Molecular mechanisms of muscular stiffness and their application to human physiology
| Project/Area Number |
24300221
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHII NAOKATA 東京大学, 総合文化研究科, 教授 (20151326)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAZATO Kouichi 日本体育大学, 保健医療学部, 教授 (00307993)
SASAKI Kazushige 日本女子大学, 家政学部, 講師 (00451849)
OCHI Eisuke 岡山大学, 教育学研究科(研究院), 講師 (90468778)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 筋スティフネス / 超音波剪断波 / 長さ－張力関係 / 長さ－スティフネス関係 / 伸張性収縮 / 短縮性収縮 / クロスブリッジ / 筋疲労 / 協同筋 / 活動交替 / 筋線維タイプ / 筋活動 / 超音波伝搬速度 / 安静時筋スティフネス / 長さースティフネス関係 / 筋伸張 / 長さ-張力関係 / 長さ-スティフネス関係 / 動物トレーニングモデル |
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| Outline of Final Research Achievements |
Molecular mechanisms underlying active stiffness (AS) and passive stiffness (PS) of human skeletal muscle were investigated in vivo, by using supersonic shear-wave measurements. In isometric contractions, AS was proportional to both the activation level of muscle and the amount of overlap between thick and thin filaments. In isotonic contractions, the ratio between contractile force and AS (force/AS) was larger under the eccentric condition than under the concentric condition. Muscular fatigue caused changes in the relationship between AS and EMG amplitude apparently in a fiber type dependent fashion. Sustained muscular tone with low activation level caused a slight increase in PS, whereas repeated dynamic contractions caused a transient decrease in PS. These results suggest that muscular stiffness is mainly originated from interactions between actin and myosin and its quantification in vivo is useful to investigate the state of muscle during a variety of human movements.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Effect of resistance training using bodyweight in the elderly:Comparison of resistance exercise movement between slowand normal speed movement.2015
Author(s)
Wtanabe, Y., Tanimoto, M., Oba, N., Sanada, K., Miyachi, M., Ishii, N.
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Journal Title
Geriatric and Gerontology International
Volume: 15
Issue: 12
Pages: 1270-1277
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between bilateral differences in single-leg jumps and asymmetry in isokinetic knee strength.2013
Author(s)
Kobayashi, Y., Kubo, J., Matsubayashi, T., Matsuo, A., Kobayashi, K., Ishii, N.
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Journal Title
J. Appl. Biomech.
Volume: 29
Pages: 61-67
Related Report
Peer Reviewed
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[Journal Article] Increased muscle size and strength from slow-movement, low-intwnsity resistance exercise and tonic force generation.2013
Author(s)
Watanabe, Y., Tanimoto, M., Ohkane, A., Miyachi, M., Ishii, N.
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Journal Title
J. Aging Phys. Activity
Volume: 21
Pages: 71-84
Related Report
Peer Reviewed
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[Journal Article] Acceleration patterns in the lower and upper trunk during running.2013
Author(s)
Kawabata, M., Goto, K., Fukuzaki, C., Sasaki, K., Hihara, T., Ishii, N.
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Journal Title
J. Sport Sci.
Volume: 31
Pages: 1841-1853
Related Report
Peer Reviewed
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