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Development and application of cell viability imaging using MEMRI

Research Project

Project/Area Number 24300167
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

Aoki Ichio  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, チームリーダー (10319519)

Co-Investigator(Kenkyū-buntansha) 田畑 泰彦  京都大学, 再生医科学研究所, 教授 (50211371)
齋藤 茂芳  大阪大学, 医学(系)研究科(研究院), 助教 (40583068)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
KeywordsMRI / 造影剤 / マンガン / 機能性 / プローブ / 低pH / がん / 細胞周期 / pH / 反応性 / センサー / 生体イメージング / 分子イメージング / 高磁場MRI / 細胞生存性 / がん・腫瘍 / 放射線 / MEMRI / 定量 / MnO / T1
Outline of Final Research Achievements

We performed in vitro and in vivo MRI experiments with Mn2+ to investigate whether manganese-enhanced MRI (MEMRI) can be used to detect cell alterations as an early-phase tumor response after radiotherapy. MEMRI was successfully used to detect cell alterations as an early-phase cellular response after tumor radiotherapy (Cancer Res. 2013). Also, we reported an nano-MRI contrast agent that rapidly amplifies MRI signals in response to pH. We confined Mn2+ within pH-sensitive calcium phosphate (CaP) nanoparticles. At a low pH, such as in solid tumors, the CaP disintegrates and releases Mn2+. Binding to proteins increases the relaxivity of Mn2+ and enhances the contrast. We show that these nanoparticles could rapidly and selectively enhanced solid tumors, identify low pH regions within the tumor (Nat Nanotechnol. 2016).

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (67 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (5 results) Journal Article (20 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 20 results,  Acknowledgement Compliant: 9 results,  Open Access: 5 results) Presentation (29 results) (of which Int'l Joint Research: 4 results,  Invited: 16 results) Book (8 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results)

  • [Int'l Joint Research] National Institutes of Health/The University of Arizona(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] The Grenoble Institute of Neuroscience(フランス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] NIH/NINDS(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Max Planck Tubingen(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach.2017

    • Author(s)
      Wells JA, Thomas DL, Saga T, Kershaw J, Aoki I.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: Jun;37(6) Issue: 6 Pages: 2076-2083

    • DOI

      10.1177/0271678x16660985

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli2017

    • Author(s)
      Wells JA, Shibata S, Fujikawa A, Takahashi M, Saga T, Aoki I.
    • Journal Title

      Sci Rep

      Volume: Jan 12;7 Issue: 1 Pages: 38325-38325

    • DOI

      10.1038/srep38325

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy.2016

    • Author(s)
      P. Mi, D. Kokuryo, H. Cabral, H. Wu, Y. Terada, T. Saga, I. Aoki, N. Nishiyama, K. Kataoka,
    • Journal Title

      Nat. Nanotechnol.

      Volume: 11 Issue: 8 Pages: 724-730

    • DOI

      10.1038/nnano.2016.72

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Density-Tunable Conjugation of Cyclic Rgd Ligands with Polyion Complex Vesicles for the Neovascular Imaging of Orthotopic Glioblastomas2015

    • Author(s)
      Kawamura W, Miura Y, Kokuryo D, Toh K, Yamada N, Nomoto T, Matsumoto Y, Sueyoshi D, Liu X, Aoki I, Kano MR, Nishiyama N, Saga T, Kishimura A, Kataoka K
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 16 Issue: 3 Pages: 035004-035004

    • DOI

      10.1088/1468-6996/16/3/035004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delivery of size-controlled long-circulating polymersomes in solid tumors, visualized by quantum dots and optical imaging in vivo.2015

    • Author(s)
      Bakalova R, Lazarova D, Nikolova B, Atanasova S, Zlateva G, Zhelev Z, Aoki I
    • Journal Title

      Biotechnol Biotech Eq.

      Volume: 29(1) Pages: 175-180

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy2015

    • Author(s)
      Mi P, Dewi N, Yanagie H, Kokuryo D, Suzuki M, Sakurai Y, Li Y, Aoki I, Ono K, Takahashi H, Cabral H, Nishiyama N, Kataoka K.
    • Journal Title

      ACS Nano

      Volume: 9(6) Issue: 6 Pages: 5913-5921

    • DOI

      10.1021/acsnano.5b00532

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy2015

    • Author(s)
      I. Aoki, M. Yoneyama, J. Hirose, Y. Minemoto, T. Koyama, D. Kokuryo, R. Bakalova, S. Murayama, T. Saga, S. Aoshima, Y. Ishizaka, K. Kono,
    • Journal Title

      Translational Research

      Volume: 166 Issue: 6 Pages: 660-673

    • DOI

      10.1016/j.trsl.2015.07.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Polymeric Micelle Platform for Multimodal Tomographic Imaging to Detect Scirrhous Gastric Cancer2015

    • Author(s)
      Yutaka Miura, Atsushi B. Tsuji, Aya Sugyo, Hitomi Sudo, Ichio Aoki, Masayuki Inubushi, Masakazu Yashiro, Kosei Hirakawa, Horacio Cabral, Nobuhiro Nishiyama, Tsuneo Saga, Kazunori Kataoka
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 1 Issue: 11 Pages: 1067-1076

    • DOI

      10.1021/acsbiomaterials.5b00142

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] γ-PARCEL: Control of Molecular Release Using γ-Rays.2015

    • Author(s)
      Shuhei Murayama, Jun-Ichiro Jo , Kazutaka Arai , Fumihiko Nishikido , Rumiana Bakalova , Taiga Yamaya , Tsuneo Saga , Masaru Kato , Ichio Aoki
    • Journal Title

      Anal. Chem.

      Volume: 87 Issue: 23 Pages: 11625-11629

    • DOI

      10.1021/acs.analchem.5b03030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Sexual dimorphism of sulcal morphology of the ferret cerebrum revealed by MRI-based sulcal surface morphometry.2015

    • Author(s)
      Sawada K, Horiuchi-Hirose M, Saito S, Aoki I
    • Journal Title

      Front Neuroanat

      Volume: 9(55) Pages: 1-14

    • DOI

      10.3389/fnana.2015.00055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of Thermo-triggered Drug Release in Intramuscular-transplanted Tumors using Thermosensitive Polymer-modified Liposomes and MRI2015

    • Author(s)
      Daisuke Kokuryo, Seiji Nakashima, Fuminori Ozaki, Kai-Hsiang Chuang, Sadahito Aoshima, Yukihito Ishizaka, Tsuneo Saga, Kenji Kono, and Ichio Aoki
    • Journal Title

      Nanomedicine

      Volume: 11 Issue: 1 Pages: 229-238

    • DOI

      10.1016/j.nano.2014.09.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion.2015

    • Author(s)
      Gündüz S, Nitta N, Vibhute S, Shibata S, Mayer ME, Logothetis NK, Aoki I, Angelovski G.
    • Journal Title

      Chem Commun (Camb)

      Volume: 51(14) Issue: 14 Pages: 2782-2785

    • DOI

      10.1039/c4cc07540d

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MR imaging techniques for nano-pathophysiology and theranostics.2014

    • Author(s)
      Bennett KM, Jo JI, Cabral H, Bakalova R, Aoki I
    • Journal Title

      Adv Drug Deliv Rev.

      Volume: 30;74C Pages: 75-94

    • DOI

      10.1016/j.addr.2014.04.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo.2013

    • Author(s)
      Saito S, Hasegawa S, Sekita A, Bakalova R, Furukawa T, Murase K, Saga T, Aoki I.
    • Journal Title

      Cancer Res

      Volume: 73(11) Issue: 11 Pages: 3216-3224

    • DOI

      10.1158/0008-5472.can-12-3837

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Simple Preparation of Polyethylene Glycol-Based Soft Nanoparticles Containing Dual Imaging Probes.2013

    • Author(s)
      Murayama S, Jo JI, Shibata Y, Liang K, Santa T, Saga T, Aoki I, Kato M.
    • Journal Title

      J Mater Chem B Mater Biol Med

      Volume: 1 Issue: 38 Pages: 4932-4938

    • DOI

      10.1039/c3tb20828a

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI)2013

    • Author(s)
      Hattori S, Hagihara H, Ohira K, Aoki I, Saga T, Suhara T, Higuchi M, Miyakawa T.
    • Journal Title

      Frontiers in Integrative Neuroscience

      Volume: 40 Pages: 125-132

    • DOI

      10.3389/fnint.2013.00076

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tissue redox activity as a hallmark of carcinogenesis: from early to terminal stages of cancer.2013

    • Author(s)
      Bakalova R, Zhelev Z, Aoki I, Saga T.
    • Journal Title

      Clin Cancer Res

      Volume: 19(9) Issue: 9 Pages: 2503-2517

    • DOI

      10.1158/1078-0432.ccr-12-3726

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Polymer-Based Magnetic Resonance Imaging Contrast Agent to Visualize Therapeutic Angiogenesis.2013

    • Author(s)
      Jo JI, Lin X, Nakahara T, Aoki I, Saga T, Tabata Y.
    • Journal Title

      Tissue Eng Part A.

      Volume: 19(1-2) Issue: 1-2 Pages: 30-39

    • DOI

      10.1089/ten.tea.2012.0131

    • NAID

      120005173385

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Giant Vesicles Containing Superparamagnetic Iron Oxide as Biodegradable Cell-Tracking MRI Probes.2012

    • Author(s)
      Toyota T, Ohguri N, Maruyama K, Fujinami M, Saga T, Aoki I
    • Journal Title

      Anal Chem.

      Volume: 84(9) Issue: 9 Pages: 3952-3957

    • DOI

      10.1021/ac2031354

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence.2012

    • Author(s)
      Kershaw J, Leuze C, Aoki I, Obata I, Kanno I, Ito H, Yamaguchi Y, Handa H.
    • Journal Title

      Neuroimage.

      Volume: 70 Pages: 10-20

    • DOI

      10.1016/j.neuroimage.2012.12.036

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Approach to Multiscale Imaging using Micro-MRI and Functional Contrast Agents.2017

    • Author(s)
      Ichio Aoki
    • Organizer
      International Symposium on Multimodal Medical Engineering (MME)
    • Place of Presentation
      千葉大学、千葉市
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional and theranostic contrast agents for preclinical MR imaging2016

    • Author(s)
      Ichio Aoki
    • Organizer
      Joint AMED-DFG Japan-German Workshop on Functional Metabolic Imaging
    • Place of Presentation
      Tübingen University, Germany
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MRI顕微鏡とマルチモーダル統合技術が生命科学にもたらすもの2016

    • Author(s)
      青木伊知男
    • Organizer
      日本学術会議公開シンポジウム「全細胞・マルチモーダル計測が拓く統合バイオサイエンス」
    • Place of Presentation
      大阪大学
    • Year and Date
      2016-01-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高磁場 MRI と機能性造影剤による小動物 in vivoイメージング2016

    • Author(s)
      青木伊知男
    • Organizer
      第63回日本実験動物学会
    • Place of Presentation
      ミューザ川崎、川崎市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高磁場MRIによる細胞トラッキングとマイクロイメージング2016

    • Author(s)
      青木伊知男
    • Organizer
      第37回日本炎症・再生医学会
    • Place of Presentation
      京都市勧業館、京都市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Functional and Theranostic Contrast Agent2016

    • Author(s)
      Ichio Aoki
    • Organizer
      日本磁気共鳴医学会 JSMRM-KSMRM joint symposium
    • Place of Presentation
      大宮ソニックシティ、さいたま市
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional and Theranostic Contrast Agents for MRI2016

    • Author(s)
      Ichio Aoki
    • Organizer
      The l8th Northeastern Asian Symposium on Molecular Imaging-based Precision Medicine
    • Place of Presentation
      Hangzhou, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 前臨床脳機能MRIによるモデル性評価の試みと問題点2016

    • Author(s)
      青木伊知男
    • Organizer
      日本認知症学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 診断と治療の一体化~セラノスティクス2015

    • Author(s)
      青木伊知男
    • Organizer
      第31回日本DDS学会
    • Place of Presentation
      新宿
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Responsive and Theranostic Nano-Contrast Agents for MRI2015

    • Author(s)
      青木伊知男
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] MRI によるナノ・セラノスティクスとニトロキシル標識抗がん剤2015

    • Author(s)
      青木伊知男
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高磁場MRIによる細胞トラッキングとマイクロイメージング2015

    • Author(s)
      青木伊知男
    • Organizer
      第14回日本再生医療学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] MR造影剤内包高分子ミセルと格子構造を有する生分解性ゲルを組み合わせた脳内薬剤投与法の検討2014

    • Author(s)
      國領大介, Peng Mi, 栗田朋香, 矢田部輝幸, Horacio Cabral, 柴田さやか, 佐賀恒夫, 青木伊知男, 片岡一則
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] High resolution OGSE DTI of cerebellar white matter in ex vivo mouse brain2014

    • Author(s)
      Jeffrey Kershaw, 柴田さやか, 青木伊知男, 小畠隆行, 伊藤浩
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Responsive and theranostic nano-contrast agents for preclinical MR imaging2014

    • Author(s)
      Ichio Aoki
    • Organizer
      2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science (PT-BMES 2014)
    • Place of Presentation
      Hsinchu, Taiwan
    • Year and Date
      2014-09-12 – 2014-09-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 炭素線照射・温度応答性リポソーム併用による腫瘍治療効果および薬剤集積性の評価2014

    • Author(s)
      國領大介, 青木伊知男, 河野健司, 佐賀恒夫
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      慶應義塾大学芝共立キャンパス
    • Year and Date
      2014-07-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炭素線照射後の温度応答性リポソームの腫瘍集積性と治療効果の評価2014

    • Author(s)
      國領大介, 青木伊知男, 河野健司, 佐賀恒夫
    • Organizer
      第9回日本分子イメージング学会
    • Place of Presentation
      大阪・千里ライフサイエンスセンター
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] デュアルプローブ包含ソフトナノゲル2014

    • Author(s)
      村山周平, 城潤一郎, 柴田悠圭, 三田智文, 佐賀恒夫, 青木伊知男, 加藤大
    • Organizer
      第9回日本分子イメージング学会・学術集会
    • Place of Presentation
      大阪・千里ライフサイエンスセンター
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Intracerebral drug delivery treatment using a regularly-structured biodegradable gel for slow-release of gadolinium-containing nano-micelles in a glioblastoma model2014

    • Author(s)
      Kokuryo D, Peng M, Kurita T, Yatabe T, Cabral H, Shibata S, Saga T, Aoki I, Kataoka K
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB
    • Place of Presentation
      イタリア・Milan
    • Year and Date
      2014-05-10 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高感度磁気共鳴イメージングを目指したマンガンイオン内包ナノカプセルの作製2014

    • Author(s)
      新井 和孝 , 城 潤一郎 , 青木 伊知男 , 佐賀 恒夫
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional- and nano-contrast agents for preclinical MRI2014

    • Author(s)
      Ichio Aoki
    • Organizer
      The 2nd International Congress on Magnetic Resonance Imaging & the 19th Annual Scientific Meeting of KSMRM
    • Place of Presentation
      Grand Hilton Hotel, Seoul
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] MEMRI法により検出される急性炎症反応の画像コントラスに関する考察2013

    • Author(s)
      岩本 成人 , 柴田 さやか , 関田 愛子 , 新田 展大 , 佐賀 恒夫 , 寺沢 宏明 , 青木 伊知男
    • Organizer
      第41回日本磁気共鳴医学会大会
    • Place of Presentation
      アスティとくしま
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高磁場MRIによる分子イメージング研究への取り組み2013

    • Author(s)
      青木伊知男
    • Organizer
      熊本大学イメージングセミナー「MRIで見えること、わかること ― 磁気共鳴イメージングの先端技術と応用 ―」
    • Place of Presentation
      熊本大学百周年記念館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 前臨床MRIによる分子イメージング研究の進展 ~機能性造影剤の開発と腫瘍への適用を中心に2013

    • Author(s)
      青木伊知男
    • Organizer
      九州大学・分子イメージング研究開発講演会
    • Place of Presentation
      九州大学大学院医学研究院
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マンガン標識移植細胞追跡と心筋梗塞マウスの心機能評価法2012

    • Author(s)
      小高謙一、青木伊知男、田所裕之、森谷純治、黒岩大悟、舘野馨、南野徹、菊池達矢、小室一成、小畠隆行、小林欣夫、佐賀恒夫、張明栄
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
  • [Presentation] マンガン造影MRIを用いた中枢神経障害モデルにおける炎症反応の検出2012

    • Author(s)
      岩本成人、青木伊知男, ら
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
  • [Presentation] マンガン造影MRIによる脳下垂体の活性化とホルモン分泌の解析2012

    • Author(s)
      平金真、國領大介、青木伊知男, ら
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 定量的マンガン造影MRIによる抗がん剤に対する主要細胞viabilityの評価2012

    • Author(s)
      関田愛子、長谷川純崇、佐賀恒夫、青木伊知男
    • Organizer
      日本化学会生体機能関連化学部会・第6回バイオ関連化学シンポジウム
    • Place of Presentation
      札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラット脳への末梢血単核球移植後の動態評価 : マンガン標識とMR I (磁気共鳴画像)2012

    • Author(s)
      小高謙一、伊藤康一、青木伊知男, ら
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Book] JST/CRDS・研究開発の俯瞰報告書(2015) ナノテクノロジー・材料分野2015

    • Author(s)
      青木伊知男
    • Total Pages
      515
    • Publisher
      CRDS/JST
    • Related Report
      2015 Annual Research Report
  • [Book] ナノDDSがもたらす新しいMRイメージングとナノ・セラノスティクス2015

    • Author(s)
      青木伊知男、城潤一郎、Horacio Cabral、Rumiana Bakalova、Kevin M. Bennett
    • Total Pages
      84
    • Publisher
      Drug Delivery System, 日本DDS学会
    • Related Report
      2014 Annual Research Report
  • [Book] 造影剤の進歩とセラノスティクスへの応用の展望、Molecular Imaging 2014「分子イメージングはどこまで進んだか」2014

    • Author(s)
      青木伊知男
    • Total Pages
      141
    • Publisher
      INNERVISION
    • Related Report
      2014 Annual Research Report
  • [Book] 遺伝子医学MOOK別冊、ここまで広がるドラッグ徐放技術の最前線、-古くて新しいドラッグデリバリーシステム(DDS)-2013

    • Author(s)
      青木伊知男
    • Total Pages
      376
    • Publisher
      株式会社メディカル ドゥ
    • Related Report
      2013 Annual Research Report
  • [Book] 高磁場MRIによる分子イメージング 機能性造影剤からセラノスティクスへ2013

    • Author(s)
      青木伊知男
    • Total Pages
      724
    • Publisher
      公益社団法人 日本薬学会
    • Related Report
      2013 Annual Research Report
  • [Book] MRIとドラッグデリバリー2013

    • Author(s)
      青木伊知男
    • Total Pages
      5
    • Publisher
      The Journal of TMIT, ISSN 0918-9475
    • Related Report
      2012 Annual Research Report
  • [Book] ここまで広がるドラッグ徐放技術の最前線、-古くて新しいドラッグデリバリーシステム(DDS)-2013

    • Author(s)
      青木伊知男、佐賀恒夫
    • Total Pages
      7
    • Publisher
      株式会社 メディカルドウ、遺伝子医学M00K別冊
    • Related Report
      2012 Annual Research Report
  • [Book] 医療とイメージング、最先端材料システムOne Pointシリーズ10「イメージング」2012

    • Author(s)
      青木伊知男、佐賀恒夫
    • Total Pages
      12
    • Publisher
      高分子学会編、共立出版
    • Related Report
      2012 Annual Research Report
  • [Remarks] 放射線がん治療の翌日に、その効果を画像で確認できる超早期診断法を開発

    • URL

      http://www.nirs.go.jp/information/press/2013/05_24.html

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 放射線等を用いた生理活性物質の活性制御方法、及び生理活性物質包含放射線等刺激応答性ゲル2016

    • Inventor(s)
      村山周平、青木伊知男、城潤一郎、佐賀恒夫
    • Industrial Property Rights Holder
      村山周平、青木伊知男、城潤一郎、佐賀恒夫
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-092524
    • Filing Date
      2016-05-02
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 高分子ナノ粒子複合体、及びそれを含むMRI造影用組成物2013

    • Inventor(s)
      片岡一則、西山伸宏、オラシオカブラル、米鵬、青木伊知男他
    • Industrial Property Rights Holder
      片岡一則、西山伸宏、オラシオカブラル、米鵬、青木伊知男他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-173866
    • Filing Date
      2013-08-23
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 固定位置表示キットおよび位置表示固定方法2013

    • Inventor(s)
      青木伊知男、城潤一郎、下村岳夫、國領大介、佐賀恒夫
    • Industrial Property Rights Holder
      青木伊知男、城潤一郎、下村岳夫、國領大介、佐賀恒夫
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-106668
    • Filing Date
      2013-05-20
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 核酸類ハイドロゲル状態変更方法、放射線分解ハイドロゲル、物質内包放射線分解ハイドロゲル、および放射線応答ハイドロゲルキット2012

    • Inventor(s)
      城潤一郎・青木伊知男・佐賀恒夫
    • Industrial Property Rights Holder
      独立行政法人放射線医学総合研究所
    • Industrial Property Number
      2012-259393
    • Filing Date
      2012-11-28
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2022-02-16  

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