Establishment of methodology for assessment of disclosure risk and confidentiality of individual genome by random partition

• Project/Area Number: 24300109
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Statistical science
• Research Institution: The Institute of Statistical Mathematics
• Principal Investigator: MANO Shuhei 統計数理研究所, 数理・推論研究系, 准教授 (20372948)
• Co-Investigator(Kenkyū-buntansha): TSUNODA Tatsuhiko 理化学研究所, 統合生命医科学研究センター, 医科学数理研究グループリーダー (10273468) ; 太田 博樹 北里大学, 医学部, 准教授 (40401228)
• Co-Investigator(Renkei-kenkyūsha): OOTA Hiroki 北里大学, 医学部, 准教授 (40401228)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: 統計数学 / ゲノム

Outline of Final Research Achievements

If an individual genome is disclosed and the holder is identified, the person's sensitive information is disclosed. This problem is similar to the statistical disclosure control problem. We need methods to suppress the probability that a sample unique genome with some concealment becomes population unique. The fundamental statistical model is a random partition. In this research, the purpose was establishment of methodology for assessment of disclosure risk and confidentiality of individual genome. A computational method for a random partition with accounting correlation among points on a genome is proposed, and asymptotic properties of Gibbs-type partitions, which are in a general class of random partitions, were discussed. The methods for assessment of disclosure risk and confidentiality were discussed with people who obtain individual genome data and use them.

Research Products

• [Journal Article] Correspondence: Human genetic research, race, ethnicity and the labeling of populations: recommendations based on an interdisciplinary workshop in Japan (2014)
  • Author(s): Takezawa, Y., Kato, K., Oota. H., Caulfield, T., Fujimoto, A., Honda, F., Kamatani, N., Kawamura, S., Kawashima, K., Kimura, R., Matsumae, H., Saito, A., Savage, P. E., Seguchi, N., Shimizu, K., Terao, S., Yamaguchi-Kabata, Y., Yasukouchi, A., Yoneda, M. and Tokunaga, K.
  • Journal Title: BMC Medical Ethics Volume: 15 Issue: 1 Pages: 33-33
  • DOI: 10.1186/1472-6939-15-33
  • Peer Reviewed / Open Access
• [Journal Article] がん研究におけるゲノムビッグデータ解析と臨床応用 (2014)
  • Author(s): 角田達彦
  • Journal Title: 実験医学 Volume: 32 Pages: 2046-2051
• [Journal Article] Asymptotics of Pitman random partition via combinatorics. (2013)
  • Author(s): Shuhei Mano
  • Journal Title: ISM Research Memorandum Volume: 1177 Pages: 1-30
• [Journal Article] Ordered sizes in exchangeable random partitions and their asymptotics. (2013)
  • Author(s): Shuhei Mano
  • Journal Title: arXiv Volume: 1306.2056 Pages: 1-30
• [Journal Article] Duality between the two-locus Wright-Fisher diffusion model and the ancestral process with recombination. (2013)
  • Author(s): Shuhei Mano
  • Journal Title: Journal of Applied Probability Volume: 50 Issue: 1 Pages: 256-271
  • DOI: 10.1239/jap/1363784437
  • Peer Reviewed
• [Presentation] Approximate Bayesian Computation and its Applications (2015)
  • Author(s): 間野修平
  • Organizer: インシリコ・メガバンク研究会
  • Place of Presentation: 横浜
  • Year and Date: 2015-03-13
  • Invited
• [Presentation] Medical Science Mathematics for Cancer Genome Analysis (2014)
  • Author(s): Tatsuhiko Tsunoda
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2014-09-26
  • Invited
• [Presentation] Ordered Sizes in the Gibbs-type Exchangeable Random Partitions (2014)
  • Author(s): Shuhei Mano
  • Organizer: 37th Conference on Stochastic Processes and Their Applications
  • Place of Presentation: Buenos Aires
  • Year and Date: 2014-07-28 – 2014-08-01
• [Presentation] 全ゲノムビッグデータ解析によるオーダーメイド医療 (2014)
  • Author(s): 角田達彦
  • Organizer: 富士通知創薬コンソーシアム
  • Place of Presentation: 東京
  • Year and Date: 2014-04-07
  • Invited
• [Presentation] Extremes of Pitman's Random Partition and their Asymptotics (2013)
  • Author(s): Mano Shuhei
  • Organizer: Asymptotic Statistics and Related Topics: Theories and Methodologies.
  • Place of Presentation: University of Tokyo
• [Presentation] ピットマン分割の漸近論への解析的組み合わせ論による接近 (2013)
  • Author(s): 間野修平
  • Organizer: 統計関連学会連合大会
  • Place of Presentation: 大阪大学
• [Presentation] 人類学の立場からパーソナルゲノムプロジェクトを考える (2013)
  • Author(s): 松前ひろみ，間野修平，太田博樹
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] ピットマン分割における極値とその漸近的性質 (2012)
  • Author(s): 関野修平
  • Organizer: 研究集会「官庁統計データの公開における諸問題の研究と他分野への応用」
  • Place of Presentation: 統計数理研究所
  • Year and Date: 2012-10-26
• [Presentation] 集団遺伝の確率モデルと統計的推測 (2012)
  • Author(s): 間野修平
  • Organizer: 日本遺伝学会ワークショップ「ゲノム時代における理論集団遺伝学」
  • Place of Presentation: 九州大学医学部
  • Year and Date: 2012-09-24
• [Presentation] ピットマン分割における極値とその漸近的性質 (2012)
  • Author(s): 間野修平
  • Organizer: 日本統計学会
  • Place of Presentation: 北海道大学高等教育推進機構
  • Year and Date: 2012-09-11
• [Presentation] Extremes of random partition and the asymptotics (2012)
  • Author(s): Shuhei Mano
  • Organizer: 研究集会'Stochastic Models and Computational Algorithms"
  • Place of Presentation: 統計数理研究所
  • Year and Date: 2012-07-19
• [Book] 生命のビッグデータ利用の最前線「個人ゲノムデータの利用と倫理的課題」 (2014)
  • Author(s): 松前ひろみ，間野修平，太田博樹（分担執筆の書籍の一部）
  • Total Pages: 7
  • Publisher: CMC出版
• [Remarks]
  • URL: http://www.ism.ac.jp/~smano