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The construction and maintenance of functional tissue-implant interface.

Research Project

Project/Area Number 24249089
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthetic dentistry
Research InstitutionKyushu University

Principal Investigator

Koyano Kiyoshi  九州大学, 歯学研究科(研究院), 教授 (50195872)

Co-Investigator(Kenkyū-buntansha) AYUKAWA Yasunori  九州大学, 大学病院, 講師 (50304697)
ATSUTA Ikiru  九州大学, 大学病院, 助教 (30423487)
MORIYAMA Yasuko  九州大学, 大学院歯学研究院, 助教 (50452769)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Yumiko  九州大学, 大学病院, 医員 (20432916)
Research Collaborator Stanford Clark M.  University of Iowa, IA, Professor
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2012: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Keywordsインプラント / 界面 / 骨 / 歯肉 / プラーク / 口腔粘膜 / 国際情報交換(米国)
Outline of Final Research Achievements

Titanium has been used as a dental implant material and osteoblast is known to attach well to titanium with moderately rough surface. In contrast, gingival epithelial cell and fibroblast are known to attach well to titanium with turned surface. The aim of the present study is to elucidate the nature of tissue-implant interface and improve the tissue response toward implant, using both implant surface functionalization and host tissue activation. As a result, we could report that the distribution of proteins which localized at the bone-titanium interface changed over time, hydrothermal treatment of titanium with CaCl2 solution improved biocompatibility, and statins enhanced the wound healing of peri-implant tissue.

Report

(4 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (14 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Invited: 3 results)

  • [Journal Article] Effects of CaCl2 hydrothermal treatment of titanium implant surfaces on early epithelial sealing2015

    • Author(s)
      Oshiro W. Ayukawa Y, Atsuta I, Furuhashi A, Yamazoe J, Kondo R, Sakaguchi M, Matsuura Y, Tsukiyama Y, Koyano K.
    • Journal Title

      Colloids and Surfaces B Biointerphases

      Volume: 未定 Pages: 141-147

    • DOI

      10.1016/j.colsurfb.2015.04.025

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vivo and in vitro studies of epithelial cell behavior around titanium implants with machined and rough surface2014

    • Author(s)
      Atsuta I, Ayukawa Y, Furuhashi A, Ogino Y, Moriyam Y, Tsukiyama Y, Koyano K.
    • Journal Title

      Clinical Implant Dentistry and Related Research

      Volume: in press Issue: 5 Pages: 772-781

    • DOI

      10.1111/cid.12043

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Integrin alpha-3 and beta-4 subunits on the process of peri-implant epithelium formation2013

    • Author(s)
      Atsuta I, Ayukawa Y, Yamaza T, Furuhashi A, Kondo R, Koyano K.
    • Journal Title

      Key Engineering Materials

      Volume: 529-530 Pages: 407-412

    • DOI

      10.4028/www.scientific.net/kem.529-530.407

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of titanium surface topography on peri-implant soft tissue integration2013

    • Author(s)
      Furuhashi A, Ayukawa Y, Atsuta I, Rakhmatia YD, Yasunami N, Koyano K.
    • Journal Title

      Key Engineering Materials

      Volume: 529-530 Pages: 559-564

    • DOI

      10.4028/www.scientific.net/kem.529-530.559

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Facilitatory Effect of Calcium-hydrothermal Treatment on Peri-implant Epithelial Sealing2015

    • Author(s)
      Wakana Oshiro; Yasunori Ayukawa; Ikiru Atsuta; Akihiro Furuhashi; Ryosuke Kondo; Kiyoshi Koyan
    • Organizer
      2015 IADR General Session & Exhibision
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Accelerated Healing of Extraction Socket and Peri-implant Tissue by Statin2015

    • Author(s)
      Noriyuki Yasunami; Yasunori Ayukawa; Akihiro Furuhashi; Ikiru Atsuta; Rakhmatia Y. Dwi; Yasuko Moriyama; Kiyoshi Koyano
    • Organizer
      2015 IADR General Session & Exhibision
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] インプラント治療に関連したマテリアル創成2014

    • Author(s)
      鮎川保則
    • Organizer
      第12回日本再生歯科医学会学術大会
    • Place of Presentation
      徳島市
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Hydrothermal treatment of titanium with divalent cation solutions enhances the fibroblastic and epithelial cell adhesion2014

    • Author(s)
      Ayukawa Y, Atsuta I, Furuhashi A, Oshiro W, Okawachi H, Koyano K.
    • Organizer
      The 9th scientific meeting of the Asian Academy of Osseointegration
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] チタンのカルシウム水熱処理による上皮封鎖性の向上2014

    • Author(s)
      大城和可奈,熱田生,鮎川保則,山添淳一,近藤綾介,坂口真実,古谷野潔
    • Organizer
      日本補綴歯科学会第123回学術大会
    • Place of Presentation
      仙台市
    • Year and Date
      2014-05-23 – 2014-05-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 二価カチオン処理チタンに対する口腔上皮様細胞および線維芽細胞接着性の検討.2012

    • Author(s)
      鮎川保則、大川内秀幸、古橋明大、熱田生、古谷野潔
    • Organizer
      第42回日本口腔インプラント学会総会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Osseo-/Soft Tissue IntegrationHow Are They Established?

    • Author(s)
      Ayukawa Y.
    • Organizer
      The First Joint Workshop on Prosthodontic Research between Shanghai JiaoTong U, Kyushu U, and Korea U
    • Place of Presentation
      Cheju, South Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effect of fluvastatin on proliferation and migration of fibroblast

    • Author(s)
      Yasunami N, Ayuakwa Y, Furuhashi A, Atsuta I, Koyano K.
    • Organizer
      2013 Biennial Joint Congress of CPS-JPS-KPS
    • Place of Presentation
      Cheju, South Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Promoting effect of CaCl₂ hydrothermal treatment to titanium implant

    • Author(s)
      Oshiro W,Ayukawa Y,Atsuta I, Yamazoe J,Kondo R, Sakaguchi M, Furuhashi A, Koyano K.
    • Organizer
      the 86th Annual Meeting of the American Prosthodontic Society
    • Place of Presentation
      Chicago, Il, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] インプラント-生体界面の統合的理解と持続性ある界面獲得のストラテジー

    • Author(s)
      鮎川保則、熱田生、古谷野潔
    • Organizer
      第29回歯科医学を中心とした総合的な研究を推進する集い
    • Place of Presentation
      東京都千代田区
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2013-05-15   Modified: 2019-07-29  

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