| Project/Area Number |
24300261
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
白土 健 杏林大学, 医学部, 助教 (60559384)
立屋敷 かおる 上越教育大学, その他部局等, その他 (20119324)
鈴木 英樹 愛知教育大学, 教育学部, 教授 (40235990)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 亜鉛（Zn）欠乏 / インスリン様成長因子‐１（IGF-1） / IGF-1受容体 （IGF-1R) / アドレナリン受容体 (AR) / 褐色脂肪組織 (BAT) / グルココルチコイド受容体 （GR) / 脱共役タンパク質（UCP)-1～３ / ラット骨格筋 / UCP-1 / ＩＧＦ-１ / 筋内IGF-1発現 / 血漿Zn濃度 / 血漿IGF-1濃度 / 褐色脂肪組織(ＢＡＴ) / 実験動物（ラット） / 亜鉛欠乏 / アドレナリン受容体 / 生体防御機能 / 白血球系細胞 / 脱共役タンパク質 / 血漿亜鉛濃度 / 亜鉛欠乏とストレス / 熱産生能 / ストレスホルモン / 熱産生 / 褐色脂肪組織 / ラット |
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| Outline of Final Research Achievements |
The effects of zinc(Zn)-deficiency on the expression of insulin-like growth factor-1（IGF-1)receptor(IGF-1R) in skeletal muscles of weaned SD male rats were studied. After the experiment for 2 and 4 weeks, the slow-twitch soleus (SOL) and fast-twitch extensor digitorum longus (EDL) muscles were isolated. Zn-deficiency for 4 weeks caused a significant reduction in the EDL of muscles. However, that of SOL muscles was not chnaged by Zn-deficiency. IGF1-R mRNA expression in EDL muscles significantly increased by 1.3 times in 2 and 4 weeks, whereas significant changes were not observed in SOL muscles. By contrast, IGF-1R protein expression in SOL muscles significantly increased by 2.1 times in 4 weeks, although significant changes were not observed in EDL muscles. These results suggest that the incresed expression of IGF-1R protein in SOL muscles in response to Zn-deficiency play an important role in the attenuation of delayed muscle development due to reduced plasma IGF-1 concentrations.
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