Dissecting genetic basis for competitive regulation of tumorigenesis
| Project/Area Number |
24300331
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kyoto University (2013-2014)
Kobe University (2012) |
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Principal Investigator |
IGAKI Tatsushi 京都大学, 生命科学研究科, 教授 (00467648)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | がん / 細胞間コミュニケーション / 細胞競合 / ショウジョウバエ / 細胞・組織 / シグナル伝達 / 遺伝学 / 癌 |
|---|
| Outline of Final Research Achievements |
In Drosophila imaginal epithelium, clones of cells deficient for apico-basal polarity are actively eliminated from the tissue as “losers” of cell competition. During cancer development and progression, such loser cells would acquire further mutations that convert them from “losers” to “winners”. In this study, we found that JNK-mediated regulation of the Hippo pathway component Warts plays a important role in the loser-to-winner switching of the oncogenic mutant cells. Furthermore, we searched through a Drosophila genetic screen for genes involved in the loser-to-winner switching and identified a cell-surface ligand and its receptor, as well as a series of genes involved in neuronal axon guidance, as responsible genes for the competitive regulation of tumorigenesis.
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Report
(4 results)
Research Products
(60 results)
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[Presentation] 細胞競合によるがん制御2013
Author(s)
井垣 達吏
Organizer
第118回日本解剖学会総会全国学術集会
Place of Presentation
かがわ国際会議場(高松)(招待講演)(口頭発表)
Year and Date
2013-03-30
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