Super-resolution measurement of motion by using tagging MRI

• Project/Area Number: 24300161
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyoto University
• Principal Investigator: MATSUDA Tetsuya 京都大学, 情報学研究科, 教授 (00209561)
• Co-Investigator(Kenkyū-buntansha): AMANO AKIRA 立命館大学, 生命科学部, 教授 (60252491)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
• Keywords: MRI / タギングMRI / 空間分解能 / デジタル符号化

Outline of Final Research Achievements

A method for super-resolution measurement of motion by using tagging MRI with tag-width identical to pixel size is proposed and its feasibility of measurement is experimentally assessed in this study. The principle of proposed method was successfully verified by a static phantom experiment and its results showed fine determination and control of tag position relative to pixel position were essential to realize super-resolution measurement. A simple method utilizing an interference phenomenon produced by a tag pattern with slightly different width from pixel size was proposed and its correctness was confirmed. When the proposed method was applied to in vivo experiment, however, the inhomogeneity of RF power distribution, magnetic susceptibility, and static magnetic field strength made the tag pattern untidy.　The proposed method requires further improvement to apply clinical examinations.

Research Products

• [Journal Article] Three-dimensional observation of palatal muscles in the human embryo and fetus: development of levator veli palatini and clinical importance of the lesser palatine nerve. (2016)
  • Author(s): Kishimoto H, Yamada S, Kanahashi T, Yoneyama A, Imai H, Matasuda T, Takeda T, Kawai K, Suzuki S.
  • Journal Title: Dev Dyn Volume: 245(2) Issue: 2 Pages: 123-31
  • DOI: 10.1002/dvdy.24364
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pharmacokinetics of chiral dendrimer-triamine-coordinated Gd-MRI contrast agents evaluated by in vivo MRI and estimated by in vitro QCM (2015)
  • Author(s): Miyake Y, Ishikawa S, Kimura Y, Son A, Imai H, Matsuda T, Yamada H, Toshimitsu A, Kondo T.
  • Journal Title: Sensors Volume: 15 Issue: 12 Pages: 31973-31986
  • DOI: 10.3390/s151229900
  • NAID: 120007141563
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 13C/15N-Enriched l-Dopa as a Triple-Resonance NMR Probe to Monitor Neurotransmitter Dopamine in the Brain and Liver Extracts of Mice (2015)
  • Author(s): Hisatsugu Yamada, Tetsuro Kameda, Yu Kimura, Hirohiko Imai, Tetsuya Matsuda, Shinsuke Sando, Akio Toshimitsu, Yasuhiro Aoyama, Teruyuki Kondo
  • Journal Title: Chemistry Open Volume: e-Pub Issue: 2 Pages: 125-128
  • DOI: 10.1002/open.201500196
  • NAID: 120005844253
  • Peer Reviewed / Open Access
• [Journal Article] Is Caffeine Abstention Necessary Before Adenosine-Induced Fractional Flow Reserve Measurement? (2015)
  • Author(s): Hidenari Matsumoto, Shunpei Ushimaru, Tetsuya Matsuda, Toshihiko Shimada, Mikiko Mikuri, Haruya Takahashi, Nobuyuki Takahashi, Teruo Kawada, Taketoshi Yamazaki
  • Journal Title: J Am Coll Cardiol Volume: 66 Issue: 17 Pages: 1943-1945
  • DOI: 10.1016/j.jacc.2015.08.034
  • Peer Reviewed
• [Journal Article] Morphogenesis of the inner ear at different stages of normal human development (2015)
  • Author(s): Toyoda S, Yamada S, Uwabe C, Imai H, Matsuda T, Yoneyama A, Takeda T, Takakuwa T
  • Journal Title: Anat Rec (Hoboken) Volume: 298(12) Issue: 12 Pages: 2081-90
  • DOI: 10.1002/ar.23268
  • NAID: 120005844258
  • Peer Reviewed / Open Access
• [Journal Article] Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo. (2015)
  • Author(s): Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, Imai H, Sone M, Taura D, Harada KH, Habu T, Takagi Y, Miyamoto S, Koizumi A.
  • Journal Title: J Am Heart Assoc. Volume: 30;4(7) Issue: 7
  • DOI: 10.1161/jaha.115.002146
  • Peer Reviewed / Open Access
• [Journal Article] Application of the Kalman Filter for Faster Strong Coupling of Cardiovascular Simulations (2015)
  • Author(s): Yuki Hasegawa, Takao Shimayoshi, Akira Amano, Tetsuya Matsuda
  • Journal Title: IEEE Journal of Biomedical and Health Informatics Volume: 99 Issue: 4 Pages: 0-0
  • DOI: 10.1109/jbhi.2015.2436212
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Decomposition of Dynamics of Mathematical Cell Models: Method and Application to Ventricular Myocyte Models (2015)
  • Author(s): Takao Shimayoshi, Chae Young Cha, Akira Amano
  • Journal Title: PLoS ONE Volume: 10(6) Issue: 6 Pages: e0124970-e0124970
  • DOI: 10.1371/journal.pone.0124970
  • NAID: 120005997770
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment (2015)
  • Author(s): Yamada H, Hasegawa Y, Suzuki Y, Imai H, Matsuda T, Kimura Y, Toshimitsu A, Aoyama Y, Kondo T.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 25 Issue: 13 Pages: 2675-2678
  • DOI: 10.1016/j.bmcl.2015.04.072
  • NAID: 120005672621
  • Peer Reviewed
• [Journal Article] Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure (2015)
  • Author(s): Kawamoto A, Kato T, Shioi T, Okuda J, Kawashima T. Tamaki Y, Niizuma S, Tanada Y, Takemura G, Narazaki M, Matsuda T, Kimura T
  • Journal Title: PLoS One. Volume: 10 Issue: 1 Pages: e0117091-e0117091
  • DOI: 10.1371/journal.pone.0117091
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer (2015)
  • Author(s): Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo
  • Journal Title: Journal of the American Chemical Society Volume: 137 Issue: 2 Pages: 799-806
  • DOI: 10.1021/ja510479v
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Volumetric Fibular Transfer Planning with Shape-Based Indicators in Mandibular Reconstruction (2015)
  • Author(s): M. Nakao, M. Hosokawa, Y. Imai, N. Ueda, T. Hatanaka, T. Kirita and T. Matsuda
  • Journal Title: IEEE Journal of Biomedical and Health Informatics Volume: 19 Issue: 2 Pages: 581-589
  • DOI: 10.1109/jbhi.2014.2320720
  • NAID: 120005867109
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Motion Tracking Method That Applies a Spread Spectrum Communication Technique to Tagging MR Imaging (2015)
  • Author(s): Yoshiaki Komori, Akira Amano, Keiko Maehara, Li Jin, Michiko Narazaki, Tetsuya Matsuda
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 14 Issue: 1 Pages: 25-34
  • DOI: 10.2463/mrms.2013-0116
  • NAID: 130004700393
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Temporal change of enhancement after gadolinium injection on contrast-enhanced CMR in reperfused acute myocardial infarction (2015)
  • Author(s): Hidenari Matsumoto, Tetsuya Matsuda, Kenichi Miyamoto, Toshihiko Shimada, Shunpei Ushimaru, Mikiko Mikuri, Taketoshi Yamazaki
  • Journal Title: Journal of Cardiology Volume: 65 Issue: 1 Pages: 76-81
  • DOI: 10.1016/j.jjcc.2014.04.005
  • Peer Reviewed
• [Journal Article] Interactive Visual Exploration of Overlapping Similar Structures for Three-dimensional Microscope Images (2014)
  • Author(s): M. Nakao, S. Takemoto, T. Sugiura, K. Sawada, R. Kawakami, T. Nemoto and T. Matsuda
  • Journal Title: BMC Bioinformatics Volume: 15 Issue: 1 Pages: 415-415
  • DOI: 10.1186/s12859-014-0415-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement (2014)
  • Author(s): Hidenari Matsumoto, Kenji Nakatsuma, Toshihiko Shimada, Shunpei Ushimaru, Mikiko Mikuri, Taketoshi Yamazaki, Tetsuya Matsuda
  • Journal Title: The Journal of invasive cardiology Volume: 26 Pages: 580-585
  • Peer Reviewed
• [Journal Article] Visualizing in vivo Brain Neural Structures Using Volume Rendered Feature Spaces (2014)
  • Author(s): Megumi Nakao, Kosuke Kurebayashi, Tadao Sugiura, Tetsuo Sato, Kazuaki Sawada, Ryosuke Kawakami, Tomomi Nemoto, Kotaro Minato, Tetsuya Matsuda
  • Journal Title: Computers in Biology and Medicine Volume: 53 Pages: 85-93
  • DOI: 10.1016/j.compbiomed.2014.07.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice (2014)
  • Author(s): Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
  • Journal Title: PLoS ONE Volume: 9 Issue: 9 Pages: e108201-e108201
  • DOI: 10.1371/journal.pone.0108201
  • NAID: 120005496630
  • Peer Reviewed / Open Access
• [Journal Article] Theoretical analysis on the relationship between left ventricular energetic efficiency and acute infarct size (2013)
  • Author(s): Takao Shimayoshi, Yuki Hasegawa, Mitsuharu Mishima, Tetsuya Matsuda
  • Journal Title: IET Systems Biology Volume: 7 Issue: 3 Pages: 74-78
  • DOI: 10.1049/iet-syb.2011.0080
  • Peer Reviewed
• [Journal Article] Specific Detection and Imaging of Enzyme Activity by Signal-Amplifiable Self-Assembling 19F MRI Probes (2013)
  • Author(s): Kazuya Matsuo, Rui Kamada, Keigo Mizusawa, Hirohiko Imai, Yuki Takayama, Michiko Narazaki, Tetsuya Matsuda, Yousuke Takaoka, Itaru Hamachi
  • Journal Title: Chemistry Volume: online Issue: 38 Pages: 12875-12883
  • DOI: 10.1002/chem.201300817
  • Peer Reviewed
• [Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice (2013)
  • Author(s): Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T.
  • Journal Title: PLoS ONE Volume: 8 Issue: 8 Pages: e72173-e72173
  • DOI: 10.1371/journal.pone.0072173
  • Peer Reviewed
• [Journal Article] 大規模ヒト胚子連続切片標本群からの3次元画像再構成とデータベース検索表示システムの構築 (2013)
  • Author(s): 水田 忍, 松田哲也, 山田重人, 塩田浩平
  • Journal Title: MEDICAL IMAGING TECHNOLOGY Volume: 31 Pages: 94-104
  • NAID: 130003374505
  • Peer Reviewed
• [Journal Article] 局所酸素消費量分布解析のための心筋組織微小循環シミュレーションモデル (2013)
  • Author(s): 嶋吉 隆夫・久保田 悠太・天野 晃・松田 哲也
  • Journal Title: 生体医工学 Volume: 51 Pages: 248-253
  • NAID: 130004947583
  • Peer Reviewed
• [Journal Article] Feasibility of free-breathing late gadolinium-enhanced cardiovascular MRI for assessment of myocardial infarction: Navigator-gated versus single-shot imaging (2012)
  • Author(s): Hidenari Matsumoto, Tetsuya Matsuda, Kenichi Miyamoto, Kenji Nakatsuma, Masataka Sugahara, Toshihiko Shimada.
  • Journal Title: International Journal of Cardiology Volume: Available online 2 October Issue: 1 Pages: 94-99
  • DOI: 10.1016/j.ijcard.2012.09.066
  • Peer Reviewed
• [Journal Article] Size-Controlled and Biocompatible Gd2O3 Nanoparticles for Dual Photoacoustic and MR Imaging (2012)
  • Author(s): Yu Kimura, Ryota Kamisugi, Michiko Narazaki, Tetsuya Matsuda, Yasuhiko Tabata, Akio Toshimitsu, and Teruyuki Kondo
  • Journal Title: Advanced Healthcare Materials Volume: 1 Issue: 5 Pages: 657-660
  • DOI: 10.1002/adhm.201200103
  • Peer Reviewed
• [Journal Article] Synthesis and functional evaluation of chiral dendrimer–triamine-coordinated Gd complexes as highly sensitive MRI contrast agents (2012)
  • Author(s): Yuka Miyake, Yu Kimura, Syungo Ishikawa, Hiroshi Tsujita, Hiroki Miura, Michiko Narazaki, Tetsuya Matsuda, Yasuhiko Tabata, Tetsuya Yano, Akio Toshimitsu, Teruyuki Kondo
  • Journal Title: Tetrahedron Letters Volume: 53 Issue: 34 Pages: 4580-4583
  • DOI: 10.1016/j.tetlet.2012.06.072
  • Peer Reviewed
• [Journal Article] 心機能評価可能なヒト乳児循環動態シミュレーションモデル (2012)
  • Author(s): 王裕ぶん、嶋吉隆夫、天野晃、松田哲也
  • Journal Title: 電子情報通信学会論文誌D Volume: J95-D Pages: 331-338
  • NAID: 110009328429
  • Peer Reviewed
• [Journal Article] Water-Soluble Fluorinated Polymer Nanoparticle as 19F MRI Contrast Agent Prepared by Living Random Copolymerization from Dendrimer Initiator (2012)
  • Author(s): Michihiro Ogawa, Hiromasa Kataoka, Satoshi Nitahara, Hiroyuki Fujimoto Hiroyuki Aoki, Shinzaburo Ito, Michiko Narazaki, Tetsuya
  • Journal Title: BULLETION OF THE CHEMICAL SOCIETY OF JAPAN Volume: 85 Pages: 79-86
  • Peer Reviewed
• [Presentation] Deformation Estimation of Elastic Bodies Using Multiple Silhouette Images for Endoscopic Image Augmentation (2015)
  • Author(s): Akira Saito, Megumi Nakao, Yuki Uranishi, Tetsuya Matsuda
  • Organizer: IEEE International Symposium on Mixed and Augmented Reality (ISMAR) 2015
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2015-09-29
• [Presentation] Endoscopic Image Augmentation Reflecting Shape Changes in Cutting Procedures (2015)
  • Author(s): Megumi Nakao , Shota Endo, Keiho Imanishi, Tetsuya Matsuda
  • Organizer: IEEE International Symposium on Mixed and Augmented Reality (ISMAR) 2015
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2015-09-20
• [Presentation] Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship (2014)
  • Author(s): Shimayoshi, T. ; Mishima, M. ; Amano, A. ; Matsuda, T.
  • Organizer: 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-08-26 – 2014-08-30
• [Presentation] Time Course Study on Glucose Metabolism in Mice by Spectroscopic Imaging with 2D Heteronuclear Multiple Quantum Coherence (2014)
  • Author(s): Hirohiko Imai, Yuki Takayama, Tetsuya Matsuda
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2014
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Volumetric surgical planning system for fibular transfer in mandibular reconstruction (2013)
  • Author(s): Megumi Nakao, Mamoru Hosokawa, Yuichiro Imai, Nobuhiro Ueda, Toshihide Hatanaka, Kotaro Minato, Tadaaki Kirita, Tetsuya Matsuda
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. (IEEE-EMBC)
  • Place of Presentation: Osaka Japan
• [Presentation] study on the relationship between electrical transmural heterogeneity and ventricular energetics (2013)
  • Author(s): Yuki Hasegawa, Mitsuharu Mishima, Takao Shimayoshi, Akira Amano, Tetsuya Matsuda
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. (IEEE-EMBC)
  • Place of Presentation: Osaka Japan
• [Presentation] A Coupling Method for a Cardiovascular Simulation Model which includes the Kalman Filter (2012)
  • Author(s): Yuki Hasegawa, Takao Shimayoshi, Akira Amano, Tetsuya Matsuda
  • Organizer: 34th Annual International Conference of the IEEE EMBS
  • Place of Presentation: San Diego, California USA