B., Paulos, C. M., Zhao, Y., Kalos, M., Milone, M. and June, C. H.
    • Journal Title

      Cancer Immunol. Res.

      Volume: 3(4) Issue: 4 Pages: 356-67

    • DOI

      10.1158/2326-6066.cir-14-0186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway.2015

    • Author(s)
      Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K, Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.
    • Journal Title

      Immunity

      Volume: 42(2) Issue: 2 Pages: 294-308

    • DOI

      10.1016/j.immuni.2015.01.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers: potential biomarker implications.2014

    • Author(s)
      Sun, Y., Furihata, T., Ishii, S., Nagai, M., Harada, M., Shimozato, O., Kamijo, T., Motohashi, S., Yoshino, I., Kamiichi, A., Kobayashi, K. and Chiba, K.
    • Journal Title

      Clin. Transl. Med.

      Volume: 3 Issue: 1 Pages: 37-37

    • DOI

      10.1186/s40169-014-0037-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.2014

    • Author(s)
      Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, DJ., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K. and Nakayama, T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 111(35) Issue: 35 Pages: 12829-34

    • DOI

      10.1073/pnas.1321245111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of carbon ion radiotherapy for locally advanced sinonasal adenocarcinoma.2014

    • Author(s)
      Koto M, Hasegawa A, Takagi R, Sasahara G, Ikawa H, Mizoe JE, Jingu K, Tsujii H, Kamada T, Okamoto Y,Organizing Committee for the Working Group for Head-and-Neck Cancer.
    • Journal Title

      Radiother Oncol.

      Volume: 113(1) Issue: 1 Pages: 60-5

    • DOI

      10.1016/j.radonc.2014.09.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.2014

    • Author(s)
      Kikkawa N, Kinoshita T, Nohata N, Hanazawa T, Yamamoto N, Fukumoto I, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
    • Journal Title

      Int J Oncol.

      Volume: 44(6) Issue: 6 Pages: 2085-92

    • DOI

      10.3892/ijo.2014.2349

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of the dose-volume relationship on and risk factors for maxillary osteoradionecrosis after carbon ion radiotherapy.2014

    • Author(s)
      Sasahara G, Koto M, Ikawa H, Hasegawa A, Takagi R, Okamoto Y, Kamada T.
    • Journal Title

      Radiat Oncol.

      Volume: 9(1) Issue: 1 Pages: 92-92

    • DOI

      10.1186/1748-717x-9-92

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma.2013

    • Author(s)
      Kinoshita T, Nohata N, Hanazawa T, Kikkawa N, Yamamoto N, Yoshino H, Itesako T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
    • Journal Title

      Br J Cancer

      Volume: 109 Issue: 10 Pages: 2636-2645

    • DOI

      10.1038/bjc.2013.607

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.2013

    • Author(s)
      Nohata N, Hanazawa T, Kinoshita T, Inamine A, Kikkawa N, Itesako T, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N.
    • Journal Title

      Br J Cancer

      Volume: 108 Issue: 8 Pages: 1648-1658

    • DOI

      10.1038/bjc.2013.122

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NKT cells as an ideal target for anti-tumor immunotherapy2013

    • Author(s)
      Fujii S, Shimizu K, Okamoto Y, Kunii N, Nakayama T, Motohashi S, Taniguchi M
    • Journal Title

      Front. Immunol

      Volume: 4 Pages: 409-409

    • DOI

      10.3389/fimmu.2013.00409

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.2013

    • Author(s)
      Hosokawa H, Tanaka T, Kato M, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Sakikawa I, Morita A, Nagira M, Suzuki Y, Nakayama T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 110(46) Issue: 46 Pages: 18626-18631

    • DOI

      10.1073/pnas.1311100110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells.2013

    • Author(s)
      Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.
    • Journal Title

      Immunity

      Volume: 39 Issue: 5 Pages: 819-32

    • DOI

      10.1016/j.immuni.2013.09.012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.2013

    • Author(s)
      Kunii N, Zhao Y, Jiang S, Liu X, Scholler J, Balagopalan L, Samelson LE, Milone MC, June CH.
    • Journal Title

      Human gene therapy

      Volume: 24 Issue: 1 Pages: 27-37

    • DOI

      10.1089/hum.2012.130

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Afibrin glue is a candidate scafford for long-term therapeutic protein expression in spontaneously differentiated adipocytes in vitro.2012

    • Author(s)
      Aoyagi Y,Kuroda M,Asada S,Tanio M,Aso M,Okamoto Y,Saito Y,Bujo H.
    • Journal Title

      Experimental Cell Reseach

      Volume: 318 Pages: 1090-1112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plectin promotes migration and invasion of cancer cells and is a novel probnostic marker for head and neck squamous cell carcinoma.2012

    • Author(s)
      Katada K,Tomonaga T, Satoh M, Matsushita K, Tonoike Y, Kodera Y, Hanazawa T, Nomura F, Okamoto Y.
    • Journal Title

      Journal of Proteomics.

      Volume: 75 Pages: 1803-1815

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressive microRNA-133a regulates novel targets: Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.2012

    • Author(s)
      Kinoshita T, Nohata N, Fuse M, Hanazawa T, Kikkawa N, Fujimura L, Takano H, Yamada Y, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 418 Pages: 1821-1830

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma.2012

    • Author(s)
      Kinoshita T, Nohata N, Watanabe-Takano H, Yoshino H, Hidaka H, Fujimura L, Fuse M, Yamasaki T, Enokida H, Nakagawa M, Hanazawa T, Okamoto Y, Seki N.
    • Journal Title

      Int J Oncol.

      Volume: 40 Pages: 1770-1778

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] がん免疫療法の進歩とNKT細胞の果たす役割2017

    • Author(s)
      本橋 新一郎
    • Organizer
      第21回輸血・細胞療法カンファレンス
    • Place of Presentation
      東京女子医科大学病院(東京都新宿)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 能動免疫療法におけるNKT細胞の果たす役割2016

    • Author(s)
      本橋 新一郎
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] The functional subsets of regulatory T cells correlate with clinical outcome and invariant NKT cells suppression in head and neck cancer patients.2016

    • Author(s)
      Ihara F, Sakurai D, Kunii N, Motohashi S, Okamoto Y.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] The functional subsets of regulatory T cells correlate with clinical outcome .2016

    • Author(s)
      Ihara F, Sakurai D, Motohashi S, Kunii N, Okamoto Y.
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] A randomized double-blind phase II trial evaluating adjuvant therapy for advanced oro- and hypo-pharyngeal cancer using the injection of alpha-GalCer-loaded DCs into the nasal submucosa.2016

    • Author(s)
      Kunii N, Makita Y, Ihara F, Sakurai D, Motohashi S, Nakayama T, Okamoto Y.
    • Organizer
      第20回日本がん免疫学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] A Randomized Double-blind Phase II Trial Evaluating Adjuvant Therapy for Advanced Oro- and Hypo-pharyngeal Cancer using the Injection of aGalCer-loaded DCs into the Nasal Submucosa.2016

    • Author(s)
      Naoki Kunii, Yuji Makita, Fumie Ihara, Daiju Sakurai, Shinichiro Motohashi, Toshinori Nakayama, Yoshitaka Okamoto.
    • Organizer
      第20回日本がん免疫学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗腫瘍免疫応答を利用したがん免疫治療の作用機序2016

    • Author(s)
      本橋 新一郎
    • Organizer
      第26回がん臨床研究フォーラム
    • Place of Presentation
      東京国際研究交流館(東京都江東区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] NKT細胞によるがん治療2016

    • Author(s)
      本橋 新一郎
    • Organizer
      日本医科大学医学会第26回シンポジウム
    • Place of Presentation
      日本医科大学(東京都文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of regulatory T cells in peripheral blood of the patients with Head and Neck cancer and their inhibitory role on NKT cells2015

    • Author(s)
      Ihara, F., Sakurai, D., Motohashi, S., and Okamoto, Y.
    • Organizer
      International Conference of Cancer Immunotherapy and Macrophages 2015
    • Place of Presentation
      Ito Hall, Ito International Research Center, The University of Tokyo
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antigen Specific Immunotherapy Based on Chimeric Antigen Receptor Expressing T Cells Targeted to Salivary Gland Tumor2015

    • Author(s)
      Kunii, N., Makita, Y., Ihara, F., Uchida, R., Fujikawa, A., Motohashi, S., Nakayama, T., and Okamoto, Y.
    • Organizer
      International Conference of Cancer Immunotherapy and Macrophages 2015
    • Place of Presentation
      Ito Hall, Ito International Research Center, The University of Tokyo
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells2015

    • Author(s)
      Kamata, T., Suzuki, A., Makita, Y., Kunii, N., Nakayama, T., and Motohashi, S.
    • Organizer
      International Conference of Cancer Immunotherapy and Macrophages 2015
    • Place of Presentation
      Ito Hall, Ito International Research Center, The University of Tokyo
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 標準治療後の進行期中・下咽頭癌症例に対するαGalCerパルス樹状細胞療法の有効性に関するランダム二重盲検試験2015

    • Author(s)
      國井直樹、蒔田勇治、伊原史英、内田亮介、佐々原剛、藤川陽、櫻井大樹、岡本美孝
    • Organizer
      日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      東武レバントホテル(東京都墨田区)
    • Year and Date
      2015-02-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Antigen Specific Immunotherapy Based on Chimeric Antigen Receptor Expressing T Cells Targeted to Salivary Gland Tumor2014

    • Author(s)
      Kunii, N., Makita, Y., Ihara, F., Uchida, R., Fujikawa, A., Sakurai, D., Motohashi, S., Nakayama, T. and Okamoto, Y.
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市左京区)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] The trithrax complex component Menin controls differentiation and maintenance of T helper 17 cells2014

    • Author(s)
      Watanabe, Y., Onodera, A., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kikuchi, M., Morimoto, Y., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K. and Nakayama, T.
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市左京区)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Human melanoma antigen-specific iNKT cells engineered by the TIL 1383I T cell receptor gene transfer2014

    • Author(s)
      Nagato, K., Motohashi, S., Nakayama, T., Yoshino, I. and Nishimura, M. I.
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市左京区)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 唾液腺癌に対する抗原特異的T細胞の細胞傷害活性は活性化NKT細胞によって相乗的に増強する2014

    • Author(s)
      蒔田勇治、國井直樹、岡本美孝
    • Organizer
      日本唾液腺学会学術集会
    • Place of Presentation
      文教学院大学(東京都文京区)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 原発性肺癌に対するNKT細胞免疫療法におけるPD-1阻害の有用性2014

    • Author(s)
      鎌田 稔子, 鈴木 茜, 藤川 陽, 三瀬 直子, 蒔田 勇治, 吉田 成利, 鈴木 秀海, 中島 崇裕, 岩田 剛和, 吉野 一郎, 中山 俊憲, 本橋 新一郎
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市左京区)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨髄系免疫抑制細胞の頭頸部腫瘍における検討2014

    • Author(s)
      堀中 敦史、本橋 新一郎、岡本 美孝
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] NKT cell-targeting immunotherapy for non-small cell lung cancer2014

    • Author(s)
      本橋 新一郎
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 原発性肺癌患者におけるNKT細胞免疫治療とPD-1阻害療法の有用性2014

    • Author(s)
      鎌田 稔子、本橋 新一郎、吉田 成利、鈴木 秀海、中島 崇裕、田川 哲三、岩田 剛和、溝渕 輝明、吉野 一郎
    • Organizer
      第31回日本呼吸器外科学会総会
    • Place of Presentation
      ホテル日航東京(東京都港区台場)
    • Year and Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Phase I/II clinical study of α-galactosylceramide-pulsed antigen presenting cells as adjuvant immunotherapy for patients with head and neck mucosal malignant melanoma after carbon ion radiotherapy.2013

    • Author(s)
      Fujikawa, A., Kunii, N., Horinaka, A., Makita, Y., Uchida, R., Ihara, F., Motohashi, S., Okamoto, Y., and Nakayama, T.
    • Organizer
      第42回日本免疫学会総会学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] NKT細胞免疫系をターゲットにしたがんの免疫細胞治療ー10年間の臨床研究の成果と今後の展望ー2013

    • Author(s)
      中山俊憲、本橋新一郎、國井直樹、岡本美孝
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 炭素イオン線治療後の頭頸部粘膜悪性黒色腫患者に対するaガラクトシルセラミドパルス抗原提示細胞を用いたアジュバント免疫治療に関する第I/II相臨床研究2013

    • Author(s)
      藤川陽,國井直樹,櫻井大樹,長谷川安都佐,鎌田正,溝江純悦,岡本美孝,本橋新一郎,中山俊憲
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部
    • Related Report
      2013 Annual Research Report
  • [Presentation] NKT cell-targeting therapy for lung cancer and head and neck cancer.2013

    • Author(s)
      Motohashi, S., Kunii, N., Taniguchi, M., Yoshino, I., Okamoto, Y., and Nakayama, T.
    • Organizer
      7th International symposium on CD1 and NKT cells
    • Place of Presentation
      Tours France
    • Related Report
      2013 Annual Research Report
  • [Presentation] ユビキチン化抵抗性LATによるT細胞の機能増強

    • Author(s)
      國井直樹、本橋新一郎、岡本美孝、中山俊憲
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      ロイトン札幌(北海道
    • Related Report
      2012 Annual Research Report
  • [Presentation] Enhanced function of primary human T cells electroporated with RNA for LAT that is resistant to ubiquitylation

    • Author(s)
      KUNII Naoki, MOTOHASHI Shinichiro, OKAMOTO Yoshitaka, NAKAYAMA Toshinori
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ユビキチン化抵抗性LATによるT細胞のエフェクター機能の強化

    • Author(s)
      國井直樹、櫻井大樹、岡本美孝
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷市芸文館(岡山県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Enhanced function of redirected human T cells expressing LAT thatis

    • Author(s)
      Naoki Kunii, Shinichiro Motohashi, Kaoru Nagato, Yoshitaka Okamoto, Toshinori Nakayama
    • Organizer
      第16回日本癌免疫学会
    • Place of Presentation
      北海道大学学術交流会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨髄系免疫抑制細胞(MDSC: myeloid-derived suppressor cells)の頭頸部腫瘍における検討

    • Author(s)
      堀中敦史
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷市芸文館(岡山県)
    • Related Report
      2012 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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