Development of communication brain: Functional connectivity

• Project/Area Number: 24300105
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cognitive science
• Research Institution: Keio University
• Principal Investigator: MINAGAWA Yasuyo 慶應義塾大学, 文学部, 准教授 (90521732)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Jun-ichi 慶應義塾大学, 文学部, 教授 (60202389) ; DAN Ippeita 中央大学, 理工学部, 教授 (20399380)
• Co-Investigator(Renkei-kenkyūsha): ARIMITSU Takeshi 慶應義塾大学, 医学部, 助教 (60383840) ; YAGIHASHI Tatsuhiko 慶應義塾大学, 医学部, 助教 (10383770)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 発達障害 / 音韻 / NIRS / 脳機能結合 / 早産児 / コミュニケーション / 母子愛着 / 音声知覚 / 言語獲得 / 社会認知 / 音声言語 / 母子 / 発達障がい / ＮＩＲＳ

Outline of Final Research Achievements

The present study investigated whether and how functional cerebral activity and connectivity in the early developmental stage relate to later language and social development. For this purpose, we performed a longitudinal study for typically developing infants, preterm infants and infants-at-risk at their age between 0 to 3 years-old to collect both behavioral and neurophysiological data. The results revealed that cerebral response to phonemic contrast can predict later language development particularly language production. Furthermore, our experiment using maternal vs. stranger’s speech indicated that exclusively for term infants, functional connectivities during listening to maternal speech were strengthened in the language brain areas and anterior superior temporal gyrus on the right side which is associated with social voice identification. These results suggest that cerebral activity in the early development can be a suitable predictor for later language and social development.

Research Products

• [Journal Article] 音声知覚の運動理論とブローカ野：マザリーズ研究が明らかにするもの (2015)
  • Author(s): 皆川泰代
  • Journal Title: ベビーサイエンス Volume: 13
• [Journal Article] “Mom called me!” behavioral and prefrontal response to self-name uttered by mother’s voice in infants (2014)
  • Author(s): Imafuku, M., Hakuno, Y., Yamamoto, J., & Minagawa-Kawai, Y.
  • Journal Title: Neuroimage Volume: 103 Pages: 476-484
  • DOI: 10.1016/j.neuroimage.2014.08.034
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Responses to vocalizations and auditory controls in the human newborn brain. (2014)
  • Author(s): Cristia, A., Minagawa, Y., Dupoux, E.
  • Journal Title: PLoS One Volume: 9 Issue: 12 Pages: e115162-e115162
  • DOI: 10.1371/journal.pone.0115162
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Performance of young children on “traveling salesperson” navigation tasks presented on a touch screen. (2014)
  • Author(s): Miyata, H., Watanabe, S., Minagawa, Y.
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed
• [Journal Article] Neural correlates of infant dialect discrimination: A fNIRS study. (2014)
  • Author(s): Cristia, A., Minagawa-Kawai, Y., Egorova, N., Gervain, J., Filippin, L., Cabrol, D., Dupoux, E.
  • Journal Title: Developmental Science Volume: 4 Issue: 4 Pages: 628-635
  • DOI: 10.1111/desc.12160
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] “Insights on NIRS sensitivity from a cross-linguistic study on the emergence of phonological grammar. (2013)
  • Author(s): Minagawa-Kawai, Y., Cristia, A., Long, B, Vendelin, Hakuno, Y., Dutat, M., Filippin, L., Cabrol, D., Dupoux, E.
  • Journal Title: Frontiers in Psychology Volume: 4 Pages: 170-170
  • DOI: 10.3389/fpsyg.2013.00170
  • Peer Reviewed
• [Journal Article] An online database of infant functional Near InfraRed Spectroscopy studies: A community-augmented systematic review. (2013)
  • Author(s): Cristia, A., Dupoux, E., Hakuno, Y., Lloyd-Fox, S., Schuetze, M., Kivits, J., Bergvelt, T., van Gelder, M., Filippin, L., Charron, S., Minagawa-Kawai, Y.
  • Journal Title: PLoS One Volume: 8 Issue: 3 Pages: e58906-e58906
  • DOI: 10.1371/journal.pone.0058906
  • Peer Reviewed
• [Journal Article] 乳児音声聴取における視聴覚情報利用の発達変化：母親と他者の場合 (2013)
  • Author(s): 森澤範子，白野陽子，皆川泰代
  • Journal Title: 音声研究 Volume: 17 Pages: 77-85
  • Peer Reviewed
• [Journal Article] Reading speed, comprehension and eye movements while reading Japanese novels : evidence from untrained readers and cases of speed-reading trainees (2012)
  • Author(s): Miyata, H., Minagawa-Kawai, Y., Watanabe, S., Sasaki, T., Ueda, K.
  • Journal Title: PLoS ONE Volume: (掲載確定) Issue: 5 Pages: e36091-e36091
  • DOI: 10.1371/journal.pone.0036091
  • Peer Reviewed
• [Journal Article] Cerebral responses to infant-directed speech and the effect of talker familiarity (2012)
  • Author(s): Naoi N, Minagawa-Kawai Y, Kobayashi A, Takeuchi K, Nakatnura K, Yamamoto J, Kojima S.
  • Journal Title: Neuroimage Volume: 59巻 Issue: 2 Pages: 1735-1744
  • DOI: 10.1016/j.neuroimage.2011.07.093
  • NAID: 40016745599
  • Peer Reviewed
• [Journal Article] 近赤外分光脳機能計測の現状と展望:臨床応用研究、認知神経科学からの知見 (2012)
  • Author(s): 皆川泰代
  • Journal Title: Brain and Nerve Volume: 64巻 Pages: 1023-1032
• [Presentation] 音声知覚の脳機能発達と発達障がい (2015)
  • Author(s): 皆川泰代
  • Organizer: 第２回「自閉症と音声」研究会
  • Place of Presentation: 工学院大学（東京都・新宿区）
  • Year and Date: 2015-03-08
  • Invited
• [Presentation] 児童期から青年期にかけての前頭葉機能発達：近赤外線分光法による研究 (2015)
  • Author(s): 矢田部清美、星野英一、直井望、山田玲子、皆川泰代
  • Organizer: 公開シンポジウム 「論理と感性の新たな学際研究に向けて」
  • Place of Presentation: 慶應義塾大学（東京都・港区）
  • Year and Date: 2015-02-01
  • Invited
• [Presentation] 子供はなぜ詩人なのか：脳科学と言語学で考える言語発達 (2014)
  • Author(s): 皆川泰代
  • Organizer: 日吉教養学センター公開講座講演
  • Place of Presentation: 慶應義塾大学（神奈川県・横浜市）
  • Year and Date: 2014-11-15
  • Invited
• [Presentation] Neonates’ hemodynamic responses to linguistic phonetic differences as a predictor of later language development. (2014)
  • Author(s): Minagawa, Y., Arimitsu, T., Matsuzaki, A., Yagihashi, T., Ikeda, K., Takahashi, T.
  • Organizer: 3rd International Conference of fNIRS,
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 2014-10-10
• [Presentation] Neonates’ cerebral response to linguistic phonetic difference predicts later language development. (2014)
  • Author(s): Minagawa, Y., Arimitsu, T., Matsuzaki, A., Yagihashi, T., Yamamoto, J., Ikeda, K., Takahashi, T.
  • Organizer: Neuroscience 2014
  • Place of Presentation: PACIFICO YOKOHAMA（神奈川県・横浜市）
  • Year and Date: 2014-09-13
• [Presentation] Learning-induced cerebral hemodynamic changes during non-native phonemic category processing in relation to maturation from late childhood to young adulthood. (2014)
  • Author(s): Yatabe, K., Hoshino, E., Akahane-Yamada, R., Naoi, N., & Minagawa, Y.
  • Organizer: Neuroscience 2014
  • Place of Presentation: PACIFICO YOKOHAMA（神奈川県・横浜市）
  • Year and Date: 2014-09-13
• [Presentation] Correlations in hemodynamic fluctuations between cortical regions during non-native phonemic category processing among participants from late childhood to young adulthood. (2014)
  • Author(s): Yatabe, K., Hoshino, E., Akahane-Yamada, R., Naoi, N., & Minagawa, Y.
  • Organizer: Architectures and Mechanisms for Language Processing XX
  • Place of Presentation: エディンバラ大学（スコットランド）
  • Year and Date: 2014-09-05
• [Presentation] 発達初期における音声知覚の脳内基盤：fNIRS研究 (2014)
  • Author(s): 皆川泰代
  • Organizer: 講演会
  • Place of Presentation: NTTコミュニケーション基礎科学研究所（神奈川県・厚木市）
  • Year and Date: 2014-07-31
  • Invited
• [Presentation] 発達認知神経科学における光イメージング (2014)
  • Author(s): 皆川泰代
  • Organizer: 第17回光脳機能イメージング学会シンポジウム講演
  • Place of Presentation: 星陵会館（東京都・千代田区）
  • Year and Date: 2014-07-30
  • Invited
• [Presentation] 光イメージングで明らかにする脳機能の発達 (2014)
  • Author(s): 皆川泰代
  • Organizer: 第5回サイエンスメルティングポット講演
  • Place of Presentation: 慶應義塾大学（神奈川県・横浜市）
  • Year and Date: 2014-07-26
  • Invited
• [Presentation] 5－6ヶ月児における前頭前野機能とDefault Mode Network (2014)
  • Author(s): 皆川泰代、矢田部清美、星野英一、松田聡一郎、佐藤大樹、吉村美奈、牧敦
  • Organizer: 第14回赤ちゃん学会
  • Place of Presentation: 日本女子大学（東京都・文京区）
  • Year and Date: 2014-06-21
• [Presentation] 近赤外分光法による母親声に対する早期産児の脳反応 (2012)
  • Author(s): 有光威志、皆川泰代、木下眞里、三輪雅之、松崎陽平、北東功、内田(太田)真理子、池田一成
  • Organizer: 第57回日本未熟児新生児学会・学術集会
  • Place of Presentation: パレアホール(熊本県)
  • Year and Date: 2012-11-26
• [Presentation] Interaction between brain maturation and experience: hemodynamic responses to speech categories in full term and preterm neonates. (2012)
  • Author(s): Minagawa-Kawai, Y.
  • Organizer: Conference of Functional Near Infrared Spectroscopy
  • Place of Presentation: University College London England
  • Year and Date: 2012-10-26
• [Presentation] 光トポグラフィーによる発達科学の最前線 (2012)
  • Author(s): 皆川泰代
  • Organizer: 第17回認知神経科学会学術集会、ランチョンセミナーI
  • Place of Presentation: 東京大学先端知ビル武田ホール
  • Year and Date: 2012-09-29
• [Presentation] Symposium "Toward phenotyping and treatment of Autism Spectrum Disorders", (2012)
  • Author(s): Minagawa-Kawai, Y.
  • Organizer: the 35th Annual Meeting of the Japan Neuroscience Society,
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2012-09-18
• [Presentation] Preterm and fullterm newborns' responses to vowel and intonation changes. (2012)
  • Author(s): Minagawa-Kawai Y.
  • Organizer: Morning Workshop for the 18th Annual Meeting of the Organization, Human Brain Mapping
  • Place of Presentation: Beijing, China
  • Year and Date: 2012-06-13
• [Presentation] 乳児のNIRS計測における血行動態反応:標準モデル構築を目指して (2012)
  • Author(s): 皆川泰代、内田真理子、Alejandrina Cristia、Emmanuel Dupoux
  • Organizer: 日本赤ちゃん学会第12回学術集会
  • Place of Presentation: 玉川大学
  • Year and Date: 2012-06-02
• [Presentation] 新生児の母親音声に対する大脳皮質局所血流反応の在胎週数による違い (2012)
  • Author(s): 内田真理子、有光威志、池田一成、高橋孝雄、皆川泰代
  • Organizer: 日本赤ちゃん学会第12回学術集会
  • Place of Presentation: 玉川大学
  • Year and Date: 2012-06-02
• [Presentation] 新生児の音声対比に対する脳反応-早期産児から正期産児まで- (2012)
  • Author(s): 有光威志、皆川泰代、柳橋達彦、木下眞里、三輪雅之、松崎陽平、北東功、内田(太田)真理子、池田一成、高橋孝雄
  • Organizer: 日本赤ちゃん学会第12回学術集会
  • Place of Presentation: 玉川大学
  • Year and Date: 2012-06-02
• [Presentation] Infants' learning of word-object relations: The role of social interaction. (2012)
  • Author(s): Hakuno Y, Omori T, Yamamoto J, Minagawa-Kawai Y.
  • Organizer: XVIII Biennial International Conference on Infant Studies
  • Place of Presentation: Minneapolis, Minnesota, U. S. A
• [Presentation] Infants' observation of mother and non-mother faces: The role of audiovisual information and effects of mother-infant bonding. (2012)
  • Author(s): Morisawa N, Hakuno Y, Minagawa-Kawai Y.
  • Organizer: XVIII Biennial International Conference on Infant Studies
  • Place of Presentation: Minneapolis, Minnesota, U. S. A
• [Presentation] Investigating the cerebral bases of language acquisition with NIRS.
  • Author(s): Minagawa, Y.
  • Organizer: Invited Lecture at Infancy Studies Laboratory, Center for Molecular & Behavioral Neuroscience (CMBN).
  • Place of Presentation: Rutgers University, U.S.A
  • Invited
• [Presentation] 新生児、乳幼児の前頭前野機能：社会認知発達の基盤として
  • Author(s): 皆川泰代
  • Organizer: 新学術領域「共感性の進化・神経基盤」系統発生班キックオフシンポ「共感性研究の現状と展望」
  • Place of Presentation: 慶應義塾大学、東京都
  • Invited
• [Presentation] Emergence of prefrontal function engaging in self-referential vs. external-focused attention in 5-6 month-old infants.
  • Author(s): Minagawa, Y., Hoshino, E., Yatabe, K., Imafuku, M., Sato, H., Yoshimura, M., Maki, A.
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Kyoto International Conference Center, Kyoto
• [Presentation] 新生児期の音声言語に対する脳反応と認知発達との相関性
  • Author(s): 皆川泰代、有光威志、池田一成
  • Organizer: 第58回未熟児新生児学会
  • Place of Presentation: ANA クラウンプラザホテル金沢、石川県
• [Presentation] 母親声に対する正期産児の心拍変化と大脳皮質の関係
  • Author(s): 有光威志、内田真理子、皆川泰代、原香織、木下眞里、古川律子、松崎陽平、池田一成
  • Organizer: 第58回未熟児新生児学会
  • Place of Presentation: ANA クラウンプラザホテル金沢、石川県
• [Presentation] DBIfNIRS：乳児NIRS研究オンラインデータベースの構築
  • Author(s): 皆川泰代、白野陽子, Emmanuel Dupoux, Alejandrina Cristia
  • Organizer: 第13回日本赤ちゃん学会
  • Place of Presentation: アクロス福岡、福岡県
• [Presentation] 乳児における単語分節化と語意獲得：社会的相互作用が果たす役割 (2)
  • Author(s): 白野陽子、山本淳一、大森貴秀、皆川泰代
  • Organizer: 第13回日本赤ちゃん学会
  • Place of Presentation: アクロス福岡、福岡県
• [Book] Frontiers in Developmental Psychology (2015)
  • Author(s): Minagawa, Y. & Tsuji, S
  • Publisher: HITUZI SYOBO publishing
• [Book] Oxford Handbook of Neurolinguistics (2015)
  • Author(s): Minagawa, Y. & Cristia, A
  • Publisher: Oxford University Press
• [Book] 新・発達心理学ハンドブック (2015)
  • Author(s): 皆川泰代
  • Publisher: 福村出版社
• [Book] 発達科学ハンドブック８ (2015)
  • Author(s): 皆川泰代
  • Publisher: 新曜社
• [Book] 発達心理学と隣接領域の理論・方法論--発達科学ハンドブック1 (2013)
  • Author(s): 皆川泰代
  • Total Pages: 400
  • Publisher: 新曜社
• [Remarks] 慶應義塾大学 赤ちゃんラボ
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