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Innovative Approaches for Oxygen Metabolism Disorder with Artificial Oxygen Carriers and Related Compounds

Research Project

Project/Area Number 24249086
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionTokai University

Principal Investigator

KAWAGUCHI Akira  東海大学, 医学部, 教授 (30195052)

Co-Investigator(Kenkyū-buntansha) INOKUCHI Sadaki  東海大学, 医学部, 教授 (60160008)
HAIDA Munetaka  東海大学医療技術短期大学, 看護学部, 教授 (20208408)
SHIRAI Mikiyasu  独立行政法人国立循環器病研究センター, 心機能生理部, 部長 (70162758)
NEYA Saburo  千葉大学, 薬学研究科(研究院), 教授 (10156169)
YAMANO Mariko  大阪府立大学, 総合リハビリテーション学部, 准教授 (80192409)
IMAI Kiyohiro  法政大学, 生命科学部, 教授 (50028528)
KANO Koji  同志社大学, 工学部, 教授 (60038031)
MURAYAMA Chieko  東海大学, 医学部, 講師 (50307295)
TAMAKI Tetsuro  東海大学, 医学部, 准教授 (10217177)
ENDO Hitoshi  東海大学, 医学部, 講師 (10550551)
TSUNESHIGE Antonio  法政大学, 生命科学部, 教授 (30409346)
OKU Naoto  静岡県立大学, 薬学部, 教授 (10167322)
Co-Investigator(Renkei-kenkyūsha) IMAI Kiyohiro  法政大学, 生命科学部, 教授 (50028528)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥34,970,000 (Direct Cost: ¥26,900,000、Indirect Cost: ¥8,070,000)
Fiscal Year 2014: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2012: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Keywords人工酸素運搬体 / 虚血 / 再灌流障害 / ヘモグロビン / 酸素代謝障害 / 一酸化炭素中毒 / シアン中毒 / 水素 / 人工酸素運搬対 / 再還流障害
Outline of Final Research Achievements

Blood circulation consists of heart(pump), vasculature(circuit)and blood(fluid). While derangement of any of them results in circulatory failure, approaches through the third component have been scarce except for transfusion. Whereas artificial oxygen carriers (AOC) remain short of red cells in health, their physical characteristics may work better in disease. In the current study, we tested various AOC and related compounds in animal models to show, 1)protection of ischemia and/or reperfusion injury in bronchus, stomach, brain, inner-ear, skin and skeletal muscle, 2)absence of competitive inhibition on antigen recognition by reticuloendothelial system after a large-dose administration, 3)enhanced radiotherapy and reduction on metastasis after chemotherapy. The results prompted us to change the hypothetical mechanism from aerobic energy synthesis to anti-inflammatory action through suppressed HIF-1a-mediated signal transduction, which better explains the current observations.

Report

(4 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (108 results)

All 2015 2014 2013 Other

All Journal Article (51 results) (of which Peer Reviewed: 51 results,  Acknowledgement Compliant: 8 results,  Open Access: 7 results) Presentation (56 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Ventricular conduction defects after transcatheter aortic valve implantation.2015

    • Author(s)
      Kawaguchi AT, D’Alesandro S, Cluzel P, Makri R, Laali M, Leprince P.
    • Journal Title

      Artif Organs

      Volume: 39

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Supramolecular ferric porphyrins and a cyclodextrin dimmer as an antidote for cyanide poisoning.2014

    • Author(s)
      Yamagiwa T, Kawaguchi AT, Saito T, Inoue S, Morita S, Watanabe K, Kitagishi H, Kano K, Inokuchi S.
    • Journal Title

      Hum Exp Toxicol

      Volume: 33 Pages: 360-368

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Artificial oxygen carrier to regulate hypoxic signal transduction.2014

    • Author(s)
      Kawaguchi AT.
    • Journal Title

      Artif Organs

      Volume: 38 Issue: 8 Pages: 617-620

    • DOI

      10.1111/aor.12372

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Liposome-encapsulated hemoglobin accelerates bronchial healing in the rats without or with preoperative radiation.2014

    • Author(s)
      Takeichi H, Kawagchi AT, Murayama C, Iwasaki H.
    • Journal Title

      Artificial Organs

      Volume: 38 Issue: 8 Pages: 634-640

    • DOI

      10.1111/aor.12278

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liposome-encapsulated hemoglobin accelerates gastric wound healing in the rat.2014

    • Author(s)
      Kawaguchi AT, Okamoto Y, Kise Y, Takekoshi S, Murayama C, Makuuchi H.
    • Journal Title

      Artif Organs

      Volume: 38 Pages: 641-649

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Liposome-encapsulated hemoglobin enhances2014

    • Author(s)
      Murayama C, Kawaguchi AT, Kamijo A, Naito K, Iwao K, Tsukamoto H, Yasuda K, Nagato Y.
    • Journal Title

      Artif Organs

      Volume: 38 Pages: 656-661

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Liposome-encapsulated hemoglobin improves learning ability in Tokai high-avoider rats after total brain ischemia and reperfusion.2014

    • Author(s)
      Kawaguchi AT, Endo H, Aikawa H, Yamano M, Kawaguchi Y, Haida M, Watanabe T.
    • Journal Title

      Artif Organs

      Volume: 38 Issue: 8 Pages: 667-674

    • DOI

      10.1111/aor.12352

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron-emission tomography.2014

    • Author(s)
      Fukuta T, Ishii T, Asai T, Nakamura G, Takeuchi Y, Sato A, Agato Y, Shimizu K, Akai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N.
    • Journal Title

      Artif Organs

      Volume: 38 Pages: 662-666

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relaxation analysis of ligand binding to the myoglobin2014

    • Author(s)
      Neya S, Yonetani S, Kawaguchi AT.
    • Journal Title

      Artif Organs

      Volume: 38 Issue: 8 Pages: 715-719

    • DOI

      10.1111/aor.12327

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Liposome-encapsulated hemoglobin accelerates gastric wound healing in the rat2014

    • Author(s)
      Kawaguchi AT, Okamoto Y, Kise Y, Tanaka M, Takekoshi S, Ogoshi S, Makuuchi H
    • Journal Title

      Artificial Organs

      Volume: 38

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Artificial Organs2014

    • Author(s)
      Murayama C, Kawaguchi AT, et al.
    • Journal Title

      Liposome-encapsulated hemoglobin

      Volume: 38

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liposome-encapsulated hemoglobin improves learning ability in Tokai high-avoider rats after total brain ischemia and reperfusion2014

    • Author(s)
      Kawaguchi AT, Aikawa H, Furuya H, Watanabe T, et al.
    • Journal Title

      Artificial Organs

      Volume: 38

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time trafficking of PEGylated liposomes in the ischemic region of ischemia model rat brain as analyzed by positron-emission tomography2014

    • Author(s)
      Fukuta T, Ishii T, Asai T, Nakamura G, Tkeuchi Y, Sato A, Agato Y, Shimizu K, Akai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N.
    • Journal Title

      Artificial Organs

      Volume: 38

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relaxation analysis of ligand binding to the myoglobin reconstituted with cobartic heme.2014

    • Author(s)
      Neya S, Yonetani S, Kawaguchi AT.
    • Journal Title

      Artificial Organs

      Volume: 38

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Artificial oxtgen carriers - Clinical point of view -2014

    • Author(s)
      Kawaguchi AT
    • Journal Title

      Artificial Organs

      Volume: 38

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circular dichroism of hemoglobin and myoglobin2014

    • Author(s)
      Masako Nagai M., Yoshifumi Nagai Y., Kiyohiro Imai K., and Saburo Neya S.
    • Journal Title

      Chrality

      Volume: 15 Issue: 9 Pages: 438-442

    • DOI

      10.1002/chir.22273

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cluster analysis on the structural diversity of protein crystals, exemplified by human immunodeficiency virus type 1 protease2014

    • Author(s)
      Que Fei, Satosih Fudo S, Saburo Neya S., Masaaki Suzuki, Tyuji Hoshino.
    • Journal Title

      Chem Pharm Bull

      Volume: 62

    • NAID

      130004137270

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skeletal recombination reaction of N-fused pentaphyrin(1,1,1,1,1) via bromination2014

    • Author(s)
      Masaaki Suzuki, Tyuji Hoshino, and Saburo Neya.
    • Journal Title

      Org Lett

      Volume: 16 Issue: 2 Pages: 327-329

    • DOI

      10.1021/ol403242z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intramolecular direct oxygen transfer from oxoferryl porphyrin to sulfide bond2014

    • Author(s)
      Ueda T, Kitagishi H, Kano K
    • Journal Title

      Inorg Chem

      Volume: 53 Issue: 1 Pages: 543-551

    • DOI

      10.1021/ic4026393

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular delivery of anionic meso-tetraarylporphyrin/pre-O-methylated Beta-cyclodextrin supramolecular complex by an oligoarginine carrier peptide2014

    • Author(s)
      Kitagichi H, Minami K, Kano K
    • Journal Title

      Chem Lett

      Volume: 43 Issue: 7 Pages: 1095-1097

    • DOI

      10.1246/cl.140298

    • NAID

      130004868276

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liposome-encapsulated hemoglobin alleviates hearing loss after transient cochlear ischemia: An experimental study in the gerbil2013

    • Author(s)
      Okada M, Kawaguchi AT, Hakuba N, Hato N, Gyo K.
    • Journal Title

      Neurosci Lett

      Volume: 553 Pages: 176

    • DOI

      10.1016/j.neulet.2013.08.043

    • URL

      https://pure.teikyo.jp/en/publications/569779b4-a128-4d44-8a57-c40b6832c172

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticles accumulate in ischemic core and penumbra region even when cerebral perfusion is reduced.2013

    • Author(s)
      Ishii T, Fukuta T, Agato Y, Oyama D, Yasuda N, Shimizu K, Kawaguchi AT, Asai T, Oku N.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 430 Issue: 4 Pages: 1201-1205

    • DOI

      10.1016/j.bbrc.2012.12.080

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Static cardiomyopathy with synthetic elastic net suppresses myocardial dysfunction after acute myocardial infarction in the rat2013

    • Author(s)
      Kato N, Kawaguchi AT, Kishida A, Yamaoka T.
    • Journal Title

      Artificial Organs

      Volume: 37 Issue: 7 Pages: 593-599

    • DOI

      10.1111/aor.12059

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liposome-encapsulated hemoglobin ameliorates ischemic stroke in nonhuman primates: longitudinal observation.2013

    • Author(s)
      Kawaguchi AT, Haida M, Ohba H, Yamano M, Fukumoto D, Tsukada H.
    • Journal Title

      Artificial Organs

      Volume: 37 Issue: 10 Pages: 904-912

    • DOI

      10.1111/aor.12091

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supramolecular ferric porphyrins and a cyclodextrin dimer as an antidote for cyanide poisoning2013

    • Author(s)
      Yamagiwa T, Kawaguchi AT, Saito T, INoue S, Morita S, Watanabe K, Kitagishi H, Koji K, Inokuchi S.
    • Journal Title

      Human and experimental toxicology

      Volume: Aug5 Issue: 4 Pages: 1-9

    • DOI

      10.1177/0960327113499041

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of pH in in vitro assessment of cyanide toxicity2013

    • Author(s)
      Yamagiwa T, Inokuchi S, Saito T, INoue S, Morita S, Kawaguchi AT.
    • Journal Title

      Tokai J Exp Clin Med

      Volume: 38 Pages: 114-122

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ralaxation analysis of ligand binding to the myoglobin reconstituted with cobartic heme.2013

    • Author(s)
      Neya S, Suzuki M, Hoshino T, Kawaguchi AT.
    • Journal Title

      Inorganic Chemistry

      Volume: 52 Issue: 13 Pages: 7387-7393

    • DOI

      10.1021/ic400078w

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of serotonin uptake and degradation to myocardial interstitial seroton in levels during ischaemia-reperfusion in rabbits.2013

    • Author(s)
      Sonobe T, Akiyama T, Du CK, Zhan DY, Shirai M.
    • Journal Title

      Acta Physiol (Oxf).

      Volume: 207 Issue: 2 Pages: 260-268

    • DOI

      10.1111/j.1748-1716.2012.02461.x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model.2013

    • Author(s)
      Fujii Y, Shirai M, Inamori S, Shimouchi A, Sonobe T, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E, Taenaka Y.
    • Journal Title

      Artif Organs.

      Volume: 37 Issue: 2 Pages: 136-141

    • DOI

      10.1111/j.1525-1594.2012.01535.x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchrotro radiation imaging for advancing our understanding of ardiovascular function2013

    • Author(s)
      Mikiyasu Shirai, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Keiji Umetani, Naoto Yagi, James T. Pearson
    • Journal Title

      Circ Res

      Volume: 112(1) Issue: 1 Pages: 209-221

    • DOI

      10.1161/circresaha.111.300096

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myosin heads are displaced from actin filaments in the in situ beating rat heart in early diabetes.2013

    • Author(s)
      Jenkins MJ, Pearson JT, Schwenke DO, Edgley AJ, Sonobe T, Fujii Y, Ishibashi-Ueda H, Kelly DJ, Yagi N, Shirai M.
    • Journal Title

      Biophys J.

      Volume: 104 Issue: 5 Pages: 1065-1072

    • DOI

      10.1016/j.bpj.2013.01.037

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anaesthetized mice.2013

    • Author(s)
      Zhan DY, Du CK, Akiyama T, Sonobe T, Tsuchimochi H, Shirai M.
    • Journal Title

      Auton Neurosci

      Volume: 176(1-2) Issue: 1-2 Pages: 91-94

    • DOI

      10.1016/j.autneu.2013.02.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired pulmonary blood flow distribution in congestive heart failure assessed using synchrotron radiation microangiography.2013

    • Author(s)
      Shirai M, Beard M, Pearson JT, Son obe T, Tsuchimochi H, Fujii Y, Gray E, Umetani K. Schwenke DO.
    • Journal Title

      J Synchrotron Radiat

      Volume: 20(3) Issue: 3 Pages: 441-448

    • DOI

      10.1107/s0909049513007413

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of intravenous magnesium infusion on in vivo release of acetylcholine and catecholamine in rat adrenal medulla.2013

    • Author(s)
      Komaki F, Akiyama T, Yamazaki T, Kitagawa H, Nosaka S, Shirai M.
    • Journal Title

      Autonomic Neuroscience

      Volume: 177 Issue: 2 Pages: 123-128

    • DOI

      10.1016/j.autneu.2013.03.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparative study of cerebral microcirculation during pulsatile and nonpulsatile selective cerebral perfusion: Assessment by synchrotron radiation microangiography.2013

    • Author(s)
      Inamori S, Shirai M, Yahagi N, Pearson JT, Fujii Y, Umetani K, Kobayashi Y, Okura Y, Yakehiro M, Minamiyama M.
    • Journal Title

      ASAIO J

      Volume: 59 Issue: 4 Pages: 374-379

    • DOI

      10.1097/mat.0b013e3182976939

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing oxidized LDL receptor.2013

    • Author(s)
      Ogura S, Shimosawa T, Mu SY, Sonobe T, Kawakami-Mori F, Wang H, Uetake y. Yoshida K, Yatomi Y, S hirai M, Fujita T.
    • Journal Title

      Am J Physiol Heart and Circ Physiol

      Volume: 305(2) Issue: 2 Pages: H155-H162

    • DOI

      10.1152/ajpheart.00169.2012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart2013

    • Author(s)
      Hideyuki Maeda, Hisashi Nagai, GenzouTakemura, Masaaki Komatsu, Sayoko Ogura, Kaori Shintani-Ishida, Toshihiko Aki, Mikiyasu Shirai, Ichiro Kuwahira, Ken-ichi Yoshida
    • Journal Title

      Biochimicaet Biophysica Acta

      Volume: 1832 Issue: 8 Pages: 1159-1166

    • DOI

      10.1016/j.bbadis.2013.02.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in th e early diabetic microcirculation.2013

    • Author(s)
      Pearson JT, Jenkins Mi. Edgley AJ, Sonobe T, Joshi M. Waddingham MT, Fujii V. Schwenkc DO, Tsuchi mochi H. Yoshimoto M, Umetani K, Kelly DJ, Shirai M.
    • Journal Title

      Cardiovasc Diabetol

      Volume: 12 Issue: 1 Pages: 111-124

    • DOI

      10.1186/1475-2840-12-111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympathetic Afferent Stimulation Inhibits Central Vagal Activation Induced by Intravenous Medetomidine in Rats2013

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Turner Michael J, Shirai M, Sugimachi M
    • Journal Title

      Acta Physiol (Oxf)

      Volume: 10 Issue: 1 Pages: 100-110

    • DOI

      10.1111/apha.12123

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Serotonin Pathway-A Therapeutic Target For Pulmonary Hypertension? Assessing Vascular Function Using Synchrotoron Radiation Microangiography.2013

    • Author(s)
      Gray EA, Tsuchimochi H, Pearson JT, Sonobe T, Fujii Y, Yoshimoto M, Umetani K, Shirai M, Schwenke DO.
    • Journal Title

      J Synchrotron Radiat

      Volume: 20(5) Issue: 5 Pages: 756-764

    • DOI

      10.1107/s0909049513021213

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperoxic condition promotes an inflammatory response during cardiopulmonary bypass in a rat model.2013

    • Author(s)
      Fujii Y, Shirai M, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E, Taenaka Y.
    • Journal Title

      Artif Organs.

      Volume: 37(12) Issue: 12 Pages: 1034-40

    • DOI

      10.1111/aor.12125

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a Novel Murine Model of Ischemic Cardiomyopathy with Multiple Diffuse Coronary Lesions.2013

    • Author(s)
      Nakaoka H, Nakagawa-Toyama Y, N ishida M, Tsubakio-Yamamoto K, Ya mashita T, Nakatani K, Kawase R, Masuda D, Ohama T, Sonobe T, Shirai M, Komuro I, Yamashita S.
    • Journal Title

      PLoS One

      Volume: 8(8) Issue: 8 Pages: e70755-e70755

    • DOI

      10.1371/journal.pone.0070755

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the Electron Density of the Heme Fe Atom and the Vibrational Frequencies of the Fe-Bound Carbon Monoxide in Myoglobin2013

    • Author(s)
      R. Nishimura, T. Shibata, H. Tai, I. Ishigami, T. Ogura, S. Nagao, T. Matsuo, S. Hirota, K. Imai, S. Neya, A. Suzuki, and Y, Yamamoto
    • Journal Title

      Inorg. Chem.

      Volume: 52 Issue: 6 Pages: 3349-3355

    • DOI

      10.1021/ic3028447

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of lipid composition on the structural stability of G-protein coupled receptor2013

    • Author(s)
      Mahmood M. Iqbal, Xinli Liu, Saburo Neya, and Tyuji Hoshino
    • Journal Title

      Chem Pharm Bull

      Volume: 61 Pages: 426-437

    • NAID

      130003360753

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic motion and rearranged molecular shape of heme in myoglobin: Structural and functional consequences2013

    • Author(s)
      Saburo Neya
    • Journal Title

      Molecules

      Volume: 18 Issue: 3 Pages: 3168-3182

    • DOI

      10.3390/molecules18033168

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A less common spin-crossover process observed in the six-coordinated model heme complexes2013

    • Author(s)
      Y. Ohgo, M. Takahashi, S. Neya, M. Nakamura, K. Takahashi, Y. Namatame, H. Konaka, H. Mori, D. Hashizume
    • Journal Title

      Polyhedron

      Volume: 66 Pages: 60

    • DOI

      10.1016/j.poly.2013.02.015

    • URL

      https://pure.teikyo.jp/en/publications/09983d00-7d7d-4129-803c-6a69706f0408

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electronic Control of Discrimination between O2 and CO in Myoglobin Lacking the Distal Histidine Residue2013

    • Author(s)
      R. Nishimura, T. Shibata, I. Ishigami, T. Ogura, H. Tai, S. Nagao, T. Matsuo, S Hirota, O. Shoji, Y. Watanabe, K. Imai, S. Neya, A. Suzuki, Y. Yamamoto
    • Journal Title

      Inorg. Chem.

      Volume: 53 Issue: 2 Pages: 1091-1099

    • DOI

      10.1021/ic402625s

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective Activity of Antioxidants in the Hypothalamic Paraventricular Nuclei of Chronic Restraint-Stressd Mice.2013

    • Author(s)
      Hideo Shinagawa, Mariko Yamano, Tatsuyoshi Saijo, and Makoto Muratsugu.
    • Journal Title

      Journal of Life Science Research

      Volume: 11 Pages: 1-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supramolecular iron porphyrin/Cyclodextrin dimer complex that mimics the functions of hemoglobin and methhemoglobin2013

    • Author(s)
      Watanabe K, Kitagishi K, Kano K
    • Journal Title

      Angew Chem Int Ed

      Volume: 52 Issue: 27 Pages: 6894-6897

    • DOI

      10.1002/anie.201302470

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intramolecular oxidative O-demethylation in a per-O-methylated beta-cyclodextrin iron porphyrin inclusion complex in aqueous solution2013

    • Author(s)
      Ueda T, Kumeda S, Kitagishi H, Kano K
    • Journal Title

      Chem Lett

      Volume: 42 Issue: 11 Pages: 1366-1368

    • DOI

      10.1246/cl.130678

    • NAID

      130004426829

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低酸素運動における前頭部多チャンネルNMIRSと前額部パルスオキシメーターの同時測定の試み-NIRS信号の拍動成分の意味-2013

    • Author(s)
      栗田 太作、寺尾 保、瀧澤 俊也、沓澤 智子、灰田 宗孝,八木原 晋、両角 速
    • Journal Title

      東海大学酢ポーツ医科学雑誌

      Volume: 25 Pages: 79-82

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] STS-score and Euroscore in indicating vascular access for transcatheter aortic valve implantation (TAVI).2014

    • Author(s)
      Kawaguchi AT, Collet JP, Cluzel P, Makri R, Laali M, DeFrance C, Leprince P.
    • Organizer
      European Society for Artificial Organs
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin preserves VO2 and protect myocardium after myocardial ischemia/infarction as a biological assist in the rat.2014

    • Author(s)
      Kawaguchi AT, Yamano M, Furuya H.
    • Organizer
      European Society for Artificial Organs
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin improves tumor oxygenation as detected by near-infrared spectroscopy (NIRS) in colon carcinoma in mice.2014

    • Author(s)
      Kawaguchi F, Kawaguchi AT, Kamijyo A, Haida M, Kurita D, Murayama C.
    • Organizer
      European Society for Artificial Organs
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Artificial oxygen carrier, liposome-encapsulated hemoglobin as the plasma oxygenizer.2014

    • Author(s)
      Kawaguchi AT, Ohba H, Kakiuchi N, Fukumoto D, Haida M, Tsukada H.
    • Organizer
      European Society for Artificial Organs
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin enhances chemotherapy to suppress metastasis in mice.2014

    • Author(s)
      Murayama C, Kawaguchi AT, Kamijo A, Naito K, Iwao K, Tsukamoto H, Yasuda K, Nagato Y.
    • Organizer
      European Society for Artificial Organs
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin accelerates skin wound healing in diabetic dBdB mice.2014

    • Author(s)
      Fukui T, Kawaguchi AT, Takekoshi S, Miyasaka M, Tanaka R.
    • Organizer
      ASAIO 60th conference
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin improves tumor oxygenation as detected by near-infrared spectroscopy (NIRS) in colon carcinoma in mice.2014

    • Author(s)
      Kawaguchi F, Kawaguchi AT, Kamijyo A, Haida M, Kurita D, Murayama C.
    • Organizer
      ASAIO 60th conference
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] EuroSCORE and STS-SCORE in indicating vascular access for transcatheter aortic valve implantation (TAVI).2014

    • Author(s)
      Kawaguchi AT, Laali M, Cluzel P, Makri R, Collet J, DeFrance C, Leprince P.
    • Organizer
      ASAIO 60th conference
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 運転行動の違いから見た前頭脳機能の計測2013

    • Author(s)
      清水 俊行、南部 起可、上野 裕史、灰田 宗孝
    • Organizer
      ヒューマンインターフェイスシンポジューム2013
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liposome-Encapsulated Hemoglobin Improves Tumor Oxygenation As Detected by Near-Infrared Spectroscopy (NIRS) in Colon Carcinoma in Mice

    • Author(s)
      Kawaguchi F, Kawaguchi AT, Murayama C, et al.
    • Organizer
      5th International Faculty of Artificial Organs (IFAO)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin enhances chemotherapy to suppress tumor growth and metastasis in mice.

    • Author(s)
      Murayama C, Kawaguchi AT, Kawaguchi F, et al.
    • Organizer
      5th International Faculty of Artificial Organs (IFAO)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin ameliorates skeletal muscular ischemia and reperfusion injury in the rat.

    • Author(s)
      Saito N, Kawaguchi AT, et al.
    • Organizer
      5th International Faculty of Artificial Organs (IFAO)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin improves learning ability in Tokai high-avoider rats after total brain ischemia and reperfusion

    • Author(s)
      Kawaguchi AT, Aikawa H, Furuya H, et al.
    • Organizer
      5th International Faculty of Artificial Organs (IFAO)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin accelerates gastric woung hearing in the rat

    • Author(s)
      Kawaguchi AT, Okamoto Y, Kise Y, et al.
    • Organizer
      5th International Faculty of Artificial Organs (IFAO)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin alleviates hearing loss after cochlear ischemia and reperfusion in the gerbil

    • Author(s)
      Okada M, Kawaguchi AT, Hata N, et al.
    • Organizer
      5th International Faculty of Artificial Organs (IFAO)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin accelerates bronchial wound healing after pneumonectomy in the rat without or with preoperative radiotherapy

    • Author(s)
      Takeichi H, Kawaguchi AT, Murayama C, et al.
    • Organizer
      5th International Faculty of Artificial Organs (IFAO)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin accelerates skin wound healing in diabetic dB/dB mice

    • Author(s)
      Fukui T, Kawaguchi AT, Tanaka R, et al.
    • Organizer
      5th International Faculty of Artificial Organs (IFAO)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ventricular conduction defects after transcatheter aortic valve implantation

    • Author(s)
      Kawaguchi AT, D'Alesandro S, Cluzel P, et al.
    • Organizer
      European Association for Cardiothoracic Surg
    • Place of Presentation
      Wienna, Austria
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tumor and HIF-1a

    • Author(s)
      Murayama C, Kawaguchi AT, et al.
    • Organizer
      European Society for Clinical Oncology
    • Place of Presentation
      Hersinki, Finland
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緩和速度法による酸化型コバルトミオグロビンへの配位子結合解析

    • Author(s)
      根矢 三郎、鈴木 優章、星野 忠次
    • Organizer
      第40回生体分子科学討論会
    • Place of Presentation
      豊中市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酸化型コバルトミオグロビンへの配位子結合と結合特性

    • Author(s)
      根矢 三郎、鈴木 優章、星野 忠次
    • Organizer
      第23回金属の関与する生体関連反応シンポジウムSRM2013
    • Place of Presentation
      西東京市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緩和法による酸化型コバルトを含むミオグロビンへの配位子結合解析

    • Author(s)
      根矢三郎、星野忠次、鈴木優章、川口 章、他
    • Organizer
      第133回 日本薬学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酸化型コバルトミオグロビンへの速度論的配位子結合解析

    • Author(s)
      根矢 三郎、鈴木 優章、星野 忠次
    • Organizer
      日本生物物理学会第51回年会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Computational analysis on the influence of membrane lipid composition on the structural invariance of G-protein coupled receptor.

    • Author(s)
      Mahmood M. I., Li X., Neya S., Hoshino T.
    • Organizer
      日本生物物理学会第51回年会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酸化型コバルトミオグロビンへの配位子結合速度解析

    • Author(s)
      根矢 三郎、鈴木 優章、星野 忠次
    • Organizer
      錯体化学会第63回討論会
    • Place of Presentation
      那覇市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 外部刺激応答型ヘムの電子状態

    • Author(s)
      大胡 惠樹、根矢 三郎、橋爪 大輔
    • Organizer
      錯体化学会第63回討論会
    • Place of Presentation
      那覇市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミオグロビンにおけるヘムと軸配位子ヒスチジンの電子的相互作用を介した外部配位子認識機構の解明

    • Author(s)
      西村 龍、柴田 友和、鈴木 秋弘、根矢 三郎、山本 泰彦
    • Organizer
      第52回NMR討論会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 体のなかではたらく金属元素

    • Author(s)
      根矢 三郎
    • Organizer
      科学技術振興機構サイエンスアゴラ2013
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高蛋白食摂餌と運動の効果―マウス筋線維の肥大と再生

    • Author(s)
      山野眞利子
    • Organizer
      日本解剖学会
    • Place of Presentation
      栃木
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genetic response upon removal of endogenous CO from the blood of mice by administration of a synthetic CO receptor

    • Author(s)
      Ueda T, Negi S, Kano K, et al
    • Organizer
      16th International Conference on Bio-inorganic Chemistry
    • Place of Presentation
      Grenoble
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hydroxylation of an axial pyridine ligand in a supramolecule composed of a porphinatoiron(III) and per-O-methyl-beta-cyclodextrin dimer with mCPBA

    • Author(s)
      Ueda T, Kumeda S, Kitagishi H, Kano K
    • Organizer
      16th International Conference on Bio-inorganic Chemistry
    • Place of Presentation
      Grenoble
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chiral twisted-structures of cyclodextrins

    • Author(s)
      Kano K
    • Organizer
      Symetry and Chirality in Chemistry and Physics
    • Place of Presentation
      Delft
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] シクロデキストリン-ポルフィリン超分子錯体による転写因子GAL4のDNA結合の可逆的制御

    • Author(s)
      根木 滋, 家出悠加, 中山千恵, 北岸宏亮, 加納航治, 杉浦幸雄
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] シクロデキストリンの超分子性

    • Author(s)
      加納航治
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 鉄ポルフィリン/メチル化シクロデキストリン超分子錯体(hemoCD)による酸化酵素モデル反応

    • Author(s)
      上田卓典, 北岸宏亮, 加納航治
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] メチル化シクロデキストリンによって包接されたアルキルコバルトポルフィリン錯体の光分解反応

    • Author(s)
      今別府洸平, 北岸宏亮, 加納航治
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] オクタアルギニン修飾シクロデキストリンの合成とその細胞内移行

    • Author(s)
      茶井文彦, 北岸宏亮, 加納航治
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] メチル化シクロデキストリン二量体で包接された鉄(III)ポルフィリンによる水中でのアニオン認識

    • Author(s)
      北岸宏亮, 齊藤友紀恵, 菅谷陽輔, 加納航治
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] hemoCDによる生体内一酸化炭素の除去とそれによる遺伝子発現の変化

    • Author(s)
      勇村亞希, 北岸宏亮, 加納航治
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 鉄(II)ポルフィリン/シクロデキストリン超分子錯体による内因性一酸化炭素の除去とそれによる細胞および動物体内における遺伝子発現変化

    • Author(s)
      北岸宏亮, 勇村亞希, 加納航治
    • Organizer
      錯体化学会第63回討論会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report
  • [Presentation] 水中における超分子ヘム酵素モデル –過酸との反応による遠位サイトの選択的O-脱メチル化とそれによるモデル機能の改変–

    • Author(s)
      上田卓典, 粂田紗規, 北岸宏亮, 加納航治
    • Organizer
      錯体化学会第63回討論会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超分子COレセプターの細胞内導入法の検討

    • Author(s)
      南 景子, 北岸宏亮, 加納航治
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超分子COレセプターによる生体内COの除去効果

    • Author(s)
      勇村亞希, 北岸宏亮, 根木 滋, 杉浦幸雄, 加納航治
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] アルキルCo(III)ポルフィリン錯体のメチル化シクロデキストリン包接状態における光分解反応

    • Author(s)
      今別府洸平, 北岸宏亮, 加納航治
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 水中におけるヒドロペルオキソ鉄(III)ポルフィリン錯体の安定化

    • Author(s)
      上田卓典, 北岸宏亮, 加納航治
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] オクタアルギニン修飾シクロデキストリン包接化合物の細胞内移行

    • Author(s)
      茶井文彦, 北岸宏亮, 加納航治
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Possible clinical significance of breath hydrogen monitoring as an anti-oxidative biomaker

    • Author(s)
      Shimouchi A, Kondo T
    • Organizer
      Breath Analysis Summit
    • Place of Presentation
      Berlin
    • Related Report
      2013 Annual Research Report
  • [Presentation] Alteration of hydrogen exhalation and carbon monoxide production in monocrotaline-induced pulmonary hypertension rats

    • Author(s)
      Mizukami T, Shimouchi A, Shirai M, et al
    • Organizer
      Breath Analysis Summit
    • Place of Presentation
      Berlin
    • Related Report
      2013 Annual Research Report
  • [Presentation] Direct detection of hydroxyl radicals emanating from human skin using laser-induced fluorescence technique

    • Author(s)
      Che DC, Shimouchi A, Mizukami T, Nose K
    • Organizer
      Breath Analysis Summit
    • Place of Presentation
      Berlin
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hydrogen gas suppresses systemic inflammatory response during cardiopulmonary bypass in a rat model

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, et al
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      Chicago
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hyperoxia condition promotes an inflamatory response during extracorporeal circulation in rat model

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, et al
    • Organizer
      51st Japanese Society of Artificial Organs
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Annual Research Report
  • [Presentation] Immidazole cyclodextrin as an antidote for acute cyanide poisoning.

    • Author(s)
      Akira T Kawaguchi
    • Organizer
      ASAIO
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Therapeutic use of liposome-encapsulated hemoglobin alleviates hearing loss after transient cochlear ischemia and reperfusion in the gerbil.

    • Author(s)
      Akira T Kawaguchi
    • Organizer
      ASAIO
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of liposome-encapsulated hemoglobin on low-grade cardiopulmonary exercise in the rat.

    • Author(s)
      Akira T Kawaguchi
    • Organizer
      ASAIO
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin is protective immediately prior to reperfusion in 2-hour cerebral ischemia model in the rat.

    • Author(s)
      Akira T Kawaguchi
    • Organizer
      ASAIO
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Liposome-encapsulated hemoglobin enhances chemotherapy to suppress tumor growth and metastasis in mice.

    • Author(s)
      Akira T Kawaguchi
    • Organizer
      ASAIO
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2012 Annual Research Report
  • [Book] Hemoglobin-Based Oxygen Carriers as Red Cell Substitute and Oxygen Therapeutics2013

    • Author(s)
      Kawaguchi AT, et al
    • Total Pages
      746
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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