| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
Long-term synaptic plasticity and memory formation require activity-dependent gene expression. However, it remains unknown how such activity-induced gene products are targeted to proper cellular compartments including synapses. In the present study, we investigated the targeting of the memory related-protein Arc from the soma to the synapses, and elucidated a novel “inverse” synaptic tagging mechanism that enables Arc to specifically target the un-potentiated synapses. The findings provide new mechanistic insights into how the contrast between strong and weak synapses is maintained during long-term synaptic plasticity. We further identified the CREB coactivator CRTC1 as a critical factor for Arc expression as well as memory function.
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