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Development of new cancer immunotherapy aiming activation of both anti-tumor killer and helper T cells

Research Project

Project/Area Number 24300334
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Tumor immunology
Research InstitutionKumamoto University

Principal Investigator

NISHIMURA Yasuharu  熊本大学, 大学院生命科学研究部, 教授 (10156119)

Co-Investigator(Kenkyū-buntansha) IRIE Atsushi  熊本大学, 大学院生命科学研究部, 講師 (30250343)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsがん免疫療法 / がん抗原 / ペプチドワクチン / キラーT細胞 / ヘルパーT細胞 / iPS細胞 / キラーT細胞 / ヘルパーT細胞 / ヒトiPS細胞 / iPS樹状細胞 / 人工抗原提示細胞
Outline of Final Research Achievements

Two tumor-associated antigens, LY6K- and IMP3-derived long peptides (LP) that can be presented to CD4+ type 1 T helper (Th1) cells through multiple HLA class II molecules frequently observed in the Japanese population were identified. Using HLA-A2/A24-transgenic mice, vaccination of those LPs including short peptides (SP) that can activate tumor-reactive cytotoxic T lymphocytes (CTL) more efficiently induced CTLs than SP-vaccination did, suggesting the effectiveness of LPs for the improvement of anti-tumor immunotherapy.
Aiming the sufficient supply of antigen presenting cells, a protocol to produce large amount of dendritic cells (DC) from proliferative myeloid-lineage cells (ML) derived from human iPS cells was established. Furthermore, using the TAP-deficient ML, iPS-ML-DC that can escape from the recognition by the alloreactive CTLs was established. These iPS-ML-DC could efficiently present antigenic peptides to both CTLs and Th cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (54 results)

All 2015 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 14 results,  Open Access: 7 results,  Acknowledgement Compliant: 4 results) Presentation (29 results) (of which Invited: 3 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] A clinical trial of multiple peptides vaccination for advanced head and neck cancer patients induced immune responses and prolonged OS.2015

    • Author(s)
      Yoshitake, Y., Nishimura Y., Nakamura Y., and Shinohara, M.
    • Journal Title

      OncoImmunology

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer immunotherapy using novel tumor-associated antigenic peptides identified by genome-wide cDNA microarray analyses.2015

    • Author(s)
      Nishimura, Y., Tomita, Y., Yuno, A., Yoshitake, Y., and Shinohara, M.
    • Journal Title

      Cancer Science

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells.2015

    • Author(s)
      Zhang, R., Liu, T-Y, Senju, S., Haruta, M., Hirosawa, N., Suzuki, M., Tatsumi, M., Ueda, N., Maki, H., Nakatsuka, R., Matsuoka, Y., Sasaki, Y., Tsuzuki, S., Nakanishi, H., Araki, R., Abe, M., Akatsuka, Y., Sakamoto, Y., Sonoda, Y., Nishimura, Y., Kuzushima, K. and Uemura, Y.
    • Journal Title

      Cancer Immunology Res.

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS2015

    • Author(s)
      Yoshitake, Y., Fukuma, D., Yuno, A., Hirayama, M., Nakayama, H., Tanaka. T., Nagata, M., Takamune, Y., Kawahara, K., Nakagawa, Y., Yoshida, R., Hirosue, A., Ogi, H., Hiraki, A. , Jono, H., Hamada, A., Yoshida, K., Nishimura, Y., Nakamura, Y., Shinohara, M.
    • Journal Title

      Clinical Cancer Research

      Volume: 21 Issue: 2 Pages: 312-321

    • DOI

      10.1158/1078-0432.ccr-14-0202

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of immunogenic LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes and eliciting CD4+ T-cell immunity in patients with malignant disease.2014

    • Author(s)
      Tomita, Y., Yuno, A., Tsukamoto, H., Senju, S., Kuroda, Y., Hirayama, M., Imamura, Y., Yatsuda, J., Sayem, M. A., Irie, A., Hamada A., Jono, H., Yoshida, K., Tsunoda, T, Daigo, Y., Kohrogi, H., Yoshitake, Y., Nakamura,Y., Shinohara, M. and Nishimura, Y.
    • Journal Title

      OncoImmunology

      Volume: 3 Issue: 3 Pages: e28100-e28100

    • DOI

      10.4161/onci.28100

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapy of peritoneally disseminated colon cancer by TAP-deficient ES cell-derived macrophages in allogeneic recipients.2014

    • Author(s)
      Haga, E., Endo, Y., Haruta, M., Koba, C., Matsumura, K., Takamatsu, K., Ikeda, T., Nishimura, Y., and Senju, S.
    • Journal Title

      Journal of Immunotherapy

      Volume: 193 Pages: 2024-2033

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.2014

    • Author(s)
      13.Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.da, T., Hirata, S., Takamatsu, K., Haruta, M., Tsukamoto, H., Ito, T., Uchino, M., Ando, Y., Nagafuchi, S., Nishimura, Y., Senju, S.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 12 Pages: e115198-e115198

    • DOI

      10.1371/journal.pone.0115198

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Application of iPS cell-derived macrophages to cancer therapy.2014

    • Author(s)
      Senju, S., Koba, C., Haruta, M., Matsunaga, Y., Matsumura, K., Haga, E., Sasaki, Y., Ikeda, T., Takamatsu, K., and Nishimura, Y.
    • Journal Title

      OncoImmunology

      Volume: 14 Issue: 3 Pages: e27927-e27927

    • DOI

      10.4161/onci.27927

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of CDCA1-derived long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients2014

    • Author(s)
      Tomita Y, Yuno A, Tsukamoto H, Senju S, Yoshimura S, Osawa R, Kuroda Y, Hirayama M, Irie A, Hamada A, Jono H, Yoshida K, Tsunoda T, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, Nishimura Y
    • Journal Title

      Int J Cancer

      Volume: 134 Issue: 2 Pages: 352-366

    • DOI

      10.1002/ijc.28376

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTLとTh1細胞を同時に活性化できるがん抗原ペプチドワクチン療法の開発2014

    • Author(s)
      湯野 晃、冨田雄介、西村泰治
    • Journal Title

      がん分子標的治療

      Volume: 12 Pages: 65-70

    • Related Report
      2013 Annual Research Report
  • [Journal Article] iPS細胞から分化させた樹状細胞とマクロファージによるがん治療2014

    • Author(s)
      千住 覚、西村泰治
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 61 Pages: 303-310

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Long peptides-based cancer immunotherapy targeting both tumor antigen-specific CD4+ and CD8+ T cells through cross-presentation.2013

    • Author(s)
      Tomita, Y., and Nishimura, Y.
    • Journal Title

      OncoImmunology

      Volume: 2 Issue: 9 Pages: e25801-e25801

    • DOI

      10.4161/onci.25801

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TAP-deficient human iPS cell-derived myloid cell lines as unlimited cell source for dendritic cell-like antigen presenting cells.2013

    • Author(s)
      Haruta, M. et al.
    • Journal Title

      Gene Therapy

      Volume: 20 Issue: 5 Pages: 504-513

    • DOI

      10.1038/gt.2012.59

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of human iPS-cell–derived myeloid cells expressing IFN-β against peritoneally disseminated cancer in xenograft models.2013

    • Author(s)
      Koba, C., Haruta, M., Matsunaga, Y., Matsumura, K., Haga, E., Sasaki, Y., Ikeda, T., Takamatsu, K., Nishimura, Y., and Senju, S.
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 6 Pages: e67567-e67567

    • DOI

      10.1371/journal.pone.0067567

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a large number of functional dendritic cells from human monocytes expanded by forced expression of cMYC plus BMI1.2013

    • Author(s)
      Haruta, M., Tomita, Y., Imamura, Y., Matsumura, K., Ikeda, T., Takamatsu, K., Nishimura,Y., and Senju, S.
    • Journal Title

      Human Immunol

      Volume: 74 Issue: 10 Pages: 1400-1408

    • DOI

      10.1016/j.humimm.2013.05.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] cDNAマイクロアレイ解析とHALトランスジェニックマウスを利用した理想的な腫瘍抗原ペプチドワクチン療法の開発2013

    • Author(s)
      冨田雄介、西村泰治
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 785-793

    • Related Report
      2013 Annual Research Report
  • [Journal Article] HLA多型を考慮したがん免疫療法の開発2013

    • Author(s)
      千住 覚、冨田雄介、入江厚、西村泰治
    • Journal Title

      血液フロンティア

      Volume: 23 Pages: 1081-1089

    • NAID

      130004647538

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Myeloid-derived suppressor cells attenuate Th1 development through IL-6 during tumor progression.2013

    • Author(s)
      Tsukamoto, H., Nishikata, R., Senju, S. and Nishimura, Y.
    • Journal Title

      Cancer. Immunol. Res.

      Volume: 1 Issue: 1 Pages: 64-76

    • DOI

      10.1158/2326-6066.cir-13-0030

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] cDNAマイクロアレイ解析とHLAトランスジェニツクマウスを利用した理想的な腫瘍抗原ペプチドワクチン療法の開発2013

    • Author(s)
      冨田雄介、西村泰治
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 785-793

    • Related Report
      2012 Annual Research Report
  • [Journal Article] HLA多型を考慮したがん免疫療法の開発(日本組織適合性学会誌 20号)2013

    • Author(s)
      冨田雄介、千住覚、入江厚、西村泰治
    • Journal Title

      日本組織適合性学会誌

      Volume: 20 Pages: 45-56

    • Related Report
      2012 Annual Research Report
  • [Presentation] An IMP-3-derived long peptide encompassing CTL and promiscuous Th cell epitopes can be efficiently cross-presented by using a novel liposome.2014

    • Author(s)
      Hirayama, M., Tomita, Y., Yuno, A., Mohammad Abu Sayem.,Tsukamoto, H., Senju, S., Yoshitake, Y., Shinohara, M., Nishimura, Y.
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      京都国際会議場(京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Efficient crosspresentaion of TAA-derived long peptides encompassing CTL and promiscuous Th cell epitopes using a novel liposome2014

    • Author(s)
      Md Abu Sayem, Tomita, Y., Yuno, A., Hirayama, M., Tsukamoto, H., Senju, S., Nakatsura, T., Nishimura, Y.
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      京都国際会議場(京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cancer Immunotherapy Using Novel Tumor-associated Antigenic Peptides and Human iPS Cell-derived Dendritic Cells2014

    • Author(s)
      Yasuharu Nishimura
    • Organizer
      45th International Symposium of the Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      パレスホテル(東京都)
    • Year and Date
      2014-11-18 – 2014-11-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 癌胎児性抗原IMP-3由来のCTLとTh細胞の誘導活性を併せ持つ癌抗原ペプチドの同定2014

    • Author(s)
      平山真敏、冨田雄介、湯野晃、塚本博丈、千住覚、MD Abu Sayem、吉武義泰、濱田哲暢、城野博史、角田卓也、中村祐輔、篠原正徳、西村泰治
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腫瘍関連抗原特異的なCTLとTh1細胞を活性化するTh細胞エピトープの同定2014

    • Author(s)
      湯野晃、冨田雄介、平山真敏、福間大喜、吉武義泰、尾木秀直、中山秀樹、平木昭光、角田卓也、醍醐弥太郎、中村祐輔、西村泰治、篠原正徳
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 癌胎児性抗原IMP-3由来のCTLとTh1細胞の誘導活性を併せ持つ単一癌抗原ペプチドの同定2014

    • Author(s)
      平山真敏、冨田雄介、湯野晃、塚本博丈、千住覚、Mohammad Abu Sayem、吉武義泰、福間大喜、吉田浩二、角田卓也、中村祐輔、篠原正徳、西村泰治
    • Organizer
      第23回日本組織適合性学会大会
    • Place of Presentation
      長崎大学医学部・坂本キャンパス(長崎市)
    • Year and Date
      2014-09-13 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Promiscuous oncoantigenic long peptides activating both tumor-reactive Th1 cells and CTLs2014

    • Author(s)
      Yasuharu NISHIMURA, Yusuke TOMITA, Akira YUNO, Hirotake TSUKAMOTO, Satoru SENJUU, Atsushi IRIE, Yasuhiro KURODA, Akinobu HAMADA, Hirofumi JONO, Koji YOSHIDA, Takuya TSUNODA, Yoshihiro YOSHITAKE, Yusuke NAKAMURA, Masanori SHINOHARA
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 癌胎児性抗原IMP-3由来のCTLとTh1細胞の誘導活性を併せ持つ単一癌抗原ペプチドの同定2014

    • Author(s)
      平山真敏、冨田雄介、湯野晃、塚本博丈、千住覚、Mohammad Abu Sayem、吉武義泰、福間大喜、角田卓也、吉田浩二、中村祐輔、篠原正徳、西村泰治
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Long peptide-based cancer immunotherapy targeting both tumor antigen-specific CTLs and Th1 cells2014

    • Author(s)
      Yasuharu Nishimura
    • Organizer
      Cancer Immunotherapy Annual Meeting
    • Place of Presentation
      Rheingold Halle Congress Center, Mainz, Germany
    • Year and Date
      2014-05-06 – 2014-05-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cancer testis antigens-specific CD4+ T-cell immunity augmented by CTL-epitopes vaccination in cancer patients.2013

    • Author(s)
      Tomita, Y., Yuno, A., Yoshitake, Y., Tsukamoto, H., Irie, A., Senju, S., Yoshida, K., Tsunoda, T., Nakamura, Y., Shinohara, M., Nishimura, Y.
    • Organizer
      AACR (American Association for Cancer Research) Annual Meeting 2013
    • Place of Presentation
      Walter E. Washington Convention Center(アメリカ合衆国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] TAP2欠損iPS-MLを基盤とするあらゆるHLA型に対応可能な樹状細胞産生システム2013

    • Author(s)
      千住 覚、春田 美和、冨田 雄介、湯野 晃、松村 桂子、池田 徳典、西村 泰治
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Th1/CTLエピトープが共存する新規CT抗原ペプチドの同定とCTL誘導ペプチド接種患者における特異的Th細胞の増加2013

    • Author(s)
      西村 泰治、冨田 雄介、湯野 晃、塚本 博丈、千住 覚、入江 厚、黒田 泰弘、濱田 哲暢、吉田 浩二、角田 卓也、吉武 義泰、中村 祐輔、篠原 正徳
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cancer therapy with human iPS cell-derived immune cells.2013

    • Author(s)
      Senju, S., Haruta, M., Matsumura, K., and Nishimura, Y.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん抗原ペプチドを用いたがん免疫療法の橋渡し研究2012

    • Author(s)
      西村 泰治
    • Organizer
      第50回熊本大学大学院生命科学研究部・化血研ジョイントセミナー
    • Place of Presentation
      熊本大学
    • Year and Date
      2012-12-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] Developmental of HLA-DR4 transgenic mice useful for identification of CD4+T cell epitope of tumor-associated antigens.2012

    • Author(s)
      矢津田 旬二
    • Organizer
      第41回日本免疫学会学術総会2012年12月5日
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of a promiscuous LY6K-derived CD4+T cell epitopethat can induce CTLs both in vitro and in vivo.2012

    • Author(s)
      湯野 晃
    • Organizer
      第41回日本免疫学会学術総会2012年12月5日
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2012-12-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cancer Immunotherapy Using Ideal Tumor-Associated Antigenic Peptidesand Human iPS Cell-Derived Dendritic Cells.2012

    • Author(s)
      Senju, S., et al.
    • Organizer
      Centennial of Hashimoto Disease
    • Place of Presentation
      アクロス福岡(福岡市)
    • Year and Date
      2012-12-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] 理想的がん抗原のCTLエピトープを含むTh1細胞エピトープペプチドによる効率良い抗腫瘍免疫の誘導2012

    • Author(s)
      西村 泰治
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規癌精巣抗原LY6K由来のCTL誘導活性を有するTh1細胞エピトープの同定2012

    • Author(s)
      湯野 晃
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] CD4+T細胞が認識するがん抗原ペプチドを迅速に同定できるHLA-DR4トランスジェニックマウスの樹立2012

    • Author(s)
      矢津田 旬二
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] HLA-DR4拘束性CD4+Th細胞に抗原提示機能を有するHLA-DR4トランスジェニツクマウスの樹立2012

    • Author(s)
      入江 厚
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学(東京都)
    • Year and Date
      2012-09-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腫瘍関連抗原CDCA1由来のCTL誘導活性を併せ持つヘルパーT細胞エピトープの同定2012

    • Author(s)
      冨田 雄介
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-07-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規癌精巣抗原LY6K由来のCTL誘導活性を有するTh1細胞エピトープの同定2012

    • Author(s)
      湯野 晃
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-07-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Establishment of HLA-DR4 (HLA-DRA/HLA-DRB1*04:05) transgenic miceuseful for rapid screening of HLA-DR4-restricted CD4+ T cell epitopePeptides2012

    • Author(s)
      入江 厚
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-07-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] がん免疫療法の臨床橋渡し研究の進展-我々の経験から-2012

    • Author(s)
      中面 哲也
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-07-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] TAP-deficient human iPS cell-derived myeloid cell lines as cell sourcefor dendritic cells.2012

    • Author(s)
      Senju, S., et al.
    • Organizer
      International Society for Stem Cell Research10th Annual Meeting,
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2012-06-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cancer immunotherapy using ideal tumor-associated antigenic peptidesand human iPS cell-derived dendritic cells2012

    • Author(s)
      Nishimura, Y., et al.
    • Organizer
      The 16th International HLA and ImmunogeneticsConference
    • Place of Presentation
      BT Convention Centre(英国・リバプール)
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Targeted disruption of the TAP2 gene in human iPS cells and generationof an infinite dendritic cell source that is applicable to vaccination therapyirrespective of HLA types of the patients2012

    • Author(s)
      Senju, S., et al.
    • Organizer
      The 16th International HLA and ImmunogeneticsConference
    • Place of Presentation
      BT Convention Centre(英国・リバプール)
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of novel tumor-associated antigenic peptides recognized bytumor-reactive and HLA-A2- or A24-restricted cytotoxic T-lymphocytesuseful for immunotherapy of lung cancer.2012

    • Author(s)
      Tomita, Y., et al
    • Organizer
      The 16th International HLA and ImmunogeneticsConference
    • Place of Presentation
      BT Convention Centre(英国・リバプール)
    • Year and Date
      2012-06-01
    • Related Report
      2012 Annual Research Report
  • [Remarks] 熊本大学大学院生命科学研究部 免疫識別学分野

    • URL

      http://www.immgenet.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 熊本大学大学院生命科学研究部免疫識別学分野

    • URL

      http://www.immgenet.jp/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] GPC3 EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING THE SAME2014

    • Inventor(s)
      西村泰治、冨田雄介、大沢龍司
    • Industrial Property Rights Holder
      西村泰治、冨田雄介、大沢龍司
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] CDCA1 EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING THE SAME2013

    • Inventor(s)
      西村泰治、冨田雄介、大沢龍司
    • Industrial Property Rights Holder
      オンコセラピー・サイエンス株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-09
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] LY6K epitope peptides for Th1cells and vaccines containing the same2012

    • Inventor(s)
      西村泰治、冨田雄介、大沢隆司
    • Industrial Property Rights Holder
      オンコセラピー・サイエンス株式会社
    • Filing Date
      2012-07-10
    • Related Report
      2012 Annual Research Report
    • Overseas

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Published: 2012-04-24   Modified: 2019-07-29  

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