Identifying older adults physical activity pattern to delay the cognitive decline process

• Project/Area Number: 24300240
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: PARK Hyuntae 独立行政法人国立長寿医療研究センター, 老年学・社会科学研究センター, 研究員 (10506976)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000); Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 認知機能 / 身体活動 / 脳機能 / 加齢 / 軽度認知症 / 高齢者 / 老年症候群 / 認知症 / 加齢・老化 / 運動 / 生活習慣

Outline of Final Research Achievements

Age-related decrements in cognitive function have been atrophy in brain structure and cognitive impairment. However, the relationships between the difference of daily physical activity and brain cortical activity associated with short term memory processes in older adults remain unclear.　The current study found that higher physically activity older adults showed increased activation in the middle frontal gyrus, cingulate gyrus, fusiform gyrus, inferior parietal gyrus, supramarginal regions compared with lower physically activity older adults, it appears possible that this finding might be explained by cognitive efficiency. In addition, physical function in the elderly, especially walking speed, was revealed to be an important factor to predict cognitive function and flail or pre-frail and long-term screening and assessment.

Research Products

• [Journal Article] Effects of a 12-week healthy-life exercise program on oxidized low-density lipoprotein cholesterol and carotid intima-media thickness in obese elderly women (2015)
  • Author(s): Park J, Park H, Lim S, Park J
  • Journal Title: J Phys Therapy Sci Volume: 27 Pages: 1-5
  • NAID: 130005072247
  • Peer Reviewed / Open Access
• [Journal Article] The Association Between Kidney Function and Cognitive Decline in Community-Dwelling, Elderly Japanese People. (2015)
  • Author(s): Lee S, Shimada H, Park H, Makizako H, Lee S, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Suzuki T.
  • Journal Title: J Am Med Dir Assoc. Volume: 16 Issue: 4 Pages: 349.e1-349.e5
  • DOI: 10.1016/j.jamda.2014.12.009
  • Peer Reviewed
• [Journal Article] Going outdoors and cognitive function among community-dwelling older adults: Moderating role of physical function. (2015)
  • Author(s): Harada K, Lee S, Park H, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Suzuki T.
  • Journal Title: Geriatr Gerontol Int. Volume: in press Issue: 1 Pages: 1-5
  • DOI: 10.1111/ggi.12437
  • NAID: 120005997092
  • Peer Reviewed / Open Access
• [Journal Article] Objectively measured physical activity, brain atrophy, and white matter lesions in older adults with mild cognitive impairment. (2015)
  • Author(s): Doi T, Makizako H, Shimada H, Tsutsumimoto K, Hotta R, Nakakubo S, Park H, Suzuki T.
  • Journal Title: Experimental Gerontology Volume: 62 Pages: 1-6
  • DOI: 10.1016/j.exger.2014.12.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment. (2015)
  • Author(s): Makizako H, Liu-Ambrose T, Shimada H, Doi T, Park H, Tsutsumimoto K, Uemura K, Suzuki T.
  • Journal Title: J Gerontol A Biol Sci Med Sci. Volume: 70 Issue: 4 Pages: 480-6
  • DOI: 10.1093/gerona/glu136
  • Peer Reviewed / Open Access
• [Journal Article] Effects of enteric-coated lactoferrin supplementation on the immune function of elderly individuals: A randomised, double-blind, placebo-controlled trial (2015)
  • Author(s): H. Kawakami, H. Park, S. Park, H. Kuwata, R.J. Shephard, Y. Aoyagi
  • Journal Title: International Dairy Journal Volume: 47 Pages: 79-85
  • DOI: 10.1016/j.idairyj.2015.02.001
  • Peer Reviewed
• [Journal Article] Depressive symptoms in older adults are associated with decreased cerebral oxygenation of the prefrontal cortex during a trail-making test. (2015)
  • Author(s): Uemura K, Shimada H, Doi T, Makizako H, Park H, Suzuki T.
  • Journal Title: Arch Gerontol Geriatr. Volume: 59 Issue: 2 Pages: 422-428
  • DOI: 10.1016/j.archger.2014.07.003
  • Peer Reviewed
• [Journal Article] Habitual physical activity and milk intake in the elderly (2015)
  • Author(s): Kawakami H, Park H, Park S, Aoyagi Y
  • Journal Title: Milk Science Volume: 63 Pages: 145-153
  • NAID: 130005003552
  • Peer Reviewed
• [Journal Article] Depressive symptoms and cognitive performance in older adults. (2014)
  • Author(s): Shimada H, Park H, Makizako H, Doi T, Lee S, Suzuki T.
  • Journal Title: Journal of Psychiatric Research Volume: 57 Pages: 149-156
  • DOI: 10.1016/j.jpsychires.2014.06.004
  • Peer Reviewed
• [Journal Article] A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly. (2014)
  • Author(s): Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Lee S, Park H, Suzuki T
  • Journal Title: Frontiers in Aging Neuroscience Volume: (未定)(印刷中) Pages: 1-9
  • DOI: 10.3389/fnagi.2014.00069
  • Peer Reviewed / Open Access
• [Journal Article] Brain activation during dual-task walking and executive function among older adults with mild cognitive impairment : a fNIRS study (2013)
  • Author(s): Doi T, Makizako H, Shimada H, Park H, Tsutsumimoto K, Uemura K, Suzuki T
  • Journal Title: Aging Clin Exp Res Volume: 25(5) Issue: 5 Pages: 539-544
  • DOI: 10.1007/s40520-013-0119-5
  • Peer Reviewed
• [Journal Article] Relationship between going outdoors daily and activation of the prefrontal cortex during verbal fluency tasks among older adults : a near-infrared spectroscopy study. (2013)
  • Author(s): Makizako H, Doi T, Shimada H, Part H, Uemura K, Yoshida D, Tsutsumimoto K, Anan Y, Suzuki T.
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 56 Issue: 1 Pages: 118-123
  • DOI: 10.1016/j.archger.2012.08.017
  • Peer Reviewed
• [Journal Article] Six-minute walking distance is correlated with memory and brain volume in older adults with mild cognitive impairment : A voxel-based morphometry study (2013)
  • Author(s): Makizako H, Shimada H, Doi T, Park H, Suzuki T.
  • Journal Title: Dementia and Geriatric Cognitive Disorders Extra Volume: 3(1) Issue: 1 Pages: 223-32
  • DOI: 10.1159/000354189
  • Peer Reviewed
• [Journal Article] Combined Prevalence of Frailty and Mild Cognitive Impairment in a Population of Elderly Japanese People. (2013)
  • Author(s): Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Ito T, Lee S, Park H, Suzuki T.
  • Journal Title: J Am Med Dir Assoc. Volume: 14 Pages: 518-518
  • Peer Reviewed
• [Journal Article] Effectiveness of rehabilitation based on recreational activities: A systematic review (2013)
  • Author(s): Kamioka H, et al
  • Journal Title: World Journal of Meta-Analysis Volume: 1 Issue: 1 Pages: 27-46
  • DOI: 10.13105/wjma.v1.i1.27
  • Peer Reviewed
• [Journal Article] Performance-based assessments and demand for personal care in older Japanese people : a cross-sectional study (2013)
  • Author(s): Shimada H, Suzuki T, Suzukawa M, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Ito T, et al
  • Journal Title: BMJ Open Volume: 3(4) Issue: 4 Pages: 1-7
  • DOI: 10.1136/bmjopen-2012-002424
  • Peer Reviewed
• [Journal Article] Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment : A randomized controlled trial. (2013)
  • Author(s): Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Lee S, Park H.
  • Journal Title: BMC Neurology Volume: 12 Issue: 1 Pages: 128-128
  • DOI: 10.1186/1471-2377-12-128
  • Peer Reviewed
• [Presentation] Sensitive task measure of memory function on the story recall test in patients with mild cognitive impairment and mild Alzheimer's disease (2015)
  • Author(s): Park H, Sohn SW, Park JH, Park H
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Washinton DC, USA
  • Year and Date: 2015-07-18 – 2015-07-23
• [Presentation] Habitual physical activity and efficiency of cognitive networks during memory task in older adults (2015)
  • Author(s): Park H, Shimada H, Makizako H, Lee S, Doi T, Thuthumimoto K, Lee S, Harada K, Bae S, Suzuki T
  • Organizer: Organization for Human Brain Mapping
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2015-06-14 – 2015-06-18
• [Presentation] Health benefits of dancing, exercise and physical activity. (2014)
  • Author(s): Park H.
  • Organizer: 2014 Asian Game International Sports Science Conference
  • Place of Presentation: Inchon,Korea
  • Year and Date: 2014-08-20 – 2014-08-22
  • Invited
• [Presentation] EFFECTS OF MULTICOMPONENT EXERCISE IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT (2014)
  • Author(s): Hiroyuki Shimada, Hyuma Makizako, Takehiko Doi, Hyuntae Park, Kota Tsutsumimoto, Takao Suzuki
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-07-12 – 2014-07-17
• [Presentation] Objectively Measured Physical Activity And Calcaneal Bone Health In Older Japanese Adults: The Nakanojo Study. (2013)
  • Author(s): Park H, Shephard RJ, Park S, Aoyagi Y.
  • Organizer: 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement
  • Place of Presentation: Massachusetts(アメリカ)(発表確定)
  • Year and Date: 2013-06-17
• [Presentation] Objectively Measured Physical Activity And Appendicular Lean Tissue In Older Japanese Adults: The Nakanojo Study. (2013)
  • Author(s): Shephard RJ, Park H, Park S, Aoyagi Y.
  • Organizer: 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement
  • Place of Presentation: Massachusetts(アメリカ)(発表確定)
  • Year and Date: 2013-06-17
• [Presentation] Active living communities: promoting health through physical activities. (2013)
  • Author(s): Hyuntae Park
  • Organizer: WHO Global Forum on Innovation for Ageing Populations
  • Place of Presentation: kobe international conference center, 神戸
  • Invited
• [Presentation] Activity living Communities: Promoting physical activity for brain health and healthy aging (2013)
  • Author(s): Hyuntae Park
  • Organizer: International Symposium on Geriatrics and Gerontology
  • Place of Presentation: Aichi Health Praza Hall、愛知
  • Invited
• [Presentation] Physical Activity, Lifestyle and Cognitive Function. (2013)
  • Author(s): Hyuntae Park
  • Organizer: The 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: COEX Convention & Exhibition Center, Seoul, Korea
  • Invited
• [Presentation] Prevention of Cognitive Decline Among The Commnity Elderly Women. (2013)
  • Author(s): Suzuki T, Yoshida D, Makisako H, Park H, Lee S, Shimada H.
  • Organizer: The 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: COEX Convention & Exhibition Center, Seoul, Korea
• [Presentation] Volunteer activity and functional capacity among community-dwelling older adults in Japan: A 3 year longitudinal study. (2013)
  • Author(s): Lee S, Saito T, Park H, Shimada H, Kai I
  • Organizer: The 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: COEX Convention & Exhibition Center, Seoul, Korea
• [Presentation] Physical activity and musculoskeletal health in older adults. (2012)
  • Author(s): Park H
  • Organizer: (Active Life) The 7th International Sport Science Symposium
  • Place of Presentation: 早稲田大学東伏見キャンパス(東京都)(招待講演)
  • Year and Date: 2012-09-03
• [Presentation] Physical activity, lifestyle and cognitive function. (2012)
  • Author(s): Park H
  • Organizer: International Association of Gerontology and Geriatrics
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2012-06-23
• [Presentation] Habitual Physical Activity is Associated With Cognitive Function And The Risk Factors For Hip Fracture In Older Adults. (2012)
  • Author(s): Park H. Kwon Y, Kim E, Park J, Park S.
  • Organizer: American College of Sports Medicine 59th AnnualMeeting
  • Place of Presentation: San Francisco(アメリカ)
  • Year and Date: 2012-05-30
• [Book] Ecercise for older adults (2015)
  • Author(s): Park H, Kang S, Kim H, Lee K,
  • Total Pages: 258
  • Publisher: Daehan Media
• [Book] Dementia Care and Manegement (2015)
  • Author(s): Park H, Park K
  • Total Pages: 41
  • Publisher: Seriyun Co. Ltd
• [Book] Environmental factors and Exercise Science (2014)
  • Author(s): Park H, Park S
  • Total Pages: 180
  • Publisher: Doang-A Publishing
• [Book] Healt Care and Management (2014)
  • Author(s): Park H, Kim E, Kwon Y, Jung H, Park S
  • Total Pages: 261
  • Publisher: Dong-A Publishing