| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
A novel coat color mutant mouse, named M2BBr, generated by saturation mutagenesis was analyzed. The mutant mouse changes its coat color from black to brown with aging (usually from the fourth or fifth postnatal hair cycle), associated with decreased expression of pigmentation genes necessary for synthesis of dark (black) melanin. In addition, in the brown coat color areas, each hair shows pigment type switching from black to brown and then to black from the tip to the base. This is a very peculiar phenomenon because the mutant mouse has homozygous nonagouti alleles (a/a) at the agouti locus and its coat color is expected to be fully black. This mutation also shows various pleiotropic effects causing unusual thickening of the skin and aberrant organization of various tissues. The candidate locus is within 1.7 Mb, in which about 60 loci are still included.
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