| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Kampo medicine has been widely used, but frequently its scientific evidence is not very clear. In this study, to find scientific evidence of two Kampo medicine, Hochuekki-to and Ninjinyoei-to, we newly create whole transcriptome data measured by microarray chip technology. The transcriptome data were measured in time-series and we prepare multiple conditions for case-control study and for Hochuekki-to transcriptome data were measured in multiple tissues. We used them to elucidate molecular mechanism of Kampo efficacy. To create simulation model for representing drug mode-of-action, we developed new data assimilation technique that can handle drug as an external variable. The relationship among molecules can be automatically determined based on the previously reported models. If the template models contain errors, the method automatically revised the models that yield more accurate prediction. This technique enables us to perform larger simulation of Kampo mode-of-action.
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