Resolving mechanism of structural-functional coupling in red nucleus in motor recovery

• Project/Area Number: 24300147
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Fusional basic brain science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Hayashi Takuya 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (50372115)
• Co-Investigator(Kenkyū-buntansha): Noriyuki Higo 国立研究開発法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (80357839) ; Hirotaka Onoe 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, グループディレクター (80214196)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
• Keywords: 脳損傷 / 拡散強調画像 / MRI / 神経突起 / 神経回路 / 拡散強調MRI / NODDI / 脳卒中 / 神経突起方向分散 / 赤核 / 拡散強調 / 拡散テンソル / 磁気共鳴画像 / 線維連絡 / 異方性 / 運動野損傷 / 運動機能障害 / 錘体路

Outline of Final Research Achievements

The mechanism of functional recovery after stroke and brain injury is not well understood. We established non-invasive imaging system for visualizing long-term changes in brain structure and function and performed experiments in animal mode to investigate how the brain gets plastic and reorganizes the functional-structural coupling. We developed a system for high-resolution diffusion-weighted magnetic resonance imaging (dMRI) and pre-processing pipeline for image analysis. The results showed the long-term functional (motor) recovery and associated microstructural changes in several motor-associated areas. These finding may contribute to the development of novel therapy and diagnosis to accelerate functional recovery after brain injury.

Research Products

• [Int'l Joint Research] University College London(United Kingdom)
• [Int'l Joint Research] Washington University St.Lous(米国)
• [Journal Article] Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H (2015)
  • Author(s): Temporal Plasticity Involved in Recovery from Manual Dexterity Deficit after Motor Cortex Lesion in Macaque Monkeys
  • Journal Title: J Neuroscience Volume: 35 Issue: 1 Pages: 84-95
  • DOI: 10.1523/jneurosci.1737-14.2015
  • Peer Reviewed / Open Access
• [Journal Article] Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke (2014)
  • Author(s): Takenobu Y, Hayashi T, Moriwaki H, Nagatsuka, K, Naritomi H, Fukuyama H
  • Journal Title: Neuroimage: Clinical Volume: 4 Pages: 201-208
  • DOI: 10.1016/j.nicl.2013.12.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke (2013)
  • Author(s): Takenobu Y, Hayashi T, Moriwaki H, Nagatsuka K, Naritomi H, Fukuyama H
  • Journal Title: Neuroimage Clin Volume: 13(4) Pages: 201-208
  • Peer Reviewed
• [Journal Article] Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma (2013)
  • Author(s): Hayashi T, Shimazawa M, Watabe H, Ose T, Inokuchi Y, Ito Y, Yamanaka H, Urayama S, Watanabe Y, Hara H, Onoe H
  • Journal Title: Molecular Neurodegeneration Volume: 8 Issue: 1 Pages: 4-4
  • DOI: 10.1186/1750-1326-8-4
  • Peer Reviewed
• [Journal Article] Dorsolateral prefrontal and orbitofronral cortex interactions during self-control of cigarette craving. (2013)
  • Author(s): Hayashi T, Ko JH, Strafella AP, Dagher A.
  • Journal Title: Proceedings of National Academy of Science USA. Volume: (in press) Issue: 11 Pages: 4422-4427
  • DOI: 10.1073/pnas.1212185110
  • Peer Reviewed
• [Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques (2013)
  • Author(s): Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M
  • Journal Title: J Clin Invest Volume: 123(1) Issue: 1 Pages: 272-284
  • DOI: 10.1172/jci62516
  • Peer Reviewed
• [Journal Article] Linkage between the midline cortical serotonergic system and social behavior traits : positron emission tomography studies of common marmosets (2012)
  • Author(s): Yokoyama C, Kawasaki A, Haveshi T, Onoe H.
  • Journal Title: Cerebral Cortex Volume: (in press)
  • Peer Reviewed
• [Presentation] High-resolution diffusion and structural MRI brain atlas of rhesus macaques (2015)
  • Author(s): Hayashi et al.
  • Organizer: Organization of Human Brain Mapping
  • Place of Presentation: Honolulu, Hawai
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] Imaging Network of Degeneracy and Plasticity (2014)
  • Author(s): Hayashi T
  • Organizer: 第37回日本神経科学大会―RIKEN Symposium - Challenges of imaging functional architecture of large-scale network
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-11
  • Invited
• [Presentation] Dynamic microstructural changes responsible for motor recovery. (2014)
  • Author(s): Hayashi T, Hayashi, Takuya, Higo N, Zhang H, Ose T, Yamamoto T, Murata Y, and Onoe H
  • Organizer: Annual Meeting of Organization of Human Brain Mapping 2014
  • Place of Presentation: CCH-Congress Center, Hamburg
  • Year and Date: 2014-06-10
• [Presentation] The role of the ventral premotor area after primary motor cortex lesion in macaque monkeys□ : involvement in functional compensation of grasping (2012)
  • Author(s): Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H.
  • Organizer: The 42_<nd> Annual Meeting of the Society for Neur oscience
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-13
• [Presentation] Change in visuomotor circuit after VI lesion revealed by positron emissi on tomography (2012)
  • Author(s): Kato R, Ikeda T, Onoe H, Kawahara M, Onoe K, Hayashi T, Yoshida M, Takaura K, Tsukada H, Isa T.
  • Organizer: The 42_<nd> Annual Meeting of the Society for Neur oscience
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-13
• [Presentation] The midline cortical serotonergic system in social behavior traits : Positron emission tomography studies of common marmosets. (2012)
  • Author(s): Yokoyama C, Kawasaki A, Hayashi T. Onoe H.
  • Organizer: The 42<nd> Annual Meeting of the Society for Neur oscience
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-13
• [Presentation] パーキンソン病モデル霊長類動物における骨髄間質幹細胞由来A9ドーパミン神経細胞自家移植 (2012)
  • Author(s): 林 拓也、若尾昌平、北田正章、合瀬恭幸、渡部浩司、松瀬大、光永佳奈枝、繁本妙子、尾上浩隆、田畑泰彦、出澤真理
  • Organizer: 第7回日本分子イメージング学会
  • Place of Presentation: 浜松、日本
  • Year and Date: 2012-05-24
• [Remarks] 脳損傷によって失われた運動機能を肩代わりする脳の変化を解明
  • URL: http://www.aist.go.jp/aist_j/press_release/pr2015/pr20150107/pr20150107.html
• [Remarks] 脳卒中による運動障害からの回復メカニズムを解明 －リハビリテーションで脳神経回路が再構築される－
  • URL: http://www.riken.jp/pr/press/2014/20140109_1/