Dissecting molecular mechanisms mediating human breast cancer metastasis
| Project/Area Number |
24300332
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Juntendo University |
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Principal Investigator |
orimo akira 順天堂大学, 医学(系)研究科(研究院), 准教授 (70275866)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Mitsue 順天堂大学, 医学部, 教授 (30205679)
HORIMOTO Yoshiya 順天堂大学, 医学部, 准教授 (40424246)
小坂 泰二郎 順天堂大学, 医学部, 助教 (40398681)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 癌微小環境 / 癌転移 / CAFｓ / 細胞接着 / ＣＡＦｓ / 転移 / 癌浸潤・転移 / 浸潤・転移 / 乳癌 / 癌内線維芽細胞 / 上皮間葉移行 |
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| Outline of Final Research Achievements |
CAFs predominantly present within the tumor-associated stroma. However, roles of CAFs on tumor malignancy haven’t fully understood yet at molecular levels. The invasion-metastatic cascade is composed of a series of multi-step processes and epi/genetic alterations are believed to be largely responsible for ability of cancer cells to metastasize. Recent emerging evidence also supports the notion that cancer metastasis depends on non-cell autonomous effect of nearby stromal cells. Here we show that CAFs induce highly metastatic ability into barely metastatic breast cancer cells via conferring self-stimulating autocrine signaling mediated by some cell adhesion molecules. These factors importantly promote cell-cell adhesions in carcinoma cells that can facilitate their metastatic dissemination and associated with poorer outcome in breast cancer patients. Taken together, these findings strongly suggest crucial roles of CAFs on promotion of tumor malignancy.
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.2016
Author(s)
Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM.
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Journal Title
Oncogene
Volume: 11
Pages: 1-1
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and CD8+ T cells is associated with better prognosis of breast cancer patients.2015
Author(s)
Englund E, Reitsma B, King BC, Escudero-Esparza A, Owen S, Orimo A, Okroj M, Anagnostaki L, Jiang WG, Jirström K, Blom AM.
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Journal Title
BMC Cancer,
Volume: 19
Pages: 737-737
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and CD8+ T cells is associated with better prognosis of breast cancer patients.2015
Author(s)
Englund E, Reitsma B, King BC, Escudero-Esparza A, Owen S, Orimo A, Okroj M, Anagnostaki L, Jiang WG, Jirström K, Blom AM
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Journal Title
BMC Cancer,
Volume: 19
Pages: 737-737
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Book] 呼吸2016
Author(s)
伊藤匠、松村優子、伊藤恭彦、折茂彰
Total Pages
94
Publisher
呼吸研究
Related Report
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[Book] 呼吸器内科2015
Author(s)
折茂彰, 松村優子，伊藤恭彦，十合晋作
Total Pages
87
Publisher
科学評論社
Related Report
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[Book] 細胞工学2014
Author(s)
松村優子，伊藤恭彦，折茂彰
Total Pages
586
Publisher
学研メディカル秀潤社
Related Report
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