| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
|---|
| Outline of Final Research Achievements |
Alkaline phosphatase (ALP) hydrolyzes a variety of monophosphate esters, and bone-type ALP is indispensable for bone mineralization. The bone mass may be determined by genetic as well as environmental factors. In this study, we demonstrated the effects of ALP gene expression on associations among aging and nutritional factors. Our data may be useful for the regulation of mineral metabolism, including the phosphate metabolism pathway. Following the research plan, we examined the effects on bone-type ALP and bone metabolism of various nutrients (vitamins and high-fat diet, etc.), and we reported our findings. Moreover, we analyzed the associations among dietary nutrients intakes, bone mass, bone-type ALP, and related genetic polymorphisms, and we published our discoveries.
|
