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Analysis of protein propagation scheme of Lewy body- related alpha- synucleinopathy

Research Project

Project/Area Number 24300133
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

MURAYAMA Shigeo  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50183653)

Co-Investigator(Kenkyū-buntansha) SAITO Yuko  独立行政法人国立精神・神経医療研究センター, 臨床検査部・臨床検査科, 医長 (60344066)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywordsレビー小体病 / 免疫組織化学 / αシヌクレイン / ブレインバンク / プリオン / パーキンソン病 / レビー小体型認知症 / 純粋自律神経不全症 / レビー小体 / アルファシヌクレイン
Outline of Final Research Achievements

The purpose of this study is to elucidate prion hypothesis of Lewy body- related alpha- synucleinopathy (LBAS). We first found LBAS in the olfactory epithelial cells and supported dual hit hypothesis by Braak’s group. We also proved that LBAS involving the olfactory bulb and amygdala pathway was independent from LBAS in the peripheral autonomic nervous system, spinal cord and brain stem. We also confirmed that LBAS in the preganglionic sympathetic nerves extended from distal axons to their perikarya, as was reported in the postganglionic sympathetic nerves. We also first demonstrated that LBAS affected the primary sensory neurons. LBAS there extended from distal to proximal axons. LBAS in the spinal cord apparently extended from the caudal to rostral extension. These data supported the prion hypothesis of LBAS that its initial peripheral seeding propagated to the central nervous system via neural network.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (107 results)

All 2014 2013 2012 Other

All Journal Article (31 results) (of which Peer Reviewed: 17 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (73 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Alpha- synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease.2014

    • Author(s)
      Ito S, …. Saito Y,…….Murayama S
    • Journal Title

      Int J Clin Exp Patholo

      Volume: 7 Pages: 1714-1723

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease.2014

    • Author(s)
      Hasegawa, M., S. Watanabe, H. Kondo, H. Akiyama, D. M. Mann, Y. Saito and S. Murayama
    • Journal Title

      Acta Neuropathol

      Volume: 127 Issue: 2 Pages: 303-305

    • DOI

      10.1007/s00401-013-1191-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropathologic analysis of Lewy- related alpha- synucleinopathy in olfactory mucosa.2013

    • Author(s)
      147. Funabe S, Takao M, Saito Y, Hatsuta H, Sugiyama M, Ito S, Kanemaru K, Sawabe M, Arai T, Mochizuki H, Hattori N, Murayama S
    • Journal Title

      Neuropathology

      Volume: 33 Pages: 47-58

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lewy body pathology in a patient with a homozygous Parkin deletion.2013

    • Author(s)
      148. Miyakawa S, Ogino M, Funabe S, Uchino A, Shimo Y, Hattori N, Ichinoe M, Mikami T, Saegusa M, Nishiyama K, Mori H, Mizuno Y, Murayama S, Mochizuki H
    • Journal Title

      Mov Disord

      Volume: 28 Pages: 388-391

    • Related Report
      2013 Annual Research Report
  • [Journal Article] YY1 binds to alpha-synuclein 3'-flanking region SNP and stimulates antisense noncoding RNA expression.2013

    • Author(s)
      162. Mizuta I, Takafuji K, Ando Y, Satake W, Kanagawa M, Kobayashi K, Nagamori S, Shinohara T, Ito C, Yamamoto M, Hattori N, Murata M, Kanai Y, Murayama S, Nakagawa M, Toda T
    • Journal Title

      J Hum Genet

      Volume: 58 Pages: 711-719

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Neuropathologic analysis of Lewy- related alpha- synucleinopathy in olfactory mucosa.2013

    • Author(s)
      Funabe S
    • Journal Title

      Neuropathology

      Volume: 33 Issue: 1 Pages: 47-58

    • DOI

      10.1111/j.1440-1789.2012.01329.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicentre multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt Jakob disease2013

    • Author(s)
      Fujita K, Harada M, Sasaki M, Yuasa T, Sakai K, Hamaguchi T, Sanjo N, Shiga y Satoh K, Atarashi R, Shirabe S, Nagata K, Maeda T, Muravama S, Izumi Y, Kaji R, Yamada M, Mizusawa H.
    • Journal Title

      BMJ Open Journal

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Abeta generation in Alzheimer's disease2012

    • Author(s)
      Saito Y
    • Journal Title

      Mol Neurodegener

      Volume: 7 Issue: 1 Pages: 50-50

    • DOI

      10.1186/1750-1326-7-50

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of familial and sporadic amyotrophic lateral sclerosis with OPTN mutations in Japanese population.2012

    • Author(s)
      Naruse H
    • Journal Title

      Amyotroph Laterl Scler

      Volume: 13(6) Issue: 6 Pages: 562-6

    • DOI

      10.3109/17482968.2012.684213

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan.2012

    • Author(s)
      Kokubo Y
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 71(7) Issue: 7 Pages: 625-630

    • DOI

      10.1097/nen.0b013e31825b9680

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced antigen retrieval of amyloid β immunohistochemistry: re-evaluation of amyloid β pathology in Alzheimer disease and its mouse model.2012

    • Author(s)
      Kai H
    • Journal Title

      J Histochem Cytochem

      Volume: 60(10) Issue: 10 Pages: 761-9

    • DOI

      10.1369/0022155412456379

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.2012

    • Author(s)
      Ishiura H
    • Journal Title

      Am J Hum Genet.

      Volume: 91(2) Issue: 2 Pages: 320-9

    • DOI

      10.1016/j.ajhg.2012.07.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered Y-secretase activity in mild cognitive impairment and Alzheimer's disease2012

    • Author(s)
      Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama s, Hashimoto Y, Miyajima M, Arai H, Nagashima Y Yamaguchi H, Kuwano R, Nagaike K, Ihara Y ; the Japanese Alzheimer's Disease Neuroimaging Initiative
    • Journal Title

      Eur J Neurol

      Volume: 4 Issue: 4 Pages: 344-352

    • DOI

      10.1002/emmm.201200214

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2012

    • Author(s)
      Tsuji H
    • Journal Title

      Brain

      Volume: 135(11) Issue: 11 Pages: 3380-91

    • DOI

      10.1093/brain/aws230

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF-immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum2012

    • Author(s)
      Takahashi M, Ishikawa K, Sato N, Obayashi M, Niimi Y, Ishiguro T, Yamada M, Toyoshima Y, Takahashi H, Kato T, Takao M, Murayama M, Mori O, Eishi Y, Mizusawa H
    • Journal Title

      Neuropathology

      Volume: (in press) Issue: 6 Pages: 593-603

    • DOI

      10.1111/j.1440-1789.2012.01302.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suspected limited efficacy of γ-secretase modulators.2012

    • Author(s)
      Kakuda N
    • Journal Title

      Neurobiol Aging

      Volume: 34(4) Issue: 4 Pages: 1101-4

    • DOI

      10.1016/j.neurobiolaging.2012.08.017

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 長大な脊髄病変を伴いmultiple biopsiesにて組織診断された血管内リンパ腫の1例2012

    • Author(s)
      白井慎一,高橋育子,加納崇裕,佐藤和則,久保田佳奈子,矢部一郎.村山繁雄、佐々木秀直
    • Journal Title

      臨床神経

      Volume: 52 Pages: 336-343

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ―CPC― 4年間,経管栄養をした高度認知症の1例2012

    • Author(s)
      砂川昌子,増田義重,沢辺元司,足立正,徳丸阿耶,井藤英喜,川田真幹,稲松孝思,村山繁雄,初田裕嗽
    • Journal Title

      Geriatric Medicine.

      Volume: 50 Pages: 653-662

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤性パーキンソン症状との鑑別が問題となった軽度認知障害の87歳男性2012

    • Author(s)
      神谷久雄,村山繁雄,舟邉さやか,齊藤祐子,福田隆浩
    • Journal Title

      BRAIN and NERVE

      Volume: 64 Pages: 1433-1442

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2012.【アルツハイマー病・先制医療に向けての展開】アルツハイマー病と脳老化の病理学2012

    • Author(s)
      村山繁雄,齊藤祐子
    • Journal Title

      カレントテラピー

      Volume: 30 Pages: 320-325

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 2012a【パーキンソン病の新しい側面】Braak仮説と非運動症状2012

    • Author(s)
      齊藤祐子,村山繁雄
    • Journal Title

      BRAIN and NERVE

      Volume: 64 Pages: 444-452

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 2012b各種疾患 自律神髞障害パーキンソン病と蚕系兪萎縮症における自律神経系の病理(皮膚を用いたレビ・一小体病の末梢自律神経病理を含めて)2012

    • Author(s)
      齊藤祐子,村山繁雄
    • Journal Title

      Annual Review神経

      Pages: 301-308

    • Related Report
      2012 Annual Research Report
  • [Journal Article] アルツハイマー病診療のスキルアップを考える-この症例をどう診るか-2012

    • Author(s)
      繁田雅弘,大野篤志,森 敏,村山肇撻,足立正、齊藤祐子,徳丸阿耶,石井賢二,浦上克哉
    • Journal Title

      老年精神医学雑誌

      Volume: 23(増刊1) Pages: 1-18

    • Related Report
      2012 Annual Research Report
  • [Journal Article] アルツハイマー病と脳老化の病理学一特集今,認知症にどう向き合うか、2012

    • Author(s)
      村山繁雄、齊藤祐子
    • Journal Title

      内科

      Volume: 109 Pages: 840-845

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 6.ブレインバンク 第1部 病理解剖の進め方、切り出し方法など c.特殊な部位、手技、検体保存2012

    • Author(s)
      村山繁雄,高尾昌樹,初田裕幸,斎藤祐子
    • Journal Title

      病理と臨床【臨時増刊号】

      Volume: 30 Pages: 103-109

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 第1部:基礎編 パーキンソン病の神経病理up to date、2012

    • Author(s)
      村山繁雄,齊藤祐子
    • Journal Title

      Progress in Medicine

      Volume: 32 Pages: 1161-1165

    • Related Report
      2012 Annual Research Report
  • [Journal Article] タウ蛋白と免疫染色2012

    • Author(s)
      村山繁雄,齊藤祐子
    • Journal Title

      検査と技術

      Volume: 40 Pages: 749-751

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 第II部4章新しい臨床研究の技術とプロジ土クト展開 2.精神・神経疾患研究のためのブレインバンク2012

    • Author(s)
      村山繁雄,齊藤祐子,丹羽真一
    • Journal Title

      実験医学

      Volume: 30 Pages: 146-155

    • Related Report
      2012 Annual Research Report
  • [Journal Article] バイオバンク構築における病理の役割【共同研究の機転として機能する我が国のバイオバンクの実例】ブレインバンクの現状,高齢者ブレインバンク,美原記念病院ブレインバンクの経験から2012

    • Author(s)
      高尾昌樹,村山繁雄,美原盤,吉田洋二
    • Journal Title

      病理と臨床

      Volume: 30 Pages: 635-645

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 膿瘍との鑑別が困難であった肺腫瘍・転移性脳腫瘍の1例2012

    • Author(s)
      高橋英気,望月英明,井藤英喜,筑井恵美子,加藤貴行,鄭仁煕,徳丸阿耶,山川通隆,安蘇良一,沢辺元司,高尾昌樹,新井冨生,村山繁箴
    • Journal Title

      内科

      Volume: 110 Pages: 469-480

    • Related Report
      2012 Annual Research Report
  • [Journal Article] バイオバンク構築における病理の役割【共同研究の起点として機能する我が国のバイオバンク】東京都健康長寿医療センターの病理由来組織バンクおよび日本における組織バンクの課題2012

    • Author(s)
      沢辺元司,新井冨生,扛山茎挑 清水孝彦,戸田行総,古田耕,増井徹
    • Journal Title

      病理と臨床

      Volume: 30 Pages: 624-628

    • Related Report
      2012 Annual Research Report
  • [Presentation] The Brain Bank for Aging Research Project, Tokyo, Japan.2014

    • Author(s)
      Murayama, S., Saito, Y.
    • Organizer
      The 3rd Congress of Asian Society of Neurophathology.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The Brain Bank Committee, the Japanese Society of Neuropathology2014

    • Author(s)
      Murayama, S., Saito, Y.
    • Organizer
      18th International Congress of Neuropathology, 2014
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2014-09-14 – 2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Assessment of CSF α- synuclein levels ditinguishes dementia with Lewy bodies from Alzheimer’s disease.2014

    • Author(s)
      Kanemaru, K., Kanemaru, A., Murayama, S.
    • Organizer
      Alzheimer’s Association International Conference 2014
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2014-07-12 – 2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinicopathological characteristics of pure type Lewy body disease with dementia (Parkinson’s disease with dementia and dementia with Lewy bodies).2014

    • Author(s)
      Sengoku, R., ... Saito, Y., Murayama, S.
    • Organizer
      18th International Congress of Parkinson’s Disease and Movement Disprders.
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-06-08 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exome sequencing of Parkinson’s disease in order to identify genetic variants with high disease-risk.2014

    • Author(s)
      Sataka, W., ... Murayama, S.,...Toda, T.
    • Organizer
      18th International Congress of Parkinson’s Disease and Movement Disprders
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-06-08 – 2014-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Autopsy-proven amyotrophic lateral sclerosis coexisted with Parkinson disease.2014

    • Author(s)
      Isumi, Y.....,Murayama, S., Kaji, R.
    • Organizer
      The 66th AAN Annual Meeting
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2014-04-26 – 2014-05-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Systemc distribution of Lewy body pathology in an aging cohort.2013

    • Author(s)
      Murayama S, Takao M, Hatsuta H, Sumikura H, Itoh S, Nogami A, Uchino A, Saito Y,
    • Organizer
      17th International Congress of Parkinson’s Disease and Movement Disorders,
    • Place of Presentation
      Sydney
    • Related Report
      2013 Annual Research Report
  • [Presentation] Immunohistochemical Study of the Cerebellum in Amyotrophic Lateral Sclelosis (ALS)/Parkinson-Dementia Complex (PDC) in Kii Peninsula (ALS/PDC Kii, Muro Disease).2013

    • Author(s)
      Morimoto S, Kokubo Y, Hatsuta H, Kuzuhara S, Murayama S
    • Organizer
      Alzheimer’s Association International Conference 2013
    • Place of Presentation
      Boston
    • Related Report
      2013 Annual Research Report
  • [Presentation] nCSF SAPPβ, Bata-Amyloid 42, Tau and P-Tau Levels in Alzheimer’s Disease and Dementia With Lewy Bodies.2013

    • Author(s)
      Kanemaru K, Kanemaru I, Murayama S
    • Organizer
      Alzheimer’s Association International Conference 2013
    • Place of Presentation
      Boston
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human prion diseases in Japan: a prospective surveillance from 1999.2013

    • Author(s)
      Sanjo N, Higuma M, Hizume M, Nakamura Y, Kitamoto T, Yamada M, Sakai K, Nozaki I, Noguchi-Shinohara M, Hamaguchi T, Moriwaka F, Aoki M, Kuroiwa Y, Koyano S, Nishizawa M, Yokoseki A, Takeda M, Yoshiyama K, Inuzuka T, Abe K, Murai H, Murayama S, Takao M, Satoh K, Harada M, Saito N, Takumi I, Mizusawa H.
    • Organizer
      The XXIth World Congress of Neurology
    • Place of Presentation
      Vienna Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] 呼吸不全で発症した筋萎縮性側索硬化症の一例2012

    • Author(s)
      八木宣泰,小尾智一,荒木邦彦,杉浦明,山崎公也,内野彰子,初田裕幸,高尾昌樹,村山繁雄,.溝口功
    • Organizer
      第102回日本神経病理学会'関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] パーキンソン症状が先行し筋萎縮性側索硬化症が続発した68歳女性例2012

    • Author(s)
      和泉唯信,藤田浩司,小泉英貴,鎌田正紀,隅蔵大幸,初田裕幸,麹彑繁雄,梶龍兒
    • Organizer
      第102回日本神経病理学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性期脳梗塞に対しt-PA投与後、頭蓋内出血をきたした43歳男性2012

    • Author(s)
      齊藤陽子,仁科裕史,徳丸阿耶,初田裕幸,村山繁雄
    • Organizer
      第203回日本神経学会関東・甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] 昏睡状態で救急入院、亜急性白質脳症と診断後脳死となり、剖検にて頭蓋内悪性リンパ腫の存在が確認された、59歳男性例2012

    • Author(s)
      鎌田正紀,宮崎由道,藤田浩司,松井尚子,和泉唯信,梶龍兒,初田裕幸,村山繁雄
    • Organizer
      第40回臨床神経病理懇話会
    • Place of Presentation
      津市
    • Year and Date
      2012-11-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] PANK2ヘテロ変異(R94G)を認めたレビー小体病例の臨床病理学的検討2012

    • Author(s)
      隅蔵大幸,初田裕幸,内野彰子,野上茜,伊藤慎治,富山弘幸,高尾昌樹,村山繁雄,
    • Organizer
      第40回臨床神経病理懇話会
    • Place of Presentation
      津市
    • Year and Date
      2012-11-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 複合Pick球(compound Pick body)を含むFUS沈着を伴う,筋萎縮性側索硬化症(ALS) ,前頭側頭型変性症(FTLD)の,臨床病理学的検討2012

    • Author(s)
      村山繁雄,高尾昌樹,石井賢二,斎藤祐子,長谷川正人
    • Organizer
      第19回東北神経病理研究会
    • Place of Presentation
      福島
    • Year and Date
      2012-11-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 臨床的に脳アミロイドアンギオパチーによる陳旧性限局性くも膜下出血を疑われ、剖検にて確定診断した一例2012

    • Author(s)
      本郷博貴,筑井恵美子,高梨成彦,松岡浩司,徳丸阿耶,村山繁雄,初田裕幸,石井賢二,小林秀
    • Organizer
      第118回日本脳神経外科学会関東支支部学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 特徴的な臨床並びに画像所見を呈し、皮膚神経筋同時生検にて診断した核内封入体病の71歳男性例2012

    • Author(s)
      森本悟,初田裕幸,小宮正,徳丸亜耶,村山繁雄
    • Organizer
      第202回日本神経学会関東・甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] 特徴的な臨床並びに画像所見を薑し、皮膚神経旌同時生検にて診断しだ核内封入体病の71歳男性例2012

    • Author(s)
      森本悟、初田裕幸,小宮正,仁科裕史,椎名豎子;広吉祐子,江口桂、砂川昌子,高尾昌樹,石井賢二,徳丸亜耶,金丸和富,村山繁雄。
    • Organizer
      第76回Neuromuscular conference
    • Place of Presentation
      東京
    • Year and Date
      2012-08-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] 臍帯血移植後脳脊髄炎の70歳女性例2012

    • Author(s)
      初田裕幸,高尾昌樹,内野彰子,隅蔵大幸,野上茜,伊藤慎治,宮腰重三郎,新井冨生,村山繁雄
    • Organizer
      第101回日本神経病理学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] FUS陽性の好塩基性封入体を認めたALSの62歳女性の剖検例2012

    • Author(s)
      徳重真一,佐々木拓也,今福一郎,角田幸雄,肥田あゆみ,清水潤,辻省次,伊藤慎治,隅蔵大幸,野上茜,内野彰子,初田裕幸,高尾昌樹、村山繁雄
    • Organizer
      第101回日本神経病理学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急速に進行する筋力低下・筋萎縮を呈した遺伝性脊髄小脳変性症の52歳男性例2012

    • Author(s)
      森本悟,仁科裕史,金丸和冨,高尾昌樹,村山繁雄
    • Organizer
      第201回日本神経学会関東・甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Results of a multicentre phase 3 trial on florbetaben for B-amyloid brain PET in Alzheimer disease2012

    • Author(s)
      Sabbagh M, Seibyl J, Akatsu H, 0uchi y Beach T, Charny A, Barthel H, Senda K, Muravama S. Ishii K, Leverenz J, Ghetti B, Ironside J, Roth K, Hoffmann A, Schulz- Schaeffer W, Reininger C, Sabri O
    • Organizer
      2012 AAN
    • Place of Presentation
      Florida
    • Related Report
      2012 Annual Research Report
  • [Presentation] Abundant Tau-Accumulation in Gerstmann-Stra'ussler-Scheinker Disease Associated with the PRNP P102L-129M Mutation.2012

    • Author(s)
      Takao M, Takada M, Ogata K, Suzuki M, Yoshida y Mihara B, Ito S, Nogami A, Funabe S, Hatsuta H, Kawai M, Murayama S,. Haga T, Kitamoto T.
    • Organizer
      The 88th Annual meeting of the American Association of Neuropathologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Immunohistochemical Study and Western Blotting of Tauopathy in ALS/Parkinson Dementia Complex(PDC), Kii, Japan.2012

    • Author(s)
      Morimoto S, Kokubo y Hasegawa M, Kuzuhara S, Muravama S
    • Organizer
      88th Annual Meeting of the American Association of Neuropathologists.
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Establishment of pathology center for ALS/ PDC- Kii, Japan2012

    • Author(s)
      Morimoto S, Kokubo y Saito y Hasegawa M, Kihira l; Yoshida S, Takahashi H, YoshLda M, Kuzuhara S, Muravama S ,
    • Organizer
      2012 AAIC
    • Place of Presentation
      Vancouber
    • Related Report
      2012 Annual Research Report
  • [Presentation] FUS-immunopositive Inclusions and Compound Pick Bodies in Two Cases of Frontotemporal Lobar Degeneration with Motor Neuron Disease (FTLDMND).2012

    • Author(s)
      Nakamoto F, Takao M, Ikemura M, Hayashi l; Ito S, Maeda D, SaitoY, Takahashi Y; Hasegawa M, Fukayama M, Tsuji S, Muravama S
    • Organizer
      The 8th International Conference on Frontotemporal Dementias.
    • Place of Presentation
      Manchester, UK.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Alfa-Synuclein pathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii Peninsula, Japan.2012

    • Author(s)
      Kokubo Y, Taniguchi A, HasegawamM, Hayakawa'Y, Morimoto S, Yoneda M, Hirokawa y Shiraishi T, Saito Y; Muravama S、 Kuzuhara S ..
    • Organizer
      The 8th International Conference on Frontotemporal Dementias.
    • Place of Presentation
      Manchester, UK.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular analysis and biochemical classification of TDP-43 proteinopathy.2012

    • Author(s)
      Hasegawa M, Tsuji H, AJ'ai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuta H, Takao M, Saito Y, Muravama S、Mann D, Akiyama H, Tamaoka A.
    • Organizer
      The 8th International Conference on Frontotemporal Dementias.
    • Place of Presentation
      Manchester, UK.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Promoter DNA methylation of neprilysin gene in Alzheimer's disease brain2012

    • Author(s)
      Nagata K, Hatsuta 'H, Muravama S, Tamaoka A, Takuma H, Saido T. C, Iwata A
    • Organizer
      Neuroscience
    • Place of Presentation
      New Orleans
    • Related Report
      2012 Annual Research Report
  • [Presentation] S0D1に新規の変異を認めた家族性筋萎縮性側索硬化症の1剖検例2012

    • Author(s)
      種井善一,池村雅子,黒飛京子,石川俊平,清水潤,村山繁雄,深山正久
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ALS神経変性の病理学的進展様式と予後2012

    • Author(s)
      村山繁雄,齊藤祐子
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 日本神経科学ブレインネットワークの構築2012

    • Author(s)
      村山繁雄,齊藤祐子,高尾昌樹,赤津裕康
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合(牟婁病 : Kii ALS/PDC)-現状と課題-2012

    • Author(s)
      小久保康昌,紀平為子,吉田宗平,岡本和士i広川佳史,白石泰三,富山弘幸,服部信孝,長谷川成人,森本悟,村山繁雄,石浦浩之,辻省次,葛原茂樹
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 早期から著しい嚥下障害を来したパーキンソン病の病態に関する臨床的検討2012

    • Author(s)
      安田勉,清水崇宏,松田俊一,肥田あゆみ,市川弥生子,清水潤,村山繁雄,辻省次
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] パーキンソン病剖検脳における小胞体ストレスマーカーの解析2012

    • Author(s)
      山川健太郎,津田秀幸,山下博史,高橋良輔,初田裕幸,齊藤祐子,村山繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 「蛋白がん」としての神経変性疾患2012

    • Author(s)
      長谷川成人,野中隆,増田雅美,辻浩史,玉岡晃,吉田眞理,村山繁雄,新井哲明,秋山治彦,,
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳局所のアミロイドβ沈着は同部位における将来の神経活動低下を予測するのか?2012

    • Author(s)
      石井賢二,金丸和富,仁科裕史,徳丸阿耶,石渡喜一,村山繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] プリオン病剖検推進の試み(日本神経科学ブレインバンクネットワークからの報告)2012

    • Author(s)
      高尾昌樹,吉田洋二,美原盤,木村浩晃,伊藤慎治,野上茜,舟辺さやか,初田裕幸,村山繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルツハイマー病における脳脊髄液sAPPβの検討2012

    • Author(s)
      金丸和富,小宮正,仁科裕史,扛也繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 進行性核上性麻痺と皮質基底核変性症の臨床病理学的検討-亜分類との対応2012

    • Author(s)
      池田謙輔,塩谷彩子,有馬邦正,村山繁雄,村田美穂,齊藤祐子
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 双極性感情障害の背景病理としての嗜銀顆粒2012

    • Author(s)
      塩谷彩子,齊藤祐子,有馬邦正,村山繁雄,玉岡晃
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Lewy小体病における梨状葉皮質の神経病理学的検討2012

    • Author(s)
      舟辺さやか,野上茜,伊藤慎治,初田裕幸,齊藤祐子,高尾昌樹,服部信孝,村山繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高度難聴を合併した前下小脳動脈(AICA)領域脳梗塞の3例2012

    • Author(s)
      加藤貴行,仁科裕史,小宮正,金丸和富,村山繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ^<11>C-Pittsburg Compound B (PIB)集積と,病理学的アミロイドβ(Aβ)沈着の,解剖学的部位別検討-6剖検例における検討2012

    • Author(s)
      初田裕幸,石井賢二,高尾昌樹,金丸和富,新井冨生,齊藤祐子,宮下哲典,桑野良三,須原哲也,島田斉,篠遠仁,村山繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] a -synucleinopathy剖検症例におけるPLA2G6およびPANK2変異解析2012

    • Author(s)
      吉野浩代,富山弘幸,舟辺さやか,山下力,李元哲,舩山学,村山繁雄,.服部信孝
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 進行性核上性麻痺の早期病変-進行性核上性麻痺のprodromal stageは病理学的に捉えられるか-2012

    • Author(s)
      野上茜,山崎峰雄,齊藤祐子,伊藤慎治,舟辺さやか,初田裕幸,高尾昌樹,片山泰朗,村山繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 行性核上性麻痺のRichardson症候群とparkinsonismの臨床病理学的検討2012

    • Author(s)
      齊藤祐子,塩谷彩子,池田謙輔,野上茜,村田美穂,有馬邦正,村山繁雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 広汎な帯状疱疹ウイルス脳炎を発症し、剖検に至った81歳男性例2012

    • Author(s)
      遠藤由理佳,関野達雄,遠藤浩信,坊野恵子,中山貴博,村山繁雄,今福一郎
    • Organizer
      586回日本内科学会関東地方会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] S0D1の減少はアルツハイマー病様病態を早期に発症させる2012

    • Author(s)
      清水孝彦,村上一馬,村田央,野田義博,初田裕幸,村山繁雄,入江一浩,白澤卓二
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 福祉村Brain Bank年次報告2012

    • Author(s)
      赤津裕康,堀映,小川倫弘,兼坂岳志,谷口知恵,售藤祐子,高尾昌樹,村山繁雄,山本孝之,橋詰良夫
    • Organizer
      第53日本神経病理学会総会学術研究会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] パーキンソン病では嗅上皮にレビー小体病理が出現する2012

    • Author(s)
      齊藤祐子,村田美穂,有馬邦正,村山繁雄
    • Organizer
      第53日本神経病理学会総会学術研究会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 進行性核上性麻痺と皮貲基軸啖性症の臨床病理釣検討半茣分類との対応2012

    • Author(s)
      池田謙輔、塩谷彩子、有馬邦正,村山繁雄、村田美穂,齊藤祐子
    • Organizer
      第53日本神経病理学会総会学術研究会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 双極性感情障害の背景病理としての嗜銀顆粒性認知症の検討2012

    • Author(s)
      塩谷彩子,有馬邦正,長谷川成人,角田幸雄,玉岡晃,村山繁雄,斎藤祐子
    • Organizer
      第53日本神経病理学会総会学術研究会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 進行性非流暢性失語を呈した進行性核上性麻痺(PSP)の2剖検例2012

    • Author(s)
      野上茜,齊藤祐子,崎山快夫,伊藤慎治,舟辺さやか,初田裕幸,高尾昌樹,山崎峰雄,村山繁雄
    • Organizer
      第53日本神経病理学会総会学術研究会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 皮質下梗塞と白質脳症を伴う常染色体劣性脳動脈症(CARASIL):遺伝子診断された3剖検例を用いた神経病理学検討2012

    • Author(s)
      伊藤慎治,高尾昌樹,野上茜,舟辺さやか,初田裕幸,仁木利郎,伊藤信夫,福武敏夫,下江豊,深山正久,村山繁雄
    • Organizer
      第53日本神経病理学会総会学術研究会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gerstraann-Straussler-Scheinker病(CSS P1021.129M)プラーク周囲に多数のタウ病変を認めた1剖検例-2012

    • Author(s)
      高田真理子,高尾昌樹,尾形克久,鈴木幹也,芳賀孝之,美原盤,伊藤慎治,野上茜,舟辺さやか,初田裕幸,川井充,村山繁雄,吉田洋二,北本哲之
    • Organizer
      第53日本神経病理学会総会学術研究会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経科学研究のためのブレインバンク2012

    • Author(s)
      村山繁雄
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経変性疾患における精神障害発現機構の解明2012

    • Author(s)
      田中元雅,遠藤良,猫沖陽子,小見悠介,村山繁雄,澤明
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖尿病がアルツハイマー病の危険因子である機序2012

    • Author(s)
      里直行,森一植田菜莉,田中稔久,武田朱公,内尾一山田こずえ,上田裕紀,篠原充,村山繁雄,武田雅俊,樂木宏実,森下竜一
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] FTLDにおけるTDP43と精神疾患関連因子の共凝集と精神障害2012

    • Author(s)
      遠藤良,小見悠介,村山繁雄,澤 明,田中元雅
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症の第一次運動野におけるSPP1発現2012

    • Author(s)
      山本竜也,村山繁雄,高尾昌樹、伊佐正,肥後範行
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] パーキンソン病剖検脳における小胞体ストレスマーカーの解析2012

    • Author(s)
      山川健太郎、澤濔秀幸、山下博史、高橋良輔,初田裕幸,齊藤祐子,村山繁雄
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症の第一次運動野におけるSPP1発現. SPP1 expression in the primary motor cortex of human with amyotrophic lateral sclerosis2012

    • Author(s)
      山本竜也,村山繁雄,高尾昌樹,伊佐正,肥後範行
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] パーキンソン病剖検脳における小胞体ストレスマーカーの解析2012

    • Author(s)
      山川健太郎,初田裕幸,村山繁雄,齊藤祐子,高橋良輔.
    • Organizer
      第6回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高齢者による臨床場面での言語流暢性の性差について~HDS-RとFABを用いての検討~2012

    • Author(s)
      小幡真希,岡田理恵子,森本康太,仁科裕史,加藤貴行,村山繁雄
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Alfa-Synuclein Pathology of ALS/PDC in the Kii Peninsula, Japan2012

    • Author(s)
      小久保康昌,谷口彰,長谷川成人,早川雄馬,森本悟,齊藤祐子,尅也繁雄,葛原茂樹
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] シード依存症な細胞内TDP-43蓄積による細胞死の誘導2012

    • Author(s)
      野中隆,鈴掛(増田)雅美,新井哲明,吉田眞理,村山繁雄, Mann David,秋山治彦,長谷川成人、
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] アミロイドβオリゴマーの形成と空間記憶障害における細胞質SODの役割2012

    • Author(s)
      村上一馬,村田央,野田義博,金子孝夫,木下憲明,初田裕幸,村山繁雄,入江一浩,白澤卓二,清水孝彦
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖尿病はAPPトランスジェニック・マウス脳においてタウのリン酸化を促進する2012

    • Author(s)
      里直行,森-植田茉莉,田中稔久,武田朱公,内尾-山田こずえ,篠原充,扛山繁雄,武田雅俊,樂木宏実,森下竜一'
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] アミロイドβオリゴマーの形成と空間記憶異常における細胞質SODの役割2012

    • Author(s)
      村上一馬,村田央,野田義博,金子孝夫,木下憲明,初田裕幸,扛也繁雄,入江一浩,白澤卓二,清水孝彦
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルツハイマー病とSOLIの関連解析2012

    • Author(s)
      宮下哲典,温雅楠,月江珠緒,初田裕幸,村山螫雄,桑野良三
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] y -Secretase modulatorはきわめて限定的な効果しか示さない?!2012

    • Author(s)
      角田伸人,赤澤宏平,初田裕幸,彑山繁雄,井原康夫
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Remarks] 高齢者ブレインバンクホームページ

    • Related Report
      2014 Annual Research Report
  • [Remarks] 高齢者ブレインバンク

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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