| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
In Drosophila imaginal epithelium, clones of cells deficient for apico-basal polarity are actively eliminated from the tissue as “losers” of cell competition. During cancer development and progression, such loser cells would acquire further mutations that convert them from “losers” to “winners”. In this study, we found that JNK-mediated regulation of the Hippo pathway component Warts plays a important role in the loser-to-winner switching of the oncogenic mutant cells. Furthermore, we searched through a Drosophila genetic screen for genes involved in the loser-to-winner switching and identified a cell-surface ligand and its receptor, as well as a series of genes involved in neuronal axon guidance, as responsible genes for the competitive regulation of tumorigenesis.
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