| Project/Area Number |
24249089
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
Koyano Kiyoshi 九州大学, 歯学研究科(研究院), 教授 (50195872)
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| Co-Investigator(Kenkyū-buntansha) |
AYUKAWA Yasunori 九州大学, 大学病院, 講師 (50304697)
ATSUTA Ikiru 九州大学, 大学病院, 助教 (30423487)
MORIYAMA Yasuko 九州大学, 大学院歯学研究院, 助教 (50452769)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Yumiko 九州大学, 大学病院, 医員 (20432916)
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| Research Collaborator |
Stanford Clark M. University of Iowa, IA, Professor
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2012: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
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| Keywords | インプラント / 界面 / 骨 / 歯肉 / プラーク / 口腔粘膜 / 国際情報交換（米国） |
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| Outline of Final Research Achievements |
Titanium has been used as a dental implant material and osteoblast is known to attach well to titanium with moderately rough surface. In contrast, gingival epithelial cell and fibroblast are known to attach well to titanium with turned surface. The aim of the present study is to elucidate the nature of tissue-implant interface and improve the tissue response toward implant, using both implant surface functionalization and host tissue activation. As a result, we could report that the distribution of proteins which localized at the bone-titanium interface changed over time, hydrothermal treatment of titanium with CaCl2 solution improved biocompatibility, and statins enhanced the wound healing of peri-implant tissue.
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