Analysis of molecular mechanism in the maintenance of cancer stem cells in the vascular niche
Project/Area Number |
24300330
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Tumor biology
|
Research Institution | Osaka University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
Keywords | 腫瘍血管新生 / 癌 / 血管新生 / ニッチ / がん幹細胞 / 血管 / 壁細胞 |
Outline of Final Research Achievements |
In this study, we defined the molecular cues surrounding blood vessels in the tumor and examined the interaction between blood vessels and cancer cells to know malignant progression of tumor. As a consequence, galactose binding lectin-3 (Gal-3) produced from tumor cells induces migration of macrophage from bone marrow into tumor for progression of tumor angiogenesis. Moreover, Tie2, a receptor tyrosine kinase, expressed in endothelial cells makes a soluble form to inhibit angiogenesis resulting in tumor growth suppression.
|
Report
(5 results)
Research Products
(72 results)
-
-
-
-
[Journal Article] APJ Regulates Parallel Alignment of Arteries and Veins in the Skin.2015
Author(s)
Kidoya H, Naito H, Muramatsu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N.
-
Journal Title
Dev Cell.
Volume: 33
Issue: 3
Pages: 247-259
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.2015
Author(s)
Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N, Kanaho Y.
-
Journal Title
Nat. Commun.
Volume: 6
Issue: 1
Pages: 7925-7925
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
[Journal Article] APJ regulates parallel alignment of arteries and veins in the skin2015
Author(s)
Kidoya K, Naito H, Muramatasu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart.2015
Author(s)
Kainuma S, Miyagawa S, Fukushima S, Pearson J, Chen YC, Saito A, Harada A, Shiozaki M, Iseoka H, Watabe T, Watabe H, Horitsugi G, Ishibashi M, Ikeda H, Tsuchimochi H, Sonobe T, Fujii Y, Naito H, Umetani K, Shimizu T, Okano T, Kobayashi E, Daimon T, Ueno T, Kuratani T, Toda K, Takakura N, Hatazawa J, Shirai M, Sawa Y.
-
Journal Title
Mol Ther
Volume: 23
Issue: 2
Pages: 374-386
DOI
Related Report
Peer Reviewed
-
[Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.2015
Author(s)
Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
-
Journal Title
Proc Natl Acad Sci USA
Volume: 112
Issue: 13
Pages: 4086-4091
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Evaluation of PSF1 as a prognostic biomarker for prostate cancer.2015
Author(s)
Tahara H, Naito H, Kise K, Wakabayashi T, Kamoi K, Okihara K, Yanagisawa A, Nakai Y, Nonomura N, Morii E, Miki T, Takakura N
-
Journal Title
Prostate Cancer Prostatic Dis
Volume: 18
Issue: 1
Pages: 56-62
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart2014
Author(s)
Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I
-
Journal Title
Nat Commun
Volume: 5
Issue: 1
Pages: 4452-4452
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014
Author(s)
Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
-
Journal Title
Diabetologia
Volume: 57
Pages: 1968-1976
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Essential role of endothelial class II PI3K-C2αin angiogenesis and vascular barrier function2012
Author(s)
Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz JR, Okamoto H, Sasaki T,Matsui O, Asano M, Adams HR, Takakura N, Takuwa Y.
-
Journal Title
Nature med
Volume: 18
Issue: 10
Pages: 1560-1569
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] The transcription factor Jun dimerization protein 2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation2012
Author(s)
kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, and Shizuo Akira
-
Journal Title
Immunity
Volume: 37
Issue: 6
Pages: 1024-1036
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 血管形成と幹細胞制御2014
Author(s)
高倉 伸幸
Organizer
第38回日本リンパ学会総会
Place of Presentation
北里大学薬学部コンベンションホール(東京)
Year and Date
2014-06-20
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-