| Project/Area Number |
24300188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
MORI Nobuyoshi 東北大学, 医学(系)研究科(研究院), 助教 (50463790)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Osamu 東北大学, 医学系研究科, 准教授 (00361072)
TOTSUNE Kazuhito 東北福祉大学, 総合福祉学部, 教授 (10217515)
HIROSE Takuo 東北大学, 医学系研究科, 助教 (20599302)
KOHZUKI Masahiro 東北大学, 医学系研究科, 教授 (70234698)
高橋 和広 (高橋 和弘) 東北大学, 医学(系)研究科(研究院), 教授 (80241628)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 心不全 / 運動療法 / 心 / 運動 / 臓器保護 / 心臓 |
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| Outline of Final Research Achievements |
Rats underwent left coronary artery ligation to induce CHF and were randomly assigned to sedentary, treadmill exercise or Candesartan-treat groups 4 weeks after myocardial infarction.
Eight weeks later, left ventricular ejection fraction of Candesartan-treated group showed an improvement trend in echocardiography. Lung weight per body weight ratio was reduced in the exercise group. Heart weight per body weight ratio was reduced by Candesartan group. It is being analyzed for changes in vasoactive substances and extracellular matrix proteins.
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