Analysis of molecular mechanism in the maintenance of cancer stem cells in the vascular niche

• Project/Area Number: 24300330
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Osaka University
• Principal Investigator: Takakura Nobuyuki 大阪大学, 微生物病研究所, 教授 (80291954)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 腫瘍血管新生 / 癌 / 血管新生 / ニッチ / がん幹細胞 / 血管 / 壁細胞

Outline of Final Research Achievements

In this study, we defined the molecular cues surrounding blood vessels in the tumor and examined the interaction between blood vessels and cancer cells to know malignant progression of tumor. As a consequence, galactose binding lectin-3 (Gal-3) produced from tumor cells induces migration of macrophage from bone marrow into tumor for progression of tumor angiogenesis. Moreover, Tie2, a receptor tyrosine kinase, expressed in endothelial cells makes a soluble form to inhibit angiogenesis resulting in tumor growth suppression.

Research Products

• [Int'l Joint Research] University of Muenster(ドイツ)
• [Journal Article] Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors (2016)
  • Author(s): Supranee Phanthanawiboon, Kriengsak Limkittikul, Yusuke Sakai, Nobuyuki Takakura, Masayuki Saijo and Takeshi Kurosu
  • Journal Title: PLOSOne Volume: 4 Issue: 2 Pages: e0148564-e0148564
  • DOI: 10.1371/journal.pone.0148564
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy. (2016)
  • Author(s): Zhang L, Takara K, Yamakawa D, Kidoya H, Takakura N.
  • Journal Title: Cancer Sci Volume: 107 Issue: 1 Pages: 36-44
  • DOI: 10.1111/cas.12836
  • Peer Reviewed / Open Access
• [Journal Article] APJ Regulates Parallel Alignment of Arteries and Veins in the Skin. (2015)
  • Author(s): Kidoya H, Naito H, Muramatsu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N.
  • Journal Title: Dev Cell. Volume: 33 Issue: 3 Pages: 247-259
  • DOI: 10.1016/j.devcel.2015.02.024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling. (2015)
  • Author(s): Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N, Kanaho Y.
  • Journal Title: Nat. Commun. Volume: 6 Issue: 1 Pages: 7925-7925
  • DOI: 10.1038/ncomms8925
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors. (2015)
  • Author(s): Han Y, Gong ZY, Takakura N.
  • Journal Title: Exp Cell Res Volume: 334 Issue: 2 Pages: 183-193
  • DOI: 10.1016/j.yexcr.2015.04.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] APJ regulates parallel alignment of arteries and veins in the skin (2015)
  • Author(s): Kidoya K, Naito H, Muramatasu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N.
  • Journal Title: Dev Cell Volume: inpress
  • Peer Reviewed
• [Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart. (2015)
  • Author(s): Kainuma S, Miyagawa S, Fukushima S, Pearson J, Chen YC, Saito A, Harada A, Shiozaki M, Iseoka H, Watabe T, Watabe H, Horitsugi G, Ishibashi M, Ikeda H, Tsuchimochi H, Sonobe T, Fujii Y, Naito H, Umetani K, Shimizu T, Okano T, Kobayashi E, Daimon T, Ueno T, Kuratani T, Toda K, Takakura N, Hatazawa J, Shirai M, Sawa Y.
  • Journal Title: Mol Ther Volume: 23 Issue: 2 Pages: 374-386
  • DOI: 10.1038/mt.2014.225
  • Peer Reviewed
• [Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. (2015)
  • Author(s): Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
  • Journal Title: Proc Natl Acad Sci USA Volume: 112 Issue: 13 Pages: 4086-4091
  • DOI: 10.1073/pnas.1417273112
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of PSF1 as a prognostic biomarker for prostate cancer. (2015)
  • Author(s): Tahara H, Naito H, Kise K, Wakabayashi T, Kamoi K, Okihara K, Yanagisawa A, Nakai Y, Nonomura N, Morii E, Miki T, Takakura N
  • Journal Title: Prostate Cancer Prostatic Dis Volume: 18 Issue: 1 Pages: 56-62
  • DOI: 10.1038/pcan.2014.46
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells. (2014)
  • Author(s): Gong Z-Y, Kidoya H, Mohri T, Han Y, Takakura N
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart (2014)
  • Author(s): Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I
  • Journal Title: Nat Commun Volume: 5 Issue: 1 Pages: 4452-4452
  • DOI: 10.1038/ncomms5552
  • Peer Reviewed / Open Access
• [Journal Article] Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity (2014)
  • Author(s): Yamamoto S, Yamazaki T, Komazaki S, Yamashita T, Osaki M, Matsubayashi M, Kidoya H, Takakura N, Yamazaki D, Kakizawa S
  • Journal Title: Dev Biol Volume: 393 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. (2014)
  • Author(s): Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
  • Journal Title: Diabetologia Volume: 57 Pages: 1968-1976
  • NAID: 120005463349
  • Peer Reviewed
• [Journal Article] CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the sternness and drug resistance of malignant cancer cells in the tumor microenvironment. (2014)
  • Author(s): Yumi Kinuoasa, Takahiro Matsui, Nobuyuki Takakura.
  • Journal Title: Stem Cells Volume: 32(1) Issue: 1 Pages: 145-156
  • DOI: 10.1002/stem.1556
  • Peer Reviewed
• [Journal Article] Regulation of niche molecules for the maintenance of cardiac stem cells. (2013)
  • Author(s): Takakura N
  • Journal Title: Circ J. Volume: 78 Pages: 69-70
  • NAID: 130003382197
  • Peer Reviewed
• [Journal Article] Development of novel DNA vaccine for VEGF in murine cancer model. (2013)
  • Author(s): Kyutoku M
  • Journal Title: Sci Rep. Volume: 3 Issue: 1 Pages: 3380-3380
  • DOI: 10.1038/srep03380
  • Peer Reviewed
• [Journal Article] Requirement of SLD5 for Early Embryogenesis. (2013)
  • Author(s): Mohri T
  • Journal Title: PLoS One Volume: 8 Issue: 11 Pages: e78961-e78961
  • DOI: 10.1371/journal.pone.0078961
  • Peer Reviewed
• [Journal Article] Heregulin Induces Resistance to Lapatinib-mediated Growth Inhibition of HER2-Amplified Cancer Cells. (2013)
  • Author(s): Sato Y
  • Journal Title: Cancer Sci Volume: 104 Issue: 12 Pages: 1618-1625
  • DOI: 10.1111/cas.12290
  • Peer Reviewed
• [Journal Article] Tumor endothelial cell-specific drug delivery system using apelin-conjugated liposomes. (2013)
  • Author(s): Kawahara H, Naito H, Takara K, Wakabayashi T, Kidoya H, Takakura N.
  • Journal Title: PLos One Volume: 8 Issue: 6 Pages: e65499-e65499
  • DOI: 10.1371/journal.pone.0065499
  • Peer Reviewed
• [Journal Article] Galectin-3 accelerates m2 macrophage infiltration and angiogenesis in tumors. (2013)
  • Author(s): Jia W
  • Journal Title: Am J Pathol. Volume: 182 Issue: 5 Pages: 1821-1831
  • DOI: 10.1016/j.ajpath.2013.01.017
  • Peer Reviewed
• [Journal Article] Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1. (2013)
  • Author(s): Yamakawa D
  • Journal Title: J Biol Chem. Volume: 288 Issue: 18 Pages: 12469-12477
  • DOI: 10.1074/jbc.m112.433979
  • Peer Reviewed
• [Journal Article] Possible role of mural cell covered mature blood vessels in inducing drug resistance in cancer-initiating cells. (2013)
  • Author(s): Takahiro Matsui, Yumi Kinugasa, Hidekazu Tahara, Yuzuru Kanakura, Nobuyuki Takakura
  • Journal Title: The American Journal of Pathology Volume: 182 Issue: 5 Pages: 1790-1799
  • DOI: 10.1016/j.ajpath.2013.01.019
  • Peer Reviewed
• [Journal Article] Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration. (2013)
  • Author(s): Wakabayashi T, Naito H, Takara K, Kidoya H, Sakimoto S, Oshima Y, Nishida K, Takakura N
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 54 Issue: 10 Pages: 6686-6693
  • DOI: 10.1167/iovs.13-12342
  • Peer Reviewed
• [Journal Article] Critical role of Tribl in differentiation of tissue-resident M2-like macrophages. (2013)
  • Author(s): Satoh T
  • Journal Title: Nature Volume: 495 Pages: 524-528
  • Peer Reviewed
• [Journal Article] An angiogenic role for adrenomedullin in choroidal neovascularization. (2013)
  • Author(s): Sakimoto S, Kidoya H, Kamei M, Naito H, Yamakawa D, Sakaguchi H, Wakabayashi T, Nishida K, Takakura N.
  • Journal Title: PLoS One Volume: 8 Issue: 3 Pages: e58096-e58096
  • DOI: 10.1371/journal.pone.0058096
  • Peer Reviewed
• [Journal Article] Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose Angiopoietin-1 (2013)
  • Author(s): Yamakawa D
  • Journal Title: J Biol Chem Volume: (掲載確定、印刷中)
  • Peer Reviewed
• [Journal Article] Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity. (2013)
  • Author(s): Sawane M
  • Journal Title: Diabetes Volume: (掲載確定、印刷中)
  • Peer Reviewed
• [Journal Article] possible role of mural cell coverd mature blood vessels in inducing drug resistance in cancer-initiating cells. (2013)
  • Author(s): Matsui T
  • Journal Title: Am J Pathol Volume: (掲載確定、印刷中)
  • Peer Reviewed
• [Journal Article] Moqoclonal antibody selectively recognizing murine but not human CD44. (2012)
  • Author(s): Yumi Kinugasa. Nobuyuki Takakura
  • Journal Title: Hybridoma (Larchmt) Volume: 31(4) Issue: 4 Pages: 262-266
  • DOI: 10.1089/hyb.2012.0021
  • Peer Reviewed
• [Journal Article] Biology of the apelin-APJ axis in vascular formation. (2012)
  • Author(s): Kidoya H, Takakura N.
  • Journal Title: J Biochem Volume: 152(2) Issue: 2 Pages: 125-131
  • DOI: 10.1093/jb/mvs071
  • NAID: 10031166121
  • Peer Reviewed
• [Journal Article] A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice (2012)
  • Author(s): Sakimoto S.
  • Journal Title: Development Volume: (In press) Issue: 7 Pages: 1327-1335
  • DOI: 10.1242/dev.072330
  • Peer Reviewed
• [Journal Article] The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy (2012)
  • Author(s): Kidoya H.
  • Journal Title: Oncogene Volume: (In press) Issue: 27 Pages: 3254-64
  • DOI: 10.1038/onc.2011.489
  • Peer Reviewed
• [Journal Article] Essential role of endothelial class II PI3K-C2αin angiogenesis and vascular barrier function (2012)
  • Author(s): Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz JR, Okamoto H, Sasaki T,Matsui O, Asano M, Adams HR, Takakura N, Takuwa Y.
  • Journal Title: Nature med Volume: 18 Issue: 10 Pages: 1560-1569
  • DOI: 10.1038/nm.2928
  • Peer Reviewed
• [Journal Article] Origins and properties of dental, thymic, and bone marrow mesenchymal cells and their stem cells (2012)
  • Author(s): Komada Y, Yamane T, Kadota D, Isono K,Takakura N, Hayashi S, Yamazaki H
  • Journal Title: PLoS One Volume: 7(11) Issue: 11 Pages: e46436-e46436
  • DOI: 10.1371/journal.pone.0046436
  • Peer Reviewed
• [Journal Article] The transcription factor Jun dimerization protein 2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation (2012)
  • Author(s): kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, and Shizuo Akira
  • Journal Title: Immunity Volume: 37 Issue: 6 Pages: 1024-1036
  • DOI: 10.1016/j.immuni.2012.08.022
  • Peer Reviewed
• [Journal Article] microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin (2012)
  • Author(s): Muramatsu F.
  • Journal Title: Oncogene Volume: (In press) Issue: 4 Pages: 414-421
  • DOI: 10.1038/onc.2012.68
  • Peer Reviewed
• [Presentation] 血管のパターン形成メカニズムと組織再生への応用 (2016)
  • Author(s): 髙倉 伸幸
  • Organizer: 第15回日本再生医療学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-03-19
  • Invited
• [Presentation] 低酸素によるがんの悪性伸展を血管の正常化により抑制する (2015)
  • Author(s): 髙倉 伸幸
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-10-30
  • Invited
• [Presentation] Pivotal Role of Apelin/APJ System in Arterial-venous Alignment (2015)
  • Author(s): Nobuyuki Takakura
  • Organizer: 2015 Asia-Australia Vascular Biology Biennale
  • Place of Presentation: 韓国、釜山
  • Year and Date: 2015-10-15
  • Int'l Joint Research / Invited
• [Presentation] Apelin/APJ system regulates parallel juxtapositional alignment of arteries and veins (2015)
  • Author(s): 高倉 伸幸
  • Organizer: The 10th World Congress for Microcirculation
  • Place of Presentation: 京都
  • Year and Date: 2015-09-26
  • Int'l Joint Research / Invited
• [Presentation] Regulation of vascular niche for cancer stem cells (2015)
  • Author(s): 高倉 伸幸
  • Organizer: 「がん微小環境ﾈｯﾄﾜｰｸの統合的研究」国際シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-09-11
  • Int'l Joint Research / Invited
• [Presentation] Molecular mechanism of arterial-venous alignment and its biological significance (2015)
  • Author(s): 高倉 伸幸
  • Organizer: 第21回日本遺伝子治療学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-25
  • Invited
• [Presentation] 血液細胞による血管新生の制御 (2015)
  • Author(s): 高倉 伸幸
  • Organizer: 第36回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-22
  • Invited
• [Presentation] Regulation and maintenance of blood vessels by endothelial stem cells (2015)
  • Author(s): 高倉 伸幸
  • Organizer: 第47回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2015-07-22
  • Invited
• [Presentation] 既存血管における血管内皮幹細胞システムの解明 (2015)
  • Author(s): 高倉伸幸
  • Organizer: 第14回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2015-03-19
  • Invited
• [Presentation] Maintenance of the stemness in cancer stem cells requires CD44 expressed by tumor stromal cells via tissue hypoxia (2015)
  • Author(s): Nobuyuki Takakura
  • Organizer: Joint International Symposium on TGF-β and Cancer
  • Place of Presentation: つくば国際会議場（つくば）
  • Year and Date: 2015-01-13
  • Invited
• [Presentation] Discovery of endothelial stem like cell for the maintenance of blood vessels (2014)
  • Author(s): Nobuyuki Takakura
  • Organizer: CREST International Symposium on Homeodynamics during Development and Diseases
  • Place of Presentation: 八芳園（東京）
  • Year and Date: 2014-12-15
  • Invited
• [Presentation] Regulation of angiogenesis in the tumor microenvironment (2014)
  • Author(s): Nobuyuki Takakura
  • Organizer: The 31st Annual Meeting of the International Society for Heart Research Japanese Section.
  • Place of Presentation: ウインク愛知（名古屋）
  • Year and Date: 2014-11-28
  • Invited
• [Presentation] Discovery of endothelial stem cells and their application in the tissue regeneration (2014)
  • Author(s): Nobuyuki Takakura
  • Organizer: 2014 Annual Meeting of Vascular Science and Medicine Organization at Busan
  • Place of Presentation: Haeundae (海雲臺) Grand Hotel（韓国釜山）
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] がん幹細胞ニッチの形成と制御 (2014)
  • Author(s): 高倉 伸幸
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2014-07-24
  • Invited
• [Presentation] 血管形成と幹細胞制御 (2014)
  • Author(s): 高倉 伸幸
  • Organizer: 第38回日本リンパ学会総会
  • Place of Presentation: 北里大学薬学部コンベンションホール（東京）
  • Year and Date: 2014-06-20
  • Invited
• [Presentation] Censer stemcells and their vascular niche formation (2014)
  • Author(s): Nobuyuki Takakura
  • Organizer: 2014 Korean Society for Biochemistry and Molecular Biology (KSBMB) Annual Meeting
  • Place of Presentation: COEX（韓国・ソウル）
  • Year and Date: 2014-05-16
  • Invited
• [Presentation] Requirement of endothelial stem cell population for the maintenance and reconstitution of blood vessels (2014)
  • Author(s): Nobuyuki Takakura
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: みやこメッセ（京都）
  • Year and Date: 2014-04-17
  • Invited
• [Presentation] New approach for cancer treatment (2014)
  • Author(s): Nobuyuki Takakura
  • Organizer: Asia Partnership Conference of Pharmaceutical Associations
  • Place of Presentation: 帝国ホテル（東京）
  • Year and Date: 2014-04-11
  • Invited
• [Presentation] Tumor mature blood vessel specific drug delivery is required for disruption of cancer stem vascular niche. (2012)
  • Author(s): Nobuyuki Takakura
  • Organizer: 第20回日本血管生物医学会学術集会
  • Place of Presentation: あわぎんホール(徳島)
  • Year and Date: 2012-12-07
• [Presentation] Requirement for perivascular niche for maintenance of cancer stem cells. (2012)
  • Author(s): Nobuyuki Takakura
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(札幌)
  • Year and Date: 2012-09-21
• [Presentation] 血管成熟化過程の分子機構 (2012)
  • Author(s): 高倉 伸幸
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: パシフィコ横浜(横浜)(招待講演)
  • Year and Date: 2012-06-22
• [Presentation] 血管成熟化過程におけるアクセサリー細胞の役割 (2012)
  • Author(s): 高倉 伸幸
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜(横浜)(招待講演)
  • Year and Date: 2012-06-14
• [Presentation] Requirement of endothelial stem-like cells and Tie2-APJ axis for mature blood vessel formation. (2012)
  • Author(s): Nobuyuki Takakura
  • Organizer: The International Vascular Biology Meeting (IVBM)2012
  • Place of Presentation: Rhein-Main-Hallen (ドイツ)(invited speaker)
  • Year and Date: 2012-06-03
• [Presentation] Identification of endothelial stem like cells in preexisting blood vessels. (2012)
  • Author(s): Nobuyuki Takakura
  • Organizer: 2012Suzhou International Symposium on Basic and Translational Vascular Research
  • Place of Presentation: Soochow University (中国)(invited speaker)
  • Year and Date: 2012-05-05
• [Presentation] 血管成熟化による血管病の治療戦略 (2012)
  • Author(s): 高倉 伸幸
  • Organizer: 第49回日本臨床分子医学会学術総会
  • Place of Presentation: みやこめつせ(京都)(招待講演)
  • Year and Date: 2012-04-13
• [Presentation] Identification of endothelial stem like cells in the preexisting blood vessels.
  • Author(s): 高倉 伸幸
  • Organizer: 第8回研究所ネットワーク国際シンポジウム
  • Place of Presentation: 京都市（京都大学・芝蘭会館）
  • Invited
• [Presentation] Growth and maintenance of blood vessels by endothelial stem like cells.
  • Author(s): 高倉 伸幸
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Invited
• [Presentation] 血管の幹細胞システム-オーバービュー
  • Author(s): 高倉 伸幸
  • Organizer: 第21回日本血管生物医学会学術総会
  • Place of Presentation: 大阪府（千里阪急ホテル）
  • Invited
• [Presentation] 血管ニッチと幹細胞性制御
  • Author(s): 高倉 伸幸
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜市(パシフィコ横浜)
  • Invited
• [Presentation] Regulation of angiogenesis in vascular diseases.
  • Author(s): 高倉 伸幸
  • Organizer: 12th US-Japan Symposium on Drug Delivery Systems（
  • Place of Presentation: Hawaii, USA
  • Invited
• [Presentation] 内皮幹細胞による血管の形成と維持
  • Author(s): 高倉 伸幸
  • Organizer: 第13回日本再生医療学会総会
  • Place of Presentation: 京都市（国立京都国際会館）
  • Invited
• [Remarks]
  • URL: http://st.biken.osaka-u.ac.jp/
• [Remarks] 大阪大学微生物病研究所情報伝達分野
  • URL: http://st.biken.osaka-u.ac.jp/
• [Remarks] 大学ホームページ
  • URL: http://st.biken.osaka-u.ac.jp/
• [Remarks]
  • URL: http://st.biken.osaka-u.ac.jp/