Preparation of Smart Biomaterials Using Dynamic Crosslinks and Their Biomedical Applications
| Project/Area Number |
24300175
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kansai University |
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Principal Investigator |
Miyata Takashi 関西大学, 化学生命工学部, 教授 (50239414)
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Yasuhiko 関西大学, 化学生命工学部, 教授 (90280990)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | スマートバイオマテリアル / 高分子ゲル / 動的架橋 / 応答材料 / インテリジェント材料 / 刺激応答性 / DDS / センサー材料 / ｽﾏｰﾄﾊﾞｲｵﾏﾃﾘｱﾙ / ｲﾝﾃﾘｼﾞｪﾝﾄ材料 |
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| Outline of Final Research Achievements |
In this study, biomolecularly stimuli-responsive gels, particles and films with molecular complexes as dynamic crosslinks were strategically designed as smart biomaterials for constructing novel medical systems. The hydrogels, particles and films underwent changes in the volume in response to a target biomolecule. We developed self-regulated drug delivery systems (DDS) and diagnostic sensors using the biomolecularly stimuli-responsive gels, particles and films. In addition, photo-responsive polymers with micro-patternable surfaces were synthesized using photo-dimerization moieties as dynamic crosslinks. Photo-irradiation to the photo-responsive polymers through photo-masks resulted in the formation of micropatterns. The micropatterned surfaces were applied to microcontact printing and cell cultures.
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Report
(5 results)
Research Products
(112 results)
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[Presentation] Surface patterning properties of photo-responsive polymer films and cell culture on their surface2015
Author(s)
Noguchi, Takafumi ; Kawamura, Akifumi ; Miyata, Takashi
Organizer
The International Chemical Congress of Pacific Basin Societies 2015 (PACIFIChem 2015)
Place of Presentation
Marriott Waikiki Beach, Hilton Hawaiian Village, Hawaii Convention Center, Hilton Waikiki Beach, Sheraton Waikiki & Royal Hawaiian, Hyatt Regency Waikiki, Honolulu, Hawai, USA
Year and Date
2015-12-15
Related Report
Int'l Joint Research
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