Intracortical mechanism of go/no-go movements

• Project/Area Number: 24300143
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tamagawa University
• Principal Investigator: ISOMURA Yoshikazu 玉川大学, 脳科学研究所, 教授 (00415077)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
• Keywords: 神経科学 / 神経生理学 / 大脳皮質 / 運動発現 / 脳・神経 / 生理学 / ラット / 運動野 / 神経細胞

Outline of Final Research Achievements

In this study, we examined how cortical pyramidal neurons and interneurons encode information for motor functions in rats performing a behavioral task requiring do or do not execute a motor action intentionally. We analyzed multi-neuronal activity that was recorded from the forelimb areas of primary and secondary motor cortices through 16 or 32ch multichannel silicon probe(s) during their task performance. We found that basal spike properties and functional activity are very similar between these two motor areas, but the functional activity was more adaptive in the secondary motor cortex than the primary one. These observations suggest that the secondary motor cortex may be functionally differentiated to integrate motor information with internal state information for an adaptation to goal-directed behaviors.

Research Products

• [Journal Article] オペラント条件づけで脳を探る (2016)
  • Author(s): 相馬 祥吾，川端 政則，礒村 宜和
  • Journal Title: 生体の科学 Volume: 67 Pages: 42-46
• [Journal Article] Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task. (2015)
  • Author(s): Masamizu, Y., Tanaka, Y.R., Tanaka, Y.H., Hira, R., Ohkubo, F., Kitamura, K., Isomura, Y., Okada, T. & Matsuzaki, M.
  • Journal Title: Nat. Neurosci Volume: 17 Pages: 987-94
  • DOI: 10.1038/nn.3739
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Different Modulation of Common Motor Information in Rat Primary and Secondary Motor Cortices (2014)
  • Author(s): Saiki A, Kimura R, Samura T, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
  • Journal Title: PLoS One Volume: 9
  • DOI: 10.1371/journal.pone.0098662
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation (2013)
  • Author(s): Hidenori Aizawa, Shin Yanagihara, Megumi Kobayashi, Kazue Niisato, Takashi Takekawa, Rie Harukuni, Thomas J. McHugh, Tomoki Fukai, Yoshikazu Isomura, Hitoshi Okamoto
  • Journal Title: Journal of Neuroscience Volume: 33 Pages: 8909-21
  • DOI: 10.1523/jneurosci.4369-12.2013
  • Peer Reviewed
• [Journal Article] Reward-modulated motor information in identified striatum neurons (2013)
  • Author(s): Yoshikazu Isomura, Takashi Takekawa, Rie Harukuni, Takashi Handa, Hidenori Aizawa, Masahiko Takada, and Tomoki Fukai
  • Journal Title: The Journal of Neuroscience Volume: 33 Pages: 10209-10220
  • DOI: 10.1523/jneurosci.0381-13.2013
  • Peer Reviewed
• [Journal Article] Long-lasting single-neuron labeling by in vivo electroporation without microscopic guidance. (2013)
  • Author(s): Kei Oyama, Shinya Ohara, Sho Satoa, Fuyuki Karube, Fumino Fujiyama, Yoshikazu Isomura, Hajime Mushiake, Toshio Iijima, Ken-Ichiro Tsutsui
  • Journal Title: J Neurosci Methods. Volume: 218 Pages: 139-147
  • DOI: 10.1016/j.jneumeth.2013.06.004
  • Peer Reviewed
• [Journal Article] A θ-γ oscillation code for neuronal coordination during motor behavior. (2013)
  • Author(s): Jun Igarashi, Yoshikazu Isomura, Kensuke Arai, Rie Harukuni, Tomoki Fukai
  • Journal Title: J Neurosci Volume: 33 Pages: 18515-18530
  • DOI: 10.1523/jneurosci.2126-13.2013
  • Peer Reviewed
• [Journal Article] [Review] Neural Dynamics and Information Representation in Microcircuits of Motor Cortex. (2013)
  • Author(s): Yasuhiro Tsubo, Yoshikazu Isomura, Tomoki Fukai
  • Journal Title: Front Neural Circuits Volume: 7 Pages: 1-10
  • DOI: 10.3389/fncir.2013.00085
  • Peer Reviewed
• [Journal Article] Spatiotemporal Dynamics of Functional Clusters of Neurons in the Mouse Motor Cortex during a Voluntary Movement. (2013)
  • Author(s): Hira R, Okubo F, Ozawa K, Isomura Y, KHamura K, Kano M, Kasai H, Matsuzaki M
  • Journal Title: J Neurosci. Volume: 33 Pages: 1-10
  • DOI: 10.1523/jneurosci.2550-12.2013
  • Peer Reviewed
• [Journal Article] Power-Law Inter-Spike Interval Distributions Infer a Conditional Maximization of Entropy in Cortical Neurons (2012)
  • Author(s): Tsubo Y, et al
  • Journal Title: PLoS Comput Biol Volume: 8
  • DOI: 10.1371/journal.pcbi.1002461
  • Peer Reviewed
• [Journal Article] Reinforcing operandum : rapid and reliable learning of skilled forelimb movements by head-fixed rodents (2012)
  • Author(s): Kimura R, et al. Sakai Y
  • Journal Title: J Neurophysiol Volume: vol.108 Pages: 1781-1792
  • DOI: 10.1152/jn.00356.2012
  • Peer Reviewed
• [Presentation] Functional activity for goal-oriented behaviors in motor cortex, striatum and hippocampus. (2016)
  • Author(s): Yoshikazu Isomura
  • Organizer: International Symposium on Adaptive Circuit Shift 2016.
  • Place of Presentation: 同志社大学（京都府京都市）
  • Year and Date: 2016-03-03
  • Int'l Joint Research / Invited
• [Presentation] Behavioral evaluation of impairment of response inhibition by habit formation. (2015)
  • Author(s): Yoshida J, Saiki A, Yamanaka K, Sakai Y & Isomura Y
  • Organizer: The 75th Annual Meeting of the Japanese Society for Animal Psychology
  • Place of Presentation: 日本女子大学（東京都文京区）
  • Year and Date: 2015-09-11
• [Presentation] A novel operant learning task to evaluate rat behavioral inhibition during habit formation. (2015)
  • Author(s): Yoshida J, Saiki A, Yamanaka K, Sakai Y & Isomura Y
  • Organizer: Neuroscience 2015, The 38th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-30
• [Presentation] Different modulation of common motor information in rodent primary and secondary motor cortices. (2014)
  • Author(s): Saiki A, Kimura R, Samura T, Fujiwara-Tsukamoto Y, Sakai Y & Isomura Y
  • Organizer: Neuroscience 2014, The 37th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11
• [Presentation] Population characteristics of spike synchrony in rat motor cortices during movement task. (2014)
  • Author(s): Kimura R, Sakai Y, Saiki A, Fujiwara-Tsukamoto Y & Isomura Y
  • Organizer: Neuroscience 2014, The 37th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11
• [Presentation] Motor and reward information in striatal direct and indirect pathway neurons. (2014)
  • Author(s): Isomura Y
  • Organizer: A quarter century after the direct and indirect pathways model of the basal ganglia and beyond. NIPS International Workshop and Satellite Symposium of Neuroscience 2014
  • Place of Presentation: 生理学研究所（愛知県岡崎市）
  • Year and Date: 2014-09-08
  • Invited
• [Presentation] Reward-modulated motor information in dorsolateral striatum neurons. (2013)
  • Author(s): Isomura Y
  • Organizer: Dynamic Brain Forum (DBF) 2013, The 4th International Conference on Cognitive Neurodynamics
  • Place of Presentation: Sigtuna, Sweden
  • Invited
• [Presentation] Neuronal ensemble activity for motor control with different forces in rat caudal and rostral forelimb areas. (2013)
  • Author(s): Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y & Isomura Y
  • Organizer: Soc Neurosci Abstr 2013: 750.10 (Neuroscience 2013, The Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Neuronal ensemble activity for motor control with different forces in rat caudal and rostral forelimb areas. (2013)
  • Author(s): Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y & Isomura Y
  • Organizer: Neuro2013, The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 国立京都国際会館(京都府京都市)
• [Presentation] Diversity and synchrony of multineuronal spike activities in rat primary and secondary motor cortices during externally- and internally-initiated movements. (2012)
  • Author(s): Kimura R, et al.
  • Organizer: The 42nd Society for Neuroscience annual meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-11-14
• [Presentation] Intracortical mechanism of voluntary movements in the rat. (2012)
  • Author(s): Isomura Y
  • Organizer: International Conference of Physiological Sciences 2012
  • Place of Presentation: Shuzou, China(招待講演)
  • Year and Date: 2012-11-03
• [Presentation] Ensemble coding for voluntary movements in rat primary and secondary motor cortices. (2012)
  • Author(s): Isomura Y
  • Organizer: Dynamic Brain Forum (DBF) 2012
  • Place of Presentation: Carmona, Spain(招待講演)
  • Year and Date: 2012-09-06
• [Presentation] ラットの運動発現の皮質回路機構．
  • Author(s): 礒村 宜和
  • Organizer: 東京都医学研究機構プロジェクトセミナー
  • Place of Presentation: 東京都医学研究機構(東京都世田谷区)
  • Invited
• [Book] 心理学辞典（下山晴彦編） (2014)
  • Author(s): 礒村 宜和（分担執筆）
  • Publisher: 誠信書房
• [Book] ブレインサイエンス・レビュー2013 (2013)
  • Author(s): 礒村宜和
  • Publisher: クバプロ
• [Remarks] Researchmap
  • URL: http://researchmap.jp/yoshikazuisomura/
• [Remarks] Researchmap礒村宜和
  • URL: http://researchmap.jp/yoshikazuisomura/
• [Remarks] 玉川大学脳科学研究所礒村研究室
  • URL: http://www.tamagawa.ac.jp/teachers/isomura/index.html
• [Remarks] 玉川大学脳科学研究所礒村研究室
  • URL: http://www.tamagawa.ac.jp/teachers/isomura/index.html
• [Remarks] Researchmap
  • URL: http://researchmap.jp/yoshikazuisomura/
• [Remarks] 礒村研究室ホームページ
  • URL: http://www.tamagawa.ac.jp/teachers/isomura/index.html
• [Remarks] Read&Researchmap
  • URL: http://researchmap.jp/yoshikazuisomura/
• [Patent(Industrial Property Rights)] 動物学習支援装置、及び動物学習支援機能付き飼育ケージ (2013)
  • Inventor(s): 礒村 宜和
  • Industrial Property Rights Holder: 礒村 宜和
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-09-30
  • Application Year: 2013