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Identification and functional analysis of motion detection circuits

Research Project

Project/Area Number 24300120
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neuroscience in general
Research InstitutionKanazawa University

Principal Investigator

Sato Makoto  金沢大学, 新学術創成研究機構, 教授 (30345235)

Co-Investigator(Renkei-kenkyūsha) Hasegawa Eri  金沢大学, 脳・肝インターフェースメディシン研究センター, 博士研究員 (50469607)
Suzuki Takumi  金沢大学, 脳・肝インターフェースメディシン研究センター, 博士研究員 (30623764)
Nakai Yasuhiro  金沢大学, 脳・肝インターフェースメディシン研究センター, 博士研究員 (00648537)
Imamura Kosuke  金沢大学, 理工研究域電子情報学系, 准教授 (00324096)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords動体認識 / 視覚情報処理 / ショウジョウバエ / 視覚中枢 / 神経科学 / 神経回路 / 視覚系
Outline of Final Research Achievements

Visual information processing in motion detection is an important topic of neuroscience. However, the details of motion detection circuits remain elusive. In this study, we used the fly visual center as a model to elucidate the structure and function of motion detection circuits.
As a first step, I constructed an insect area, in which various visual stimuli can be presented to a fly and its response can be quantified using an infrared sensor. Using this system, I examined the roles of potential motion detection neurons such as Mi1, Lawf1 and Lawf2. As a result, I found that Mi1 plays a central role in motion detection and that Lawf1 and Lawf2 act co-operatively.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (16 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 4 results,  Open Access: 4 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] eyeless/Pax6 Controls the Production of Glial Cells in the Visual Center of Drosophila melanogaster.2016

    • Author(s)
      Suzuki, T., Takayama, R. and Sato, M.
    • Journal Title

      Developmental Biology

      Volume: 409 Issue: 2 Pages: 343-353

    • DOI

      10.1016/j.ydbio.2015.12.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Super-resolution mapping of neuronal circuitry using an index optimized clearing agent2016

    • Author(s)
      Meng-Tsen Ke, Yasuhiro Nakai, Satoshi Fujimoto, Rie Takayama, Shuhei Yoshida, Tomoya S. Kitajima, Makoto Sato, Takeshi Imai
    • Journal Title

      Cell Reports

      Volume: 14 Issue: 11 Pages: 2718-2732

    • DOI

      10.1016/j.celrep.2016.02.057

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center2016

    • Author(s)
      Suzuki, T., Hasegawa, E., Nakai, Y., Kaido, M., Takayama, R. and Sato, M.
    • Journal Title

      Cell Reports

      Volume: 15 Issue: 3 Pages: 499-509

    • DOI

      10.1016/j.celrep.2016.03.056

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurogenesis and neuronal circuit formation in the Drosophila visual center2014

    • Author(s)
      Suzuki, T. and Sato, M.
    • Journal Title

      Development Growth and Differentiation

      Volume: 56 Issue: 7 Pages: 491-498

    • DOI

      10.1111/dgd.12151

    • NAID

      40020214695

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Waves of differentiation in the fly visual system2013

    • Author(s)
      Sato, M., Suzuki, T. and Nakai, T.
    • Journal Title

      Developmental Biology

      Volume: 380 Issue: 1 Pages: 1-11

    • DOI

      10.1016/j.ydbio.2013.04.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A temporal mechanism that produces neuronal diversity in the Drosophila visual center2013

    • Author(s)
      Suzuki, T., Kaido, M., Takayama, R. and Sato, M.
    • Journal Title

      Developmental Biology

      Volume: 380 Issue: 1 Pages: 12-24

    • DOI

      10.1016/j.ydbio.2013.05.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Visualization of neural activity in insect brains using a conserved immediate early gene, Hr38.2013

    • Author(s)
      Nozomi Fujita, Takumi Nishiuchi, Makoto Sato, Masafumi Iwami, and Taketoshi Kiya
    • Journal Title

      Current Biology

      Volume: 23 Issue: 20 Pages: 2063-2070

    • DOI

      10.1016/j.cub.2013.08.051

    • NAID

      120005349182

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain-specific-homeobox is required for the specification of neuronal types in the Drosophila optic lobe2013

    • Author(s)
      Hasegawa, E., Kaido, M., Takayama, R. and Sato, M.
    • Journal Title

      Developmental Biology

      Volume: 377 Issue: 1 Pages: 90-99

    • DOI

      10.1016/j.ydbio.2013.02.012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Waves of differentiation in the fly visual system2013

    • Author(s)
      Sato. M, Suzuki, T. and Nakai, T.
    • Journal Title

      Developmental Biology

      Volume: 380(掲載確定) Pages: 1-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Formation of neuronal circuits by interactions between neuronal populations derived from different origins in the Drosophila visual center.2015

    • Author(s)
      Suzuki, T., Hasegawa, E., Nakai, Y., Kaido, M., Takayama, R. and Sato, M.
    • Organizer
      24th European Drosophila Research Conference
    • Place of Presentation
      ハイデルベルグ
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mathematical modeling and genetic analysis of the wave of differentiation in the Drosophila visual center2015

    • Author(s)
      Sato, M., Miura, T. and Nagayama, M.
    • Organizer
      3rd Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      北京
    • Year and Date
      2015-05-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mathematical modeling and genetic analysis of the wave of differentiation in the Drosophila visual center2014

    • Author(s)
      Sato, M., Miura, T. and Nagayama, M.
    • Organizer
      Society for Mathematical Biology 2014
    • Place of Presentation
      大阪国際コンベンションセンター
    • Year and Date
      2014-07-28 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] A temporal mechanism that produces neuronal diversity in the Drosophila visual center2013

    • Author(s)
      Suzuki, T., Kaido, M., Takayama, R. and Sato, M.
    • Organizer
      The 2nd Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      ソウル
    • Year and Date
      2013-05-13 – 2013-05-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] A birth-order dependent mechanism that produces neuronal diversity in the Drosophila visual center2012

    • Author(s)
      Sato, M.
    • Organizer
      Gordon Research Conference, Visual System Deve lopment
    • Place of Presentation
      Colby-Sawyer College, USA
    • Related Report
      2012 Annual Research Report
  • [Remarks] 神経発生学研究分野

    • URL

      http://fsosato.w3.kanazawa-u.ac.jp/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://fsosato.w3.kanazawa-u.ac.jp/index.html

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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