Assessment of myocardial ischemic memory using 3D speckle tracking echocardiography

• Project/Area Number: 24300181
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Osaka University
• Principal Investigator: ASANUMA Toshihiko 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (80379271)
• Co-Investigator(Kenkyū-buntansha): MASUDA Kasumi 大阪大学, 医学系研究科, 助教 (20533293) ; NAKATANI Satoshi 大阪大学, 医学系研究科, 教授 (50393221) ; 中谷 敏 大阪大学, 医学(系)研究科(研究院), 教授 (80393221)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: 診断システム / 超音波 / 心筋虚血 / 心エコー / 3D / 虚血診断 / 虚血メモリー

Outline of Final Research Achievements

Recently developed 3D speckle tracking echocardiography (3D-STE) has the potential to address the several issues of ischemic memory imaging by the 2D speckle tracking technique. We evaluated whether 3D-STE could be used for the assessment of myocardial ischemic memory with the animal experiments. In the results, subtle abnormal myocardial motion could be detected by 3D-STE after recovery from ischemia. In conclusion, we think that 3D-STE can assess myocardial ischemic memory.

Research Products

• [Journal Article] Myocardial ischaemia and post-systolic shortening (2015)
  • Author(s): Asanuma T, Nakatani S
  • Journal Title: Heart Volume: 101 Issue: 7 Pages: 509-516
  • DOI: 10.1136/heartjnl-2013-305403
  • Peer Reviewed
• [Journal Article] 壁運動評価にストレインは役立つか (2015)
  • Author(s): 浅沼俊彦, 中谷敏
  • Journal Title: 心エコー Volume: 16 Pages: 348-352
• [Journal Article] EFの一歩先行く収縮能評価 (2014)
  • Author(s): 浅沼俊彦, 中谷敏
  • Journal Title: 心エコー Volume: 15 Pages: 4-11
• [Journal Article] Myocardial layer-specific analysis of ischemic memory imaging using speckle tracking echocardiography (2014)
  • Author(s): Sakurai D, Asanuma T, Masuda K, Hioki A, Nakatani S.
  • Journal Title: Int J Cardiovasc Imaging Volume: 30 Issue: 4 Pages: 739-748
  • DOI: 10.1007/s10554-014-0388-x
  • Peer Reviewed
• [Journal Article] ストレインエコー法でみえるもの (2013)
  • Author(s): 浅沼俊彦, 中谷敏
  • Journal Title: Heart View Volume: 17 Pages: 89-95
• [Journal Article] ストレインはどのようなときに有用か (2013)
  • Author(s): 浅沼俊彦, 中谷敏
  • Journal Title: 心エコー Volume: 14 Pages: 186-193
• [Journal Article] Post-systolic shorteningについて (2013)
  • Author(s): 浅沼俊彦, 中谷敏
  • Journal Title: 循環器内科 Volume: 73 Pages: 218-223
  • NAID: 40019592035
• [Presentation] Post-systolic shortening and early systolic lengthening in the ischemic segment are affected by the contractility in its adjacent segment (2014)
  • Author(s): Sakurai D, Asanuma T, Masuda K, Oka M, Kotani K, Inoue K, Nakatani S
  • Organizer: Scientific Sessions 2014 of the American Heart Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Myocardial ischemic memory assessed by 3D speckle tracking echocardiography: comparison of circumferential, longitudinal, and radial strains (2014)
  • Author(s): Masuda K, Asanuma T, Koriyama H, Sakurai D, Oka M, Kotani K, Nakatani S
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Diagnostic ability of early systolic lengthening in evaluating myocardial ischemic memory (2014)
  • Author(s): Masuda K, Asanuma T, Koriyama H, Sakurai D, Oka M, Kotani K, Nakatani S
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] ストレイン技術の臨床応用 (2014)
  • Author(s): 浅沼俊彦
  • Organizer: 第39回日本超音波検査学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-06-13 – 2014-06-15
  • Invited
• [Presentation] 3Dスペックルトラッキング法による心筋虚血評価: Activation Imagingを用いた検討 (2014)
  • Author(s): 岡雅通, 浅沼俊彦, 増田佳純, 櫻井大輔, 郡山晃, 中谷敏
  • Organizer: 第25回日本心エコー図学会学術集会
  • Place of Presentation: 石川県立音楽堂, 金沢市アートホール
  • Year and Date: 2014-04-17 – 2014-04-19
• [Presentation] Evaluation of myocardial ischemic memory using 3-dimensional speckle tracking echocardiography. (2013)
  • Author(s): 浅沼俊彦,増田佳純, 中谷敏.
  • Organizer: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: パシフィコ横浜(招待講演)
  • Year and Date: 2013-03-15
• [Presentation] Mechanism of myocardial ischemic memory: why does post-systolic shortening persist after brief ischemia? (2013)
  • Author(s): Masuda K, Asannuma T, Sakurai D, Koriyama H, Nakatani S.
  • Organizer: European Society of Cardiology Congress 2013
  • Place of Presentation: Amsterdam (Netherlands)
• [Presentation] Post-systolic shorteningによる虚血メモリー評価はラットにおいても可能か (2013)
  • Author(s): 種谷遼太, 浅沼俊彦, 増田佳純, 中谷敏
  • Organizer: 第24回日本心エコー図学会学術集会
  • Place of Presentation: 東京
• [Presentation] 心筋虚血メモリーのメカニズム：なぜpost-systolic shorteningは残存するのか (2013)
  • Author(s): 増田佳純, 浅沼俊彦, 櫻井大輔, 郡山晃, 中谷敏
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪
• [Presentation] Post-systolic shorteningとdiastolic stunningについての事実と考察 (2013)
  • Author(s): 浅沼俊彦
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪
• [Presentation] Assessment of myocardial ischemic memory using 3-dimensional speckle tracking echocardiography. (2012)
  • Author(s): Masuda K, Asanuma T, Koriyama H, Sakurai D, Nakatani S.
  • Organizer: Scientific Sessions 2012 of the American Heart Association
  • Place of Presentation: Los Angeles, USA(招待講演)
  • Year and Date: 2012-11-07