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Molecular and cellular basis for dendritic development and maintenance

Research Project

Project/Area Number 24300124
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neuroscience in general
Research InstitutionThe University of Tokyo (2013-2015)
Osaka Bioscience Institute (2012)

Principal Investigator

Emoto Kazuo  東京大学, 理学(系)研究科(研究院), 教授 (80300953)

Co-Investigator(Kenkyū-buntansha) Koizumi Hiroyuki  東京大学, 大学院理学系研究科, 助教 (10334335)
金井 誠  公益財団法人大阪バイオサイエンス研究所, 「神経細胞生物学部門」, 研究員 (50598034)
金森 麗 (森川 麗)  公益財団法人大阪バイオサイエンス研究所, 「神経細胞生物学部門」, 研究員 (50534575)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords受容領域 / 樹状突起 / 感覚ニューロン / ショウジョウバエ / Wntシグナル / Hippo-Ndrシグナル / 再編 / 維持 / リン酸化酵素 / シグナル伝達 / 樹上突起 / リン酸化シグナル
Outline of Final Research Achievements

In Drosophila larvae, dendrites of C4da neurons completely but non-redundantly cover the whole epidermis, and the boundaries of these tiled dendritic fields are specified through repulsive interactions between homotypic dendrites. Here we report that, unlike the larval C4da neurons, adult C4da neurons rely on both dendritic repulsive interactions and external positional cues to delimit the boundaries of their dendritic fields. We identify Wnt5 derived from sternites, the ventral most part of the adult abdominal epidermis, as the critical determinant for the ventral boundaries. Further genetic data indicate that Wnt5 promotes dendrite termination on the periphery of sternites through the Ryk receptor family kinase Drl and the Rho GTPase guanine nucleotide exchange factor Trio in C4da neurons. Our findings thus uncover the dendritic contact-independent mechanism that is required for dendritic boundary specification.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Adult Drosophila sensory neurons specify dendrite boundaries independent of dendritic contact through the Wnt5-Drl signaling pathway.2015

    • Author(s)
      Yasunaga K, Tezuka A, Ishikawa N, Dairyo Y, Togashi K, Koizumi H and Emoto K
    • Journal Title

      Genes and Development

      Volume: 29 Issue: 16 Pages: 1763-1775

    • DOI

      10.1101/gad.262592.115

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons2015

    • Author(s)
      Takahiro Kanamori, Jiro Yoshino, Kei-ichiro Yasunaga, Yusuke Dairyo, Kazuo Emoto
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6515-6515

    • DOI

      10.1038/ncomms7515

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dendrite remodeling: lessons from invertebrate model systems.2015

    • Author(s)
      Kanamori T, Togashi K, Koizumi H and Emoto K
    • Journal Title

      Int Rev Cell Mol Biol

      Volume: 318 Pages: 1-38

    • DOI

      10.1016/bs.ircmb.2015.05.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Compartmentalized Calcium Transients Trigger Dendrite Pruning in Drosophila Sensory Neurons2013

    • Author(s)
      Takahiro Kanamori, Makoto I. Kanai, Yusuke Dairyo, Kei-ichiro Yasunaga, Rei K. Morikawa, and Kazuo Emoto
    • Journal Title

      Science

      Volume: 340 Issue: 6139 Pages: 1475-1478

    • DOI

      10.1126/science.1234879

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Select interneuron clusters determine female sexual receptivity in Drosophila.2013

    • Author(s)
      Sakurai, A., Koganezawa, M., Yasunaga, K., Emoto, K. and Yamamoto, D.
    • Journal Title

      Nat. Commun.

      Volume: 4 Issue: 1 Pages: 1825-1833

    • DOI

      10.1038/ncomms2837

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role for phospholipid flippase complex of ATP8A1 and CDC50A in cell migration.2013

    • Author(s)
      Kato, U., Inadome, H., Emoto, K., Kobayashi, T., Umeda, M.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 7 Pages: 4922-4934

    • DOI

      10.1074/jbc.m112.402701

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signaling mechanisms that coordinate the development and maintenance of dendritic fields.2012

    • Author(s)
      Emoto, K.
    • Journal Title

      Curr. Opin. Neurobiol.

      Volume: 22 Issue: 5 Pages: 805-811

    • DOI

      10.1016/j.conb.2012.04.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Local calcium signaling in dendrite remodeling.2015

    • Author(s)
      Kazuo Emoto
    • Organizer
      Gordon Research Conference “Dendrite: Molecules, Structure & Function”
    • Place of Presentation
      Ventura Beach, USA
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Calcium signaling in dendrite development and remodeling2015

    • Author(s)
      Kazuo Emoto
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Los Angels
    • Year and Date
      2015-03-15 – 2015-03-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Calcium signaling in dendrite development and remodeling2014

    • Author(s)
      Kazuo Emoto
    • Organizer
      EMBO workshop "Neuronal Remodeling"
    • Place of Presentation
      キブッツアインゲディ(Kibbutz Ein-Gedi),イスラエル
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Molecular and cellular basis for dendrite development2012

    • Author(s)
      Kazuo Emoto
    • Organizer
      EMBOカンファレンス
    • Place of Presentation
      ギリシアクレタ島
    • Year and Date
      2012-06-20
    • Related Report
      2012 Annual Research Report
  • [Book] 実験医学2015

    • Author(s)
      榎本和生
    • Publisher
      羊土社
    • Related Report
      2015 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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