Physiological and mathematical modeling of periodic synchronized neural firing phenomenon by data driven approach
| Project/Area Number |
24300108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | The Institute of Statistical Mathematics |
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Principal Investigator |
ISHIGURO Makio 統計数理研究所, 大学共同利用機関等の部局等, 名誉教授 (10000217)
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| Co-Investigator(Kenkyū-buntansha) |
MIWAKEICHI Fumikazu 統計数理研究所, モデリング研究系, 准教授 (30360647)
OKU Yoshitaka 兵庫医科大学, 医学部, 教授 (20252512)
OKADA Yasumasa 独立行政法人国立病院機構村山医療センター(臨床研究センター), 内科, 医長 (80160688)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 時系列解析 / 神経情報学 / 生体イメージングデータ解析 / 階層神経モデリング |
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| Outline of Final Research Achievements |
We have developed practical preprocessing methods to correct incompleteness of the image such as non-uniform illumination, motion artifact and so on. Further, we suggested an efficient strategy to discriminate neurons and astrocytes in the respiratory-related region in the brainstem using statistical maps such as variances, time-lagged cross correlation coefficients and so on. From the physiological point of view, we obtained findings suggesting the existence of slowly oscillating astrocytic network weakly coupled with neuronal network and stochastic activation among inspiratory neurons within the respiratory rhythm-generating kernel. These results will provide us new paradigms for further mathematical studies of neuronal network exhibiting synchronous bursting activity.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Standardization of Size, Shape and Internal Structure of Spinal Cord Images: Comparison of Three Transformation Methods2013
Author(s)
Fujiki, Y., Yokoota, S., Okada, Y., Oku, Y., Tamura, Y., Ishiguro, M., Miwakeichi, F.
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Journal Title
PLOS ONE
Volume: 8(11)
Issue: 11
Pages: e76415-e76415
DOI
Related Report
Peer Reviewed
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[Presentation] Sensory information processing by astrocytes and neurons in the spinal corddorsal horn via P2X receptors : voltage-imaging, patch clamp and anatomical analyses2012
Author(s)
Okada Y, Aoyama R, Yokota S, Yasui Y, Fukuda K, Shinozaki Y, Yoshida H, Nakamura M, Chiba K, Yasui Y, Kato F, Toyama Y.
Organizer
Purine 2012 : Adenine Nucleosides and Nucleotides in Biomedicine
Place of Presentation
九州大学医学部百年講堂(福岡)
Year and Date
2012-06-01
Related Report
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