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Human size OMRI scanner system

Research Project

Project/Area Number 24300183
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical systems
Research InstitutionKyushu University

Principal Investigator

ICHIKAWA Kazuhiro  九州大学, 先端融合医療創成センター, 教授 (10271115)

Co-Investigator(Kenkyū-buntansha) HYODO Fuminori  九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (10380693)
YASUKAWA Keiji  九州大学, 大学院薬学研究院, 助教 (80372738)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords生体レドックス / イメージング / フリーラジカル / 酸化ストレス / 生物・生体工学 / 可視化 / 生物物理 / バイオテクノロジー
Outline of Final Research Achievements

Changes in reduction-oxidation (redox) status are believed to be related with onsets or propagation of various diseases. In this project, technologies to improve redox-imaging apparatus for large object was developed for establishing clinical redox scanner as future goal. Based on a human size low field magnet, all major components including MRI T/R coil, ESR coil, preamplifier and digital detection systems have been carefully upgraded to achieve high signal-to-noise ration of redox images. As the results, under clinically relevant scan conditions such as scan time SAR a highly sensitive redox imaging system has been constructed.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (15 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (7 results)

  • [Journal Article] Change in Overhauser Effect-Enhaced MRI Signal in Response to uPA Highly Expressing in Tumor.2014

    • Author(s)
      Niidome T, Chijiwa N, Yamasaki T, Yamada K, Mori T, Naganuma T, Utsumi H, Ichikawa K, Katayaama Y
    • Journal Title

      Chem Letters

      Volume: 43 Issue: 7 Pages: 999-1001

    • DOI

      10.1246/cl.140209

    • NAID

      130004868241

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitroxyl Radicals-Modified Dendritic Poly(L-Lysine) that Images Tumor by Overhauser-Enhanced MRI.2014

    • Author(s)
      Niidome T, Gokuden R, Watanabe K, Mori T, Naganuma T, Utsumi H, Ichikawa K, Katayama Y:
    • Journal Title

      J Biomater Sci Polym Ed.

      Volume: 25 Issue: 13 Pages: 1425-1439

    • DOI

      10.1080/09205063.2014.943538

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer.2013

    • Author(s)
      Benial AM, Dhas MK, Ichikawa K, Yamada KI, Hyodo F , Jawahar A, Utsumi H
    • Journal Title

      Appl Magn Reson

      Volume: 44(4) Issue: 4 Pages: 439-47

    • DOI

      10.1007/s00723-012-0383-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A platform for designing hyperpolarized magnetic resonance chemical probes.2013

    • Author(s)
      H. Nonaka, R. Hata, T. Doura, T. Nishihara, K. Kymagai, M Akakabe, M. Tsuda, K. Ichikawa, S. Sando
    • Journal Title

      Nature Communication

      Volume: 4 Issue: 1 Pages: 1-7

    • DOI

      10.1038/ncomms3411

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo toxicity and antitumor activity of mangosteen extract.2012

    • Author(s)
      Kosem N
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 2 Pages: 255-263

    • DOI

      10.1007/s11418-012-0673-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo toxicity and antitumor activity of mangosteen extract2012

    • Author(s)
      Kosem N, Ichikawa K, Utsumi H, Moongkarndi P
    • Journal Title

      J Nat Med

      Volume: 67(2) Issue: 2 Pages: 255-63

    • DOI

      10.1016/j.freeradbiomed.2012.04.026

    • NAID

      40019608907

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress imaging in live animals with techniques based on electron paramagnetic resonance.2012

    • Author(s)
      Elas M, Ichikawa K, Halpern HJ
    • Journal Title

      Radiat Res.

      Volume: 177 Issue: 4 Pages: 514-523

    • DOI

      10.1667/rr2668.1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of a 13C Magnetic Resonance Probe Using a DeuteratedMethoxy Group as a Long-Lived Hyperpolarization Unit.2012

    • Author(s)
      Doura T, Hata R, Nonaka H, Ichikawa K, Sando S
    • Journal Title

      Angewandte Chemie

      Volume: 51(40) Issue: 40 Pages: 10114-7

    • DOI

      10.1002/anie.201202885

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Redox Molecular Imaging of Mouse Inflammation Model2014

    • Author(s)
      S.Sato, Y.Takeshita, K. Yamada, K. Ichikawa
    • Organizer
      Society of Free Radical Research International 2014
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Construction of OMRI scanner for imaging redox status of large animal2014

    • Author(s)
      R.Kobayashi, C.Tamura, K. Ichikawa
    • Organizer
      Society of Free Radical Research International 2014
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] 磁気共鳴法による生理機能イメージング法の開発2012

    • Author(s)
      市川和洋
    • Organizer
      蛋白研セミナー「磁気共鳴の先端計測技術と生体系への展開」
    • Place of Presentation
      大阪大学タンパク質研究所(招待講演)
    • Year and Date
      2012-07-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Imaging in vivo oxidative diseases using OMRI.2012

    • Author(s)
      K. Ichikawa
    • Organizer
      Conference of Zavoisky Award in ESR Spectroscopy
    • Place of Presentation
      Kazan, Russia(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of Overhauser enhanced MRI for imaging in vivo Physiological function.2012

    • Author(s)
      K. Ichikawa
    • Organizer
      10th International Sylposium for Future Drug Discovery & Medical care
    • Place of Presentation
      Hokkaido University(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Imaging in vivo oxidative diseases using OMRI.2012

    • Author(s)
      K. Ichikawa
    • Organizer
      Asia-Pasific EPR/ESR Symposium.
    • Place of Presentation
      Beijing, China(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Redox Molecular Imaging of Mouse Inflammation Model.2012

    • Author(s)
      K. Ichikawa, S. Sato, et al.
    • Organizer
      EPR Symposium of the 2012 Rocky Mountain Conference on analytical Chemistry
    • Place of Presentation
      Colorado USA
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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