| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
Sarcopenia is the age-related loss of skeletal muscle mass and strength leading to physical frailty, loss of independent daily living, increased lifestyle-related disease, and high health care costs. However, the mechanisms of sarcopenia remain unclear. Exercise is well established as the most effective non-pharmacological intervention to prevent sarcopenia. This study examined the effect of physical activity or inactivity on histone modification in the skeletal muscle. Our results suggest that physical activity or inactivity induce epigenetic modification in the skeletal muscle.
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