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Treatment Time Reduction in Ultrasound Thermal Therapy using Cavitation Bubbles in a Large Region

Research Project

Project/Area Number 24300178
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

YOSHIZAWA Shin  東北大学, 工学(系)研究科(研究院), 准教授 (30455802)

Co-Investigator(Kenkyū-buntansha) UMEMURA Shin-ichiro  東北大学, 大学院医工学研究科, 教授 (20402787)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords超音波治療 / キャビテーション / HIFU / マイクロバブル / 非線形超音波
Outline of Final Research Achievements

High-intensity focused ultrasound has attracted much attention as a modality for the noninvasive thermal treatment of cancer. However, it has a problem of long treatment time. The objective of this study is to develop a method for the ultrasonic heating with high efficiency by using cavitation clouds generated in a large region. Cavitation clouds were generated and used in a large region by electronically scanning HIFU focus in a plane perpendicular to the HIFU propagation direction. Applying this method to a tissue mimicking phantom, the temperature rise measured with a thermocouple was two to three times of that without cavitation generation. The coagulation volume of chicken breast tissues showed a high efficiency of the developed method for a HIFU thermal treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (14 results)

All 2015 2014 2013 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 3 results) Presentation (10 results) (of which Invited: 2 results)

  • [Journal Article] Effect of controlled offset of focal position in cavitation-enhanced high-intensity focused ultrasound treatment2015

    • Author(s)
      Kota Goto, Ryo Takagi, Takuya Miyashita, Hayato Jinbo, Shin Yoshizawa, and Shin-ichiro Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 54

    • NAID

      210000145443

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of rose bengal on cavitation generation in gel phantom investigated using high-speed camera2014

    • Author(s)
      Jun Yasuda, Takuya Miyashita, Shin Yoshizawa, Shin-ichiro Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 53 Issue: 7S Pages: 07KF20-07KF20

    • DOI

      10.7567/jjap.53.07kf20

    • NAID

      210000144271

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Quantitative measurement of focused ultrasound pressure field by background-subtracted shadowgraph using holographic diffuser as screen2014

    • Author(s)
      Ryo Miyasaka, Jun Yasuda, Mohd Syahid, Shin Yoshizawa, and Shin-ichiro Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 53 Issue: 7S Pages: 07KF24-07KF24

    • DOI

      10.7567/jjap.53.07kf24

    • NAID

      210000144275

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Efficient Generation of Cavitation Bubbles in Gel Phantom by Ultrasound Exposure with Negative-Followed by Positive-Peak-Pressure Emphasized Waves2013

    • Author(s)
      Jun Yasuda, Ayumu Asai, Shin Yoshizawa, Shin-ichiro Umemura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: (掲載確定)

    • NAID

      210000142532

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] キャビテーション気泡生成位置を考慮した焦点位置制御が加熱凝固領域に与える影響2014

    • Author(s)
      後藤 功太, 高木 亮, 神保 勇人, 宮下 拓也, 吉澤 晋, 梅村 晋一郎
    • Organizer
      第35回 超音波エレクトロニクスの基礎と応用に関するシンポジウム (USE2014)
    • Place of Presentation
      明治大学,東京
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] キャビテーション気泡発生領域近傍および遠方における超音波加熱増強効果の解析2014

    • Author(s)
      宮下 拓也, 安田 惇, 田口 渓, 吉澤 晋, 梅村 晋一郎
    • Organizer
      第35回 超音波エレクトロニクスの基礎と応用に関するシンポジウム (USE2014)
    • Place of Presentation
      明治大学,東京
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 強力集束超音波によって生成したキャビテーション気泡の高速超音波イメージング2014

    • Author(s)
      吉澤 晋, 高木 亮, 安田 惇, 後藤 功太, 宮下 拓也, 梅村 晋一郎
    • Organizer
      キャビテーションに関するシンポジウム(第17回)
    • Place of Presentation
      東京大学,東京
    • Year and Date
      2014-11-20 – 2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超音波による集束超音波治療のガイドとモニタ2014

    • Author(s)
      吉澤 晋, 梅村 晋一郎
    • Organizer
      第13回 日本超音波治療研究会 (JSTU2014)
    • Place of Presentation
      仙台情報・産業プラザ,仙台
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Ultrasonic Cavitation Monitoring in High-Intensity Focused Ultrasound Treatment by Pulse Inversion Harmonic Imaging with Plane Wave Transmission Pulses2014

    • Author(s)
      Shin Yoshizawa, Ryo Takagi, Hiroshi Sasaki, Kota Goto, Takuya Miyashita, and Shin-ichiro Umemura
    • Organizer
      2014 IEEE International Ultrasonics Symposium
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-09-03 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高速度撮影を用いたローズベンガルのキャビテーション気泡の成長における効果の解析2013

    • Author(s)
      安田惇, 宮下拓也, 吉澤晋, 梅村晋一郎
    • Organizer
      第34回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロバブルを援用した強力集束超音波治療法2013

    • Author(s)
      吉澤晋, 梅村晋一郎
    • Organizer
      日本ハイパーサーミア学会第30回大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超音波加熱治療の高速化を目的とした多点キャビテーション生成による広範囲焼灼手法2011

    • Author(s)
      吉澤晋, 中村高太郎, 浅井歩, 安田惇, 梅村晋一郎
    • Organizer
      第11回 日本超音波治療研究会(JSTU)
    • Place of Presentation
      宮崎
    • Year and Date
      2011-11-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] High-speed observation of cavitation bubbles generated at multiple focal spots for bubble-enhanced heating in a large focal region2011

    • Author(s)
      Shin Yoshizawa, Kotaro Nakamura, Ayumu Asai, Shin-ichiro Umemura
    • Organizer
      2012 IEEE International Ultrasonics Symposium
    • Place of Presentation
      ドレスデン,ドイツ
    • Year and Date
      2011-11-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] キャビテーション気泡による加熱増強効果を利用した強力集束超音波治療法

    • Author(s)
      吉澤晋
    • Organizer
      超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      大津
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2012-04-24   Modified: 2019-07-29  

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