| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
We observed strong association between rs10509373 in C10orf11 and clinical outcome of 240 patients treated with tamoxifen through genome-wide association study. To clarify the function of C10orf11, whose function is unknown, we carried out some assays for investigation of gene expression of C10orf11, the effect on cell growth and screening of the interacting protein. We did not observe the expression of this gene in normal human tissues except adrenal gland, nor its effect on the cell growth. However, C10orf11 was suggested to be related to the wnt signaling in breast cancer. Further analysis focusing on the relationship between wnt signaling and estrogen receptor would clarify the mechanism of regulation of sensitivity to tamoxifen.
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