| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
In this study, we made a prototype of a compact ECMO system for long-term use. This ECMO system is consisted of a disposable unit, a driver unit and a gas bomb unit. The disposable unit was designed as a pre-connected ECMO circuit using a compact oxygenator (BIOCUBE6000) and a novel hydrodynamically levitated centrifugal blood pump. And its entire blood-contacting surface was treated with heparin bonding material (T-NCVC). The prototype system had a small size (W290 x D205 x H405 mm) and lightweight (8.9 kg). Veno-arterial bypass ECMO with a prototype system was conducted for 18 days using an adult goat. Chronic animal experiment could run continuously with keeping 2.5 L/min of bypass flow rate. O2 and CO2 transfer rates were kept at sufficient levels (140 ± 14 and 90 ± 22 mL/min, respectively). After the experiment, no thrombi were observed in the ECMO circuit. The prototype of ultra compact ECMO system indicated the possibility of durability for over 2 weeks.
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