| Project/Area Number |
24300128
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KAWATA Mitsuhiro 京都府立医科大学, 医学(系)研究科(研究院), 教授 (60112512)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Shunji 京都府立医科大学, 医学研究科, 講師 (40454079)
TANIDA Takashi 京都府立医科大学, 医学研究科, 助教 (30589453)
TOKITA Miwako 京都府立医科大学, 医学研究科, 助教 (10420712)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Hirotaka 岡山大学, 自然科学研究科, 准教授 (20363971)
MATSUDA Kenichi 京都府立医科大学, 医学研究科, 准教授 (40315932)
TAKANAMI Keiko 京都府立医科大学, 医学研究科, プロジェクト研究員 (70578830)
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| Research Collaborator |
OHYA Miku
LI Meihua
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 性分化 / 性ホルモン分子 / モニターニューロン / イメージング / エピジェネティック / 性行動 / シナプス / 臨界期 / 臨海期 / GFPイメージング |
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| Outline of Final Research Achievements |
The project was to pursue the mechanism of sexual difference at developing as well as adult stages from molecular, cellular, neuronal circuit, and behavioral levels. At the developing stage epigenetic mechanism including histone acetylation was sequentially regulated and androgen receptor activation/inactivation influenced the sexual behavior at phase specific regardless of apparent histological differences of neuronal tissue. Female sexual behavior, lordosis in particular, was controled by specific neuronal connection between midbrain and medulla oblongata by using glutamate neurotransmitter and gastrin releasing peptide which controls female itching behavior was identified as peculiar synaptic structure in the principal sensory nucleus of trigeminal nerve and posterior horn of spinal cord by using 3D analysis. Molecular interaction between estrogen receptor and transcription factor, estrogen related receptor, was visualized by imaging method, suggesting ligand specific regulation.
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