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Development of early diagnostic method and order-made immunotherapy for oral cancer by using anti-tumor T cells

Research Project

Project/Area Number 24249091
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

Nakamura Seiji  九州大学, 歯学研究院, 教授 (60189040)

Co-Investigator(Kenkyū-buntansha) 豊嶋 健史  九州大学, 歯学研究科(研究院), 研究員 (20546569)
吉田 裕樹  佐賀大学, 医学部, 教授 (40260715)
山田 亮  久留米大学, 付置研究所, 教授 (50158177)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥34,970,000 (Direct Cost: ¥26,900,000、Indirect Cost: ¥8,070,000)
Keywordsオーダーメイド免疫療法 / 口腔扁平上皮癌 / RCAS1 / PD-L1 / 腫瘍会合性マクロファージ / 腫瘍免疫 / 免疫チェックポイント分子 / 腫瘍随伴性マクロファージ / 癌ペプチド / オーダーメイドワクチン / 口腔癌 / T細胞 / アポトーシス
Outline of Final Research Achievements

Receptor-binding cancer antigen expressed on SiSo cell (RCAS1) is derived from uterine adenocarcinoma and can induce apoptosis in lymphocytes. In this study, we investigated expression patterns of RCAS1 and the effect on apoptosis in oral squamous cell carcinoma (OSCC). RCAS1 mRNA and proteins were expressed in all of OSCC cell lines. Membranous pattern were expressed in all cell lines, while soluble pattern was detected in all supernatants. RCAS1 mRNA, membranous and soluble RCAS1 were significantly seen in SQUU-B more than the other 3 cell lines. K562 apoptosis was induced in co-culture with each of all cell lines, particularly with SQUU-B. Apoptosis was markedly reduced in co-culture with RCAS1 knockdown cells, but was induced in co-culture without cell contract of SQUU-B. Our study suggests that RCAS1 has an apoptotic function via membranous/soluble expression pattern in OSCC cells. RCAS1 may thus affect tumor escape from immune surveillance in OSCC by inducing apoptosis.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (4 results)

  • [Journal Article] CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma.2017

    • Author(s)
      Kubota K, Moriyama M, Furukawa S, Haque R ASM, Maruse Y, Jinno T, Tanaka A, Ohta M, Ishiguro N, Yamauchi M, Sakamoto M, Maehara T, Hayashida JN, Kawano S, Kiyoshima T, and Nakamura S
    • Journal Title

      Sci Rep

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] GLI-mediated Keratin 17 expression promotes tumor cell growth through the anti-apoptotic function in oral squamous cell carcinomas2017

    • Author(s)
      Mikami Y, Fujii S, Nagata K, Wada H, Hasegawa K, Abe M, Yoshimoto RU, Kawano S, Nakamura S, Kiyoshima T
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 印刷中 Issue: 8 Pages: 1381-1393

    • DOI

      10.1007/s00432-017-2398-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloprotease-2 via ΔNp63β-mediated epithelial-mesenchymal transition.2017

    • Author(s)
      Sakamoto T, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Kaneko N, Hashiguchi Y, Hattori T, Tanaka S, Kitamura R, Kiyoshima T, Nakamura S
    • Journal Title

      Oral Oncol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis.2015

    • Author(s)
      Ohta M, Moriyama M, Goto Y, Kawano S, Tanaka A, Maehara T, Furukawa S, J Hayashida JN, Kiyoshima T, Shimizu M, Arinobu Y, Nakamura S.
    • Journal Title

      World J Surg Oncol

      Volume: 13 Issue: 1 Pages: 67-67

    • DOI

      10.1186/s12957-015-0459-z

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.2015

    • Author(s)
      Jinno T, Kawano S, Maruse Y, Matsubara R, Goto Y, Sakamoto T, Hashiguchi Y, Kaneko N, Tanaka H, Kitamura R, Toyoshima T, Jinno A, Moriyama M, Oobu K, Kiyoshima T, Nakamura S.
    • Journal Title

      Oncol Rep

      Volume: 33 Issue: 5 Pages: 2161-2168

    • DOI

      10.3892/or.2015.3838

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease2015

    • Author(s)
      Hayashi Y, Moriyama M, M Takashi, Goto Y, Kawano S, Ohta M, Tanaka A, Furukawa S, Hayashida JN, Kiyoshima T, Shimizu M, Chikui T, Nakamura S.
    • Journal Title

      World J Surg Oncol

      Volume: 13 Issue: 1 Pages: 225-225

    • DOI

      10.1186/s12957-015-0644-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype2014

    • Author(s)
      Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinno, Yasuyuki Maruse, Toyoshima Takeshi, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura
    • Journal Title

      Clinical & Experimental Metastasis

      Volume: 214 Issue: 3 Pages: 289-306

    • DOI

      10.1007/s10585-013-9628-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma2014

    • Author(s)
      Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura
    • Journal Title

      Journal of Translational Medicine

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro induction of specific CD8(+) T lymphocytes by tumorassociated antigenic peptides in patients with oral squamous cell carcinoma2012

    • Author(s)
      Toyoshima, T., Kumamaru, W., Hayashida, J.-N., Moriyama, M., Kitamura, R., Tanaka, H., Yamada, A., Itoh, K., and Nakamura, S.
    • Journal Title

      Cancer Lett

      Volume: 322 Issue: 1 Pages: 86-91

    • DOI

      10.1016/j.canlet.2012.02.016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔扁平上皮癌における免疫回避機構と腫瘍随伴性マクロファージとの関連2016

    • Author(s)
      久保田 恵吾、森山 雅文、古川 祥子、Haque ASM Rafiul、丸瀬 靖之、川野 真太郎、林田 淳之介、太田 美穂、清島 保、中村 誠司
    • Organizer
      第44回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1(receptor-binding caner antigen expressed on SiSo cells)の発現と機能についての検討2013

    • Author(s)
      田中 秀明
    • Organizer
      第 31 回日本口腔腫瘍学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1の発現、分泌と機能についての検討

    • Author(s)
      田中秀明,豊嶋健史,園田顕三,北村亮二,川野真太郎,平野充広,神野哲平,丸瀬靖之,笹栗正明,大部一成,中村誠司
    • Organizer
      第67回日本口腔科学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1の発現と機能についての検討

    • Author(s)
      田中秀明,豊嶋健史,園田顕三,北村亮二,川野真太郎,平野充広,神野哲平,丸瀬靖之,笹栗正明,大部一成,中村誠司
    • Organizer
      第58回日本口腔外科学会総会•学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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