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Development of pulmonary rehabilitation improving prognosis by focusing on cough and swallowing functions.

Research Project

Project/Area Number 24300187
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionToho University (2013-2015)
Tohoku University (2012)

Principal Investigator

EBIHARA Satoru  東邦大学, 医学部, 教授 (90323013)

Co-Investigator(Kenkyū-buntansha) KOHZUKI Masahiro  東北大学, 医学系研究科, 教授 (70234698)
Co-Investigator(Renkei-kenkyūsha) OSAKA Ken  東北大学, 歯学研究科, 教授 (60300935)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords咳 / 嚥下障害 / 咳嗽障害 / 誤嚥性肺炎 / 呼吸リハビリテーション / 間質性肺炎 / Somatic cough syndrome / Unexplained cough / Dystussia / Aspiration pneumonia / 咳嗽 / 咳衝動 / 性差 / 咳嗽評価法 / 咳反射 / 振動刺激 / 呼吸困難 / 痛み / TRPV1 / TRPA1 / 医療費 / 予後
Outline of Final Research Achievements

In order to improve the prognosis of the respiratory patients who received the pulmonary rehabilitation, we developed the efficient rehabilitation program focusing on dyspnea, dysphagia and dystussia. We developed the several methods to inhibit cough in patients with excessive cough. We also developed the methods to ameliorate dyspnea in respiratory patients with shortness of breathing. In addition, we developed the methods to restore the functioning cough in patients with aspiration pneumonia. Using the methods, we found the paradigm shift of pulmonary rehabilitation. Program in interstitial pneumonia is to recover swallowing function and inhibit cough reflex sensitivity. Program in COPD and aspiration pneumonia is to slow the functional decline “dementia → dysphagia → dystussia → atussia → silent aspiration.” Atussia is ultimate dysfunction of cough physiology, and aspiration with atussia is called silent aspiration, which leads to the development of aspiration pneumonia.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (27 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (19 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 19 results,  Open Access: 8 results,  Acknowledgement Compliant: 5 results) Presentation (7 results) (of which Invited: 6 results) Remarks (1 results)

  • [Journal Article] Dysphagia, dystussia, and aspiration pneumonia in elderly people.2016

    • Author(s)
      Ebihara S, Sekiya H, Miyagi M, Ebihara T, Okazaki T.
    • Journal Title

      J Thorac Dis

      Volume: 8 Issue: 3 Pages: 632-9

    • DOI

      10.21037/jtd.2016.02.60

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The wish to die among palliative home care clients in Ontario, Canada: A cross-sectional study.2016

    • Author(s)
      Freeman S, Smith TF, Neufeld E, Fisher K, Ebihara S.
    • Journal Title

      BMC Palliat Care

      Volume: 15 Issue: 1 Pages: 24-24

    • DOI

      10.1186/s12904-016-0093-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Somatic Cough Syndrome(Previously Referred to as Psychogenic Cough)and Tic Cough(Previously Referred to as Habit Cough)in Adults and Children2015

    • Author(s)
      Vertigan AE, Ebihara S, et al (58人中28番目).
    • Journal Title

      Chest

      Volume: 148 Issue: 1 Pages: 24-31

    • DOI

      10.1378/chest.15-0423

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assessment of Intervention Fidelity and Recommendations for Researchers Conducting Studies on the Diagnosis and Treatment of Chronic Cough in the Adult:2015

    • Author(s)
      French CT, Ebihara S, et al (58人中28番目).
    • Journal Title

      Chest

      Volume: 148 Issue: 1 Pages: 32-35

    • DOI

      10.1378/chest.15-0164

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Treatment of Unexplained Chronic Cough2015

    • Author(s)
      Gibson P, Ebihara S, et al (58人中28番目).
    • Journal Title

      Chest

      Volume: 149 Issue: 1 Pages: 27-44

    • DOI

      10.1378/chest.15-1496

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tools for assessing outcomes in studies of chronic cough2015

    • Author(s)
      Boulet LP, Ebihara S, et al.
    • Journal Title

      Chest

      Volume: 146 Issue: 3 Pages: 804-814

    • DOI

      10.1378/chest.14-2506

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overview of the Management of Cough2014

    • Author(s)
      Irwin RS, Ebihara S, et al.
    • Journal Title

      Chest

      Volume: 146 Issue: 4 Pages: 885-889

    • DOI

      10.1378/chest.14-1485

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methodologies for the development of the management of cough2014

    • Author(s)
      Lewis SZ, Ebihara S, et al.
    • Journal Title

      Chest

      Volume: 146 Issue: 5 Pages: 1395-1402

    • DOI

      10.1378/chest.14-1484

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anatomy and neurophysiology of cough2014

    • Author(s)
      Canning BJ, Ebihara S, et al.
    • Journal Title

      Chest

      Volume: 146 Issue: 6 Pages: 1633-1648

    • DOI

      10.1378/chest.14-1481

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement in taste sensitivity following pulmonary rehabilitation in patients with chronic obstructive pulmonary disease.2014

    • Author(s)
      Ito K, Kohzuki M, Takahashi T, Ebihara S
    • Journal Title

      J Rehabil Med

      Volume: 46 Issue: 9 Pages: 932-936

    • DOI

      10.2340/16501977-1861

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gender differences in the effect of urge-to-cough and dyspnea on perception of pain in healthy adults2014

    • Author(s)
      Gui P, Ebihara T, Sato R, Ito K, Kohzuki M, Ebihara S
    • Journal Title

      Physiological Reports

      Volume: 2 Issue: 8 Pages: 1-9

    • DOI

      10.14814/phy2.12126

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Thermal Taste and Anti-Aspiration Drugs: a Novel Drug Discovery against Pneumonia.2014

    • Author(s)
      Ebihara S, Ebihara T, Gui P, Osaka K, Sumi Y, Kohzuki M.
    • Journal Title

      Curr Pharm Des.

      Volume: In press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of cervical trachea and chest wall vibrations on cough reflex sensitivity and perception of urge-to-cough in healthy male never-smokers2013

    • Author(s)
      Kashiwazaki N, Ebihara S, Gui P, Katayama N, Ito K, Sato R, Oyama C, Ebihara T, Kohzuki M.
    • Journal Title

      Cough

      Volume: 9 Issue: 1 Pages: 22-22

    • DOI

      10.1186/1745-9974-9-22

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro2013

    • Author(s)
      Kaijun Niu, Hui Guo, Yinting Guo, Satoru Ebihara, Masanori Asada, Takashi Ohrui, Katsutoshi Furukawa, Masakazu Ichinose,Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai, Tatsuma Okazaki, and Ryoichi Nagatomi
    • Journal Title

      Journal of Gerontology: Biological Sciences

      Volume: (掲載確定) Issue: 12 Pages: 1482-1492

    • DOI

      10.1093/gerona/glt041

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between pulmonary function and brain volume in healthy elderly subjects2013

    • Author(s)
      Taki Y, Kinomura S, Ebihara S, Thyreau B, Sato K, Goto R, Kakizaki M, Tsuji I, Kawashima R, Fukuda H
    • Journal Title

      Neuroradiology

      Volume: 55 Issue: 6 Pages: 689-695

    • DOI

      10.1007/s00234-013-1157-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Response letter to Lakin and Doe.2013

    • Author(s)
      Ebihara S, Shannon F, Sakamoto Y et al.
    • Journal Title

      J Am Geriatr Soc

      Volume: 61 Issue: 2 Pages: 313-314

    • DOI

      10.1111/jgs.12108

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urge-to-cough and dyspnea conceal perception of pain in healthy adults.2012

    • Author(s)
      Gui P, Ebihara S, Ebihara T, Kanezaki M, Kashiwazaki N, Ito K, Kohzuki M
    • Journal Title

      Respir Physiol Neurobiol

      Volume: 81 Pages: 214-219

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of blunted perception of dyspnea on medical care use and expenditure, and mortality in elderly people.2012

    • Author(s)
      Ebihara S, Niu K, Ebihara T, Kuriyama S, Hozawa A, Ohmori-Matsuda K, Nakaya N, Nagatomi R, Arai H, Kohzuki M, Tsuji I.
    • Journal Title

      Front Physiol.

      Volume: 3 Pages: 238-238

    • DOI

      10.3389/fphys.2012.00238

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urge to cough and dyspnea conceal perception of pain in healthy adults2012

    • Author(s)
      Gui P, Ebihara S, Ebihara T, Kanezaki M, Kashiwazaki N, Ito K, Kohzuki M
    • Journal Title

      Respir Physiol Neurobiol

      Volume: 181 Issue: 2 Pages: 214-9

    • DOI

      10.1016/j.resp.2012.03.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 誤嚥性肺炎最新発症メカニズムと嚥下ニューロリハビリテーション2015

    • Author(s)
      海老原覚
    • Organizer
      第21回日本摂食嚥下リハビリテーション学会学術集会
    • Place of Presentation
      京都国際会館(京都市、左京区)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Cough in elderly people and aspiration pneumonia2015

    • Author(s)
      Satoru Ebihara
    • Organizer
      China-USA-Japan-NZ Joint Summit on Cough, 2015
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 感覚を刺激して嚥下機能の改善を図る2015

    • Author(s)
      海老原覚
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都、千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 東邦大学における呼吸器関連リハビリテーションの取り組み2015

    • Author(s)
      海老原 覚
    • Organizer
      第37回日本リハビリテーション医学会東北地方会
    • Place of Presentation
      仙台市情報産業プラザ(宮城県・仙台市)
    • Year and Date
      2015-03-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cough in older people2014

    • Author(s)
      Ebihara S
    • Organizer
      European Respiratory Society International Conference
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 頚部気管および胸壁の振動刺激の健常成人における呼吸困難と咳反射・咳衝動に対する影響の検討.2014

    • Author(s)
      海老原 覚, 大国 生幸, 後藤 加奈子, 上月 正博
    • Organizer
      第51回日本リハビリテーション医学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2014-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cough sensitivity and aspiration in the elderly

    • Author(s)
      Satoru Ebihara
    • Organizer
      The First International Cough Conference (China, 2013)
    • Place of Presentation
      Guangzhou, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 東邦大学 教育・研究業績データベース

    • URL

      http://gyoseki.toho-u.ac.jp/thuhp/KgApp?kyoinId=ymiegogsggo&sessionId=6430106315

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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