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Molecular mechanisms for astringency recognition of tea polyphenols

Research Project

Project/Area Number 24300252
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKobe Gakuin University (2016)
University of Shizuoka (2012-2015)

Principal Investigator

ISHII TAKESHI  神戸学院大学, 栄養学部, 准教授 (50448700)

Co-Investigator(Kenkyū-buntansha) 新井 映子  静岡県立大学, 食品栄養科学部, 教授 (90134783)
中山 勉  日本獣医生命科学大学, 公私立大学の部局等, 教授 (50150199)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords渋味 / 茶ポリフェノール / カテキン類 / テアフラビン類 / 分子間相互作用 / 発現機構 / 苦味 / 苦渋味評価 / 苦渋味抑制素材 / タンパク質凝集 / 生体応答 / 苦渋味抑制 / 酸化 / 分子会合 / 脂質膜蓄積 / 官能試験 / 分子間相互作用解析 / タンパク質凝集能 / 細胞膜結合能 / 会合能 / 渋味抑制素材
Outline of Final Research Achievements

Astringency is an important determinant of tea taste and is believed to be caused by aggregation of salivary proteins by polyphenols. But the details of molecular mechanisms for astringency recognition of tea polyphenols remain poorly understood. In this study, we characterized the astringency of tea polyphenols based on the new methods for the interaction of polyphenols with casein and phospholipid membranes. Validity and reliability of these methods on the evaluation of tea astringency were confirmed by the comparison with results of the taste sensor and human sensory evaluations. Based on the results obtained by these methods, we proposed a molecular mechanism for astringency recognition of catechins and theaflavins.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (57 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (42 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (2 results) Remarks (5 results)

  • [Journal Article] Activation of transient receptor potential ankyrin 1 by quercetin and its analogs.2016

    • Author(s)
      Toshiyuki Nakamura, Noriyuki Miyoshi, Takeshi Ishii, Miyu Nishikawa, Shinichi Ikushiro, Tatsuo Watanabe
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 80 Issue: 5 Pages: 949-954

    • DOI

      10.1080/09168451.2015.1132148

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes2015

    • Author(s)
      Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T., and Osakabe, N.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 9 Pages: e0137809-e0137809

    • DOI

      10.1371/journal.pone.0137809

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tea polyphenols ameliorate fat storage induced by high-fat diet in Drosophila melanogaster.2015

    • Author(s)
      Kayashima Y., Murata S., Sato M., Matsuura K., Asanuma T., Chimoto J., Ishii T., Mochizuki K., Kumazawa S., Nakayama T., Yamakawa-Kobayashi K
    • Journal Title

      Biochem. Biophys. Reports

      Volume: 4 Pages: 417-424

    • DOI

      10.1016/j.bbrep.2015.10.013

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A New Method for Detection of Self-associated Tea Polyphenols Using Native-polyacrylamide Gel Electrophoresis2014

    • Author(s)
      安井美奈、石井剛志
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 63 Issue: 8 Pages: 687-692

    • DOI

      10.2116/bunsekikagaku.63.687

    • NAID

      130004687306

    • ISSN
      0525-1931
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins2014

    • Author(s)
      Yamazaki, T., Sagisaka, M., Ikeda, R., Nakamura, T., Matsuda, N., Ishii, T., Nakayama, T., Watanabe, T.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 78 Issue: 10 Pages: 1753-1756

    • DOI

      10.1080/09168451.2014.930326

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural specificity of electric potentials in the coulometric-array analysis of catechins and theaflavins2014

    • Author(s)
      Matsuura, K., Usui, Y., Kan, T., Ishii, T., and Nakayama, T.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 55 Issue: 2 Pages: 103-109

    • DOI

      10.3164/jcbn.13-101

    • NAID

      130004678427

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats2014

    • Author(s)
      Aruga, N., Toriigahara, M., Shibata, M., Ishii, T., Nakayama, T., and Osakabe, N.
    • Journal Title

      J. Funct. Foods

      Volume: 10 Pages: 355-363

    • DOI

      10.1016/j.jff.2014.06.025

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of tea catechins with phsopholipid-roles in their tastes and biological activities.2012

    • Author(s)
      Nakayama, T., Ishii, T., Uekusa, Y, Kato, K., and Kumazawa, S.
    • Journal Title

      J. Food. Drug. Anal.

      Volume: 20(Suppl. 1) Pages: 305-308

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 渋味マスキング剤の開発を志向するロスマリン酸結合性大豆ペプチドの網羅的解析2017

    • Author(s)
      伊藤圭祐、増田百花、石井剛志
    • Organizer
      日本農芸化学会 2017年度大会
    • Place of Presentation
      京都市
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 茶殻の有効活用を目指した機能性ペプチドの探索2017

    • Author(s)
      伊藤圭祐、石井剛志、中村順行、河原崎泰昌
    • Organizer
      第32回茶学術研究会
    • Place of Presentation
      静岡市
    • Year and Date
      2017-03-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大豆ペプチドによるロスマリン酸の渋味マスキング2017

    • Author(s)
      増田百花、石井剛志、伊藤圭祐
    • Organizer
      第18回静岡ライフサイエンスシンポジウム
    • Place of Presentation
      静岡市
    • Year and Date
      2017-03-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 難吸収性ポリフェノールの渋味受容とその生理的意義の解析、2016

    • Author(s)
      石井剛志、越阪部奈緒美
    • Organizer
      フードサイエンスフォーラム第 22回 学術集会
    • Place of Presentation
      岡山県
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 食素材蛋白質の網羅的ペプチドアレイを用いた苦味マスキング剤の新規探索法 〜茶殻RubisCo由来EGCG結合ペプチドの解析例〜2016

    • Author(s)
      小池麻友、黒田侑希、伊藤圭祐、石井剛志、中村順行、渡辺達夫、河原崎泰昌
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 緑茶の苦渋味マスキング剤となる茶殻由来ペプチド2015

    • Author(s)
      小池麻友、黒田侑希、伊藤圭祐、石井剛志、中村順行、渡辺達夫、河原崎泰昌
    • Organizer
      平成27年度日本食品科学工学会中部支部大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] カテキン類とテアフラビン類のタンパク質凝集反応の分子挙動解析2015

    • Author(s)
      木村明博、安井美奈、小林彰子、赤川 貢、石井剛志
    • Organizer
      第12回日本カテキン学会年次学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] EGCG-binding peptides from green tea leaves as bitterness-masking agents2015

    • Author(s)
      Koike, M., Ito, K., Kuroda, Y., Ishii, T., Nakamura, Y., Watanabe, T., and Kawarasaki, Y.
    • Organizer
      The 20th Shizuoka Forum on Health and Longevity
    • Place of Presentation
      静岡市
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] テアフラビン類の脂質膜における分子挙動2014

    • Author(s)
      石井剛志、竹内由紀、安井美奈、小林彰子、保田倫子、下位香代子、越阪部奈緒美、中山 勉
    • Organizer
      第19回日本フードファクター学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] テアフラビン摂取後の急性的な循環動態の変化動2014

    • Author(s)
      齊藤晃子、中里李沙、柴田政廣、石井剛志、中山 勉、福井敏樹、越阪部奈緒美
    • Organizer
      第19回日本フードファクター学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂質膜透過性の低い茶ポリフェノールの会合挙動解析2014

    • Author(s)
      石井剛志、安井美奈、竹内由紀、中山 勉
    • Organizer
      日本分析化学会第63年会
    • Place of Presentation
      広島
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural specificity of electric potentials in the coulometric-array analysis of catechins, methylated catechins and theaflavins2014

    • Author(s)
      Nakayama, T., Matsuura, K., Usui, Y., Kan, T., and Ishii, T.
    • Organizer
      27th International Conference on Polyphenols
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食品および酸化ストレス関連因子による生体タンパク質の翻訳後修飾に関する研究2014

    • Author(s)
      石井剛志
    • Organizer
      日本農芸化学会中部支部-日本農芸化学会創立90周年・中部支部創立60周年記念-第170回例会
    • Place of Presentation
      静岡
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ポリフェノールーカフェイン複合体の形成を介した紅茶クリームダウンの分子機構解析2013

    • Author(s)
      石井剛志、太田有香、浅沼俊倫、鈴木俊美、望月一男、中山勉
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] テアフラビン類と蛋白質チオールとの共有結合反応2013

    • Author(s)
      林美香、石井剛志、浅沼俊倫、望月一男、中山勉
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] 茶ポリフェノールの渋味評価 -良薬口に渋し-2013

    • Author(s)
      加藤大地、安井美奈、新井映子、中山勉、石井剛志
    • Organizer
      第14回静岡ライフサイエンスシンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2013-03-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] 紅茶テアフラビン類の蛋白質に対する反応の解析2013

    • Author(s)
      林美香、石井剛志、加藤大地、安井美奈、浅沼俊倫、望月一男、中山勉
    • Organizer
      第28回茶学術研究会総会・講演会
    • Place of Presentation
      静岡
    • Year and Date
      2013-03-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 茶タンニンによるタンパク質凝集作用の解析2012

    • Author(s)
      石井剛志、加藤大地、市川達也、中山勉
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      博多
    • Year and Date
      2012-12-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular interaction of tea catechins with phospholipids-roles on their biological activities and tastes2012

    • Author(s)
      Nakayama, T., and Ishii, T.
    • Organizer
      The 18t International Conference on Pharma-Food
    • Place of Presentation
      静岡(招待講演)
    • Year and Date
      2012-11-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 茶ポリフェノールのタンパク質凝集作用が渋みの発現に及ぼす影響の解析2012

    • Author(s)
      加藤大地、石井剛志、安井美奈、中山勉
    • Organizer
      第17回日本フードファクター学会学術集会・第9回日本カテキン学会総会合同大会2012
    • Place of Presentation
      静岡
    • Year and Date
      2012-11-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 味認識装置を用いた茶ポリフェノールの渋味評価2012

    • Author(s)
      安井美奈、石井剛志、加藤大地、中山勉
    • Organizer
      第17回日本フードファクター学会学術集会・第9回日本カテキン学会総会合同大会2012
    • Place of Presentation
      静岡
    • Year and Date
      2012-11-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 紅茶のクリームダウン機構の解析2012

    • Author(s)
      太田有香、石井剛志、浅沼俊倫、望月一男、鈴木俊美、中山勉
    • Organizer
      第17回日本フードファクター学会学術集会・第9回日本カテキン学会総会合同大会2012
    • Place of Presentation
      静岡
    • Year and Date
      2012-11-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 太田有香、石井剛志、鈴木俊美、中山勉2012

    • Author(s)
      太田有香、石井剛志、鈴木俊美、中山勉
    • Organizer
      日本分析化学会第61年会
    • Place of Presentation
      金沢
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] ポリフェノールの味質と機能-分子間相互作用の立場から-2012

    • Author(s)
      中山勉、石井剛志
    • Organizer
      第17回国際食品素材/添加物展・会議JSoFFミニシンポ
    • Place of Presentation
      東京
    • Year and Date
      2012-05-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] ポリフェノール類の渋味評価法と渋味抑制素材の探索法の構築2012

    • Author(s)
      御手洗晴日、石井剛志、山田智、中山勉
    • Organizer
      第72回分析化学討論会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-05-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tea polyphenols: bane or bonanza? Interaction with phospholipids and proteins

    • Author(s)
      Nakayama, T. and Ishii, T.
    • Organizer
      Pharma-Nutrition 2013
    • Place of Presentation
      シンガポール
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 科学の目で見る茶の苦渋味

    • Author(s)
      石井剛志
    • Organizer
      世界お茶まつ2013春の祭典プログラムお茶の機能性・効用セミナー
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ネイティブ電気泳動を利用したポリフェノール会合体の検出法とその渋味評価への応用

    • Author(s)
      安井美奈、加藤大地、林 美香、中山 勉、石井剛志
    • Organizer
      第73回分析化学討論会
    • Place of Presentation
      函館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 渋味物質のタンパク質凝集能と細胞膜結合能の評価法

    • Author(s)
      林 美香、安井美奈、加藤大地、中山 勉、石井剛志
    • Organizer
      第73回分析化学討論会
    • Place of Presentation
      函館
    • Related Report
      2013 Annual Research Report
  • [Presentation] クーロアレイHPLCを用いたカテキン類とそのメチル誘導体の電気化学的解析

    • Author(s)
      松浦加奈子、臼井由美子、石井剛志、中山 勉
    • Organizer
      第73回分析化学討論会
    • Place of Presentation
      函館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 茶ポリフェノールの渋味発現に寄与する構造因子の解析

    • Author(s)
      石井剛志、安井美奈、加藤大地、林 美香、新井映子、中山 勉
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 茶ポリフェノールのタンパク質凝集能と細胞膜結合能が渋味の発現に及ぼす影響、第67回日本栄養・食糧学会大会

    • Author(s)
      加藤大地、安井美奈、林 美香、御手洗晴日、竹内由紀、中山 勉、石井剛志
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 茶ポリフェノールによるタンパク質凝集機構の解析

    • Author(s)
      林 美香、加藤大地、市川達也、安井美奈、浅沼俊倫、中山 勉、石井剛志
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] ネイティブ電気泳動を利用したポリフェノール会合体の検出法とその応用

    • Author(s)
      安井美奈、加藤大地、中山 勉、石井剛志
    • Organizer
      日本食品科学工学会第60回記念大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] タンパク質凝集能を指標とした飲料の渋味評価

    • Author(s)
      林 美香、安井美奈、加藤大地、中山 勉、石井剛志
    • Organizer
      日本食品科学工学会第60回記念大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of a new soybean-protein derived taste-masking agent that lowers bitterness and/or astringency of tea polyphenols

    • Author(s)
      Shiotani, S., Takahashi, C., Ogawa, M., Shibuya, E., Mitarai, H., Yasui, M., Saito, N., Ito, S., Suzuki, T., Yanai, N., Nakayama, T., and Ishii, T.
    • Organizer
      The 5th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Application of bitterness and/or astringency control material to tea products

    • Author(s)
      Watase, T., Ikegaya, A., Yugami, T., Hakamata, M., Takagi, H., Kamimura, M., Dohi, S., Tanzawa, N., Shiotani, S., Takahashi, C., Suzuki, T., Nakayama, T., and Ishii, T.
    • Organizer
      The 5th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] TAS2R39 is a bitter taste receptor for theaflavins

    • Author(s)
      Yamazaki, T., Sagisaka, M., Matsuda, N., Ishii, T., Nakayama, T., and Watanabe, T.
    • Organizer
      The 5th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] A new method involving detection of protein aggregation for evaluating the astringency of tea polyphenols

    • Author(s)
      Hayashi, M., Yasui, M., Saito, N., Nakayama, T., Ishii, T.
    • Organizer
      The 5th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structural specificity of electric potential in coulometric-array analysis of tea polyphenols

    • Author(s)
      Matsuura, K., Usui, Y., Ishii, T., and Nakayama T.
    • Organizer
      The 5th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] テアフラビンの抗酸化性と酸化安定性の解析

    • Author(s)
      松浦加奈子、石井剛志、中山 勉
    • Organizer
      第29回茶学術研究会講演会
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食品および酸化ストレス関連因子による生体タンパク質の翻訳後修飾に関する研究

    • Author(s)
      石井剛志
    • Organizer
      日本農芸化学会2014年度大会・奨励賞受賞者講演
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 新版 茶の機能 ヒト試験から分かった新たな役割 「苦味、渋味」2013

    • Author(s)
      石井剛志、中山 勉
    • Total Pages
      6
    • Publisher
      農山漁村文化協会
    • Related Report
      2013 Annual Research Report
  • [Book] 茶の機能と科学 「カテキン類とタンパク質との相互作用」2013

    • Author(s)
      石井剛志
    • Total Pages
      1
    • Publisher
      朝倉書店
    • Related Report
      2012 Annual Research Report
  • [Remarks] 神戸学院大学栄養学部食品機能学部門HP

    • URL

      http://www.nutr.kobegakuin.ac.jp/~foodsci/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 神戸学院大学Social in「渋味のメカニズムを解明してアジアから世界へと発信したい 」

    • URL

      http://www.kobegakuin.ac.jp/gakuho-net/infocus/2015/10.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 神戸学院大学HP 大学紹介 情報の公表-教員総覧(栄養学部)

    • URL

      https://www.kobegakuin.ac.jp/information/public/teacher/nutrition/ishii.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 静岡県立大学食品分子工学研究室HP「メンバー・石井剛志」

    • URL

      http://sfns.u-shizuoka-ken.ac.jp/foodbioc/member-isit.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://sfns.u-shizuoka-ken.ac.jp/foodbioc/woek.html

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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