Development of whole brain recording system

• Project/Area Number: 24300148
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Fusional brain recording science
• Research Institution: Doshisha University
• Principal Investigator: Takahashi Susumu 同志社大学, 研究開発推進機構, 准教授 (20510960)
• Co-Investigator(Kenkyū-buntansha): FUJIYAMA Fumino 同志社大学, 大学院脳科学研究科, 教授 (20244022)
• Co-Investigator(Renkei-kenkyūsha): SAKURAI Yoshio 同志社大学, 大学院脳科学研究科, 教授 (60153962)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 全脳記録 / 全脳記録法 / 脳波 / マルチニューロン活動

Outline of Final Research Achievements

We developed a whole brain recording system which can simultaneously record neuronal activity and EEG over several brain regions. Specifically, using 3D printing technology, we tested the performance of the developed system in a rapid prototyping fashion. Consequently, we made an independently movable microdrive which can access not only deep brain areas but also superficial of the cortex. To evaluate the performance of the system, we recorded place-cell activity while the animal paused. Results suggested that the sequential activation of place-cells are replayed about 10 times faster than that during running. We conclude that our developed system can record both neuronal activity and EEG over several brain regions.

Research Products

• [Journal Article] 海馬にある場所細胞群の活動から意図した移動行動を解読する (2016)
  • Author(s): 高橋晋
  • Journal Title: Clinical Neuroscience Volume: 34 Pages: 164-167
• [Journal Article] Episodic-like memory trace in awake replay of hippocampal place cell activity sequences (2015)
  • Author(s): Takahashi, S.
  • Journal Title: eLife Volume: 4 Pages: 1-22
  • DOI: 10.7554/elife.08105
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Theta oscillation and neuronal activity in rat hippocampus are involved in temporal discrimination of time in seconds (2015)
  • Author(s): Nakazono, T., Sano, T., Takahashi, S., Sakurai, Y.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 9 Pages: 1-12
  • DOI: 10.3389/fnsys.2015.00095
  • NAID: 120005947020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 大脳基底核を巡る伝導路 (2015)
  • Author(s): 高橋晋、藤山文乃
  • Journal Title: Clinical Neuroscience Volume: 33 Pages: 767-771
• [Journal Article] 大脳基底核を巡る伝導路 (2015)
  • Author(s): 高橋 晋、藤山文乃
  • Journal Title: Clinical Neuroscience Volume: In press
• [Journal Article] Morphological elucidation of basal ganglia circuits contributing reward prediction (2015)
  • Author(s): 2.Fujiyama, S., Takahashi, S., and Karube, F.
  • Journal Title: Frontiers in Neuroscience Volume: 9:6 Pages: 1-8
  • DOI: 10.3389/fnins.2015.00006
  • Peer Reviewed / Open Access
• [Journal Article] 脳内ナビゲーション・システム ―場所細胞と格子細胞の発見 (2015)
  • Author(s): 高橋 晋
  • Journal Title: 現代化学 Volume: 525 Pages: 22-26
• [Journal Article] Volitional enhancement of firing synchrony and oscillation by neuronal operant conditioning: interaction with neurorehabilitation and brain-machine interface. (2014)
  • Author(s): Sakurai, Y., Song, K., Tachibana, S. and Takahashi, S.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 8 Pages: 1-11
  • DOI: 10.3389/fnsys.2014.00011
  • NAID: 120005385894
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oscillatory interaction between amygdala and hippocampus coordinates behavioral modulation based on reward expectation. (2013)
  • Author(s): Terada, S., Takahashi, S., and Sakurai, Y.
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 7 (177) Pages: 1-12
  • DOI: 10.3389/fnbeh.2013.00177
  • NAID: 120005349005
  • Peer Reviewed
• [Journal Article] Diverse synchrony of firing reflects diverse cell-assemlby coding in the prefrontal cortex (2013)
  • Author(s): Sakurai, Y., Nakazono, T., Ishino, S., Terada, S., Yamaguchi, K. and Takahashi, S.
  • Journal Title: Journal of Physiology-Paris Volume: 107 Issue: 6 Pages: 459-470
  • DOI: 10.1016/j.jphysparis.2013.05.004
  • Peer Reviewed
• [Journal Article] Exploring the neural substrate for supporting episodic memory in the hippocampus from a place cell perspective (2013)
  • Author(s): Takahashi, S.
  • Journal Title: Japanese Psychological Review Volume: 56 Pages: 186-200
  • Peer Reviewed
• [Journal Article] Hierarchical organization of context in the hippocampal episodic code (2013)
  • Author(s): Takahashi, S
  • Journal Title: eLife Volume: 2 Pages: 1-17
  • DOI: 10.7554/elife.00321
  • Peer Reviewed
• [Presentation] Transfer of operantly conditioned firings between different neuron groups with BMI in rats (2015)
  • Author(s): Song, K., Takahashi, S., Sakurai Y.
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] ルールスイッチングにおけるラット海馬のシータ・ガンマカップリング (2015)
  • Author(s): 中園智晶、高橋晋、櫻井芳雄
  • Organizer: 第24 回海馬と高次脳機能学会
  • Place of Presentation: 岐阜市、岐阜県
  • Year and Date: 2015-10-11
• [Presentation] 海馬場所細胞群の活動リプレイは記憶に基づくナビゲーション計画を表現する (2015)
  • Author(s): 高橋晋
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸市、兵庫県
  • Year and Date: 2015-07-30
• [Presentation] ルール学習中のラット海馬におけるシータ―ガンマ・カップリングはガンマ波のタイプによって異なる (2015)
  • Author(s): 中園智晶、高橋晋、櫻井芳雄
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸市、兵庫県
  • Year and Date: 2015-07-30
• [Presentation] Rule switching affects cross-frequency couplings in rat hippocampus (2015)
  • Author(s): Nakazono, T., Takahashi, S., Sakurai, Y.
  • Organizer: 5th International Conference on Cognitive Neurodynamics 2015
  • Place of Presentation: Sanya, China
  • Year and Date: 2015-06-05
  • Int'l Joint Research
• [Presentation] Hippocampal-prefrontal coordination is involved in recall of learned sequences in rats (2014)
  • Author(s): Ishino, S., Takahashi, S. and Sakurai, Y.
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: Washington, DC
  • Year and Date: 2014-11-19
• [Presentation] Timed pauses of simple spikes and up-and-down patterns of deep cerebellar nucleus activity code cerebellar temporal processing during voluntary movement tasks (2014)
  • Author(s): Yamaguchi, K., Takahashi, S. and Sakurai, Y.
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: Washington, DC
  • Year and Date: 2014-11-18
• [Presentation] 衝動性の制御における内側前頭皮質の機能と可塑性を解明するためのブレイン―マシン・インターフェイス (2014)
  • Author(s): 立花 湘太,高橋 晋,櫻井 芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-13
• [Presentation] パーキンソン病症状を改善する閉回路式脳深部刺激法の開発に向けた試み (2014)
  • Author(s): 高橋 晋
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-12
• [Presentation] ラット皮質におけるオペラント条件づけした発火のニューロン集団間での転移 (2014)
  • Author(s): 宋 基燦,高橋 晋,櫻井 芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-12
• [Presentation] 学習した系列の想起に関連する海馬-前頭連合野ネットワークの協調的活動 (2014)
  • Author(s): 石野 誠也、高橋 晋、櫻井 芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-12
• [Presentation] ラット海馬シータオシレーションは時間間隔弁別に関与する (2014)
  • Author(s): 中園 智晶、高橋 晋、櫻井 芳雄
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11
• [Presentation] Rule switching affects theta-gamma coupling in rat hippocampus (2013)
  • Author(s): Nakazono, T, Takahashi, S. and Sakurai, Y.
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: USA
• [Presentation] 海馬は文脈情報を階層化してエピソードを形成する (2013)
  • Author(s): 高橋 晋
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] ラット淡蒼球外節の投射様式を領域ごとに解析する (2013)
  • Author(s): 藤山 文乃,中野 隆,松田 和郎,呉 胤美,水谷 和子,古田 隆寛,苅部 冬紀,高橋 晋,雲財 知,宇田川 潤,金子 武嗣
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] ラット淡蒼球外節と直接路・間接路との関係を形態学的に解析する (2013)
  • Author(s): 水谷 和子,苅部 冬紀,高橋 晋,雲財 知,藤山 文乃
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] ラットのリズムに基づく行動中または時間間隔に基づく行動中に見られる小脳活動 (2013)
  • Author(s): 山口 健治,高橋 晋,櫻井 芳雄
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] 海馬と扁桃体間のガンマオシレーションの同期は報酬予測による行動調節に寄与する (2013)
  • Author(s): 寺田 慧、高橋 晋、 櫻井 芳雄
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Dynamic synchrony of firing in the prefrontal cortex in monkeys and rats (2012)
  • Author(s): 櫻井芳雄
  • Organizer: International symposium on prefrontal cortex
  • Place of Presentation: 京都大学稲盛財団記念館3F会議室(京都府)(招待講演)
  • Year and Date: 2012-11-19
• [Presentation] Cerebellar Purkinje-cell spikes interaction during a timing behavior task in the rat (2012)
  • Author(s): 山口健治
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: Morial convention center (New Orleans, USA)
  • Year and Date: 2012-10-17
• [Presentation] Planning-based behavior and neuronal activity in sequential order information task in rats (2012)
  • Author(s): 石野誠也
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: Morial convention center (New Orleans, USA)
  • Year and Date: 2012-10-16
• [Presentation] Multi-neuronal activities in prefrontal cortex and hippocampus during a rule-switching task in rats (2012)
  • Author(s): 中園 智晶
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: Morial convention center (New Orleans, USA)
  • Year and Date: 2012-10-16
• [Presentation] Interacted neuronal activities between hippocampus and amygdala modulate discrimination behavior expecting for different probability of reward in the rat (2012)
  • Author(s): 寺田慧
  • Organizer: Society for Neuroscience meeting
  • Place of Presentation: Morial convention center (New Orleans, USA)
  • Year and Date: 2012-10-15
• [Presentation] ラット海馬CA1野における目標志向的選択の表現 (2012)
  • Author(s): 高橋晋
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-09-21
• [Presentation] ラットのタイミング行動課題中における時間知覚と小脳プルキンエ細胞のスパイク発火 (2012)
  • Author(s): 山口健治
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-09-20
• [Presentation] ラットは系列順序情報を想起したプランニング行動を示した (2012)
  • Author(s): 石野誠也
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-09-19
• [Presentation] ラットの異なる報酬予測を担う海馬と扁桃体の相互作用 (2012)
  • Author(s): 寺田慧
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-09-18