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HCN4-luciferase knock-in mouse is a new tool for pacemaker cell reprogramming

Research Project

Project/Area Number 24300145
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionKurume University

Principal Investigator

TAKANO Makoto  久留米大学, 医学部, 教授 (30236252)

Co-Investigator(Kenkyū-buntansha) ITOH Masayuki  久留米大学, 医学部, 助教 (20442535)
TAKEYA Mitsue  久留米大学, 医学部, 助教 (30289433)
Co-Investigator(Renkei-kenkyūsha) YAMASHITA Jun  京都大学, iPS細胞研究所, 教授 (50335288)
KUWAHARA Koichiro  京都大学, 医学研究科, 講師 (30402887)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords洞房結節 / ペースメーカー細胞 / イオンチャネル / 心臓 / 再プログラミング / 再生心筋 / バイオペースメーカー / HCN4 / 転写因子 / iPS細胞 / 直接再プログラミング / Hcn4
Outline of Final Research Achievements

As a next-generation therapy for bradyarrhythmia, development of biologically engineered pacemaker cells is anticipated. HCN4 channel is widely known as a specific molecular marker for the pacemaker cell of sinoatrial node. In order to visualize HCN4-expressing bio-pacemaker cell, we generated transgenic mouse, in which cDNA of firefly luciferase-GFP fusion protein was knocked in at HCN4 locus (HCN4+/Luc). 15 min after intraperitoneal injection of 50 mg/kg luciferin, we could successfully visualized HCN4-expresssing myocyte in SAN area. Weak but significant luminescence of cultured neonatal ventricular myocyte (NVM) could be also detected using LAS4000 system. However, lentiviral transfection of Tbx3 or Tbx18 into NVM failed to increase HCN4-derived luminescence.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (70 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (42 results) Book (1 results) Remarks (6 results)

  • [Journal Article] The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites2016

    • Author(s)
      Itoh, M., Ishihara, K., Nakashima, N., Takano, M.
    • Journal Title

      J Physiol Sci

      Volume: 66 Issue: 3 Pages: 241-8

    • DOI

      10.1007/s12576-015-0420-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical Concentrations of Local Anesthetics Bupivacaine and Lidocaine Differentially Inhibit Human Kir2.x Inward Rectifier K+ Channels2016

    • Author(s)
      Nakahira, K., Oshita, K., Itoh, M., Takano, M., Sakaguchi, Y., Ishihara, K.
    • Journal Title

      Anesth Analg

      Volume: 122 Issue: 4 Pages: 1038-47

    • DOI

      10.1213/ane.0000000000001137

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal and glial expression of inward rectifier potassium channel subunits Kir2.x in rat dorsal root ganglion and spinal cord2016

    • Author(s)
      Murata Y, Yasaka T, Takano M, Ishihara K
    • Journal Title

      Neuroscience Letters

      Volume: 617 Pages: 59-65

    • DOI

      10.1016/j.neulet.2016.02.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning2015

    • Author(s)
      Oba T, Yasukawa H, Nagata T, Kyogoku S, Minami T, Nishihara M, Ohshima H, Mawatari K, Nohara S, Takahashi J, Sugi S, Igata S, Iwamoto Y, Kai H, Matsuoka H, Takano M, Aoki H, Fukumoto Y, Imaizumi I.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 7 Pages: 1557-1567

    • DOI

      10.1253/circj.CJ-14-1171

    • NAID

      130005083944

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genotype-dependent differences in age of manifestation and arrhythmia complications in short QT syndrome.2015

    • Author(s)
      Harrell DT, Ashihara T, Ishikawa T, et al.
    • Journal Title

      International Journal of Cardiology.

      Volume: 190 Pages: 393-402

    • DOI

      10.1016/j.ijcard.2015.04.090

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ペースメーカーチャネル(HCN)の病態生理2015

    • Author(s)
      鷹野 誠
    • Journal Title

      臨と研

      Volume: 92 Pages: 134-137

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.2015

    • Author(s)
      Hara M, Takahashi T, Mistumasu C, Igata S, Takano M, Minami T, Yasukawa H, Okayama S, Nakamura K, Okabe Y, Tanaka E, Takemura G, Kosai K, Yamashita Y, Matsuishi T.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 11204-11204

    • DOI

      10.1038/srep11204

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhancement of Spontaneous Activity by HCN4 overexpression in Mouse Embryonic Stem Cell-derived Cardiomyocytes - a Possible Biological Pacemaker.2015

    • Author(s)
      SaitoY, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, Furukawa T, Takano M, Nagase S, Morita H, Kusano KF, Ito H.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 9 Pages: e0138193-e0138193

    • DOI

      10.1371/journal.pone.0138193

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2.2015

    • Author(s)
      Oshita K, Itoh M, Hirashima S, Kuwabara Y, Ishihara K, Kuwahara K, Nakao K, Kimura T, Nakamura K, Ushijima K, Takano M.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 80 Pages: 81-89

    • DOI

      10.1016/j.yjmcc.2014.12.019

    • NAID

      120007100131

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of the complete block of the Kir2.1 inward rectifier K+ channel under the external K+-free condition.2015

    • Author(s)
      Yanagi-Ishihara K, Itoh M, Takano M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Zdhhc3/7, the members of protein-palmitoylation enzymes, inhibit the current amplitude of HCN2 channel.2015

    • Author(s)
      Itoh M, Ishihara K, Takano M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Luminescence imaging of HCN4 expression and phenotypic analysis of HCN4 TET-off mouse.2015

    • Author(s)
      Kozasa Y, Ohshita K, Nakashima N, Ushijima K, Takano M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Epithelium-dependent periodical excitation in response to stretch of guinea pig seminal vesicle.2015

    • Author(s)
      Takeya M, Hayashi T, Nakamura K, Takano M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 過分極誘発陽イオンチャネル(HCN2)の潜在的な催不整脈性.2014

    • Author(s)
      大下健輔, 伊藤政之, 井形幸代, 桒原佳宏, 桑原宏一郎, 牛島一男, 鷹野 誠
    • Journal Title

      日本生理学雑誌

      Volume: 76 Pages: 83-83

    • Related Report
      2014 Annual Research Report
  • [Journal Article] QT短縮症候群に同定されたK チャネル変異の電気生理学的特性と臨床像.2014

    • Author(s)
      ダニエル・トシオ・ハーレル, 芦原貴司, 冨永伊知子, 阿部圭祐, 石川泰輔, 住友直方, 鵜野起久也, 鷹野 誠, 蒔田直昌
    • Journal Title

      日本生理学雑誌

      Volume: 76 Pages: 79-79

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Persistent α1-adrenergic receptor function in the nucleus locus coeruleus causes hyperexcitability in AD/HD model rats2014

    • Author(s)
      Igata S, Hayashi T, Itoh M, Akasu T, Takano M, Ishimatsu M
    • Journal Title

      J Neurophysiol

      Volume: 111 Issue: 4 Pages: 777-786

    • DOI

      10.1152/jn.01103.2012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts.2013

    • Author(s)
      Kuwabara, Y., Kuwahara, K., Takano, M., Kinoshita, H., Arai, Y., Yasuno, S., Nakagawa, Y., Igata, S., Usami, S., Minami, T., Yamada, Y., Nakao, K., Yamada, C., Shibata, J., Nishikimi, T., Ueshima, K., Nakao, K.
    • Journal Title

      Journal of the American Heart Association

      Volume: 2(3) Issue: 3

    • DOI

      10.1161/jaha.113.000150

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arrhythmogenic coupling between the Na^<+->Ca^<2+> exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes2012

    • Author(s)
      Okamoto Y, Takano M, Ohba T, Ono K
    • Journal Title

      J Mol Cell Cardiol

      Volume: 52(5) Issue: 5 Pages: 988-997

    • DOI

      10.1016/j.yjmcc.2012.01.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 過分極誘発陽イオンチャネルの発現制御と病態生理2012

    • Author(s)
      鷹野誠
    • Journal Title

      久留米医会誌

      Volume: 75 Pages: 173-179

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 肺静脈心筋細胞におけるノルエピネフリン誘発自動能へのCaクロックの関与2012

    • Author(s)
      尾野恭一
    • Journal Title

      日生誌

      Volume: 74 Pages: 211-213

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 次世代走査型電子顕微鏡FIB/SEMによる平滑筋組織間質細胞の解析2012

    • Author(s)
      中村桂一郎
    • Journal Title

      日生誌

      Volume: 74 Pages: 293-294

    • Related Report
      2012 Annual Research Report
  • [Presentation] HCN4過剰発現・ノックアウトマウスにおける洞房結節機能の変化.2016

    • Author(s)
      鷹野 誠, 小佐々優子, 武谷三恵, 中島則行, 石原圭子
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2016-04-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of mucosa in generating spontaneous activity in the guinea pig seminal vesicle.2016

    • Author(s)
      Takeya M, Hashitani H, Hayashi T, Nakamura K, Takano M
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo Convention Center(札幌)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Revisiting K+ dependence of conductance and gating of strong inward rectifier K+ channels.2016

    • Author(s)
      Ishihara K, Itoh M, Igata S, Takano M.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo Convention Center(札幌)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] he role of pacemaker channel HCN4 against bradycardic response.2016

    • Author(s)
      Kozasa Y, Takeya M, Nakashima N, Ushijima K, Takano M
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo Convention Center(札幌)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Visualization of HCN4-expressing neurons with GFP using Tet-expression system.2016

    • Author(s)
      Nakashima N, Takano M.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo Convention Center(札幌)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Arrhythmogenic properties of rat pulmonary vein cardiomyocytes.2016

    • Author(s)
      Okamoto Y, Takano M, Ono K.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo Convention Center(札幌)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ペースメーカーチャネルHCN4の陰性変時作用における新たな機能.2015

    • Author(s)
      小佐々優子, 武谷三恵, 中島則行, 牛島一男, 鷹野 誠
    • Organizer
      第66回西日本生理学会
    • Place of Presentation
      久留米大学筑水会館(久留米市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] ノックインマウスを使ったHCN4 発現ニューロンの可視化.2015

    • Author(s)
      中島則行, 鷹野 誠
    • Organizer
      第66回西日本生理学会
    • Place of Presentation
      久留米大学筑水会館(久留米市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 内向き整流性カリウムチャネルのポアの開口には細胞外カリウムイオンの存在を必要としない.2015

    • Author(s)
      柳(石原)圭子, 井形幸代, 伊藤政之, 鷹野 誠
    • Organizer
      平成27年度生理学研究所研究会「膜システムの機能的・構造的統合」
    • Place of Presentation
      生理学研究所(岡崎)
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] モルモット精嚢平滑筋自動性における粘膜の役割.2015

    • Author(s)
      武谷三恵, 橋谷 光, 林 篤正, 中村桂一郎, 鷹野 誠
    • Organizer
      第57回日本平滑筋学会総会
    • Place of Presentation
      山口大学小串キャンパス(医学部)総合研究棟(山口)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Controversy still goes on; lessons from HCN4 knock-out mice.2015

    • Author(s)
      Takano M, Kozasa Y, Takeya M, Ohshita K, Ito M, Ishihara K, Nakashima N.
    • Organizer
      The Joint Meeting of the 30th Annual Meeting of the Japanese Heart Rhythm Society and the 32nd Annual Scientific Meeting of the Japanese Society of Electrocardiology
    • Place of Presentation
      Kyoto International Conference Center(京都)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Atrial fibrillation and arrhythmogenic activities of pulmonary vein cardiomyocytes.2015

    • Author(s)
      Ono K, Okamoto Y, Umehara S, Adachi T, Ohba T, Amano A, Takano M.
    • Organizer
      The Joint Meeting of the 30th Annual Meeting of the Japanese Heart Rhythm Society and the 32nd Annual Scientific Meeting of the Japanese Society of Electrocardiology
    • Place of Presentation
      Kyoto International Conference Center(京都)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Priori Silvia G, Makita N: Meta-analysis of short QT syndrome discloses genotype-dependent clinical characteristics in age of manifestation and arrhythmia complications.2015

    • Author(s)
      Harrell Daniel T, Ashihara T, Ishikawa T, Mazzanti A, Takahashi K, Oginosawa Y, Abe H, Maemura K, Sumitomo N, Uno K, Takano M, Priori Silvia G, Makita N.
    • Organizer
      The Joint Meeting of the 30th Annual Meeting of the Japanese Heart Rhythm Society and the 32nd Annual Scientific Meeting of the Japanese Society of Electrocardiology
    • Place of Presentation
      Kyoto International Conference Center(京都)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Luminescence imaging of HCN4 expression and phenotypic analysis of HCN4 TET-off mouse.2015

    • Author(s)
      Kozasa Y, Ohshita K, Nakashima N, Ushijima K, Takano M.
    • Organizer
      The 92nd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Epithelium-dependent periodical excitation in response to stretch of guinea pig seminal vesicle.2015

    • Author(s)
      Takeya M, Hayashi T, Nakamura K, Takano M.
    • Organizer
      The 92nd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mechanism of the complete block of the Kir2.1 inward rectifier K+ channel under the external K+-free condition.2015

    • Author(s)
      Yanagi-Ishihara K, Itoh M, Takano M.
    • Organizer
      The 92nd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Zdhhc3/7, the members of protein-palmitoylation enzymes, inhibit the current amplitude of HCN2 channel.2015

    • Author(s)
      Itoh M, Ishihara K, Takano M.
    • Organizer
      The 92nd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 化学発光によるHCN4発言部位の可視化.2014

    • Author(s)
      小佐々優子
    • Organizer
      第65回西日本生理学会
    • Place of Presentation
      琉球大学(沖縄県中頭郡西原町)
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Differential expression of Kir2.x inward rectifier K+ channels in neurons and glial cells in rat dorsal root ganglion and spinal cord.2014

    • Author(s)
      Murata Y, Honda Y, Yasaka T, Takano M, Masuko S, Ishihara K.
    • Organizer
      The 37th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of cardiac arrhythmias and gene expression in MeCP2-null Mouse.2014

    • Author(s)
      Hara M, Takahashi T, Mitsumasu C, Igata S, Takano M, Okabe Y, Tanaka E, Matsuishi T.
    • Organizer
      13th Rett Syndrome Symposium
    • Place of Presentation
      Chantilliy, VA, USA
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional consequences of a gain-of-function mutation in the Kir2.1 inward rectifier K+ channel associated with short QT syndrome2014

    • Author(s)
      Ishihara K, Itoh M, Igata S, Takano M
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島郡元キャンパス(鹿児島)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of palmitoylation enzymes for the HCN2 channel2014

    • Author(s)
      Itoh M, Takano M
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Induced automaticity in ventricular myocytes from transgenic mice overexpressing HCN22014

    • Author(s)
      Oshita K, Itoh M, Yanagi(Ishihara) K, Kuwabara Y, Kuwahara K, Ushijima K, Takano M
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Epithelium of seminal vesicle modulates neural activity dependent contraction and originates stretch-sensitive contraction2014

    • Author(s)
      Takeya M, Itoh M, Ishihara K, Hayashi T, Nakamura K, Takano M
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pathophysiological roles of HCN channel family in the heart2014

    • Author(s)
      Takano M, Oshita K, Itoh M, Ishihara K, Kuwahara K
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Arrhythmogenic nature of pulmonary vein cardiomyocyes.2013

    • Author(s)
      尾野恭一
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船橋(東京都)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Clinical manifestations and electrophysiological characteristics of K channel mutations responsible for short QT syndrome.2013

    • Author(s)
      Harrell D
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船橋(東京都)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Epithelium of seminal vesicle confers stretch sensitivity and modulates noradrenaline-induced contraction.2013

    • Author(s)
      武谷三恵
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船橋(東京都)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Isoproterenol-induced spontaneous action potentials in the cardiac myocytes of transgenic mouse overexpressing HCN2.2013

    • Author(s)
      大下健輔
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船橋(東京都)
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Stromal cells play important roles in tissue compartmentalization: A FIB/SEM study.2013

    • Author(s)
      中村桂一郎
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船橋(東京都)
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of the palmitoylation sites of HCN2 channel.2013

    • Author(s)
      伊藤政之
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船橋(東京都)
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] HCN2過剰発現マウス心室筋のイソプロテレノール誘発自動能2013

    • Author(s)
      大下健輔, 井形幸代, 桑原佳宏, 桑原宏一郎, 鷹野 誠, 牛島一男
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌市教育文化会館(札幌)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Induced automaticity in the ventricular myocytes of transgenic mouse overexpressing HCN22013

    • Author(s)
      Oshita K, Igata S, Kuwabara Y, Kuwahara K, Ushijima K, Takano M
    • Organizer
      IUPS 2013
    • Place of Presentation
      International Convention Center(Birmingham, UK)
    • Related Report
      2013 Annual Research Report
  • [Presentation] QT短縮症候群患者に同定された新規K+チャネル変異の電気生理学的特性と臨床像2013

    • Author(s)
      ダニエル ハーレル, 冨永伊知子, 安部圭祐, 渡部太一, 荻ノ沢泰司, 安部治彦, 住友直方, 鵜野起久也, 鷹野 誠, 蒔田直昌
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lasting activity of alpha1-AR during postnatal development alters membrane properties of LC in SHR2013

    • Author(s)
      Igata S, Hayashi T, Itoh M, Takano M, Ishimatsu M
    • Organizer
      Society for Neuroscience, 43rd Annual Meeting (Neuroscience 2013)
    • Place of Presentation
      San Diego Convention Center(San Diego, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] S-palmitoylation regulates the HCN channels.2012

    • Author(s)
      Itoh M
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      マリンメッセ福岡(福岡市)
    • Year and Date
      2012-12-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] HCN2を心臓特異的に発現する遺伝子改変マウス心室筋のイソプロテレノール誘発自動能2012

    • Author(s)
      大下健輔
    • Organizer
      平成24年度生理学研究所研究会「イオンチャネル・トランスポーターと心血管機能:細胞機能の分子機序とその統合的理解」
    • Place of Presentation
      生理学研究所(岡崎市)
    • Year and Date
      2012-11-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] モルモット精嚢の収縮特性に対する内膜の影響2012

    • Author(s)
      武谷三恵
    • Organizer
      第63回西日本生理学会
    • Place of Presentation
      全労済ソレイユ(大分市)
    • Year and Date
      2012-10-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] HCN2過剰発現マウス心室筋のイソプロテレノール誘発自動能2012

    • Author(s)
      大下健輔
    • Organizer
      第63回西日本生理学会
    • Place of Presentation
      全労済ソレイユ(大分市)
    • Year and Date
      2012-10-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] パルミトイル化によるHCNチャネルの機能制御2012

    • Author(s)
      伊藤政之
    • Organizer
      第63回西日本生理学会
    • Place of Presentation
      全労済ソレイユ(大分市)
    • Year and Date
      2012-10-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] An α1 adrenergic receptor (AR) stimulation compensates α2-AR induced outward current in locus coeru'eus neurons from spontaneous hypertensive rats, ADHD model animal.2012

    • Author(s)
      Igata S
    • Organizer
      Society for Neuroscience, 42nd Annual Meeting (Neuroscience 2012)
    • Place of Presentation
      Emest N. Morial Convention Center (New Orleans, USA)
    • Year and Date
      2012-10-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 過分極誘発陽イオンチャネル(HCN2)の潜在的な催不整脈性

    • Author(s)
      大下健輔, 伊藤政之, 井形幸代, 桑原佳宏, 桑原宏一郎, 牛島一男, 鷹野 誠
    • Organizer
      第23回日本循環薬理学会
    • Place of Presentation
      福岡大学メディカルホール(福岡)
    • Related Report
      2013 Annual Research Report
  • [Book] 不整脈学2012

    • Author(s)
      鷹野誠
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report
  • [Remarks] 久留米大学研究者紹介

    • URL

      http://research.kurume-u.ac.jp/data.php?scode=14905632890988

    • Related Report
      2015 Annual Research Report
  • [Remarks] 久留米大学研究者紹介

    • URL

      http://research.kurume-u.ac.jp/data.php?scode=76735632890988

    • Related Report
      2014 Annual Research Report
  • [Remarks] 久留米大学医学部生理学講座統合自失機能部門研究業績

    • URL

      http://www.med.kurume-u.ac.jp/med/physiol2/paper.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 久留米大学研究者紹介

    • URL

      http://research.kurume-u.ac.jp/data.php?scode=73005632890988

    • Related Report
      2013 Annual Research Report
  • [Remarks] 久留米大学医学部生理学講座統合自律機能部門研究業績

    • URL

      http://www.med.kurume-u.ac.jp/med/physiol2/paper.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kurume-u.ac.jp/med/physiol2/paper.html

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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