Development of an ultra compact and durable cardiopulmonary support system with a portability for one-operator
| Project/Area Number |
24300168
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Taenaka Yoshiyuki 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, センター長 (00142183)
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| Co-Investigator(Kenkyū-buntansha) |
TATSUMI EISUKE 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (00216996)
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| Co-Investigator(Renkei-kenkyūsha) |
KATAGIRI NOBUMASA 国立研究開発法人国立循環器病研究センター, 研究所 (00463274)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 超小型 / 軽量 / ポータブル / 心肺補助 / 耐久性 / 準備迅速性 / 結露防止 / 人工肺 / 遠心ポンプ / 数値解析 / ガス交換機能 |
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| Outline of Final Research Achievements |
In this study, we made a prototype of a compact ECMO system for long-term use. This ECMO system is consisted of a disposable unit, a driver unit and a gas bomb unit. The disposable unit was designed as a pre-connected ECMO circuit using a compact oxygenator (BIOCUBE6000) and a novel hydrodynamically levitated centrifugal blood pump. And its entire blood-contacting surface was treated with heparin bonding material (T-NCVC). The prototype system had a small size (W290 x D205 x H405 mm) and lightweight (8.9 kg). Veno-arterial bypass ECMO with a prototype system was conducted for 18 days using an adult goat. Chronic animal experiment could run continuously with keeping 2.5 L/min of bypass flow rate. O2 and CO2 transfer rates were kept at sufficient levels (140 ± 14 and 90 ± 22 mL/min, respectively). After the experiment, no thrombi were observed in the ECMO circuit. The prototype of ultra compact ECMO system indicated the possibility of durability for over 2 weeks.
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Report
(5 results)
Research Products
(83 results)
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[Presentation] Practical operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation2013
Author(s)
Togo K, Takawa Y, Mizuno T, Tsukiya T, Atsuta Y, Arakawa M, Kishinmoto S, Katagiri N, Kakuta Y, Fujii Y, Sumikura H, Ohnuma K, Taenaka Y, Miyamoto Y, Tatsumi E
Organizer
American Society for Artificial Internal Organs (59)
Place of Presentation
Chicago
Related Report
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[Presentation] Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation and decarboxylation2013
Author(s)
Togo K, Takewa Y, Tsukiya T, Mizuno T, Katagiri N, Atsuta Y, Fujii Y, Kishimoto S, Date K, Sumikura H, Ohnuma K, Kakuta Y, Miyamoto Y, Tatsumi E
Organizer
International Society for Rotary Blood Pumps (21)
Place of Presentation
Yokohama
Related Report
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[Presentation] Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation2013
Author(s)
Togo K, Atsuta Y, Fujii Y, Kakuta Y, Katagiri N, Kishimoto Y, Miyamoto T, Mizuno T, Ohnuma K, Sumikura H, Taenaka Y, Takewa Y, Tatsumi E, Tsukiya T
Organizer
European Society for Artificial Organs (40)
Place of Presentation
Glasgow
Related Report
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[Presentation] VVECMOを効率良く行うためのバイパス流量と送血位置の検討2013
Author(s)
東郷好美，武輪能明、築谷朋典、水野敏秀、片桐伸将、熱田祐一、藤井 豊、岸本 諭、伊達数馬、住倉博仁、大沼健太郎、角田幸秀、宮本裕治、巽 英介
Organizer
日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
Place of Presentation
横浜市
Related Report
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[Presentation] VVECMOを効率よく行うには?カニュレーション位置からの検討2013
Author(s)
東郷好美, 武輪能明, 水野敏秀, 築谷朋典, 岸本祐一郎, 荒川 衛, 熱田 祐一, 片桐伸将, 角田幸秀、藤井 豊, 住倉博仁, 大沼健太郎, 妙中義之, 宮本祐冶, 巽 英介
Organizer
人工心臓と補助循環懇話会学術集会(41)
Place of Presentation
下高井戸郡山ノ内町
Related Report
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