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Development of whole brain recording system

Research Project

Project/Area Number 24300148
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Fusional brain recording science
Research InstitutionDoshisha University

Principal Investigator

Takahashi Susumu  同志社大学, 研究開発推進機構, 准教授 (20510960)

Co-Investigator(Kenkyū-buntansha) FUJIYAMA Fumino  同志社大学, 大学院脳科学研究科, 教授 (20244022)
Co-Investigator(Renkei-kenkyūsha) SAKURAI Yoshio  同志社大学, 大学院脳科学研究科, 教授 (60153962)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords全脳記録 / 全脳記録法 / 脳波 / マルチニューロン活動
Outline of Final Research Achievements

We developed a whole brain recording system which can simultaneously record neuronal activity and EEG over several brain regions. Specifically, using 3D printing technology, we tested the performance of the developed system in a rapid prototyping fashion. Consequently, we made an independently movable microdrive which can access not only deep brain areas but also superficial of the cortex. To evaluate the performance of the system, we recorded place-cell activity while the animal paused. Results suggested that the sequential activation of place-cells are replayed about 10 times faster than that during running. We conclude that our developed system can record both neuronal activity and EEG over several brain regions.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (39 results)

All 2016 2015 2014 2013 2012

All Journal Article (12 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (27 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 海馬にある場所細胞群の活動から意図した移動行動を解読する2016

    • Author(s)
      高橋晋
    • Journal Title

      Clinical Neuroscience

      Volume: 34 Pages: 164-167

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Episodic-like memory trace in awake replay of hippocampal place cell activity sequences2015

    • Author(s)
      Takahashi, S.
    • Journal Title

      eLife

      Volume: 4 Pages: 1-22

    • DOI

      10.7554/elife.08105

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Theta oscillation and neuronal activity in rat hippocampus are involved in temporal discrimination of time in seconds2015

    • Author(s)
      Nakazono, T., Sano, T., Takahashi, S., Sakurai, Y.
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 9 Pages: 1-12

    • DOI

      10.3389/fnsys.2015.00095

    • NAID

      120005947020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 大脳基底核を巡る伝導路2015

    • Author(s)
      高橋晋、藤山文乃
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 767-771

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 大脳基底核を巡る伝導路2015

    • Author(s)
      高橋 晋、藤山文乃
    • Journal Title

      Clinical Neuroscience

      Volume: In press

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Morphological elucidation of basal ganglia circuits contributing reward prediction2015

    • Author(s)
      2.Fujiyama, S., Takahashi, S., and Karube, F.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 9:6 Pages: 1-8

    • DOI

      10.3389/fnins.2015.00006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳内ナビゲーション・システム ―場所細胞と格子細胞の発見2015

    • Author(s)
      高橋 晋
    • Journal Title

      現代化学

      Volume: 525 Pages: 22-26

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Volitional enhancement of firing synchrony and oscillation by neuronal operant conditioning: interaction with neurorehabilitation and brain-machine interface.2014

    • Author(s)
      Sakurai, Y., Song, K., Tachibana, S. and Takahashi, S.
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 8 Pages: 1-11

    • DOI

      10.3389/fnsys.2014.00011

    • NAID

      120005385894

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oscillatory interaction between amygdala and hippocampus coordinates behavioral modulation based on reward expectation.2013

    • Author(s)
      Terada, S., Takahashi, S., and Sakurai, Y.
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 7 (177) Pages: 1-12

    • DOI

      10.3389/fnbeh.2013.00177

    • NAID

      120005349005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diverse synchrony of firing reflects diverse cell-assemlby coding in the prefrontal cortex2013

    • Author(s)
      Sakurai, Y., Nakazono, T., Ishino, S., Terada, S., Yamaguchi, K. and Takahashi, S.
    • Journal Title

      Journal of Physiology-Paris

      Volume: 107 Issue: 6 Pages: 459-470

    • DOI

      10.1016/j.jphysparis.2013.05.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploring the neural substrate for supporting episodic memory in the hippocampus from a place cell perspective2013

    • Author(s)
      Takahashi, S.
    • Journal Title

      Japanese Psychological Review

      Volume: 56 Pages: 186-200

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hierarchical organization of context in the hippocampal episodic code2013

    • Author(s)
      Takahashi, S
    • Journal Title

      eLife

      Volume: 2 Pages: 1-17

    • DOI

      10.7554/elife.00321

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Transfer of operantly conditioned firings between different neuron groups with BMI in rats2015

    • Author(s)
      Song, K., Takahashi, S., Sakurai Y.
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ルールスイッチングにおけるラット海馬のシータ・ガンマカップリング2015

    • Author(s)
      中園智晶、高橋晋、櫻井芳雄
    • Organizer
      第24 回海馬と高次脳機能学会
    • Place of Presentation
      岐阜市、岐阜県
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 海馬場所細胞群の活動リプレイは記憶に基づくナビゲーション計画を表現する2015

    • Author(s)
      高橋晋
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸市、兵庫県
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] ルール学習中のラット海馬におけるシータ―ガンマ・カップリングはガンマ波のタイプによって異なる2015

    • Author(s)
      中園智晶、高橋晋、櫻井芳雄
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸市、兵庫県
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Rule switching affects cross-frequency couplings in rat hippocampus2015

    • Author(s)
      Nakazono, T., Takahashi, S., Sakurai, Y.
    • Organizer
      5th International Conference on Cognitive Neurodynamics 2015
    • Place of Presentation
      Sanya, China
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hippocampal-prefrontal coordination is involved in recall of learned sequences in rats2014

    • Author(s)
      Ishino, S., Takahashi, S. and Sakurai, Y.
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      Washington, DC
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Timed pauses of simple spikes and up-and-down patterns of deep cerebellar nucleus activity code cerebellar temporal processing during voluntary movement tasks2014

    • Author(s)
      Yamaguchi, K., Takahashi, S. and Sakurai, Y.
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      Washington, DC
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 衝動性の制御における内側前頭皮質の機能と可塑性を解明するためのブレイン―マシン・インターフェイス2014

    • Author(s)
      立花 湘太,高橋 晋,櫻井 芳雄
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] パーキンソン病症状を改善する閉回路式脳深部刺激法の開発に向けた試み2014

    • Author(s)
      高橋 晋
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット皮質におけるオペラント条件づけした発火のニューロン集団間での転移2014

    • Author(s)
      宋 基燦,高橋 晋,櫻井 芳雄
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 学習した系列の想起に関連する海馬-前頭連合野ネットワークの協調的活動2014

    • Author(s)
      石野 誠也、高橋 晋、櫻井 芳雄
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット海馬シータオシレーションは時間間隔弁別に関与する2014

    • Author(s)
      中園 智晶、高橋 晋、櫻井 芳雄
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Rule switching affects theta-gamma coupling in rat hippocampus2013

    • Author(s)
      Nakazono, T, Takahashi, S. and Sakurai, Y.
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海馬は文脈情報を階層化してエピソードを形成する2013

    • Author(s)
      高橋 晋
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット淡蒼球外節の投射様式を領域ごとに解析する2013

    • Author(s)
      藤山 文乃,中野 隆,松田 和郎,呉 胤美,水谷 和子,古田 隆寛,苅部 冬紀,高橋 晋,雲財 知,宇田川 潤,金子 武嗣
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット淡蒼球外節と直接路・間接路との関係を形態学的に解析する2013

    • Author(s)
      水谷 和子,苅部 冬紀,高橋 晋,雲財 知,藤山 文乃
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラットのリズムに基づく行動中または時間間隔に基づく行動中に見られる小脳活動2013

    • Author(s)
      山口 健治,高橋 晋,櫻井 芳雄
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海馬と扁桃体間のガンマオシレーションの同期は報酬予測による行動調節に寄与する2013

    • Author(s)
      寺田 慧、高橋 晋、 櫻井 芳雄
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dynamic synchrony of firing in the prefrontal cortex in monkeys and rats2012

    • Author(s)
      櫻井芳雄
    • Organizer
      International symposium on prefrontal cortex
    • Place of Presentation
      京都大学稲盛財団記念館3F会議室(京都府)(招待講演)
    • Year and Date
      2012-11-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cerebellar Purkinje-cell spikes interaction during a timing behavior task in the rat2012

    • Author(s)
      山口健治
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      Morial convention center (New Orleans, USA)
    • Year and Date
      2012-10-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Planning-based behavior and neuronal activity in sequential order information task in rats2012

    • Author(s)
      石野誠也
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      Morial convention center (New Orleans, USA)
    • Year and Date
      2012-10-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multi-neuronal activities in prefrontal cortex and hippocampus during a rule-switching task in rats2012

    • Author(s)
      中園 智晶
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      Morial convention center (New Orleans, USA)
    • Year and Date
      2012-10-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Interacted neuronal activities between hippocampus and amygdala modulate discrimination behavior expecting for different probability of reward in the rat2012

    • Author(s)
      寺田慧
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      Morial convention center (New Orleans, USA)
    • Year and Date
      2012-10-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラット海馬CA1野における目標志向的選択の表現2012

    • Author(s)
      高橋晋
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラットのタイミング行動課題中における時間知覚と小脳プルキンエ細胞のスパイク発火2012

    • Author(s)
      山口健治
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラットは系列順序情報を想起したプランニング行動を示した2012

    • Author(s)
      石野誠也
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラットの異なる報酬予測を担う海馬と扁桃体の相互作用2012

    • Author(s)
      寺田慧
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-18
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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