• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Intracortical mechanism of go/no-go movements

Research Project

Project/Area Number 24300143
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionTamagawa University

Principal Investigator

ISOMURA Yoshikazu  玉川大学, 脳科学研究所, 教授 (00415077)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords神経科学 / 神経生理学 / 大脳皮質 / 運動発現 / 脳・神経 / 生理学 / ラット / 運動野 / 神経細胞
Outline of Final Research Achievements

In this study, we examined how cortical pyramidal neurons and interneurons encode information for motor functions in rats performing a behavioral task requiring do or do not execute a motor action intentionally. We analyzed multi-neuronal activity that was recorded from the forelimb areas of primary and secondary motor cortices through 16 or 32ch multichannel silicon probe(s) during their task performance. We found that basal spike properties and functional activity are very similar between these two motor areas, but the functional activity was more adaptive in the secondary motor cortex than the primary one. These observations suggest that the secondary motor cortex may be functionally differentiated to integrate motor information with internal state information for an adaptation to goal-directed behaviors.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (34 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (2 results) Remarks (7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 特集 記憶ふたたび 9.オペラント条件づけで脳を探る2016

    • Author(s)
      相馬 祥吾,川端 政則,礒村 宜和
    • Journal Title

      生体の科学

      Volume: 67 Issue: 1 Pages: 42-46

    • DOI

      10.11477/mf.2425200396

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2016-02-15
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Different modulation of common motor information in rat primary and secondary motor cortices.2014

    • Author(s)
      Saiki A, Kimura R, Samura T, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 6 Pages: e98662-e98662

    • DOI

      10.1371/journal.pone.0098662

    • NAID

      120006799370

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task.2014

    • Author(s)
      Masamizu Y, Tanaka YR, Tanaka YH, Hira R, Ohkubo F, Kitamura K, Isomura Y, Okada T, Matsuzaki M.
    • Journal Title

      Nat. Neurosci

      Volume: 17 Issue: 7 Pages: 987-994

    • DOI

      10.1038/nn.3739

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation2013

    • Author(s)
      Hidenori Aizawa, Shin Yanagihara, Megumi Kobayashi, Kazue Niisato, Takashi Takekawa, Rie Harukuni, Thomas J. McHugh, Tomoki Fukai, Yoshikazu Isomura, Hitoshi Okamoto
    • Journal Title

      J. Neurosci.

      Volume: 33 Issue: 20 Pages: 8909

    • DOI

      10.1523/jneurosci.4369-12.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reward-modulated motor information in identified striatum neurons.2013

    • Author(s)
      Yoshikazu Isomura, Takashi Takekawa, Rie Harukuni, Takashi Handa, Hidenori Aizawa, Masahiko Takada, and Tomoki Fukai
    • Journal Title

      J. Neurosci.

      Volume: 33 Issue: 25 Pages: 10209-10220

    • DOI

      10.1523/jneurosci.0381-13.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-lasting single-neuron labeling by in vivo electrop oration without microscopic guidance2013

    • Author(s)
      Kei Oyama, Shinya Ohara, Sho Satoa, Fuyuki Karube, Fumino Fujiyama, Yoshikazu Isomura, Hajime Mushiake, Toshio Iijima, Ken-Ichiro Tsutsui
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 218 Issue: 2 Pages: 139-147

    • DOI

      10.1016/j.jneumeth.2013.06.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A θ-γ Oscillation Code for Neuronal Coordination during Motor Behavior.2013

    • Author(s)
      Jun Igarashi, Yoshikazu Isomura, Kensuke Arai, Rie Harukuni, Tomoki Fukai
    • Journal Title

      J. Neurosci.

      Volume: 33 Issue: 47 Pages: 18515-18530

    • DOI

      10.1523/jneurosci.2126-13.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural dynamics and information representation in microcircuits of motor cortex.2013

    • Author(s)
      Yasuhiro Tsubo, Yoshikazu Isomura, Tomoki Fukai
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 7 Pages: 1-10

    • DOI

      10.3389/fncir.2013.00085

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement2013

    • Author(s)
      Hira R, Okubo F, Ozawa K, Isomura Y, KHamura K, Kano M, Kasai H, Matsuzaki M
    • Journal Title

      Journal of Neuroscience

      Volume: 33 Issue: 4 Pages: 1377

    • DOI

      10.1523/jneurosci.2550-12.2013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Power-law inter-spike interval distributions infer a conditional maximization of entropy in cortical neurons2012

    • Author(s)
      Tsubo Y, et al
    • Journal Title

      PLoS Comput.Biol.

      Volume: 8 Issue: 4 Pages: e1002461-e1002461

    • DOI

      10.1371/journal.pcbi.1002461

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reinforcing operandum: rapid andreliable learning of skilled forelimbmovements by head-fixed rodents2012

    • Author(s)
      Kimura R, et al. Sakai Y
    • Journal Title

      Journal of Neurophysiology

      Volume: vol.108 Issue: 6 Pages: 1781-1792

    • DOI

      10.1152/jn.00356.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Functional activity for goal-oriented behaviors in motor cortex, striatum and hippocampus.2016

    • Author(s)
      Yoshikazu Isomura
    • Organizer
      International Symposium on Adaptive Circuit Shift 2016.
    • Place of Presentation
      同志社大学(京都府京都市)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Behavioral evaluation of impairment of response inhibition by habit formation.2015

    • Author(s)
      Yoshida J, Saiki A, Yamanaka K, Sakai Y & Isomura Y
    • Organizer
      The 75th Annual Meeting of the Japanese Society for Animal Psychology
    • Place of Presentation
      日本女子大学(東京都文京区)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] A novel operant learning task to evaluate rat behavioral inhibition during habit formation.2015

    • Author(s)
      Yoshida J, Saiki A, Yamanaka K, Sakai Y & Isomura Y
    • Organizer
      Neuroscience 2015, The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Different modulation of common motor information in rodent primary and secondary motor cortices.2014

    • Author(s)
      Saiki A, Kimura R, Samura T, Fujiwara-Tsukamoto Y, Sakai Y & Isomura Y
    • Organizer
      Neuroscience 2014, The 37th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Population characteristics of spike synchrony in rat motor cortices during movement task.2014

    • Author(s)
      Kimura R, Sakai Y, Saiki A, Fujiwara-Tsukamoto Y & Isomura Y
    • Organizer
      Neuroscience 2014, The 37th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Motor and reward information in striatal direct and indirect pathway neurons.2014

    • Author(s)
      Isomura Y
    • Organizer
      A quarter century after the direct and indirect pathways model of the basal ganglia and beyond. NIPS International Workshop and Satellite Symposium of Neuroscience 2014
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2014-09-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Reward-modulated motor information in dorsolateral striatum neurons.2013

    • Author(s)
      Isomura Y
    • Organizer
      Dynamic Brain Forum (DBF) 2013, The 4th International Conference on Cognitive Neurodynamics
    • Place of Presentation
      Sigtuna, Sweden
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Neuronal ensemble activity for motor control with different forces in rat caudal and rostral forelimb areas.2013

    • Author(s)
      Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y & Isomura Y
    • Organizer
      Soc Neurosci Abstr 2013: 750.10 (Neuroscience 2013, The Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neuronal ensemble activity for motor control with different forces in rat caudal and rostral forelimb areas.2013

    • Author(s)
      Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y & Isomura Y
    • Organizer
      Neuro2013, The 36th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diversity and synchrony of multineuronal spike activities in rat primary and secondary motor cortices during externally- and internally-initiated movements.2012

    • Author(s)
      Kimura R, et al.
    • Organizer
      The 42nd Society for Neuroscience annual meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-11-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Intracortical mechanism of voluntary movements in the rat.2012

    • Author(s)
      Isomura Y
    • Organizer
      International Conference of Physiological Sciences 2012
    • Place of Presentation
      Shuzou, China(招待講演)
    • Year and Date
      2012-11-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ensemble coding for voluntary movements in rat primary and secondary motor cortices.2012

    • Author(s)
      Isomura Y
    • Organizer
      Dynamic Brain Forum (DBF) 2012
    • Place of Presentation
      Carmona, Spain(招待講演)
    • Year and Date
      2012-09-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラットの運動発現の皮質回路機構.

    • Author(s)
      礒村 宜和
    • Organizer
      東京都医学研究機構プロジェクトセミナー
    • Place of Presentation
      東京都医学研究機構(東京都世田谷区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 心理学辞典(下山晴彦編)2014

    • Author(s)
      礒村 宜和(分担執筆)
    • Publisher
      誠信書房
    • Related Report
      2014 Annual Research Report
  • [Book] ブレインサイエンス・レビュー20132013

    • Author(s)
      礒村宜和
    • Publisher
      クバプロ
    • Related Report
      2012 Annual Research Report
  • [Remarks] Researchmap

    • URL

      http://researchmap.jp/yoshikazuisomura/

    • Related Report
      2015 Annual Research Report
  • [Remarks] Researchmap礒村宜和

    • URL

      http://researchmap.jp/yoshikazuisomura/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 玉川大学脳科学研究所礒村研究室

    • URL

      http://www.tamagawa.ac.jp/teachers/isomura/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 玉川大学脳科学研究所礒村研究室

    • URL

      http://www.tamagawa.ac.jp/teachers/isomura/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] Researchmap

    • URL

      http://researchmap.jp/yoshikazuisomura/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 礒村研究室ホームページ

    • URL

      http://www.tamagawa.ac.jp/teachers/isomura/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] Read&Researchmap

    • URL

      http://researchmap.jp/yoshikazuisomura/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 動物学習支援装置、及び動物学習支援機能付き飼育ケージ2013

    • Inventor(s)
      礒村 宜和
    • Industrial Property Rights Holder
      礒村 宜和
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-09-30
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi