Use of maternal blood and the umbilical cord for the assessment of fetal exposure to multiple chemicals: implications for future generations

• Project/Area Number: 24310021
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental impact assessment/Environmental policy
• Research Institution: Chiba University
• Principal Investigator: MORI Chisato 千葉大学, 医学(系)研究科(研究院), 教授 (90174375)
• Co-Investigator(Kenkyū-buntansha): KOMIYAMA Masatoshi 千葉大学, 大学院看護学研究科, 教授 (70175339) ; TODAKA Emiko 千葉大学, 予防医学センター, 教授 (30334212) ; HANAZATO Masamichi 千葉大学, 予防医学センター, 准教授 (00608656) ; MATSUNO Yoshiharu 千葉大学, 予防医学センター, 准教授 (00376378) ; NAKAOKA Hiroko 千葉大学, 予防医学センター, 助教 (60588648)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 環境影響評価 / 科学物質 / 次世代影響 / 複合曝露 / 化学物質

Outline of Final Research Achievements

In this study, we aimed to assess the levels of polychlorinated biphenyl (PCB) in the maternal blood (serum PCB) to ascertain fetal exposure to multiple chemicals. We studied 419 mothers in early pregnancy, with mean age being 30.36 ± 5.30 years. The mean level of PCB in maternal blood was 0.26 ± 0.13 ng/g-wet. The PCB levels correlated with increasing age of the mother. However, we were unable to clearly differentiate the PCB levels between nulliparous and multiparas.

Research Products

• [Presentation] Do PCBs, OCPs, and dioxin-like compounds with high molecular weight decrease human maternal-fetal placental transfer rates? (2014)
  • Author(s): Masamichi Hanazato,Akifumi Eguchi,Emiko Todaka,Yoshiharu Matsuno,Hiroko Nakaoka,Chie Koga,Chisato Mori
  • Organizer: 34th International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: Madrid,Spain
  • Year and Date: 2014-08-31 – 2014-09-05
• [Presentation] Correlations between maternal-fetal transfer rates and physico-chemical properties of PCBs, OCPs, PBDEs, and dioxin-like compounds (2014)
  • Author(s): Akifumi Eguchi,Masamichi Hanazato,Norimichi Suzuki,Yoshiharu Matsuno,Chisato Mori
  • Organizer: 34th International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: Madrid,Spain
  • Year and Date: 2014-08-31 – 2014-09-05
• [Presentation] Possibility of high-exposure group sampling regarding PCB and POPs from questionnaire in birth cohort study (2013)
  • Author(s): E. Todaka, et'al
  • Organizer: Society of Toxicology 2013
  • Place of Presentation: Henry B Gonzalez Convention Center. USA
  • Year and Date: 2013-03-14
• [Presentation] Relationship between blood Polychlorinated Biphenyl level and distance towards the nearest fishing port: A Birth Cohort Study (2013)
  • Author(s): M. Hanazato, M. Watanabe, E. Todaka, Y. Matsuno, H. Nakaoka, C. Mori
  • Organizer: 8th World Congress on Developmental Origins of Health and Disease - DOHaD 2013
  • Place of Presentation: Singapore
• [Presentation] Relationship between seafood intake, residential area and blood PCB level among pregnant women in Chiba Prefecture, Japan (2013)
  • Author(s): M. Hanazato, N. Suzuki, C. Koga, M. Otake,M. Watanabe, E. Todaka,M. Yamamoto, H. Nakaoka and C. Mori
  • Organizer: 環境ホルモン学会第16回研究発表会
  • Place of Presentation: 東京