| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Both increased levels of glucocorticoid concentration and dysfunction of BDNF (brain-derived neurotrophic factor) have been suggested to be involved in the onset of depressive disorder. Here, to approach the cellular and molecular mechanism behind the depressive behavior, we focused on functional crosstalk between glucocorticoid and BDNF. Using dissociated cortical neurons obtained from rat brain, we found significant influence of glucocorticoid exposure on action of BDNF, including transport of BDNF protein in neurites. Furthermore, we made transgenic mouse which expresses high levels of cortical GR, low affinity glucocorticoid receptor, to approach behavioral change under the stress, as we confirmed that GR-TrkB (BDNF receptor) interaction is important for the BDNF-mediated neurotransmission.
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