Association between functional alkaline phosphatase gene expression and aging and/or nutritional factors
| Project/Area Number |
24300259
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Japan Women's University |
|---|
Principal Investigator |
Goseki Masae 日本女子大学, 家政学部, 教授 (00170449)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
|---|
| Keywords | 骨量調節 / アルカリホスファターゼ / 遺伝子発現 / 栄養因子 / 食生活 |
|---|
| Outline of Final Research Achievements |
Alkaline phosphatase (ALP) hydrolyzes a variety of monophosphate esters, and bone-type ALP is indispensable for bone mineralization. The bone mass may be determined by genetic as well as environmental factors. In this study, we demonstrated the effects of ALP gene expression on associations among aging and nutritional factors. Our data may be useful for the regulation of mineral metabolism, including the phosphate metabolism pathway. Following the research plan, we examined the effects on bone-type ALP and bone metabolism of various nutrients (vitamins and high-fat diet, etc.), and we reported our findings. Moreover, we analyzed the associations among dietary nutrients intakes, bone mass, bone-type ALP, and related genetic polymorphisms, and we published our discoveries.
|
Report
(5 results)
Research Products
(32 results)
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Peyer’s patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy．2014
Author(s)
Haruyo Nakajima-Adachi, Akira Kikuchi, Yoko Fujimura, Kyoko Shibahara, Tsuyoshi Makino, Masae Goseki-Sone, Miran Kihara-Fujioka, Tomonori Nochi, Yosuke Kurashima, Osamu Igarashi, Masafumi Yamamoto, Jun Kunisawa, Masako Toda, Shuichi Kaminogawa, Ryuichiro Sato, Hiroshi Kiyono, Satoshi Hachimura
-
Journal Title
ＰＬｏＳ Ｏｎｅ
Volume: 9
Issue: 10
Pages: e107492-e107492
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Comparative study of the effects of milk and dairy products on bone metabolism in ovariectomized rats2012
Author(s)
Tanabe R, Haraikawa M, Sogabe N, Sugimoto A, Kawamura Y, Takasugi S,Nagata N, Yamaguchi A, Iimura T, Goseki-Sone M,
Organizer
34th Annual Meeting of the American Society for Bone and Mineral Research (USA)
Place of Presentation
Minneapolis, Minnesota, USA
Year and Date
2012-10-13
Related Report
-
-
-
-
-
-
-
-
-
