| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
Gasc1 gene encodes a histone H3 lysine 9 (H3K9) demethylating enzyme, which we previously found is expressed in post-mitotic neurons in the mouse brain. We showed that GASC1 hypomorphic mutant mice exhibit mental disorder-like abnormal behaviors. In the present study, we have newly detected increased dendritic spine densities of the mutant hippocampal neurons. Electrophysiological studies on hippocampal slices have further demonstrated increased long-term potentiation. Further studies will enable us to discuss the cause of human neurological/psychiatric symptoms and future drug discoveries. We have also found that one of the ten-eleven translocation (TET) proteins, TET3, is involved in the timing of astrocyte development most likely through oxidization of the 5-methylcytosine.
We have also provided a novel molecular mechanism for NSC self-renewal in which one of the growth promoting signaling components, cyclin D1, which is induced by FGF2- and Wnts inhibits astrocyte differentiation.
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