| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
Magnetic particle imaging (MPI) has attracted interest for the early diagnosis of cancer and cardiovascular disease. This procedure can be used for signal acquisition with high sensitivity and spatial resolution compared with magnetic resonance imaging. However, because an unnecessary magnetization response will be detected from the target region near the magnetic nanoparticle (MNP), the spatial resolution deteriorates and/or an artifact will appear in the region where an MNP originally does not exist.
In this study, the image quality and spatial resolution of MPI are improved using an image reconstruction method based on the correlation information of an observed magnetization signal and system function. In particular, the particle distribution is estimated iteratively from the difference between a reference image reconstructed using correlation information and an image calculated theoretically by numerical analysis.
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