| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
In this study, biomolecularly stimuli-responsive gels, particles and films with molecular complexes as dynamic crosslinks were strategically designed as smart biomaterials for constructing novel medical systems. The hydrogels, particles and films underwent changes in the volume in response to a target biomolecule. We developed self-regulated drug delivery systems (DDS) and diagnostic sensors using the biomolecularly stimuli-responsive gels, particles and films. In addition, photo-responsive polymers with micro-patternable surfaces were synthesized using photo-dimerization moieties as dynamic crosslinks. Photo-irradiation to the photo-responsive polymers through photo-masks resulted in the formation of micropatterns. The micropatterned surfaces were applied to microcontact printing and cell cultures.
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