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Design and Implementation of high-performance spatial model simulator

Research Project

Project/Area Number 24300112
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Bioinformatics/Life informatics
Research InstitutionKeio University

Principal Investigator

FUNAHASHI Akira  慶應義塾大学, 理工学部, 准教授 (70324548)

Co-Investigator(Renkei-kenkyūsha) HIROI Noriko  慶應義塾大学, 理工学部・生命情報学科, 専任講師 (20548408)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords情報工学 / 並列処理 / GPGPU / 空間モデル / 偏微分方程式 / 数値積分 / SBML / ハイパフォーマンス・コンピューティング / システムバイオロジー / 生体生命情報学 / バイオテクノロジー
Outline of Final Research Achievements

On a spatial model simulation based on PDEs, the simulation space is discretized by grid and simulators will compute on each grid sequentially which will increase the simulation time enormously depending on the number of grids. In order to solve this problem, we have applied parallelization of this sequential numerical integration on GPGPU (General Purpose computing on GPU).
In this research, we parallelized a CPU-based SBML spatial model simulator by GPGPU. We implemented numerical integration of advection, reaction and diffusion equation with NVIDIA CUDA. For the evaluation of the CPU application, we used Intel Xeon X5687 and for the evaluation of GPU case, we used Tesla K40. As a result, we achieved 52x performance improvement in advection equation, 64x in reaction equation, 63x in diffusion equation for 512x512 grids.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Invited: 3 results)

  • [Journal Article] High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexes2015

    • Author(s)
      Yuichiro Nakai, Mitsunori Ozeki, Takumi Hiraiwa, Ryuichi Tanimoto, Akira Funahashi, Noriko Hiroi, Atsushi Taniguchi, Shigenori Nonaka, Viviane Boilot, Roshan Shrestha, Joanna Clark, Naoka Tamura, Viji M Draviam, Hiromasa Oku
    • Journal Title

      Review of Scientific Instruments

      Volume: 86 Issue: 1 Pages: 013707-013707

    • DOI

      10.1063/1.4905330

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acceleration of discrete stochastic biochemical simulation using GPGPU2015

    • Author(s)
      Kei Sumiyoshi, Kazuki Hirata, Noriko Hiroi, Akira Funahashi
    • Journal Title

      Frontiers in physiology

      Volume: 6 Pages: 1-1

    • DOI

      10.3389/fphys.2015.00042

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The systems biology simulation core algorithm2013

    • Author(s)
      Keller, R., Dorr, A., Tabira, A., Funahashi, A., Ziller, M.J., Adams, R., Rodriguez, N., Le Novere, N., Hiroi, N., Planatscher, H., Zell, A. and Drager, A.
    • Journal Title

      BMC Systems Biology

      Volume: 7 Issue: 1 Pages: 5-5

    • DOI

      10.1186/1752-0509-7-55

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Computational Platform for Systems Biology2014

    • Author(s)
      Akira Funahashi
    • Organizer
      Dagstuhl Seminar on Multiscale Spatial Computational Systems Biology
    • Place of Presentation
      Wadern, Germany
    • Year and Date
      2014-11-23 – 2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] CellDesigner2014

    • Author(s)
      Akira Funahashi, Noriko Hiroi
    • Organizer
      Modelling and Simulation of Biological Models
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fabrication method to a high resolution control in the space of cell culturing environment with microfluidic system.2014

    • Author(s)
      Hiraiwa, T., Kimura, T., Takenaka, Y., Tanamoto, R., Ota, H., Kimura, H., Taguchi, Y., Miki, N., Matsumoto, Y., Oka, K., Funahashi, A. and Hiroi, N.
    • Organizer
      Micro Eloctro Mechanical Systems (MEMS)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Numerical Investigation for in vivo Oriented Modeling in 3D Crowded Space2013

    • Author(s)
      久保島剛
    • Organizer
      The 10th NIBB-EMBL Symposium 2013 Quantitative Bioimaging
    • Place of Presentation
      基礎生物学研究所・岡崎
    • Year and Date
      2013-03-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Understanding the characteristics of intracellular reaction space from the point of view of bio-molecular organization using spatial simulation2013

    • Author(s)
      奥原嵩弘
    • Organizer
      The 10th NIBB-EMBL Symposium 2013 Quantitative Bioimaging
    • Place of Presentation
      基礎生物学研究所・岡崎
    • Year and Date
      2013-03-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Physiological intracellular crowdedness is defined by the surface-to-volume ratio of sub-cellular compartments2013

    • Author(s)
      広井賀子
    • Organizer
      First Annual Winter Q-Bio Meeting
    • Place of Presentation
      ハワイ・アメリカ
    • Year and Date
      2013-02-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] Q-BioJP : Japanese Society for Quantitative Biology2013

    • Author(s)
      舟橋啓
    • Organizer
      First Annual Winter Q-Bio Meeting
    • Place of Presentation
      ハワイ・アメリカ
    • Year and Date
      2013-02-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] CellDesigner: A process diagram editor for gene-regulatory and biochemical networks.2013

    • Author(s)
      Funahashi, A. and Hiroi, N.
    • Organizer
      CellDesigner Workshop
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CellDesigner: A process diagram editor for gene-regulatory and biochemical networks2013

    • Author(s)
      Funahashi, A. and Hiroi, N.
    • Organizer
      Computational and Mathematical Biology Course
    • Place of Presentation
      Okinawa, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Setting up quantitative models in CellDesigner2013

    • Author(s)
      Funahashi, A. and Hiroi, N.
    • Organizer
      Tutorials at international Conference on Systems Biology 2013 (ICSB2013)
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2013 Annual Research Report
  • [Presentation] A neural differentiation model of pluripotent stem cells2013

    • Author(s)
      Takiguchi, R., Iwasaki, T., Hiraiwa, T., Kimura, T., Yamazaki, K., Funahashi, A. and Hiroi, N.
    • Organizer
      International Conference on Systems Biology 2013 (ICSB2013)
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of microfluidic system for high resolution control of cell culturing environment2013

    • Author(s)
      Hiraiwa, T., Kimura, T., Tanamoto, R., Ota, H., Kimura, H., Taguchi, Y., Miki, N., Matsumoto, Y., Oka, K., Funahashi, A. and Hiroi, N.
    • Organizer
      International Conference on Systems Biology 2013 (ICSB2013)
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of microfluidic system for high resolution control of long-term cell culturing environment2013

    • Author(s)
      Hiraiwa, T., Kimura, T., Tanamoto, R., Ota, H., Kimura, H., Taguchi, Y., Miki, N., Matsumoto, Y., Oka, K., Funahashi, A. and Hiroi, N.
    • Organizer
      International Workshop on Quantitative Biology 2013
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Design and Implementation of CellDesigner2013

    • Author(s)
      Funahashi, A., Matsuoka, Y., Ghosh, S., Hiroi, N. and Kitano, H.
    • Organizer
      International Workshop on Quantitative Biology 2013
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of High-speed 3D imaging system with electrically tunable lenses for deeper probing of subcellular structures2013

    • Author(s)
      Nakai, Y., Tamura, N., Hiraiwa, T., Okuhara, T., Draviam, V.M., Funahashi, A. and Hiroi, N.
    • Organizer
      International Workshop on Quantitative Biology 2013
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Implementation of a spatial model simulator and its SBML support2012

    • Author(s)
      松井達広
    • Organizer
      HARMONY2012
    • Place of Presentation
      マーストリヒト・オランダ
    • Year and Date
      2012-05-24
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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