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Development of statistical methodology for imaging mass spectrometry

Research Project

Project/Area Number 24300110
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Statistical science
Research InstitutionTeikyo University (2014)
Japanese Foundation for Cancer Research (2012-2013)

Principal Investigator

MATSUURA Masaaki  帝京大学, 大学院公衆衛生学研究科, 教授 (40173794)

Co-Investigator(Kenkyū-buntansha) EGUCHI Shinto  統計数理研究所, 数理推論研究系, 教授 (10168776)
SETOU Mitsutoshi  浜松医科大学, 医学部, 教授 (20302664)
USHIJIMA Masaru  公益財団法人がん研究会, ゲノムセンター, 研究員 (60328565)
MIYATA Satoshi  東北大学, 医学系研究科, 准教授 (60360343)
YAO Ikuko  浜松医科大学, メディカルフォトニクス研究センター, 准教授 (60399681)
HOSHIKAWA Yutaka  公益財団法人がん研究会, がん研究所, 研究員 (80280626)
WAKUI Masatoshi  慶應義塾大学, 医学部, 講師 (90240465)
森 誠一  公益財団法人がん研究会, がん研究会 がんゲノム研究部, 主任研究員 (10334814)
Co-Investigator(Renkei-kenkyūsha) KAJIHARA Shigeki  島津製作所, 基盤技術研究所, 主任研究員 (10395246)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords質量分析 / 統計 / 画像 / 画像処理 / 顕微質量装置 / イメージ / 質量顕微鏡法
Outline of Final Research Achievements

In imaging mass spectrometry, we can obtain lazar captured mass spectrometry data from cancer tissues or normal cells using a microscope. These data generate imaging data in which each spot has a spectrum with many peaks for small molecules. We have developed statistical algorithm and software which can detect important similar peaks including of a cancer site, for example.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (11 results)

All 2015 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Identification of nitrated tyrosine residues of protein kinase G-Ia by mass spectrometry.2014

    • Author(s)
      Lu J, Yao I, Shimojo M, Katano T, Uchida H, Setou M, Ito S
    • Journal Title

      Analytical and bioanalytical chemistry

      Volume: 406 Issue: 5 Pages: 1387-1396

    • DOI

      10.1007/s00216-013-7535-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of imaging mass spectrometry2012

    • Author(s)
      Saito Y, Waki M, Hameed S, Hayasaka T, Setou M.
    • Journal Title

      Biol Pharm Bull.

      Volume: 35 Pages: 1417-1424

    • NAID

      130001872090

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of acetylcholine distribution in central nervous system tissue sections by tandem imaging mass spectrometry.2012

    • Author(s)
      Sugiura Y, Zaima N, Setou M, Ito S, Yao I.
    • Journal Title

      Anal Bioanal Chem.

      Volume: 403 Issue: 7 Pages: 1851-1861

    • DOI

      10.1007/s00216-012-5988-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Imaging Mass Spectrometry2012

    • Author(s)
      Yamazaki H, Chijiwa T, Inoue Y, Abe Y, Suemizu H, Kawai K, Wakui M, Furukawa D, Mukai M, Kuwao S, Saegusa M, Nakamura M.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 9 Pages: 1417-1424

    • DOI

      10.1248/bpb.b212007

    • NAID

      130001872090

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Similarity index for image patterns from imaging mass spectrometry.2015

    • Author(s)
      Matsuura M, Ushijima M, Kajihara S
    • Organizer
      Pacific Symposium on Biocomputing 2015
    • Place of Presentation
      Hawaii (USA)
    • Year and Date
      2015-01-04 – 2015-01-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Classification of breast cancer subtypes using lasso clustering methods2013

    • Author(s)
      Ushijima M, Eguchi S, Komori S, Miki Y, Matsuura M
    • Organizer
      9th Japan America Joint International Mass Spectrometry Conference
    • Place of Presentation
      Hawaii, America
    • Year and Date
      2013-02-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量分析イメージングによる脳情報の可視化-医学への貢献を目指して2013

    • Author(s)
      矢尾育子
    • Organizer
      第38回医用マススペクトル学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optimization of conditions for acetylcholine detection in the nerve tissue sections by imaging mass spectrometry2012

    • Author(s)
      Yao I, Sugiura Y, Zaima N, Setou M, Ito S
    • Organizer
      9th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2012-09-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of imaging pattern for Imaging mass spectrometry data2012

    • Author(s)
      Ushijima M, Eguchi S, Kajihara S, Matsuura M.
    • Organizer
      International Biometrics Conference 2012
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2012-08-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] Visualization of acetylcholine distribution in the brain by imaging mass spectrometry2012

    • Author(s)
      Yao I, Sugiura Y, Zaima N, Setou M, Ito S
    • Organizer
      60th ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2012-05-21
    • Related Report
      2012 Annual Research Report
  • [Book] Imaging Mass Spectrometry (IMS) for Biological Application Mass Spectrometry Handbook, pp41-842012

    • Author(s)
      Sugiura Y, Yao I, Setou M
    • Total Pages
      44
    • Publisher
      Wiley
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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