Evaluation a novel molecular mechanism protecting lifestyle-related diseases by the food-derived components
| Project/Area Number |
24300255
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
INOUE Hiroyasu 奈良女子大学, 生活環境科学系, 教授 (40183743)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Rieko 奈良女子大学, 生活環境科学系, 講師 (90198119)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | PPAR / レスベラトロール / 誘導型シクロオキシゲナーゼ / 食品機能成分 / 生活習慣病予防 / 運動 / シクロオキシゲナーゼ / シクロオキシゼナーゼ |
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| Outline of Final Research Achievements |
We evaluated a novel molecular mechanism targeted PPAR activation, protecting lifestyle-related diseases by the food-derived components such as resveratrol. 4-week intake of resveratrol reduced plasma triglycerides, and upregulated the hepatic expression of PPARα-responsive genes in the wild-type (WT), but not in PPARα-knockout (KO) mice, and that, long-term intake of resveratrol in combination with a high-fat diet prevented the accumulation of lipids in both the white adipose tissue and the liver, improving life span. Moreover, habitual exercise with a intake of resveratrol induced the muscular expression of PPARα-responsive genes in WT, but not in KO mice and improved endurance capacity. We also found that 4’-hydroxyl group of resveratrol is critical for the direct activation of PPARα. Furthermore, a pungent component derived from plants and a major component of cinnamon bark oil activated PPAR and suppressed COX-2 expression.
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Report
(4 results)
Research Products
(43 results)
