| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
Lipids exhibit vast physicochemical diversity and may participate in biological processes inaccessible to protein-based mechanisms. Here we identify lyso-phosphatidyl-β-D-glucoside (LysoPtdGlc), a novel hydrophilic glycerophospholipid that is synthesised and released by radial glia in a patterned spatial distribution. LysoPtdGlc regulates the development of sensory circuits in the vertebrate spinal cord by sorting nociceptive and proprioceptive afferents at a previously unexplained axon segregation checkpoint. The G protein-coupled receptor GPR55 is a high-affinity receptor for LysoPtdGlc, and GPR55 deletion phenocopies LysoPtdGlc loss-of-function in vivo, misdirecting nociceptive axons into proprioceptive zones. This study demonstrates LysoPtdGlc/GPR55 as a crucial mediator of glia-neuron communication for axon spatial patterning and suggests a broader role for lipids in coordinating diverse biological functions.
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